{"id":"https://openalex.org/W7224108267","doi":"https://doi.org/10.52338/tjoai.2026.6099","title":"Beyond Anti-Ttg Antibodies: Diagnostic Value Of Antibodies Against Deamidated Gliadin Peptides In Celiac Disease","display_name":"Beyond Anti-Ttg Antibodies: Diagnostic Value Of Antibodies Against Deamidated Gliadin Peptides In Celiac Disease","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7224108267","doi":"https://doi.org/10.52338/tjoai.2026.6099"},"language":"en","primary_location":{"id":"doi:10.52338/tjoai.2026.6099","doi":"https://doi.org/10.52338/tjoai.2026.6099","is_oa":true,"landing_page_url":"https://doi.org/10.52338/tjoai.2026.6099","pdf_url":"https://directivepublications.org/pdf/1811/beyond-anti-ttg-antibodies-diagnostic-value-of-antibodies-against-deamidated-gliadin-peptides-in-celiac-disease.pdf","source":{"id":"https://openalex.org/S7407121702","display_name":"The Journal of Autoimmunity","issn_l":"3064-688X","issn":["3064-688X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Autoimmunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://directivepublications.org/pdf/1811/beyond-anti-ttg-antibodies-diagnostic-value-of-antibodies-against-deamidated-gliadin-peptides-in-celiac-disease.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117700179","display_name":"Nabil Gaougaou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088687","display_name":"Universit\u00e9 Ibn Zohr","ror":"https://ror.org/006sgpv47","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210088687"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Nabil Gaougaou","raw_affiliation_strings":["Laboratory of Immunology and Histology, Faculty of Medicine and Pharmacy, Ibn Zohr University, Laayoune, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology and Histology, Faculty of Medicine and Pharmacy, Ibn Zohr University, Laayoune, Morocco","institution_ids":["https://openalex.org/I4210088687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073714178","display_name":"Oussama Aazzane","orcid":"https://orcid.org/0000-0002-9032-8848","observed_orcids":["https://orcid.org/0000-0002-9032-8848"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Oussama Aazzane","raw_affiliation_strings":["Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco; Immunology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco; Immunology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091974079","display_name":"Hasnaa Bazhar","orcid":"https://orcid.org/0000-0001-9061-2673","observed_orcids":["https://orcid.org/0000-0001-9061-2673"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Hasnaa Bazhar","raw_affiliation_strings":["Immunology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102831240","display_name":"Hassan Fellah","orcid":"https://orcid.org/0000-0001-6778-0484","observed_orcids":["https://orcid.org/0000-0001-6778-0484"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Hassan Fellah","raw_affiliation_strings":["Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco; Immunology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco; Immunology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84651677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10733","display_name":"Wheat and Barley Genetics and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/celiac-disease","display_name":"celiac disease","score":0.972000002861023},{"id":"https://openalex.org/keywords/anti-tissue-transglutaminase-antibodies","display_name":"anti-tissue transglutaminase antibodies","score":0.9129999876022339},{"id":"https://openalex.org/keywords/deamidated-gliadin-peptides","display_name":"deamidated gliadin peptides","score":0.9359999895095825},{"id":"https://openalex.org/keywords/anti-gliadin-antibodies","display_name":"anti-gliadin antibodies","score":0.7570000290870667},{"id":"https://openalex.org/keywords/serological-diagnosis","display_name":"serological diagnosis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6380000114440918},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6290000081062317},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6069999933242798},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.5360999703407288},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.534500002861023},{"id":"https://openalex.org/C2780092158","wikidata":"https://www.wikidata.org/wiki/Q279074","display_name":"Gliadin","level":3,"score":0.4293999969959259},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.3366999924182892},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.33219999074935913},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.29910001158714294},{"id":"https://openalex.org/C2780349322","wikidata":"https://www.wikidata.org/wiki/Q11088","display_name":"Coeliac disease","level":3,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.52338/tjoai.2026.6099","doi":"https://doi.org/10.52338/tjoai.2026.6099","is_oa":true,"landing_page_url":"https://doi.org/10.52338/tjoai.2026.6099","pdf_url":"https://directivepublications.org/pdf/1811/beyond-anti-ttg-antibodies-diagnostic-value-of-antibodies-against-deamidated-gliadin-peptides-in-celiac-disease.pdf","source":{"id":"https://openalex.org/S7407121702","display_name":"The Journal of Autoimmunity","issn_l":"3064-688X","issn":["3064-688X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Autoimmunity","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.52338/tjoai.2026.6099","doi":"https://doi.org/10.52338/tjoai.2026.6099","is_oa":true,"landing_page_url":"https://doi.org/10.52338/tjoai.2026.6099","pdf_url":"https://directivepublications.org/pdf/1811/beyond-anti-ttg-antibodies-diagnostic-value-of-antibodies-against-deamidated-gliadin-peptides-in-celiac-disease.pdf","source":{"id":"https://openalex.org/S7407121702","display_name":"The Journal of Autoimmunity","issn_l":"3064-688X","issn":["3064-688X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Autoimmunity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224108267.pdf","grobid_xml":"https://content.openalex.org/works/W7224108267.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W81942398","https://openalex.org/W1982780106","https://openalex.org/W2001623226","https://openalex.org/W2100456727","https://openalex.org/W4321124434","https://openalex.org/W4385684805","https://openalex.org/W4391400556","https://openalex.org/W4403835662","https://openalex.org/W4403896740","https://openalex.org/W4411107744","https://openalex.org/W4414545677"],"related_works":["https://openalex.org/W2796180145","https://openalex.org/W1607220381","https://openalex.org/W2346685371","https://openalex.org/W2972433890","https://openalex.org/W2020154562","https://openalex.org/W2142451758","https://openalex.org/W2015241237","https://openalex.org/W291083406","https://openalex.org/W3197991193","https://openalex.org/W4365787520"],"abstract_inverted_index":{"Celiac":[0],"disease":[1,102,151],"is":[2],"an":[3],"autoimmune":[4],"enteropathy":[5],"whose":[6],"diagnosis":[7],"primarily":[8],"relies":[9],"on":[10],"serological":[11,230,280],"testing,":[12],"with":[13,85,99,148,166,244],"IgA":[14,39,107,115,208,212,241,259],"anti-tissue":[15],"transglutaminase":[16],"(anti-tTG)":[17],"antibodies":[18,274],"serving":[19],"as":[20,112,114],"the":[21,69,123,131,157,176,197,265],"first-line":[22],"biomarker.":[23],"However,":[24],"their":[25,57],"diagnostic":[26,60,70],"performance":[27,71],"may":[28],"be":[29],"limited":[30],"in":[31,35,59,80,82,254],"certain":[32],"situations,":[33],"particularly":[34],"cases":[36],"of":[37,72,140,181,229,235,256,268],"selective":[38],"deficiency":[40],"or":[41,79],"atypical":[42],"clinical":[43],"presentations.":[44],"Antibodies":[45],"directed":[46],"against":[47],"deamidated":[48],"gliadin":[49],"peptides":[50],"(anti-DGP)":[51],"represent":[52],"a":[53,167,186,278],"promising":[54],"alternative,":[55],"but":[56],"role":[58],"strategies":[61],"remains":[62],"controversial.":[63],"This":[64,88],"study":[65,91],"aimed":[66],"to":[67,272],"evaluate":[68],"anti-tTG":[73,110,273],"and":[74,103,108,116,152,162,184,219,260,275],"anti-DGP":[75,118,223,250],"antibodies,":[76,111,119],"used":[77],"alone":[78],"combination,":[81],"Moroccan":[83],"patients":[84,98,147,236,257],"celiac":[86,101,150],"disease.":[87],"retrospective":[89],"single-center":[90],"included":[92],"96":[93,141],"serum":[94],"samples":[95],"from":[96],"49":[97,146],"confirmed":[100,149],"47":[104,153],"healthy":[105,154],"controls.":[106,155],"IgG":[109,117,216,222,247],"well":[113],"were":[120,128,143,160,164,194,205],"detected":[121],"using":[122,134],"immunodot":[124],"technique.":[125],"Serological":[126],"profiles":[127,231],"compared":[129,243],"between":[130],"two":[132],"groups":[133],"Pearson's":[135],"\u03c7\u00b2":[136],"test.":[137],"A":[138],"total":[139],"participants":[142],"included,":[144],"comprising":[145],"Among":[156,201],"patients,":[158,202],"65%":[159],"children":[161],"35%":[163],"adults,":[165],"female":[168],"predominance":[169],"(63%;":[170],"sex-ratio":[171],"=":[172],"0.58).":[173],"In":[174],"contrast,":[175],"control":[177],"group":[178],"consisted":[179],"predominantly":[180],"adults":[182],"(59%)":[183],"showed":[185,232],"balanced":[187],"sex":[188],"distribution":[189],"(51%":[190],"male).":[191],"All":[192],"controls":[193],"seronegative":[195],"for":[196,207,211,215,221,246,258,262],"four":[198],"biomarkers":[199,270],"investigated.":[200],"positivity":[203,251],"rates":[204],"59.2%":[206],"anti-tTG,":[209],"46.9%":[210],"anti-DGP,":[213],"40.8%":[214],"anti-":[217],"tTG,":[218],"49.0%":[220],"(p":[224],"<":[225],"0.0001).":[226],"Combined":[227],"analysis":[228],"that":[233,277],"87.8%":[234],"had":[237],"at":[238],"least":[239],"one":[240],"autoantibody,":[242],"61.2%":[245],"autoantibodies.":[248],"Isolated":[249],"was":[252],"observed":[253],"28.6%":[255],"20.4%":[261],"IgG,":[263],"highlighting":[264],"complementary":[266],"value":[267],"these":[269],"relative":[271],"suggesting":[276],"multi-marker":[279],"appr":[281]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}
