{"id":"https://openalex.org/W7224102162","doi":"https://doi.org/10.64898/2026.10.27.762112","title":"TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles","display_name":"TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224102162","doi":"https://doi.org/10.64898/2026.10.27.762112"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.27.762112","doi":"https://doi.org/10.64898/2026.10.27.762112","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.27.762112","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/28/2026.10.27.762112.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/28/2026.10.27.762112.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077729009","display_name":"S\u00f6nke Rudnik","orcid":"https://orcid.org/0000-0003-2858-0476","observed_orcids":["https://orcid.org/0000-0003-2858-0476"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S\u00f6nke Rudnik","raw_affiliation_strings":["Institut f\u00fcr Biochemie, Christian-Albrechts-Universit\u00e4t zu Kiel, 24098 Kiel, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2858-0476","affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biochemie, Christian-Albrechts-Universit\u00e4t zu Kiel, 24098 Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079419410","display_name":"Chun Hei Li","orcid":"https://orcid.org/0000-0002-5252-5904","observed_orcids":["https://orcid.org/0000-0002-5252-5904"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Chun Hei Li","raw_affiliation_strings":["Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, 3584 CH, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-5252-5904","affiliations":[{"raw_affiliation_string":"Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, 3584 CH, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053794426","display_name":"Dieter-Christian Gottschling","orcid":"https://orcid.org/0000-0001-7837-043X","observed_orcids":["https://orcid.org/0000-0001-7837-043X"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dieter-Christian Gottschling","raw_affiliation_strings":["Department of Molecular Prevention, University of Kiel, Heinrich-Hecht-Platz 10, 24118 Kiel, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7837-043X","affiliations":[{"raw_affiliation_string":"Department of Molecular Prevention, University of Kiel, Heinrich-Hecht-Platz 10, 24118 Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005269590","display_name":"Alexander Veh","orcid":"https://orcid.org/0009-0000-4558-1329","observed_orcids":["https://orcid.org/0009-0000-4558-1329"]},"institutions":[{"id":"https://openalex.org/I20121455","display_name":"Bielefeld University","ror":"https://ror.org/02hpadn98","country_code":"DE","type":"education","lineage":["https://openalex.org/I20121455"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Veh","raw_affiliation_strings":["Faculty of Chemistry, Biochemistry I (BCI), University of Bielefeld, Bielefeld, Germany"],"raw_orcid":"https://orcid.org/0009-0000-4558-1329","affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, Biochemistry I (BCI), University of Bielefeld, Bielefeld, Germany","institution_ids":["https://openalex.org/I20121455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160031367","display_name":"Daniel J. Barbosa","orcid":"https://orcid.org/0000-0002-7687-8181","observed_orcids":["https://orcid.org/0000-0002-7687-8181"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210096930","display_name":"Cooperativa de Ensino Superior Polit\u00e9cnico e Universit\u00e1rio","ror":"https://ror.org/00w7bj245","country_code":"PT","type":"education","lineage":["https://openalex.org/I4210096930"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]},{"id":"https://openalex.org/I4391767960","display_name":"Unidade em Ci\u00eancias Biomoleculares Aplicadas","ror":"https://ror.org/04c3k8v21","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4391767960","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I4403386637","display_name":"Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade","ror":"https://ror.org/02nxphm19","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210096930","https://openalex.org/I4403386637"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Daniel J. Barbosa","raw_affiliation_strings":["Associate Laboratory i4HB - Institute for Health and Bioeconomy, CESPU University, 4585-116 Gandra, Portugal;","Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade - i3S, Universidade do Porto, 4200-135 Porto, Portugal","UCIBIO - Research Unit on Applied Molecular Biosciences, Translational Toxicology Research Laboratory, CESPU University, 4585-116 Gandra, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-7687-8181","affiliations":[{"raw_affiliation_string":"Associate Laboratory i4HB - Institute for Health and Bioeconomy, CESPU University, 4585-116 Gandra, Portugal;","institution_ids":["https://openalex.org/I4210096930","https://openalex.org/I4403386637"]},{"raw_affiliation_string":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade - i3S, Universidade do Porto, 4200-135 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]},{"raw_affiliation_string":"UCIBIO - Research Unit on Applied Molecular Biosciences, Translational Toxicology Research Laboratory, CESPU University, 4585-116 Gandra, Portugal","institution_ids":["https://openalex.org/I4210096930","https://openalex.org/I4391767960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102449132","display_name":"Julia Richter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Richter","raw_affiliation_strings":["Department of Pathology, Hematopathology Section, University Hospital Schleswig-Holstein, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hematopathology Section, University Hospital Schleswig-Holstein, Kiel, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029730460","display_name":"Stijn Stroobants","orcid":"https://orcid.org/0000-0002-7838-824X","observed_orcids":["https://orcid.org/0000-0002-7838-824X"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Stijn Stroobants","raw_affiliation_strings":["Laboratory of Biological Psychology, University of Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-7838-824X","affiliations":[{"raw_affiliation_string":"Laboratory of Biological Psychology, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016303922","display_name":"Bjoern Schuster","orcid":"https://orcid.org/0000-0002-1712-4718","observed_orcids":["https://orcid.org/0000-0002-1712-4718"]},"institutions":[{"id":"https://openalex.org/I4210138103","display_name":"Czech Academy of Sciences, Institute of Molecular Genetics","ror":"https://ror.org/045syc608","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210138103"]},{"id":"https://openalex.org/I4405257745","display_name":"Czech Centre for Phenogenomics","ror":"https://ror.org/05m92zc22","country_code":"CZ","type":"funder","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210138103","https://openalex.org/I4405257745"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Schuster","raw_affiliation_strings":["Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, V\u00edde\u0148sk\u00e1 1083, Prague, 142 20, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0002-1712-4718","affiliations":[{"raw_affiliation_string":"Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, V\u00edde\u0148sk\u00e1 1083, Prague, 142 20, Czech Republic","institution_ids":["https://openalex.org/I4210138103","https://openalex.org/I4405257745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003960054","display_name":"Inken M. Beck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138103","display_name":"Czech Academy of Sciences, Institute of Molecular Genetics","ror":"https://ror.org/045syc608","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210138103"]},{"id":"https://openalex.org/I4405257745","display_name":"Czech Centre for Phenogenomics","ror":"https://ror.org/05m92zc22","country_code":"CZ","type":"funder","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210138103","https://openalex.org/I4405257745"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Inken M. Beck","raw_affiliation_strings":["Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, V\u00edde\u0148sk\u00e1 1083, Prague, 142 20, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, V\u00edde\u0148sk\u00e1 1083, Prague, 142 20, Czech Republic","institution_ids":["https://openalex.org/I4210138103","https://openalex.org/I4405257745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047486697","display_name":"Radislav Sedl\u00e1\u010dek","orcid":"https://orcid.org/0000-0002-3352-392X","observed_orcids":["https://orcid.org/0000-0002-3352-392X"]},"institutions":[{"id":"https://openalex.org/I4210138103","display_name":"Czech Academy of Sciences, Institute of Molecular Genetics","ror":"https://ror.org/045syc608","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210138103"]},{"id":"https://openalex.org/I4405257745","display_name":"Czech Centre for Phenogenomics","ror":"https://ror.org/05m92zc22","country_code":"CZ","type":"funder","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210138103","https://openalex.org/I4405257745"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Radislav Sedlack","raw_affiliation_strings":["Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, V\u00edde\u0148sk\u00e1 1083, Prague, 142 20, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0002-3352-392X","affiliations":[{"raw_affiliation_string":"Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, V\u00edde\u0148sk\u00e1 1083, Prague, 142 20, Czech Republic","institution_ids":["https://openalex.org/I4210138103","https://openalex.org/I4405257745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091101086","display_name":"Robert H\u00e4sler","orcid":"https://orcid.org/0000-0003-4174-8229","observed_orcids":["https://orcid.org/0000-0003-4174-8229"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert H\u00e4sler","raw_affiliation_strings":["Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4174-8229","affiliations":[{"raw_affiliation_string":"Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052430237","display_name":"Mara Riechmann","orcid":"https://orcid.org/0000-0002-4611-5351","observed_orcids":["https://orcid.org/0000-0002-4611-5351"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mara Riechmann","raw_affiliation_strings":["Institut f\u00fcr Biochemie, Christian-Albrechts-Universit\u00e4t zu Kiel, 24098 Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biochemie, Christian-Albrechts-Universit\u00e4t zu Kiel, 24098 Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066342591","display_name":"Frank D\u00f6ring","orcid":"https://orcid.org/0009-0001-9356-247X","observed_orcids":["https://orcid.org/0009-0001-9356-247X"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank D\u00f6ring","raw_affiliation_strings":["Department of Molecular Prevention, University of Kiel, Heinrich-Hecht-Platz 10, 24118 Kiel, Germany"],"raw_orcid":"https://orcid.org/0009-0001-9356-247X","affiliations":[{"raw_affiliation_string":"Department of Molecular Prevention, University of Kiel, Heinrich-Hecht-Platz 10, 24118 Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032467961","display_name":"Paul S\u00e4ftig","orcid":"https://orcid.org/0000-0003-2637-7052","observed_orcids":["https://orcid.org/0000-0003-2637-7052"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Paul Saftig","raw_affiliation_strings":["Institut f\u00fcr Biochemie, Christian-Albrechts-Universit\u00e4t zu Kiel, 24098 Kiel, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2637-7052","affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biochemie, Christian-Albrechts-Universit\u00e4t zu Kiel, 24098 Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073347333","display_name":"Rudi D\u2019Hooge","orcid":"https://orcid.org/0000-0003-2243-2106","observed_orcids":["https://orcid.org/0000-0003-2243-2106"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rudi D\u2019Hooge","raw_affiliation_strings":["Laboratory of Biological Psychology, University of Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-2243-2106","affiliations":[{"raw_affiliation_string":"Laboratory of Biological Psychology, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068377786","display_name":"Katsuji Yoshioka","orcid":"https://orcid.org/0000-0002-2378-3541","observed_orcids":["https://orcid.org/0000-0002-2378-3541"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4405286179","display_name":"Cancer Research Institute of Kanazawa University","ror":"https://ror.org/01bve4846","country_code":"JP","type":"facility","lineage":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuji Yoshioka","raw_affiliation_strings":["Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, Kanazawa, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2378-3541","affiliations":[{"raw_affiliation_string":"Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032878421","display_name":"Reto Gassmann","orcid":"https://orcid.org/0000-0002-0360-2977","observed_orcids":["https://orcid.org/0000-0002-0360-2977"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Reto Gassmann","raw_affiliation_strings":["Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade - i3S, Universidade do Porto, 4200-135 Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-0360-2977","affiliations":[{"raw_affiliation_string":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade - i3S, Universidade do Porto, 4200-135 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022227900","display_name":"Ginny G. Far\u0131\u0301as","orcid":"https://orcid.org/0000-0002-7376-9692","observed_orcids":["https://orcid.org/0000-0002-7376-9692"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ginny G. Farias","raw_affiliation_strings":["Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, 3584 CH, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-7376-9692","affiliations":[{"raw_affiliation_string":"Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, 3584 CH, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081896057","display_name":"Markus Da\u03bc\u03bce","orcid":"https://orcid.org/0000-0002-9699-9351","observed_orcids":["https://orcid.org/0000-0002-9699-9351"]},"institutions":[{"id":"https://openalex.org/I20121455","display_name":"Bielefeld University","ror":"https://ror.org/02hpadn98","country_code":"DE","type":"education","lineage":["https://openalex.org/I20121455"]},{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Markus Damme","raw_affiliation_strings":["Faculty of Chemistry, Biochemistry I (BCI), University of Bielefeld, Bielefeld, Germany","Institut f\u00fcr Biochemie, Christian-Albrechts-Universit\u00e4t zu Kiel, 24098 Kiel, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9699-9351","affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, Biochemistry I (BCI), University of Bielefeld, Bielefeld, Germany","institution_ids":["https://openalex.org/I20121455"]},{"raw_affiliation_string":"Institut f\u00fcr Biochemie, Christian-Albrechts-Universit\u00e4t zu Kiel, 24098 Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5081896057"],"corresponding_institution_ids":["https://openalex.org/I20121455","https://openalex.org/I32021983"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.21529999375343323,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysosome-trafficking","display_name":"lysosomal trafficking","score":0.6740000247955322},{"id":"https://openalex.org/keywords/anterograde-transport","display_name":"anterograde transport","score":0.9259999990463257},{"id":"https://openalex.org/keywords/jip4","display_name":"JIP4","score":0.7570000290870667},{"id":"https://openalex.org/keywords/dynein-motor","display_name":"dynein motor","score":0.7440000176429749},{"id":"https://openalex.org/keywords/kinesin-motors","display_name":"kinesin motors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/lysosome-positioning","display_name":"lysosome positioning","score":0.753000020980835},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.6570000052452087},{"id":"https://openalex.org/keywords/cholinergic-neurons","display_name":"cholinergic neurons","score":0.8080000281333923},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.8641999959945679},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7840999960899353},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.717199981212616},{"id":"https://openalex.org/C106987784","wikidata":"https://www.wikidata.org/wiki/Q410134","display_name":"Dynein","level":3,"score":0.7088000178337097},{"id":"https://openalex.org/C59006786","wikidata":"https://www.wikidata.org/wiki/Q15319390","display_name":"Kinesin","level":3,"score":0.6330000162124634},{"id":"https://openalex.org/C70192387","wikidata":"https://www.wikidata.org/wiki/Q792602","display_name":"Axoplasmic transport","level":2,"score":0.5785999894142151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5358999967575073},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.5264999866485596},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3937999904155731},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36059999465942383},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3596000075340271},{"id":"https://openalex.org/C93126451","wikidata":"https://www.wikidata.org/wiki/Q2383767","display_name":"Motor protein","level":3,"score":0.33500000834465027},{"id":"https://openalex.org/C2778264360","wikidata":"https://www.wikidata.org/wiki/Q675010","display_name":"Lysosomal storage disease","level":3,"score":0.3230000138282776},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3156000077724457},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.30720001459121704},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.3000999987125397},{"id":"https://openalex.org/C2780301495","wikidata":"https://www.wikidata.org/wiki/Q13359588","display_name":"Dynein ATPase","level":4,"score":0.28119999170303345},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C135903288","wikidata":"https://www.wikidata.org/wiki/Q559423","display_name":"Growth cone","level":3,"score":0.2653999924659729},{"id":"https://openalex.org/C61081601","wikidata":"https://www.wikidata.org/wiki/Q1102066","display_name":"Microtubule-associated protein","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.2522999942302704}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.27.762112","doi":"https://doi.org/10.64898/2026.10.27.762112","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.27.762112","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/28/2026.10.27.762112.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.27.762112","doi":"https://doi.org/10.64898/2026.10.27.762112","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.27.762112","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/28/2026.10.27.762112.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1751328538","display_name":null,"funder_award_id":"RVO68378050","funder_id":"https://openalex.org/F4320322482","funder_display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G2832770583","display_name":null,"funder_award_id":"LM202303","funder_id":"https://openalex.org/F4320322482","funder_display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G4070457812","display_name":null,"funder_award_id":"SA 683/9-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4345769068","display_name":null,"funder_award_id":"DA 1785/2\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5511180595","display_name":null,"funder_award_id":"68378050","funder_id":"https://openalex.org/F4320322482","funder_display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G7562382621","display_name":null,"funder_award_id":"DA 1785/2-2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G771060767","display_name":null,"funder_award_id":"FOR 2625","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320322482","display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky","ror":"https://ror.org/053avzc18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224102162.pdf","grobid_xml":"https://content.openalex.org/works/W7224102162.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7064683556","https://openalex.org/W7110680627","https://openalex.org/W3011714286","https://openalex.org/W2770609313","https://openalex.org/W3128839225","https://openalex.org/W2041017990","https://openalex.org/W3184746592","https://openalex.org/W2790775254","https://openalex.org/W3192332445","https://openalex.org/W2156514097"],"abstract_inverted_index":{"Abstract":[0],"Lysosomal":[1],"function":[2,189,269],"throughout":[3],"life":[4],"is":[5,79,270],"vital":[6],"for":[7,272],"the":[8,48,60,105,110,145,196,214,279],"proper":[9],"functioning":[10],"and":[11,21,33,73,109,130,147,165,236,248,288],"survival":[12],"of":[13,50,63,216,281],"post-mitotic":[14],"neurons":[15],"by":[16,258],"mediating":[17],"cellular":[18],"signaling,":[19],"degradation,":[20],"recycling":[22],"processes.":[23],"Their":[24],"intracellular":[25],"transport":[26,150],"relies":[27],"on":[28],"microtubule-dependent":[29],"mechanisms":[30],"involving":[31,297],"kinesin":[32,166],"dynein":[34,164],"motors.":[35,167],"While":[36],"lysosomes":[37],"were":[38,152],"long":[39],"thought":[40],"absent":[41],"from":[42],"axons,":[43,257],"recent":[44],"studies":[45],"have":[46],"demonstrated":[47],"importance":[49,280],"LAMP1-positive":[51,83],"endo-/lysosomal":[52],"organelles":[53,84],"in":[54,70,76,82,85,99,104,120,127,136,144,173,180,190,204,220,253,256,283,294],"axonal":[55],"compartments.":[56],"This":[57,268],"study":[58,277],"investigates":[59],"physiological":[61],"role":[62],"TMEM55B,":[64],"a":[65,158,291],"lysosomal":[66,97,128,133,202,274,298],"membrane":[67],"protein":[68],"involved":[69],"lysosome":[71,142,223,251],"positioning":[72,98],"motor":[74,265],"coupling":[75],"neurons.":[77,87,100],"TMEM55B":[78,124,161,168,188,197,247],"highly":[80],"expressed":[81],"cortical":[86],"We":[88],"generated":[89,226],"viable":[90],"Tmem55b":[91],"knockout":[92],"mice":[93],"that":[94,245],"exhibited":[95],"altered":[96,201],"Lysosomes":[101],"clustered":[102],"abnormally":[103],"pre-axonal":[106],"exclusion":[107],"zone":[108],"proximal":[111,146],"axon,":[112],"with":[113,154],"many":[114],"forming":[115],"elongated":[116],"tubular":[117],"structures.":[118],"Similarly,":[119],"primary":[121],"rat":[122],"neurons,":[123,206,254],"depletion":[125],"resulted":[126],"tubulation":[129],"impaired":[131,232],"bidirectional":[132],"transport,":[134],"particularly":[135,255],"distal":[137],"axon":[138],"segments,":[139],"without":[140],"affecting":[141],"velocity":[143],"mid-axon.":[148],"These":[149],"defects":[151],"consistent":[153],"disrupted":[155],"JIP4":[156],"function,":[157],"scaffold":[159],"linking":[160],"to":[162],"both":[163,246],"deficiency":[169],"did":[170],"not":[171],"result":[172],"neurodegeneration,":[174],"behavioral":[175],"deficits,":[176],"or":[177],"reduced":[178],"lifespan":[179],"mice.":[181],"As":[182],"an":[183,208,237],"orthogonal":[184],"approach,":[185],"we":[186,225],"analyzed":[187],"C.":[191],"elegans":[192],".":[193],"Worms":[194],"lacking":[195],"homolog":[198],"Y71H2AM.2":[199],"showed":[200],"dynamics":[203,287],"cholinergic":[205],"supporting":[207],"evolutionarily":[209],"conserved":[210],"role.":[211],"To":[212],"test":[213],"involvement":[215],"TMEM55B\u2019s":[217],"paralog,":[218],"TMEM55A,":[219],"regulating":[221,284],"neuronal":[222,285],"positioning,":[224],"Tmem55a/b":[227],"double-knockout":[228],"mice,":[229],"which":[230],"exhibit":[231],"growth,":[233],"premature":[234],"death,":[235],"overall":[238],"aggravated":[239],"phenotype.":[240],"Collectively,":[241],"our":[242],"findings":[243],"demonstrate":[244],"TMEM55A":[249],"regulate":[250],"distribution":[252],"influencing":[259],"JIP4-dependent":[260],"retro-":[261],"and,":[262],"notably,":[263],"anterograde":[264],"protein-mediated":[266],"transport.":[267],"critical":[271],"spatial":[273],"homeostasis.":[275],"Our":[276],"underscores":[278],"TMEM55A/TMEM55B":[282],"organelle":[286],"may":[289],"be":[290],"factor":[292],"considered":[293],"neurodegenerative":[295],"diseases":[296],"trafficking":[299],"defects.":[300]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-29T00:00:00"}
