{"id":"https://openalex.org/W7224093963","doi":"https://doi.org/10.1002/anie.8507021","title":"Adaptation of a Fluorogenic RNA to N1\u2010Methylpseudouridine Nucleoside Chemistry","display_name":"Adaptation of a Fluorogenic RNA to N1\u2010Methylpseudouridine Nucleoside Chemistry","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7224093963","doi":"https://doi.org/10.1002/anie.8507021","pmid":"https://pubmed.ncbi.nlm.nih.gov/42946975"},"language":"en","primary_location":{"id":"doi:10.1002/anie.8507021","doi":"https://doi.org/10.1002/anie.8507021","is_oa":true,"landing_page_url":"https://doi.org/10.1002/anie.8507021","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.8507021","source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.8507021","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160040242","display_name":"Patrick P.A. Bertrand","orcid":"https://orcid.org/0000-0001-5398-9666","observed_orcids":["https://orcid.org/0000-0001-5398-9666"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210128885","display_name":"Architecture et R\u00e9activit\u00e9 de l'arN","ror":"https://ror.org/03xmjtz19","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210128885","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrick P.A. Bertrand","raw_affiliation_strings":["Universit\u00e9 De Strasbourg, CNRS Architecture et R\u00e9activit\u00e9 de l'ARN Strasbourg France"],"raw_orcid":"https://orcid.org/0000-0001-5398-9666","affiliations":[{"raw_affiliation_string":"Universit\u00e9 De Strasbourg, CNRS Architecture et R\u00e9activit\u00e9 de l'ARN Strasbourg France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210128885","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160041217","display_name":"Roger Cubi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210128885","display_name":"Architecture et R\u00e9activit\u00e9 de l'arN","ror":"https://ror.org/03xmjtz19","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210128885","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Roger Cubi","raw_affiliation_strings":["Universit\u00e9 De Strasbourg, CNRS Architecture et R\u00e9activit\u00e9 de l'ARN Strasbourg France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 De Strasbourg, CNRS Architecture et R\u00e9activit\u00e9 de l'ARN Strasbourg France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210128885","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084980467","display_name":"Claire Husser","orcid":"https://orcid.org/0000-0003-3478-6403","observed_orcids":["https://orcid.org/0000-0003-3478-6403"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210128885","display_name":"Architecture et R\u00e9activit\u00e9 de l'arN","ror":"https://ror.org/03xmjtz19","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210128885","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claire Husser","raw_affiliation_strings":["Universit\u00e9 De Strasbourg, CNRS Architecture et R\u00e9activit\u00e9 de l'ARN Strasbourg France"],"raw_orcid":"https://orcid.org/0000-0003-3478-6403","affiliations":[{"raw_affiliation_string":"Universit\u00e9 De Strasbourg, CNRS Architecture et R\u00e9activit\u00e9 de l'ARN Strasbourg France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210128885","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010715794","display_name":"Magali Frugier","orcid":"https://orcid.org/0000-0002-8079-5303","observed_orcids":["https://orcid.org/0000-0002-8079-5303"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210128885","display_name":"Architecture et R\u00e9activit\u00e9 de l'arN","ror":"https://ror.org/03xmjtz19","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210128885","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Magali Frugier","raw_affiliation_strings":["Universit\u00e9 De Strasbourg, CNRS Architecture et R\u00e9activit\u00e9 de l'ARN Strasbourg France"],"raw_orcid":"https://orcid.org/0000-0002-8079-5303","affiliations":[{"raw_affiliation_string":"Universit\u00e9 De Strasbourg, CNRS Architecture et R\u00e9activit\u00e9 de l'ARN Strasbourg France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210128885","https://openalex.org/I68947357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015424123","display_name":"Micha\u00ebl Ryckelynck","orcid":"https://orcid.org/0000-0002-2225-3733","observed_orcids":["https://orcid.org/0000-0002-2225-3733"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210128885","display_name":"Architecture et R\u00e9activit\u00e9 de l'arN","ror":"https://ror.org/03xmjtz19","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210128885","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Michael Ryckelynck","raw_affiliation_strings":["Universit\u00e9 De Strasbourg, CNRS Architecture et R\u00e9activit\u00e9 de l'ARN Strasbourg France"],"raw_orcid":"https://orcid.org/0000-0002-2225-3733","affiliations":[{"raw_affiliation_string":"Universit\u00e9 De Strasbourg, CNRS Architecture et R\u00e9activit\u00e9 de l'ARN Strasbourg France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210128885","https://openalex.org/I68947357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015424123"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210128885","https://openalex.org/I68947357"],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":{"value":5510,"currency":"USD","value_usd":5510},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71120789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"e8507021","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.14259999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.09359999746084213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n1-methylpseudouridine","display_name":"N1-methylpseudouridine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/modified-nucleosides","display_name":"modified nucleosides","score":0.7760000228881836},{"id":"https://openalex.org/keywords/flaps","display_name":"flaps","score":0.7599999904632568},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.6209999918937683},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.5270000100135803},{"id":"https://openalex.org/keywords/rational-design","display_name":"rational design","score":0.9160000085830688},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7346000075340271},{"id":"https://openalex.org/C2781259782","wikidata":"https://www.wikidata.org/wiki/Q422573","display_name":"Uridine","level":4,"score":0.7204999923706055},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6833000183105469},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.6507999897003174},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.6140000224113464},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.5407999753952026},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5396000146865845},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5145000219345093},{"id":"https://openalex.org/C148625055","wikidata":"https://www.wikidata.org/wiki/Q418840","display_name":"Riboswitch","level":5,"score":0.48539999127388},{"id":"https://openalex.org/C9418097","wikidata":"https://www.wikidata.org/wiki/Q440681","display_name":"Directed evolution","level":4,"score":0.46650001406669617},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4569000005722046},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.4514000117778778},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.44999998807907104},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4487000107765198},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4334000051021576},{"id":"https://openalex.org/C2777333352","wikidata":"https://www.wikidata.org/wiki/Q2689559","display_name":"Nucleoside analogue","level":3,"score":0.3874000012874603},{"id":"https://openalex.org/C2779810333","wikidata":"https://www.wikidata.org/wiki/Q420445","display_name":"Pseudouridine","level":5,"score":0.3765000104904175},{"id":"https://openalex.org/C2777610669","wikidata":"https://www.wikidata.org/wiki/Q422564","display_name":"Inosine","level":3,"score":0.35850000381469727},{"id":"https://openalex.org/C2781184954","wikidata":"https://www.wikidata.org/wiki/Q422538","display_name":"Cytidine","level":3,"score":0.357699990272522},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3361000120639801},{"id":"https://openalex.org/C2778021871","wikidata":"https://www.wikidata.org/wiki/Q648006","display_name":"Footprinting","level":4,"score":0.32420000433921814},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.3125999867916107},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.30000001192092896},{"id":"https://openalex.org/C122682173","wikidata":"https://www.wikidata.org/wiki/Q907101","display_name":"Systematic evolution of ligands by exponential enrichment","level":4,"score":0.2953999936580658},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.27880001068115234},{"id":"https://openalex.org/C2776043002","wikidata":"https://www.wikidata.org/wiki/Q2687447","display_name":"Phosphoramidite","level":4,"score":0.27129998803138733},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.262800008058548},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.25839999318122864},{"id":"https://openalex.org/C153574943","wikidata":"https://www.wikidata.org/wiki/Q408939","display_name":"Nucleotidyltransferase","level":4,"score":0.2574999928474426},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.2515999972820282}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/anie.8507021","doi":"https://doi.org/10.1002/anie.8507021","is_oa":true,"landing_page_url":"https://doi.org/10.1002/anie.8507021","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.8507021","source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},{"id":"pmid:42946975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42946975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie (International ed. in English)","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05850081v1","doi":null,"is_oa":true,"landing_page_url":"https://univoak.hal.science/hal-05850081","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Angewandte Chemie International Edition, 2026, pp.e8507021. ⟨10.1002/anie.8507021⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/anie.8507021","doi":"https://doi.org/10.1002/anie.8507021","is_oa":true,"landing_page_url":"https://doi.org/10.1002/anie.8507021","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.8507021","source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320322147","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224093963.pdf","grobid_xml":"https://content.openalex.org/works/W7224093963.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1215958058","https://openalex.org/W2130573623","https://openalex.org/W2253352802","https://openalex.org/W2265234877","https://openalex.org/W2293575659","https://openalex.org/W2332645767","https://openalex.org/W2483473419","https://openalex.org/W2522303658","https://openalex.org/W2563987835","https://openalex.org/W2589945527","https://openalex.org/W2609333968","https://openalex.org/W2758319026","https://openalex.org/W2803572544","https://openalex.org/W2804357191","https://openalex.org/W2811323147","https://openalex.org/W2915388137","https://openalex.org/W2921158767","https://openalex.org/W2923404906","https://openalex.org/W2923639686","https://openalex.org/W2936498246","https://openalex.org/W2951512456","https://openalex.org/W2953295872","https://openalex.org/W2955231772","https://openalex.org/W2973830670","https://openalex.org/W2983889514","https://openalex.org/W2995302222","https://openalex.org/W3008941348","https://openalex.org/W3126657865","https://openalex.org/W3128452905","https://openalex.org/W3133787915","https://openalex.org/W3134732507","https://openalex.org/W3140429722","https://openalex.org/W3151588074","https://openalex.org/W3188622419","https://openalex.org/W3211077113","https://openalex.org/W4210869675","https://openalex.org/W4220991830","https://openalex.org/W4283579886","https://openalex.org/W4309862014","https://openalex.org/W4313706607","https://openalex.org/W4317500710","https://openalex.org/W4388983747","https://openalex.org/W4389391264","https://openalex.org/W4389537897","https://openalex.org/W4390974286","https://openalex.org/W4392654875","https://openalex.org/W4398240041","https://openalex.org/W4400221930","https://openalex.org/W4400307683","https://openalex.org/W4401211109","https://openalex.org/W4402580721","https://openalex.org/W4404374778","https://openalex.org/W4405374827","https://openalex.org/W4405567020","https://openalex.org/W4405781439","https://openalex.org/W4405877131","https://openalex.org/W4406104106","https://openalex.org/W4406193580","https://openalex.org/W4406849402","https://openalex.org/W4406873290","https://openalex.org/W4407593610","https://openalex.org/W4407735672","https://openalex.org/W4409176656","https://openalex.org/W4410831142","https://openalex.org/W4411067027","https://openalex.org/W4411731213","https://openalex.org/W4412365300","https://openalex.org/W4412395868","https://openalex.org/W4412783324","https://openalex.org/W4412976636","https://openalex.org/W4413357892","https://openalex.org/W4414105405","https://openalex.org/W4415619505","https://openalex.org/W7119550109","https://openalex.org/W7124148249","https://openalex.org/W7138930649","https://openalex.org/W7153623009","https://openalex.org/W7155802910","https://openalex.org/W7161009819"],"related_works":["https://openalex.org/W3008941348","https://openalex.org/W4291450052","https://openalex.org/W2589945527","https://openalex.org/W4406873290","https://openalex.org/W1215958058","https://openalex.org/W4402580721","https://openalex.org/W7213506953","https://openalex.org/W4389743622","https://openalex.org/W2900391652","https://openalex.org/W4385348274"],"abstract_inverted_index":{"ABSTRACT":[0],"N1\u2010methylpseudouridine":[1],"(":[2],"m":[3,79,124,134,153,177],"\u03a8)":[4],"is":[5,87],"a":[6,133,145],"modified":[7,186],"nucleoside":[8],"that":[9,75],"entirely":[10],"replaces":[11],"uridine":[12,122],"in":[13,42,57,81,179],"the":[14,37,58,61,96,114,119,130,139,149,166,169],"design":[15,108],"of":[16,39,60,92,98,121,132,152,171,181],"many":[17],"therapeutic":[18,185],"messenger":[19],"RNAs":[20,45,63,175],"(mRNA)":[21],"to":[22,31,89,112,128],"alleviate":[23],"their":[24,29,66,90,99],"intrinsic":[25],"immunogenicity":[26],"while":[27],"preserving":[28],"capacity":[30,91],"be":[32],"translated":[33],"into":[34],"protein.":[35],"However,":[36],"impact":[38],"such":[40],"replacement":[41,120],"functional":[43,173],"non\u2010coding":[44,136,174],"has":[46],"only":[47,111],"been":[48],"scarcely":[49],"studied,":[50],"and":[51,94,106,156,183],"most":[52],"studies":[53],"have":[54],"shown":[55],"impairment":[56],"function":[59,131],"tested":[62],"thereby":[64],"limiting":[65],"potential":[67],"applications.":[68],"In":[69],"this":[70],"work,":[71],"we":[72],"further":[73],"show":[74],"exchanging":[76],"uridines":[77],"by":[78,118,123],"\u03a8":[80,178],"green\u2010emitting":[82],"Fluorogenic":[83],"Light\u2010up":[84],"Aptamers":[85],"(FLAP)":[86],"detrimental":[88],"binding":[93],"enhancing":[95],"fluorescence":[97],"cognate":[100],"fluorogen.":[101],"Moreover,":[102],"combining":[103],"directed":[104],"evolution":[105],"rational":[107],"allowed":[109],"not":[110],"pinpoint":[113],"structural":[115],"elements":[116],"impacted":[117],"\u03a8,":[125],"but":[126],"also":[127],"re\u2010establish":[129],"\u03a8\u2010modified":[135,154],"RNA":[137],"for":[138,148,158,168],"first":[140],"time.":[141],"This":[142,162],"yielded":[143],"\u03a8\u2010Spinach,":[144],"FLAP":[146],"suited":[147],"precise":[150],"labelling":[151],"mRNA":[155],"usable":[157],"human":[159],"cells":[160],"transfection.":[161],"work":[163],"thus":[164],"paves":[165],"way":[167],"adaptation":[170],"other":[172],"with":[176],"view":[180],"engineering":[182],"optimizing":[184],"mRNAs.":[187]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-29T00:00:00"}