{"id":"https://openalex.org/W7224108256","doi":"https://doi.org/10.1002/adhm.71914","title":"Targeting Neutrophil Hitchhiking for Drug Delivery to Block CCL5\u2010CCR1 and Effectively Alleviate Acute Lung Injury","display_name":"Targeting Neutrophil Hitchhiking for Drug Delivery to Block CCL5\u2010CCR1 and Effectively Alleviate Acute Lung Injury","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224108256","doi":"https://doi.org/10.1002/adhm.71914","pmid":"https://pubmed.ncbi.nlm.nih.gov/42949824"},"language":"en","primary_location":{"id":"doi:10.1002/adhm.71914","doi":"https://doi.org/10.1002/adhm.71914","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adhm.71914","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.71914","source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.71914","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160013987","display_name":"Qian\u2010yu Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian\u2010yu Huang","raw_affiliation_strings":["Department of Critical Care Medicine The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114155481","display_name":"Zhi-Ying Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi\u2010ying Kang","raw_affiliation_strings":["Department of Critical Care Medicine The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082471688","display_name":"Mengjia Yu","orcid":"https://orcid.org/0000-0003-3012-6141","observed_orcids":["https://orcid.org/0000-0003-3012-6141","https://orcid.org/0000-0001-8250-578X"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng\u2010jia Yu","raw_affiliation_strings":["Department of Critical Care Medicine The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159988709","display_name":"Xi\u2010quan Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147389","display_name":"Hunan Provincial People's Hospital","ror":"https://ror.org/03wwr4r78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147389"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi\u2010quan Yan","raw_affiliation_strings":["Department of Emergency Medicine Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University  Changsha Hunan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University  Changsha Hunan China","institution_ids":["https://openalex.org/I4210147389"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069673066","display_name":"Bao\u2010Ping Tian","orcid":"https://orcid.org/0000-0003-2621-5336","observed_orcids":["https://orcid.org/0000-0003-2621-5336"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bao\u2010ping Tian","raw_affiliation_strings":["Department of Critical Care Medicine The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"],"raw_orcid":"https://orcid.org/0000-0003-2621-5336","affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069673066"],"corresponding_institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81475991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.06459999829530716,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.06080000102519989,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.984000027179718},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.7910000085830688},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ccr1","display_name":"CCR1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neutrophil-chemotaxis","display_name":"neutrophil chemotaxis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.7620000243186951},{"id":"https://openalex.org/keywords/bone-marrow-homing","display_name":"bone marrow homing","score":0.8690000176429749},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.9129999876022339},{"id":"https://openalex.org/keywords/targeted-drug-release","display_name":"targeted drug release","score":0.8370000123977661},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.5877000093460083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5666000247001648},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.48820000886917114},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4862000048160553},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4731999933719635},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43720000982284546},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.43130001425743103},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3912000060081482},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.37400001287460327},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.3727000057697296},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3483999967575073},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.34779998660087585},{"id":"https://openalex.org/C2909621147","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"Acute respiratory distress","level":3,"score":0.3395000100135803},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.3375999927520752},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.33320000767707825},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32260000705718994},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.32089999318122864},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.3100999891757965},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.3025999963283539},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.2928999960422516},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.27799999713897705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2667999863624573},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.2612999975681305},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.25600001215934753}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/adhm.71914","doi":"https://doi.org/10.1002/adhm.71914","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adhm.71914","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.71914","source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},{"id":"pmid:42949824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42949824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced healthcare materials","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/adhm.71914","doi":"https://doi.org/10.1002/adhm.71914","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adhm.71914","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.71914","source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3841969843","display_name":null,"funder_award_id":"82372185","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5859953026","display_name":"\u6025\u6027\u80ba\u635f\u4f24\u4e2d\u5de8\u566c\u7ec6\u80de\u4e0e\u4e2d\u6027\u7c92\u7ec6\u80de\u4e92\u4f5c\u901a\u8def\u53ca\u4ee5\u5176\u4e3a\u6cbb\u7597\u9776\u70b9\u7684\u7814\u7a76","funder_award_id":"LMS25H150002","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322927","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884"},{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224108256.pdf","grobid_xml":"https://content.openalex.org/works/W7224108256.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W2089782191","https://openalex.org/W2112671019","https://openalex.org/W2143727368","https://openalex.org/W2167992469","https://openalex.org/W2169685811","https://openalex.org/W2762316287","https://openalex.org/W2763257724","https://openalex.org/W2792895473","https://openalex.org/W2914524806","https://openalex.org/W3094125068","https://openalex.org/W3157841475","https://openalex.org/W4225534586","https://openalex.org/W4246557706","https://openalex.org/W4292869918","https://openalex.org/W4296794294","https://openalex.org/W4319160623","https://openalex.org/W4321996938","https://openalex.org/W4323568459","https://openalex.org/W4387312263","https://openalex.org/W4393258826","https://openalex.org/W4396520403","https://openalex.org/W4407873529","https://openalex.org/W4412090244","https://openalex.org/W4416738050"],"related_works":["https://openalex.org/W7163553759","https://openalex.org/W4410301248","https://openalex.org/W4402668793","https://openalex.org/W4406998765","https://openalex.org/W4407485155","https://openalex.org/W4379654609","https://openalex.org/W4404406252","https://openalex.org/W3211348587","https://openalex.org/W4401845189","https://openalex.org/W3181562891"],"abstract_inverted_index":{"ABSTRACT":[0],"Acute":[1],"lung":[2,201],"injury/acute":[3],"respiratory":[4,11],"distress":[5],"syndrome":[6],"(ALI/ARDS)":[7],"is":[8],"a":[9,23,111,182,191],"severe":[10],"condition":[12],"characterized":[13],"by":[14,157],"acute,":[15],"diffuse":[16],"inflammatory":[17,200],"damage":[18],"to":[19,26,35,68,144,174],"the":[20,42,78,119,137,145,148,167],"lungs,":[21],"posing":[22],"significant":[24],"threat":[25],"human":[27],"health.":[28],"Although":[29],"neutrophils":[30],"and":[31,52,104,161,176,189],"macrophages":[32,65],"are":[33,58],"known":[34],"play":[36],"critical":[37],"roles":[38],"in":[39,80,187,199],"ALI/ARDS":[40,188],"pathogenesis,":[41],"precise":[43],"cellular":[44,184],"pathways":[45,57],"governing":[46],"their":[47],"interaction":[48],"remain":[49],"poorly":[50],"defined,":[51],"targeted":[53,133,197],"therapeutics":[54],"modulating":[55],"these":[56],"currently":[59],"lacking.":[60],"Here,":[61],"we":[62,109],"show":[63],"that":[64,117],"secrete":[66],"CCL5":[67],"activate":[69],"CCR1":[70,98],"on":[71],"neutrophils,":[72],"thereby":[73],"driving":[74],"neutrophil":[75,142],"chemotaxis":[76],"toward":[77],"lungs":[79,146],"ALI.":[81],"Mechanistically,":[82],"this":[83,102],"signaling":[84],"axis":[85,186],"operates":[86],"primarily":[87],"through":[88],"Gi\u03b12\u2010dependent":[89],"suppression":[90],"of":[91,97,124,171],"intracellular":[92],"cAMP":[93],"levels.":[94],"Pharmacological":[95],"inhibition":[96],"with":[99],"BX471":[100,116],"blocks":[101],"pathway":[103],"attenuates":[105],"ALI":[106,156],"progression.":[107],"Furthermore,":[108],"developed":[110],"nanoparticle\u2010based":[112],"delivery":[113],"system":[114],"encapsulating":[115],"exploits":[118],"intrinsic":[120],"bone":[121,138],"marrow\u2010homing":[122],"property":[123],"CXCR4":[125],"high":[126],"senescent":[127],"neutrophils.":[128],"This":[129,150],"neutrophil\u2011guided":[130],"strategy":[131,195],"enables":[132],"drug":[134,159],"release":[135],"within":[136],"marrow,":[139],"effectively":[140],"inhibiting":[141],"egress":[143],"at":[147],"source.":[149],"approach":[151],"not":[152],"only":[153],"significantly":[154],"alleviates":[155],"reducing":[158],"dosage":[160],"administration":[162],"frequency":[163],"but":[164],"also":[165],"offers":[166],"superior":[168],"safety":[169],"advantage":[170],"being":[172],"non\u2010toxic":[173],"cells":[175],"tissues.":[177],"Together,":[178],"our":[179],"findings":[180],"reveal":[181],"key":[183],"communication":[185],"present":[190],"novel,":[192],"cell\u2011guided":[193],"therapeutic":[194],"for":[196],"intervention":[198],"injury.":[202]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}
