{"id":"https://openalex.org/W7224090837","doi":"https://doi.org/10.3390/cells15211963","title":"Histone Acetylation in Bone Remodeling: Metabolic Regulation, Lineage-Specific Chromatin Programs, and Therapeutic Implications","display_name":"Histone Acetylation in Bone Remodeling: Metabolic Regulation, Lineage-Specific Chromatin Programs, and Therapeutic Implications","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224090837","doi":"https://doi.org/10.3390/cells15211963"},"language":"en","primary_location":{"id":"doi:10.3390/cells15211963","doi":"https://doi.org/10.3390/cells15211963","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells15211963","pdf_url":null,"source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cells15211963","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159741667","display_name":"Jianhong Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhong Dong","raw_affiliation_strings":["Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137128802","display_name":"Xianji Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18925743","display_name":"Shanghai University of Sport","ror":"https://ror.org/0056pyw12","country_code":"CN","type":"education","lineage":["https://openalex.org/I18925743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianji Wei","raw_affiliation_strings":["College of Athletic Performance, Shanghai University of Sport, No. 399 Changhai Road, Yangpu District, Shanghai 200438, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Athletic Performance, Shanghai University of Sport, No. 399 Changhai Road, Yangpu District, Shanghai 200438, China","institution_ids":["https://openalex.org/I18925743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103152561","display_name":"Yifan Qian","orcid":"https://orcid.org/0009-0008-2021-9372","observed_orcids":["https://orcid.org/0009-0008-2021-9372"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I4210148790","display_name":"Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine","ror":"https://ror.org/05pwsw714","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148790"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Qian","raw_affiliation_strings":["Department of Pharmacy, Affiliated Hangzhou First People\u2019s Hospital, School of Medicine, Westlake University, No. 261 Huansha Road, Shangcheng District, Hangzhou 310006, China","Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Affiliated Hangzhou First People\u2019s Hospital, School of Medicine, Westlake University, No. 261 Huansha Road, Shangcheng District, Hangzhou 310006, China","institution_ids":["https://openalex.org/I4210148790"]},{"raw_affiliation_string":"Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160054966","display_name":"Yiming Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I4210148790","display_name":"Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine","ror":"https://ror.org/05pwsw714","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148790"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yiming Qian","raw_affiliation_strings":["Department of Pharmacy, Affiliated Hangzhou First People\u2019s Hospital, School of Medicine, Westlake University, No. 261 Huansha Road, Shangcheng District, Hangzhou 310006, China","Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Affiliated Hangzhou First People\u2019s Hospital, School of Medicine, Westlake University, No. 261 Huansha Road, Shangcheng District, Hangzhou 310006, China","institution_ids":["https://openalex.org/I4210148790"]},{"raw_affiliation_string":"Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159998417","display_name":"Wei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18925743","display_name":"Shanghai University of Sport","ror":"https://ror.org/0056pyw12","country_code":"CN","type":"education","lineage":["https://openalex.org/I18925743"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["School of Exercise and Health, Shanghai University of Sport, No. 399 Changhai Road, Yangpu District, Shanghai 200438, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Exercise and Health, Shanghai University of Sport, No. 399 Changhai Road, Yangpu District, Shanghai 200438, China","institution_ids":["https://openalex.org/I18925743"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5159998417","https://openalex.org/A5160054966"],"corresponding_institution_ids":["https://openalex.org/I18925743","https://openalex.org/I2802390878","https://openalex.org/I4210148790","https://openalex.org/I76130692"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76743296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"21","first_page":"1963","last_page":"1963"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":1.0},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/acetyl-coa-metabolism","display_name":"acetyl-CoA metabolism","score":0.9539999961853027},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.8220000267028809},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9980000257492065},{"id":"https://openalex.org/keywords/osteocytes","display_name":"osteocytes","score":1.0},{"id":"https://openalex.org/keywords/chromatin-regulation","display_name":"chromatin regulation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/histone-deacetylation","display_name":"histone deacetylation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mechanical-loading","display_name":"mechanical loading","score":0.5509999990463257},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7559999823570251},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.8790000081062317},{"id":"https://openalex.org/keywords/bone-formation-and-resorption","display_name":"bone formation and resorption","score":0.8920000195503235},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7950000166893005},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.7376999855041504},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.7347999811172485},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7282000184059143},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.6419000029563904},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5382000207901001},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48840001225471497},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.4758000075817108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4661000072956085},{"id":"https://openalex.org/C110455231","wikidata":"https://www.wikidata.org/wiki/Q897788","display_name":"Compartmentalization (fire protection)","level":3,"score":0.4426000118255615},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.388700008392334},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.35740000009536743},{"id":"https://openalex.org/C56952853","wikidata":"https://www.wikidata.org/wiki/Q5773144","display_name":"Histone-modifying enzymes","level":5,"score":0.3560999929904938},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34360000491142273},{"id":"https://openalex.org/C10058791","wikidata":"https://www.wikidata.org/wiki/Q910897","display_name":"Histone code","level":5,"score":0.34060001373291016},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3402000069618225},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.32190001010894775},{"id":"https://openalex.org/C2779240191","wikidata":"https://www.wikidata.org/wiki/Q6822340","display_name":"Metabolic bone disease","level":3,"score":0.30320000648498535},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2770000100135803},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.25360000133514404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/cells15211963","doi":"https://doi.org/10.3390/cells15211963","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells15211963","pdf_url":null,"source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/cells15211963","doi":"https://doi.org/10.3390/cells15211963","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells15211963","pdf_url":null,"source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3183191859","https://openalex.org/W4404048306","https://openalex.org/W7220695460","https://openalex.org/W3114994106","https://openalex.org/W7169492487","https://openalex.org/W4401713356","https://openalex.org/W3006138245","https://openalex.org/W2564411563","https://openalex.org/W2968618046","https://openalex.org/W4404141458"],"abstract_inverted_index":{"Bone":[0],"remodeling":[1],"requires":[2],"coordinated":[3],"transcriptional":[4],"regulation":[5],"across":[6,76],"osteoblasts,":[7],"osteoclasts,":[8],"and":[9,41,61,88,91,103,110,117,129,145,158,174,184],"osteocytes.":[10],"Histone":[11],"acetylation":[12,75,87],"connects":[13],"cellular":[14,29],"metabolism":[15,72],"to":[16,47,73,123,136,141],"these":[17,55,107],"lineage-specific":[18],"programs,":[19],"yet":[20],"its":[21],"regulatory":[22,108],"effects":[23],"depend":[24],"not":[25],"simply":[26],"on":[27,34],"total":[28],"acetyl-CoA":[30,39,71,143],"abundance,":[31],"but":[32],"also":[33],"metabolic":[35,84,104,127,147,170],"carbon":[36,148],"routing,":[37,171],"subcellular":[38],"availability,":[40],"the":[42,64,80,112,124,137],"targeting":[43,161],"of":[44,83],"chromatin-modifying":[45],"enzymes":[46],"specific":[48],"genomic":[49],"regions.":[50],"This":[51],"review":[52],"examines":[53],"how":[54,98],"processes":[56],"shape":[57],"skeletal-cell":[58],"differentiation,":[59],"function,":[60],"communication":[62,176],"within":[63],"bone-remodeling":[65],"unit.":[66],"We":[67,95],"integrate":[68],"evidence":[69],"linking":[70],"histone":[74,150],"skeletal":[77,182],"lineages,":[78],"highlighting":[79],"distinct":[81],"contributions":[82],"substrate":[85],"utilization,":[86],"deacetylation":[89],"machinery,":[90],"locus-specific":[92],"chromatin":[93,131,172],"regulation.":[94],"further":[96],"discuss":[97],"mechanical":[99],"loading,":[100],"aging,":[101],"inflammation,":[102],"disease":[105],"reshape":[106],"networks":[109],"influence":[111],"balance":[113],"between":[114,126],"bone":[115,167],"formation":[116],"resorption.":[118],"Particular":[119],"attention":[120],"is":[121],"given":[122],"distinction":[125],"changes":[128],"their":[130],"consequences,":[132],"as":[133,135],"well":[134],"experimental":[138],"approaches":[139],"needed":[140],"resolve":[142],"compartmentalization":[144],"trace":[146],"into":[149],"acetyl":[151],"groups.":[152],"Finally,":[153],"we":[154],"evaluate":[155],"therapeutic":[156,189],"opportunities":[157],"challenges":[159],"in":[160],"metabolic\u2013chromatin":[162],"pathways":[163],"while":[164],"preserving":[165],"physiological":[166],"remodeling.":[168],"Integrating":[169],"regulation,":[173],"intercellular":[175],"provides":[177],"a":[178],"framework":[179],"for":[180,188],"understanding":[181],"adaptation":[183],"identifying":[185],"new":[186],"avenues":[187],"development.":[190]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-10-29T00:00:00"}
