{"id":"https://openalex.org/W7224092856","doi":"https://doi.org/10.1186/s12894-026-02450-5","title":"Evaluation of bladder function in newly diagnosed thyrotoxicosis patients: a prospective controlled study","display_name":"Evaluation of bladder function in newly diagnosed thyrotoxicosis patients: a prospective controlled study","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224092856","doi":"https://doi.org/10.1186/s12894-026-02450-5"},"language":"en","primary_location":{"id":"doi:10.1186/s12894-026-02450-5","doi":"https://doi.org/10.1186/s12894-026-02450-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12894-026-02450-5","pdf_url":null,"source":{"id":"https://openalex.org/S155033327","display_name":"BMC Urology","issn_l":"1471-2490","issn":["1471-2490"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12894-026-02450-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160061861","display_name":"Bet\u00fcl \u015eahin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405277310","display_name":"Ankara E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/027wtj018","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I1303077703","https://openalex.org/I4405277310"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Bet\u00fcl \u015eahin","raw_affiliation_strings":["Department of Internal Medicine, Ankara Training and Research Hospital, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Ankara Training and Research Hospital, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I4405277310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160047225","display_name":"G\u00fclce Ecem K\u0131l\u0131\u00e7","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405277310","display_name":"Ankara E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/027wtj018","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I1303077703","https://openalex.org/I4405277310"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00fclce Ecem K\u0131l\u0131\u00e7","raw_affiliation_strings":["Division of Endocrinology, Ankara Training and Research Hospital, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Ankara Training and Research Hospital, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I4405277310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022544023","display_name":"Arif Bedirhan Bayraktar","orcid":"https://orcid.org/0000-0002-2373-5929","observed_orcids":["https://orcid.org/0000-0002-2373-5929"]},"institutions":[{"id":"https://openalex.org/I4405277310","display_name":"Ankara E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/027wtj018","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I1303077703","https://openalex.org/I4405277310"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Arif Bedirhan Bayraktar","raw_affiliation_strings":["Department of Urology, Ankara Training and Research Hospital, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Ankara Training and Research Hospital, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I4405277310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138268411","display_name":"Mustafa Kemal Y\u0131lmaz","orcid":"https://orcid.org/0009-0009-1509-4381","observed_orcids":["https://orcid.org/0009-0009-1509-4381"]},"institutions":[{"id":"https://openalex.org/I4405277310","display_name":"Ankara E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/027wtj018","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I1303077703","https://openalex.org/I4405277310"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Baran Y\u0131lmaz","raw_affiliation_strings":["Department of Urology, Ankara Training and Research Hospital, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Ankara Training and Research Hospital, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I4405277310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033990979","display_name":"Berat Cem \u00d6zg\u00fcr","orcid":"https://orcid.org/0000-0003-1480-8441","observed_orcids":["https://orcid.org/0000-0003-1480-8441"]},"institutions":[{"id":"https://openalex.org/I4405277310","display_name":"Ankara E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/027wtj018","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I1303077703","https://openalex.org/I4405277310"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Berat Cem \u00d6zg\u00fcr","raw_affiliation_strings":["Department of Urology, Ankara Training and Research Hospital, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Ankara Training and Research Hospital, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I4405277310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063135868","display_name":"\u015eerife Mehlika Ku\u015fkonmaz","orcid":"https://orcid.org/0000-0002-2602-1657","observed_orcids":["https://orcid.org/0000-0002-2602-1657"]},"institutions":[{"id":"https://openalex.org/I4405277310","display_name":"Ankara E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/027wtj018","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I1303077703","https://openalex.org/I4405277310"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u015eerife Mehlika Ku\u015fkonmaz","raw_affiliation_strings":["Division of Endocrinology, Ankara Training and Research Hospital, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Ankara Training and Research Hospital, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I4405277310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5160061861"],"corresponding_institution_ids":["https://openalex.org/I4405277310"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86136421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyrotoxicosis","display_name":"thyrotoxicosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lower-urinary-tract-symptoms","display_name":"lower urinary tract symptoms","score":0.9580000042915344},{"id":"https://openalex.org/keywords/bladder-function","display_name":"bladder function","score":0.9750000238418579},{"id":"https://openalex.org/keywords/autonomic-imbalance","display_name":"autonomic imbalance","score":0.5799999833106995},{"id":"https://openalex.org/keywords/beta-adrenergic-activity","display_name":"beta-adrenergic activity","score":0.8270000219345093},{"id":"https://openalex.org/keywords/euthyroidism","display_name":"euthyroidism","score":0.7070000171661377},{"id":"https://openalex.org/keywords/antithyroid-drug-therapy","display_name":"antithyroid drug therapy","score":0.8389999866485596},{"id":"https://openalex.org/keywords/international-prostate-symptom-score","display_name":"International Prostate Symptom Score","score":0.8610000014305115},{"id":"https://openalex.org/keywords/uroflowmetry","display_name":"uroflowmetry","score":0.8700000047683716},{"id":"https://openalex.org/keywords/post-void-residual-urine","display_name":"post-void residual urine","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nocturia","display_name":"nocturia","score":0.7850000262260437},{"id":"https://openalex.org/keywords/urinary-frequency","display_name":"urinary frequency","score":0.8999999761581421},{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.871999979019165},{"id":"https://openalex.org/keywords/sympathetic-and-parasympathetic-activity","display_name":"sympathetic and parasympathetic activity","score":0.7329999804496765},{"id":"https://openalex.org/keywords/storage-symptoms","display_name":"storage symptoms","score":0.4620000123977661},{"id":"https://openalex.org/keywords/maximum-flow-rate","display_name":"maximum flow rate","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9599999785423279},{"id":"https://openalex.org/C2779478474","wikidata":"https://www.wikidata.org/wiki/Q446372","display_name":"Lower urinary tract symptoms","level":4,"score":0.6341000199317932},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.6086000204086304},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.590399980545044},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5698000192642212},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.5493000149726868},{"id":"https://openalex.org/C2778840127","wikidata":"https://www.wikidata.org/wiki/Q712838","display_name":"Thyroid function tests","level":3,"score":0.46540001034736633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4309000074863434},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.39500001072883606},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.3896999955177307},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.37310001254081726},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.36090001463890076},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.35280001163482666},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.30320000648498535},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.29789999127388},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2890999913215637},{"id":"https://openalex.org/C2777912814","wikidata":"https://www.wikidata.org/wiki/Q3858636","display_name":"Urinary urgency","level":4,"score":0.28850001096725464},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.28630000352859497},{"id":"https://openalex.org/C2776547966","wikidata":"https://www.wikidata.org/wiki/Q1283551","display_name":"International Prostate Symptom Score","level":5,"score":0.27149999141693115},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2687999904155731},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.2687000036239624},{"id":"https://openalex.org/C2777501473","wikidata":"https://www.wikidata.org/wiki/Q1796666","display_name":"Body surface area","level":2,"score":0.25380000472068787},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.2522999942302704},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.25049999356269836},{"id":"https://openalex.org/C64946054","wikidata":"https://www.wikidata.org/wiki/Q4874476","display_name":"Bayesian multivariate linear regression","level":3,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12894-026-02450-5","doi":"https://doi.org/10.1186/s12894-026-02450-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12894-026-02450-5","pdf_url":null,"source":{"id":"https://openalex.org/S155033327","display_name":"BMC Urology","issn_l":"1471-2490","issn":["1471-2490"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Urology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12894-026-02450-5","doi":"https://doi.org/10.1186/s12894-026-02450-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12894-026-02450-5","pdf_url":null,"source":{"id":"https://openalex.org/S155033327","display_name":"BMC Urology","issn_l":"1471-2490","issn":["1471-2490"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2106494527","https://openalex.org/W1538916022","https://openalex.org/W4214709614","https://openalex.org/W4389603403","https://openalex.org/W2731918234","https://openalex.org/W4409958989","https://openalex.org/W7140247877","https://openalex.org/W4406920659","https://openalex.org/W2769152137","https://openalex.org/W2419733241"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Thyroid":[2],"hormone":[3],"excess":[4],"increases":[5],"\u03b2-adrenergic":[6],"activity":[7],"and":[8,20,28,51,60,91,99,126,130,140,157,162,169,174,221,229,247,264,268,289,317,329,352],"causes":[9],"autonomic":[10],"imbalance,":[11],"particularly":[12],"in":[13,77,94,225,250,315,345],"the":[14,66,151],"cardiovascular":[15],"system.":[16],"Because":[17],"bladder":[18,62,92,158],"storage":[19,260],"voiding":[21],"depend":[22],"on":[23],"a":[24,44,335],"balance":[25],"between":[26,285],"sympathetic":[27],"parasympathetic":[29],"activity,":[30],"thyrotoxicosis":[31,78,97,121,316],"may":[32,79,339],"also":[33],"affect":[34],"lower":[35,56,87],"urinary":[36,57,75,88,145,310],"tract":[37,58,89,146,311],"function.":[38],"However,":[39],"evidence":[40],"is":[41,71],"limited":[42],"to":[43,85,203,215,302],"few":[45],"small":[46],"studies":[47,348],"with":[48,103,118,132,150,160,349],"inconsistent":[49],"findings,":[50],"it":[52],"remains":[53],"unclear":[54],"whether":[55],"symptoms":[59,76,90,147,312],"objective":[61],"function":[63,93,159],"change":[64,208,272,333],"after":[65,100,127,189,230,240,273,320],"restoration":[67],"of":[68,323],"euthyroidism.":[69],"This":[70,82],"clinically":[72],"relevant,":[73],"as":[74],"be":[80,340],"overlooked.":[81],"study":[83],"aimed":[84],"evaluate":[86],"newly":[95,119],"diagnosed":[96,120],"before":[98,228],"treatment,":[101,190,321],"compared":[102,131],"healthy":[104,134],"controls.":[105,278],"Methods":[106],"In":[107],"this":[108],"prospective":[109],"controlled":[110],"cohort":[111],"study,":[112],"40":[113],"patients":[114,184,251],"aged":[115],"18\u201350":[116],"years":[117],"were":[122,148,178,257],"evaluated":[123],"at":[124],"baseline":[125],"achieving":[128],"euthyroidism,":[129],"37":[133],"controls":[135,226],"matched":[136],"for":[137,342],"age,":[138],"sex":[139],"body":[141],"mass":[142],"index.":[143],"Lower":[144,309],"assessed":[149],"International":[152],"Prostate":[153],"Symptom":[154],"Score":[155],"(IPSS),":[156],"uroflowmetry":[161],"ultrasonographic":[163],"post-void":[164],"residual":[165],"(PVR)":[166],"volume.":[167],"Parametric":[168],"non-parametric":[170],"tests,":[171],"Spearman":[172],"correlation":[173,282],"multivariable":[175,241],"linear":[176],"regression":[177],"used.":[179],"Results":[180],"At":[181],"baseline,":[182],"28":[183],"(70%)":[185],"had":[186,193],"moderate":[187],"symptoms;":[188],"38":[191],"(95%)":[192],"mild":[194],"symptoms.":[195],"Mean":[196],"IPSS":[197,338],"decreased":[198],"from":[199,277],"7.03":[200],"\u00b1":[201,205],"3.32":[202],"1.95":[204],"1.71":[206],"(mean":[207],"\u2212":[209,213,216,296,300,303],"5.08,":[210],"95%":[211,298],"CI":[212,299],"6.10":[214],"4.05;":[217],"p":[218,233,244,305],"<":[219,234,245],"0.001)":[220,246],"was":[222,248,283],"higher":[223],"than":[224],"both":[227],"treatment":[231,274],"(":[232,243,293],"0.001).":[235],"The":[236],"improvement":[237],"remained":[238],"significant":[239],"adjustment":[242],"similar":[249],"not":[252,271,332],"receiving":[253],"antithyroid":[254],"drugs.":[255],"Symptoms":[256],"almost":[258],"exclusively":[259],"symptoms,":[261],"mainly":[262],"frequency":[263],"nocturia.":[265],"Uroflowmetric":[266],"parameters":[267,328],"PVR":[269,330],"did":[270],"or":[275],"differ":[276],"A":[279],"borderline":[280],"inverse":[281],"found":[284],"pre-treatment":[286],"free":[287],"thyroxine":[288],"maximum":[290],"flow":[291],"rate":[292],"\u03c1":[294],"=":[295,306],"0.31,":[297],"0.57":[301],"0.00;":[304],"0.050).":[307],"Conclusions":[308],"are":[313,355],"common":[314],"improve":[318],"significantly":[319],"independently":[322],"measured":[324],"confounders,":[325],"whereas":[326],"uroflowmetric":[327],"do":[331],"within":[334],"short":[336],"follow-up.":[337],"useful":[341],"symptom":[343],"assessment":[344,354],"thyrotoxicosis.":[346],"Larger":[347],"longer":[350],"follow-up":[351],"urodynamic":[353],"needed.":[356],"Trial":[357],"registration":[358],"Not":[359],"applicable.":[360]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-29T00:00:00"}