{"id":"https://openalex.org/W7224104493","doi":"https://doi.org/10.21276/amrp.2026.v1.i1.5","title":"Retrospective Quality-By-Design Optimization of Memantine-Loaded Pegylated Plga Liposomal Formulation for Enhanced Nose-To-Brain Delivery in Alzheimer\u2019s Disease","display_name":"Retrospective Quality-By-Design Optimization of Memantine-Loaded Pegylated Plga Liposomal Formulation for Enhanced Nose-To-Brain Delivery in Alzheimer\u2019s Disease","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224104493","doi":"https://doi.org/10.21276/amrp.2026.v1.i1.5"},"language":"en","primary_location":{"id":"doi:10.21276/amrp.2026.v1.i1.5","doi":"https://doi.org/10.21276/amrp.2026.v1.i1.5","is_oa":true,"landing_page_url":"https://doi.org/10.21276/amrp.2026.v1.i1.5","pdf_url":"https://www.parsvnath.in/assets/uploads/journals/advances-in-medical-research-and-practice/1/1/5-article-edit.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Medical Research and Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.parsvnath.in/assets/uploads/journals/advances-in-medical-research-and-practice/1/1/5-article-edit.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104021443","display_name":"Ranjodh Jeet Singh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ranjodh Jeet Singh","raw_affiliation_strings":["Department of Pharmacology , MMIMSR , MMDU , Mullana , Haryana , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology , MMIMSR , MMDU , Mullana , Haryana , India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5104021443"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.80765091,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"1","first_page":"25","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.049800001084804535,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/nose-to-brain-drug-delivery","display_name":"nose-to-brain delivery","score":0.8849999904632568},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.8669999837875366},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9580000042915344},{"id":"https://openalex.org/keywords/quality-by-design","display_name":"quality by design","score":0.8109999895095825},{"id":"https://openalex.org/keywords/nasal-permeation","display_name":"nasal permeation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.8529999852180481},{"id":"https://openalex.org/keywords/higuchi-kinetics","display_name":"Higuchi model","score":0.796999990940094},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7239999771118164},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.6769999861717224},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.7710000276565552},{"id":"https://openalex.org/keywords/particle-size-and-zeta-potential","display_name":"particle size and zeta potential","score":0.7289999723434448},{"id":"https://openalex.org/keywords/formulation-stability","display_name":"formulation stability","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.6434000134468079},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.6269000172615051},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.5814999938011169},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.5525000095367432},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5388000011444092},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5200999975204468},{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.5077999830245972},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4950999915599823},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.4932999908924103},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4900999963283539},{"id":"https://openalex.org/C11432220","wikidata":"https://www.wikidata.org/wiki/Q1975334","display_name":"Dispersity","level":2,"score":0.48820000886917114},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4447000026702881},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.42829999327659607},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4065000116825104},{"id":"https://openalex.org/C134728086","wikidata":"https://www.wikidata.org/wiki/Q966900","display_name":"Drug delivery to the brain","level":4,"score":0.3930000066757202},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.3700000047683716},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.33180001378059387},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.3292999863624573},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.32429999113082886},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.3167000114917755},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.314300000667572},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.31360000371932983},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.2937000095844269},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.29260000586509705},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.26429998874664307}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21276/amrp.2026.v1.i1.5","doi":"https://doi.org/10.21276/amrp.2026.v1.i1.5","is_oa":true,"landing_page_url":"https://doi.org/10.21276/amrp.2026.v1.i1.5","pdf_url":"https://www.parsvnath.in/assets/uploads/journals/advances-in-medical-research-and-practice/1/1/5-article-edit.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Medical Research and Practice","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21276/amrp.2026.v1.i1.5","doi":"https://doi.org/10.21276/amrp.2026.v1.i1.5","is_oa":true,"landing_page_url":"https://doi.org/10.21276/amrp.2026.v1.i1.5","pdf_url":"https://www.parsvnath.in/assets/uploads/journals/advances-in-medical-research-and-practice/1/1/5-article-edit.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Medical Research and Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224104493.pdf","grobid_xml":"https://content.openalex.org/works/W7224104493.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1979151430","https://openalex.org/W2464808437","https://openalex.org/W2795171026","https://openalex.org/W3035836034","https://openalex.org/W3175526367","https://openalex.org/W4210669406","https://openalex.org/W4281992128","https://openalex.org/W4285585258","https://openalex.org/W4288722279","https://openalex.org/W4302759860","https://openalex.org/W4304633205","https://openalex.org/W4309087416","https://openalex.org/W4387662988","https://openalex.org/W7159801538"],"related_works":["https://openalex.org/W7159801538","https://openalex.org/W7113601115","https://openalex.org/W2795171026","https://openalex.org/W3126697961","https://openalex.org/W3175526367","https://openalex.org/W4402039153","https://openalex.org/W3015821244","https://openalex.org/W7217764296","https://openalex.org/W4410176501","https://openalex.org/W3037874935"],"abstract_inverted_index":{"Background:":[0],"Alzhimer's":[1],"Disease":[2],"is":[3,12],"one":[4],"of":[5,15,21,24,35,48,51,118,157,173,180,186,194,206,212,253,274,281,287,295,307,313,354],"the":[6,22,28,37,46,56,70,81,155,170,209,225,254,257,263,271,310,326,355,358,364],"major":[7],"neurodegenerative":[8],"disorders":[9],"where":[10],"there":[11],"limited":[13],"efficacy":[14],"therapeutic":[16],"drug":[17,137,207,255,308,356,377],"action,":[18],"primarily":[19],"because":[20],"lack":[23],"gene":[25],"transfer":[26],"across":[27],"blood\u2013brain":[29],"barrier.":[30],"Nanocarrier-based":[31],"delivery":[32],"systems":[33],"capable":[34],"targeting":[36,50],"brain":[38,49],"following":[39],"intranasal":[40],"administration":[41],"are":[42],"under":[43],"investigation":[44],"for":[45,59],"improvement":[47],"anti-Alzheimer":[52],"drugs.":[53],"To":[54],"find":[55],"optimal":[57],"formulation":[58,148,168,269],"carrying":[60],"memantine":[61,93,237,338],"in":[62,75,135,262,363],"PEGylated":[63,95,370],"PLGA":[64,96,112,371],"liposomal":[65],"nanoparticles":[66],"towards":[67],"nasal\u2013brain":[68],"delivery,":[69,374],"present":[71],"study":[72,258,359],"was":[73,245,346],"designed":[74],"a":[76,98],"retro":[77],"view":[78],"manner":[79],"employing":[80],"Quality":[82],"by":[83,116,153,161],"Design":[84],"(QbD).":[85],"Materials":[86],"and":[87,102,121,143,160,191,228,292,329],"methods:":[88],"In":[89],"order":[90],"to":[91,208,309],"formulate":[92],"loaded-":[94],"liposomes,":[97,372],"modified":[99],"solvent":[100,119],"evaporation":[101,120],"thin-film":[103,122],"($":[104,123],"\u043c\u0430\u0440\u0442":[105,124],"as":[106,260,361],"per":[107],"previously":[108],"mentioned":[109],"technique.":[110,125],"Memantine-loaded-PEGylated":[111],"liposomes":[113],"were":[114,145,232,333],"prepared":[115],"modification":[117],"The":[126,147,166,198,242,267,299,343],"particle":[127,171,272],"size,":[128],"zeta":[129,184,285],"potential,":[130],"polydispersity":[131,178,279],"index,":[132],"entrapment":[133,192,293],"efficiency,":[134],"vitro":[136],"release,":[138],"ex":[139],"vivo":[140,220,321],"nasal":[141,229,330],"permeation":[142,221,226,322,327],"stability":[144,244,264,345,365],"measured.":[146],"optimization":[149],"has":[150],"been":[151],"done":[152],"applying":[154],"principle":[156],"retrospective":[158],"QbD":[159],"using":[162],"statistical":[163],"assessment.":[164],"Results:":[165],"optimized":[167,268],"gave":[169,270],"size":[172,273],"156.2":[174,275],"\u00b1":[175,182,188,196,214,276,283,289,297,315],"3.9":[176,277],"nm,":[177,278],"index":[179,280],"0.184":[181,282],"0.01,":[183,284],"potential":[185,286],"\u221229.4":[187,288],"1.5":[189,290],"mV":[190,291],"efficiency":[193,294],"89.8":[195,296],"1.9%.":[197,298],"Higuchi":[199,300],"diffusion":[200,301],"kinetic":[201,302],"model":[202,303],"showed":[203,304],"sustained":[204,305],"release":[205,306],"greater":[210,311],"extent":[211,312],"91.8":[213,314],"3.2%":[215,316],"after":[216,317],"24":[217,318],"hours.":[218,319],"Ex":[219,320],"studies":[222,323],"revealed":[223,324],"that":[224,325],"flux":[227,328],"tissue":[230,331],"retention":[231,332],"significantly":[233,334],"better":[234,335],"than":[235,336],"pure":[236,337],"solution":[238,339],"(p":[239,340],"<":[240,341],"0.001).":[241,342],"physicochemical":[243,344],"acceptable":[246,347],"with":[247,348],"no":[248,349],"significant":[249,350],"aggregation":[250,351],"or":[251,352],"leakage":[252,353],"throughout":[256,357],"period":[259,360],"observed":[261,362],"analysis.":[265,366],"Conclusion:":[266],"Keywords:":[367],"Alzheimer\u2019s":[368],"disease,":[369],"Nose-to-brain":[373],"Nanoparticles,":[375],"Intranasal":[376],"delivery.":[378]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}
