{"id":"https://openalex.org/W7224104115","doi":"https://doi.org/10.3748/wjg.127135","title":"Immunosenescence and microbial ecology in gastrointestinal and hepatobiliary infection-associated cancers","display_name":"Immunosenescence and microbial ecology in gastrointestinal and hepatobiliary infection-associated cancers","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224104115","doi":"https://doi.org/10.3748/wjg.127135"},"language":"en","primary_location":{"id":"doi:10.3748/wjg.127135","doi":"https://doi.org/10.3748/wjg.127135","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.127135","pdf_url":"https://www.f6publishing.com/Forms/Main/DownloadFile.aspx?type=m&typeid=2&id=127135&filepath=8E31D0401EB18CD6271A9142AB7E05E3344D0972F2976CAD5E4B5B2C2AC578DD5E0AB6D7F683560D","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.f6publishing.com/Forms/Main/DownloadFile.aspx?type=m&typeid=2&id=127135&filepath=8E31D0401EB18CD6271A9142AB7E05E3344D0972F2976CAD5E4B5B2C2AC578DD5E0AB6D7F683560D","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160064717","display_name":"Wen-Ge Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124931","display_name":"Fuzhou Pulmonary Hospital of Fujian","ror":"https://ror.org/03d5yat74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124931"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-Ge Li","raw_affiliation_strings":["Department of Oncology , Fuzhou Pulmonary Hospital of Fujian , Fuzhou 350008 , Fujian Province , China","Department of Oncology , Fuzhou Pulmonary Hospital of Fujian , No. 8 Beiyuan Road , Cangshan District , Fuzhou 350008 , Fujian Province , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , Fuzhou Pulmonary Hospital of Fujian , Fuzhou 350008 , Fujian Province , China","institution_ids":["https://openalex.org/I4210124931"]},{"raw_affiliation_string":"Department of Oncology , Fuzhou Pulmonary Hospital of Fujian , No. 8 Beiyuan Road , Cangshan District , Fuzhou 350008 , Fujian Province , China","institution_ids":["https://openalex.org/I4210124931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160040232","display_name":"Xin Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124931","display_name":"Fuzhou Pulmonary Hospital of Fujian","ror":"https://ror.org/03d5yat74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124931"]},{"id":"https://openalex.org/I4210143087","display_name":"Fujian Provincial Hospital","ror":"https://ror.org/045wzwx52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143087"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Yu","raw_affiliation_strings":["Department of Breast Surgery , Fuzhou University Affiliated Provincial Hospital , Fuzhou 350001 , Fujian Province , China","Department of Oncology , Fuzhou Pulmonary Hospital of Fujian , Fuzhou 350008 , Fujian Province , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery , Fuzhou University Affiliated Provincial Hospital , Fuzhou 350001 , Fujian Province , China","institution_ids":["https://openalex.org/I4210143087","https://openalex.org/I80947539"]},{"raw_affiliation_string":"Department of Oncology , Fuzhou Pulmonary Hospital of Fujian , Fuzhou 350008 , Fujian Province , China","institution_ids":["https://openalex.org/I4210124931"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71180607,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":1.0},{"id":"https://openalex.org/keywords/microbial-ecology","display_name":"microbial ecology","score":0.9269999861717224},{"id":"https://openalex.org/keywords/gastrointestinal-cancer","display_name":"gastrointestinal cancer","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hepatobiliary-cancer","display_name":"hepatobiliary cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/infection-related-cancers","display_name":"infection-associated cancer","score":0.8460000157356262},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6809999942779541},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.6633999943733215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6158000230789185},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.42170000076293945},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3962000012397766},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3939000070095062},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39160001277923584},{"id":"https://openalex.org/C69562835","wikidata":"https://www.wikidata.org/wiki/Q3054637","display_name":"Microbial ecology","level":3,"score":0.35749998688697815},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.33719998598098755},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.322299987077713},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.31940001249313354},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.3133000135421753},{"id":"https://openalex.org/C2910671496","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter Infections","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2930000126361847},{"id":"https://openalex.org/C3017712846","wikidata":"https://www.wikidata.org/wiki/Q4891747","display_name":"Tumor immunology","level":4,"score":0.290800005197525},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.28690001368522644},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.27129998803138733},{"id":"https://openalex.org/C2909812603","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microflora","level":3,"score":0.2669000029563904},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C542804219","wikidata":"https://www.wikidata.org/wiki/Q5526839","display_name":"Gastrointestinal cancer","level":4,"score":0.25999999046325684},{"id":"https://openalex.org/C2908810495","wikidata":"https://www.wikidata.org/wiki/Q327663","display_name":"Clostridium Infections","level":4,"score":0.2533000111579895}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3748/wjg.127135","doi":"https://doi.org/10.3748/wjg.127135","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.127135","pdf_url":"https://www.f6publishing.com/Forms/Main/DownloadFile.aspx?type=m&typeid=2&id=127135&filepath=8E31D0401EB18CD6271A9142AB7E05E3344D0972F2976CAD5E4B5B2C2AC578DD5E0AB6D7F683560D","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3748/wjg.127135","doi":"https://doi.org/10.3748/wjg.127135","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.127135","pdf_url":"https://www.f6publishing.com/Forms/Main/DownloadFile.aspx?type=m&typeid=2&id=127135&filepath=8E31D0401EB18CD6271A9142AB7E05E3344D0972F2976CAD5E4B5B2C2AC578DD5E0AB6D7F683560D","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224104115.pdf","grobid_xml":"https://content.openalex.org/works/W7224104115.grobid-xml"},"referenced_works_count":130,"referenced_works":["https://openalex.org/W1594981111","https://openalex.org/W1620160353","https://openalex.org/W1964114293","https://openalex.org/W1971907346","https://openalex.org/W1984746971","https://openalex.org/W1987375206","https://openalex.org/W1998630067","https://openalex.org/W1999906527","https://openalex.org/W2003342633","https://openalex.org/W2006292369","https://openalex.org/W2008694543","https://openalex.org/W2060185417","https://openalex.org/W2069378448","https://openalex.org/W2077116159","https://openalex.org/W2085153086","https://openalex.org/W2088170171","https://openalex.org/W2096139589","https://openalex.org/W2103392467","https://openalex.org/W2114097264","https://openalex.org/W2119896120","https://openalex.org/W2126547130","https://openalex.org/W2132406938","https://openalex.org/W2149010238","https://openalex.org/W2152095262","https://openalex.org/W2156305960","https://openalex.org/W2161548174","https://openalex.org/W2172687959","https://openalex.org/W2225038386","https://openalex.org/W2298181742","https://openalex.org/W2478467838","https://openalex.org/W2513922839","https://openalex.org/W2545009331","https://openalex.org/W2548403525","https://openalex.org/W2607434574","https://openalex.org/W2739778494","https://openalex.org/W2742147437","https://openalex.org/W2743598935","https://openalex.org/W2765111042","https://openalex.org/W2765279273","https://openalex.org/W2765314233","https://openalex.org/W2783874580","https://openalex.org/W2786541232","https://openalex.org/W2801167100","https://openalex.org/W2804448077","https://openalex.org/W2844364183","https://openalex.org/W2883291178","https://openalex.org/W2886401819","https://openalex.org/W2888529823","https://openalex.org/W2901845253","https://openalex.org/W2906721882","https://openalex.org/W2912648593","https://openalex.org/W2927453907","https://openalex.org/W2949004447","https://openalex.org/W2951598503","https://openalex.org/W2963531283","https://openalex.org/W2965688238","https://openalex.org/W2975736685","https://openalex.org/W2982566732","https://openalex.org/W2995167300","https://openalex.org/W2997490540","https://openalex.org/W3002445804","https://openalex.org/W3003924738","https://openalex.org/W3008359597","https://openalex.org/W3012615718","https://openalex.org/W3014819129","https://openalex.org/W3036603151","https://openalex.org/W3040384889","https://openalex.org/W3048281202","https://openalex.org/W3109742059","https://openalex.org/W3111836013","https://openalex.org/W3113645277","https://openalex.org/W3126208996","https://openalex.org/W3132024224","https://openalex.org/W3151021440","https://openalex.org/W3160268512","https://openalex.org/W3161778279","https://openalex.org/W3171336969","https://openalex.org/W3175895832","https://openalex.org/W3184541229","https://openalex.org/W3202205923","https://openalex.org/W3213763607","https://openalex.org/W3217580822","https://openalex.org/W4205089181","https://openalex.org/W4210913993","https://openalex.org/W4211248913","https://openalex.org/W4220661700","https://openalex.org/W4225316232","https://openalex.org/W4281658223","https://openalex.org/W4281913683","https://openalex.org/W4291016468","https://openalex.org/W4306411778","https://openalex.org/W4311612274","https://openalex.org/W4313460910","https://openalex.org/W4313531093","https://openalex.org/W4353077229","https://openalex.org/W4362664359","https://openalex.org/W4366598306","https://openalex.org/W4366822705","https://openalex.org/W4367548616","https://openalex.org/W4376631082","https://openalex.org/W4385232541","https://openalex.org/W4385858278","https://openalex.org/W4386932910","https://openalex.org/W4389626376","https://openalex.org/W4390029588","https://openalex.org/W4390494387","https://openalex.org/W4390511662","https://openalex.org/W4392938448","https://openalex.org/W4392984046","https://openalex.org/W4393398521","https://openalex.org/W4393905373","https://openalex.org/W4393935425","https://openalex.org/W4395447498","https://openalex.org/W4396746532","https://openalex.org/W4399732078","https://openalex.org/W4402622976","https://openalex.org/W4402984043","https://openalex.org/W4404105354","https://openalex.org/W4404172344","https://openalex.org/W4405261544","https://openalex.org/W4406411162","https://openalex.org/W4406960971","https://openalex.org/W4407988672","https://openalex.org/W4408663946","https://openalex.org/W4409289374","https://openalex.org/W4411589926","https://openalex.org/W4413023521","https://openalex.org/W4413994527","https://openalex.org/W4415827875","https://openalex.org/W7161408042"],"related_works":["https://openalex.org/W4416019430","https://openalex.org/W2418401273","https://openalex.org/W4416019524","https://openalex.org/W4416019511","https://openalex.org/W7208816218","https://openalex.org/W4322500970","https://openalex.org/W4401417561","https://openalex.org/W1519953002","https://openalex.org/W4404056410","https://openalex.org/W2415027321"],"abstract_inverted_index":{"Infection-associated":[0],"cancers":[1],"of":[2,11,88],"the":[3,85],"gastrointestinal":[4],"and":[5,22,43,62,65,73,83,102,130,138,153,159],"hepatobiliary":[6],"tract":[7],"develop":[8],"over":[9],"years":[10],"interaction":[12],"among":[13],"persistent":[14],"pathogens,":[15],"injured":[16],"tissues,":[17],"anatomically":[18],"distinct":[19],"microbial":[20,67,98,124],"communities,":[21],"a":[23,53,121],"progressively":[24],"remodeled":[25],"immune":[26,100,128],"system.This":[27],"narrative":[28],"review":[29],"examines":[30],"these":[31],"interactions":[32],"in":[33,119],"Helicobacter":[34],"pylori-associated":[35],"gastric":[36],"cancer,":[37],"hepatitis":[38],"B/C":[39],"virus-associated":[40],"hepatocellular":[41],"carcinoma,":[42],"liver-fluke-associated":[44],"cholangiocarcinoma,":[45],"with":[46,155],"microbially":[47],"driven":[48],"colorectal":[49],"cancer":[50,103,132],"used":[51],"as":[52,151],"mechanistic":[54],"boundary":[55],"comparator.We":[56],"distinguish":[57],"immunosenescence":[58],"from":[59],"T-cell":[60],"exhaustion":[61],"cellular":[63],"senescence":[64],"evaluate":[66],"evidence":[68,77],"according":[69],"to":[70,126],"anatomical":[71],"compartment":[72],"evidentiary":[74],"directness.Established":[75],"human":[76,114],"is":[78],"strongest":[79],"for":[80,84],"pathogen":[81,89],"carcinogenicity":[82],"clinical":[86],"benefit":[87],"eradication":[90],"or":[91,112],"suppression.By":[92],"contrast,":[93],"many":[94],"proposed":[95],"links":[96],"between":[97],"function,":[99],"aging,":[101],"are":[104],"supported":[105],"mainly":[106],"by":[107],"animal":[108],"models,":[109],"experimental":[110],"perturbation,":[111],"cross-sectional":[113],"studies.A":[115],"complete":[116],"longitudinal":[117],"sequence":[118],"humans-from":[120],"defined":[122],"compartment-specific":[123],"change":[125],"measurable":[127],"aging":[129],"subsequent":[131],"progression-has":[133],"not":[134],"been":[135],"demonstrated.Pathogen":[136],"control":[137],"guideline-based":[139],"surveillance":[140],"therefore":[141],"remain":[142],"foundational,":[143],"whereas":[144],"microbiota-and":[145],"immune-aging-directed":[146],"interventions":[147],"should":[148],"be":[149],"regarded":[150],"investigational":[152],"tested":[154],"compartment-matched":[156],"functional":[157],"biomarkers":[158],"clinically":[160],"meaningful":[161],"endpoints.":[162]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}
