{"id":"https://openalex.org/W7224109672","doi":"https://doi.org/10.1097/fjc.0000000000001896","title":"Prognostic Value of Non-Invasive Hepatic Fibrosis Scores Across Acute Coronary Syndrome Subtypes","display_name":"Prognostic Value of Non-Invasive Hepatic Fibrosis Scores Across Acute Coronary Syndrome Subtypes","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224109672","doi":"https://doi.org/10.1097/fjc.0000000000001896","pmid":"https://pubmed.ncbi.nlm.nih.gov/42949435"},"language":"en","primary_location":{"id":"doi:10.1097/fjc.0000000000001896","doi":"https://doi.org/10.1097/fjc.0000000000001896","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fjc.0000000000001896","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103100435","display_name":"A. Kaya","orcid":"https://orcid.org/0000-0003-0544-0657","observed_orcids":["https://orcid.org/0000-0003-0544-0657"]},"institutions":[{"id":"https://openalex.org/I1303077703","display_name":"Ministry of Health","ror":"https://ror.org/00pkvys92","country_code":"TR","type":"government","lineage":["https://openalex.org/I1303077703"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ahmet Ferhat Kaya","raw_affiliation_strings":["Department of Cardiology, Van Regional Education and Research Hospital, Van, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Van Regional Education and Research Hospital, Van, Turkey","institution_ids":["https://openalex.org/I1303077703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089071667","display_name":"Fuat Polat","orcid":"https://orcid.org/0000-0002-6414-3743","observed_orcids":["https://orcid.org/0000-0002-6414-3743"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fuat Polat","raw_affiliation_strings":["Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Education Research Hospital, \u0130stanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-6414-3743","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Education Research Hospital, \u0130stanbul, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076974856","display_name":"G\u00f6rkem Ayhan","orcid":"https://orcid.org/0000-0002-6682-5414","observed_orcids":["https://orcid.org/0000-0002-6682-5414"]},"institutions":[{"id":"https://openalex.org/I1303077703","display_name":"Ministry of Health","ror":"https://ror.org/00pkvys92","country_code":"TR","type":"government","lineage":["https://openalex.org/I1303077703"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00f6rkem Ayhan","raw_affiliation_strings":["Department of Cardiology, Van Regional Education and Research Hospital, Van, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Van Regional Education and Research Hospital, Van, Turkey","institution_ids":["https://openalex.org/I1303077703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073782918","display_name":"Furkan Yetmi\u015f","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Furkan Yetmi\u015f","raw_affiliation_strings":["Department of Cardiology, Mu\u015f State Hospital, Mu\u015f, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Mu\u015f State Hospital, Mu\u015f, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116816319","display_name":"Emrah \u00d6zbek","orcid":"https://orcid.org/0000-0003-0724-6700","observed_orcids":["https://orcid.org/0000-0003-0724-6700"]},"institutions":[{"id":"https://openalex.org/I1303077703","display_name":"Ministry of Health","ror":"https://ror.org/00pkvys92","country_code":"TR","type":"government","lineage":["https://openalex.org/I1303077703"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Emrah \u00d6zbek","raw_affiliation_strings":["Department of Cardiology, Van Regional Education and Research Hospital, Van, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Van Regional Education and Research Hospital, Van, Turkey","institution_ids":["https://openalex.org/I1303077703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158484518","display_name":"Veysi Can","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1303077703","display_name":"Ministry of Health","ror":"https://ror.org/00pkvys92","country_code":"TR","type":"government","lineage":["https://openalex.org/I1303077703"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Veysi Can","raw_affiliation_strings":["Department of Cardiology, Van Regional Education and Research Hospital, Van, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Van Regional Education and Research Hospital, Van, Turkey","institution_ids":["https://openalex.org/I1303077703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028008617","display_name":"\u00d6mer K\u00fcmet","orcid":"https://orcid.org/0000-0001-5369-5414","observed_orcids":["https://orcid.org/0000-0001-5369-5414"]},"institutions":[{"id":"https://openalex.org/I1303077703","display_name":"Ministry of Health","ror":"https://ror.org/00pkvys92","country_code":"TR","type":"government","lineage":["https://openalex.org/I1303077703"]},{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00d6mer K\u00fcmet","raw_affiliation_strings":["Department of Cardiology, Van Regional Education and Research Hospital, Van, Turkey","Sa\u011fl\u0131k Bilimleri \u00dcniversitesi, \u0130stanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Van Regional Education and Research Hospital, Van, Turkey","institution_ids":["https://openalex.org/I1303077703"]},{"raw_affiliation_string":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I4210128276"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080373663","display_name":"Adem Aktan","orcid":"https://orcid.org/0000-0003-0505-9784","observed_orcids":["https://orcid.org/0000-0003-0505-9784"]},"institutions":[{"id":"https://openalex.org/I217764696","display_name":"Mardin Artuklu University","ror":"https://ror.org/0396cd675","country_code":"TR","type":"education","lineage":["https://openalex.org/I217764696"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Adem Aktan","raw_affiliation_strings":["Department of Cardiology, Mardin Artuklu University, Mardin, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Mardin Artuklu University, Mardin, Turkey","institution_ids":["https://openalex.org/I217764696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85472119,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.11990000307559967,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.11490000039339066,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.8849999904632568},{"id":"https://openalex.org/keywords/apri","display_name":"APRI","score":0.7400000095367432},{"id":"https://openalex.org/keywords/fib-4-index","display_name":"FIB-4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/in-hospital-mortality","display_name":"in-hospital mortality","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cardiogenic-shock","display_name":"cardiogenic shock","score":1.0},{"id":"https://openalex.org/keywords/st-elevation-myocardial-infarction","display_name":"ST-elevation myocardial infarction","score":0.9309999942779541},{"id":"https://openalex.org/keywords/non-st-elevation-myocardial-infarction","display_name":"non-ST-elevation myocardial infarction","score":0.9750000238418579},{"id":"https://openalex.org/keywords/unstable-angina","display_name":"unstable angina","score":0.9150000214576721},{"id":"https://openalex.org/keywords/acute-myocardial-injury","display_name":"acute myocardial injury","score":0.9169999957084656},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7620000243186951},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.7979999780654907},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.9710000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8909000158309937},{"id":"https://openalex.org/C2776850375","wikidata":"https://www.wikidata.org/wiki/Q2477062","display_name":"Cardiogenic shock","level":3,"score":0.8601999878883362},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.838699996471405},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7251999974250793},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.6891999840736389},{"id":"https://openalex.org/C2777785093","wikidata":"https://www.wikidata.org/wiki/Q2032041","display_name":"Unstable angina","level":3,"score":0.5098999738693237},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4706000089645386},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.430400013923645},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.40709999203681946},{"id":"https://openalex.org/C2778425758","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Angina","level":3,"score":0.40119999647140503},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.398499995470047},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.3871999979019165},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.37119999527931213},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.3057999908924103},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.29820001125335693},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.2816999852657318},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C2993958921","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Stable angina","level":3,"score":0.25130000710487366}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/fjc.0000000000001896","doi":"https://doi.org/10.1097/fjc.0000000000001896","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fjc.0000000000001896","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:42949435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42949435","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4317233296","https://openalex.org/W4413892464","https://openalex.org/W4290973239","https://openalex.org/W4317233350","https://openalex.org/W4413329881","https://openalex.org/W4200432509","https://openalex.org/W4306320342","https://openalex.org/W4324333277","https://openalex.org/W7167079807","https://openalex.org/W4413941446"],"abstract_inverted_index":{"Hepatic":[0],"fibrosis":[1,147,174],"indices":[2,60,148],"have":[3],"emerged":[4],"as":[5],"potential":[6],"prognostic":[7,193],"markers":[8],"in":[9,115,178,199],"cardiovascular":[10],"disease.":[11],"This":[12],"observational":[13],"study":[14],"included":[15],"760":[16],"consecutive":[17],"patients":[18,78,106,200],"with":[19,201],"acute":[20,186,202],"coronary":[21,203],"syndrome":[22],"(STEMI,":[23],"NSTEMI,":[24],"and":[25,33,44,49,56,67,71,94,103,111,117,129,153,163],"unstable":[26,104],"angina":[27,105],"pectoris)":[28],"admitted":[29],"between":[30],"March":[31],"2020":[32],"May":[34],"2024":[35],"to":[36],"evaluate":[37],"the":[38,145,183],"distribution":[39],"of":[40,119,144,185],"APRI,":[41],"FIB-4,":[42],"FIB-5,":[43],"FIB-6":[45],"across":[46],"ACS":[47],"subtypes":[48],"their":[50,154],"predictive":[51],"value":[52,194],"for":[53,161,165],"in-hospital":[54],"mortality":[55,110,162],"cardiogenic":[57,112,141,166],"shock.":[58,142],"Fibrosis":[59],"were":[61,75],"calculated":[62],"from":[63],"admission":[64],"laboratory":[65],"values,":[66],"multivariate":[68],"logistic":[69],"regression":[70],"ROC":[72],"curve":[73],"analyses":[74],"performed.":[76],"STEMI":[77],"had":[79],"significantly":[80],"higher":[81],"APRI":[82],"(0.95\u00b11.43":[83],"vs.":[84,86,90,92,97,99],"0.41\u00b10.71":[85],"0.20\u00b10.11),":[87],"FIB-4":[88],"(3.68\u00b14.03":[89],"1.98\u00b12.17":[91],"1.17\u00b10.52),":[93],"FIB-5":[95],"(5.16\u00b11.08":[96],"4.66\u00b10.84":[98],"4.38\u00b10.43)":[100],"than":[101,190],"NSTEMI":[102],"(all":[107],"p<0.001).":[108],"In-hospital":[109],"shock":[113],"occurred":[114],"3.8%":[116],"3.2%":[118],"patients,":[120],"respectively.":[121],"Cardiogenic":[122],"shock,":[123],"reduced":[124],"left":[125],"ventricular":[126],"ejection":[127],"fraction,":[128],"lower":[130],"serum":[131],"albumin":[132],"independently":[133,139,149],"predicted":[134,140,150],"mortality,":[135],"whereas":[136],"older":[137],"age":[138],"None":[143],"hepatic":[146,173],"either":[151],"outcome,":[152],"discriminative":[155],"performance":[156],"was":[157],"limited":[158],"(AUC":[159],"0.526-0.632":[160],"0.570-0.662":[164],"shock).":[167],"These":[168],"findings":[169],"indicate":[170],"that":[171],"although":[172],"scores":[175],"are":[176],"elevated":[177],"STEMI,":[179],"they":[180],"primarily":[181],"reflect":[182],"severity":[184],"myocardial":[187],"injury":[188],"rather":[189],"providing":[191],"incremental":[192],"beyond":[195],"established":[196],"clinical":[197],"predictors":[198],"syndrome.":[204]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-10-29T00:00:00"}