{"id":"https://openalex.org/W7224090355","doi":"https://doi.org/10.18452/39808","title":"Developing mathematical models to study the Plasmodium falciparum infection and lipid metabolism during the intraerythrocytic life stage","display_name":"Developing mathematical models to study the Plasmodium falciparum infection and lipid metabolism during the intraerythrocytic life stage","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224090355","doi":"https://doi.org/10.18452/39808"},"language":"en","primary_location":{"id":"pmh:oai:edoc.hu-berlin.de:18452/40491","doi":null,"is_oa":true,"landing_page_url":"https://edoc.hu-berlin.de/18452/40491","pdf_url":"https://edoc.hu-berlin.de/bitstreams/1009ea01-f3c9-43ba-bdb4-ce6110d94353/download","source":{"id":"https://openalex.org/S4306400923","display_name":"edoc Publication server (Humboldt University of Berlin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39343248","host_organization_name":"Humboldt-Universit\u00e4t zu Berlin","host_organization_lineage":["https://openalex.org/I39343248"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://edoc.hu-berlin.de/bitstreams/1009ea01-f3c9-43ba-bdb4-ce6110d94353/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075751838","display_name":"Maxim Karnetzki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karnetzki, Maxim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075751838"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12178","display_name":"Bird parasitology and diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9980000257492065},{"id":"https://openalex.org/keywords/malaria","display_name":"malaria","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.5730000138282776},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.906000018119812},{"id":"https://openalex.org/keywords/artemisinin-based-combination-therapy","display_name":"artemisinin-based combination therapy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7369999885559082},{"id":"https://openalex.org/keywords/phospholipid-synthesis","display_name":"phospholipid synthesis","score":0.746999979019165},{"id":"https://openalex.org/keywords/genome-scale-metabolic-models","display_name":"genome-scale metabolic models","score":0.7870000004768372},{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"flux balance analysis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.5889999866485596},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.5418999791145325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43790000677108765},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.39640000462532043},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.34540000557899475},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33649998903274536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2935999929904938},{"id":"https://openalex.org/C3019824283","wikidata":"https://www.wikidata.org/wiki/Q353172","display_name":"Protozoal disease","level":3,"score":0.17970000207424164},{"id":"https://openalex.org/C2986762682","wikidata":"https://www.wikidata.org/wiki/Q964754","display_name":"Basic research","level":2,"score":0.17239999771118164},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17180000245571136},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.16529999673366547}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:edoc.hu-berlin.de:18452/40491","doi":null,"is_oa":true,"landing_page_url":"https://edoc.hu-berlin.de/18452/40491","pdf_url":"https://edoc.hu-berlin.de/bitstreams/1009ea01-f3c9-43ba-bdb4-ce6110d94353/download","source":{"id":"https://openalex.org/S4306400923","display_name":"edoc Publication server (Humboldt University of Berlin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39343248","host_organization_name":"Humboldt-Universit\u00e4t zu Berlin","host_organization_lineage":["https://openalex.org/I39343248"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"doi:10.18452/39808","doi":"https://doi.org/10.18452/39808","is_oa":true,"landing_page_url":"https://doi.org/10.18452/39808","pdf_url":null,"source":{"id":"https://openalex.org/S4306400923","display_name":"edoc Publication server (Humboldt University of Berlin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39343248","host_organization_name":"Humboldt-Universit\u00e4t zu Berlin","host_organization_lineage":["https://openalex.org/I39343248"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:edoc.hu-berlin.de:18452/40491","doi":null,"is_oa":true,"landing_page_url":"https://edoc.hu-berlin.de/18452/40491","pdf_url":"https://edoc.hu-berlin.de/bitstreams/1009ea01-f3c9-43ba-bdb4-ce6110d94353/download","source":{"id":"https://openalex.org/S4306400923","display_name":"edoc Publication server (Humboldt University of Berlin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39343248","host_organization_name":"Humboldt-Universit\u00e4t zu Berlin","host_organization_lineage":["https://openalex.org/I39343248"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224090355.pdf","grobid_xml":"https://content.openalex.org/works/W7224090355.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7052289034","https://openalex.org/W6962859775","https://openalex.org/W3161157697","https://openalex.org/W7020718004","https://openalex.org/W2746358455","https://openalex.org/W2003234450","https://openalex.org/W6887330726","https://openalex.org/W2914190259","https://openalex.org/W1552339669","https://openalex.org/W6969332519"],"abstract_inverted_index":{"Malaria":[0],"ist":[1],"mit":[2,78,93,173],"\u00fcber":[3,63],"200":[4],"Millionen":[5],"F\u00e4llen":[6],"und":[7,67,85,107,161,197,201,220,226],"mehr":[8],"als":[9,209],"einer":[10,89],"halben":[11],"Million":[12],"Todesf\u00e4llen":[13],"pro":[14],"Jahr":[15],"weiterhin":[16],"eine":[17,111],"gro\u00dfe":[18],"globale":[19],"Gesundheitsgefahr.":[20],"Die":[21,100,186],"meisten":[22],"Todesf\u00e4lle":[23],"verursacht":[24],"Plasmodium":[25],"falciparum,":[26],"ein":[27],"Parasit,":[28],"der":[29,96,117,120,140,218,234],"regional":[30],"Resistenzen":[31],"gegen":[32],"alle":[33],"verf\u00fcgbaren":[34],"Malariamedikamente":[35],"entwickelt.":[36],"Neue":[37],"therapeutische":[38,70],"Strategien":[39],"werden":[40],"daher":[41],"dringend":[42],"ben\u00f6tigt.":[43],"Diese":[44],"Arbeit":[45,133],"pr\u00e4sentiert":[46],"zwei":[47],"mathematische":[48],"Modelle":[49,54],"von":[50,199,223,232],"P.":[51,83,151,224],"falciparum.":[52],"Solche":[53],"erm\u00f6glichen":[55],"es,":[56],"komplexe":[57],"Wirt-Parasit-Interaktionen":[58],"systematisch":[59],"zu":[60,65,72],"untersuchen,":[61],"Hypothesen":[62],"Mechanismen":[64],"generieren":[66],"so":[68],"neue":[69,178],"Ansatzpunkte":[71],"identifizieren.":[73],"Das":[74],"erste":[75],"Modell":[76,179],"beschreibt":[77],"gew\u00f6hnlichen":[79],"Differentialgleichungen":[80],"(ODE)":[81],"die":[82,86,126,132,134,167,190,230],"falciparum-Infektion":[84],"Genesung":[87],"nach":[88],"Artemisinin-basierten":[90],"Kombinationstherapie":[91],"(ACT),":[92],"Fokus":[94],"auf":[95],"post-therapeutischen":[97],"H\u00e4molyse":[98],"(PTH).":[99],"Analyse":[101],"identifiziert":[102],"wichtige":[103],"Treiber":[104,119],"dieses":[105],"Effekts":[106],"legt":[108],"nahe,":[109],"dass":[110],"Reaktion":[112],"des":[113,115,136,182,193,221],"Immunsystems":[114],"Wirts":[116],"mechanistische":[118],"PTH":[121],"ist.":[122,150],"Damit":[123],"st\u00fctzt":[124],"sie":[125],"derzeitige":[127],"klinische":[128],"Forschungsrichtung.":[129],"Zudem":[130],"untersucht":[131],"Abh\u00e4ngigkeit":[135],"Parasiten":[137,183,194],"vom":[138],"Lipidstoffwechsel,":[139],"f\u00fcr":[141,229],"seine":[142],"schnelle":[143],"Vermehrung":[144],"im":[145],"asexuellen":[146],"intraerythrozyt\u00e4ren":[147],"Zyklus":[148],"entscheidend":[149],"falciparum":[152,225],"versechsfacht":[153],"in":[154],"dieser":[155],"Phase":[156],"seinen":[157],"Phospholipidgehalt,":[158],"durch":[159],"de-novo-Synthese":[160],"Aufnahme":[162,196],"aus":[163],"dem":[164,174],"Wirt.":[165],"Durch":[166],"Neuanpassung":[168],"eines":[169,206],"genomweiten":[170],"Stoffwechselmodells":[171],"(GEM)":[172],"SLIMEr-Framework":[175],"bildet":[176],"das":[177,180,204,215],"Lipidnetzwerk":[181],"besser":[184],"ab.":[185],"Flussbilanzanalyse":[187],"(FBA)":[188],"zeigt":[189],"metabolische":[191],"Flexibilit\u00e4t":[192],"bei":[195],"Synthese":[198],"Lipidvorl\u00e4ufern":[200],"erkl\u00e4rt":[202],"mechanistisch":[203],"Versagen":[205],"Cholin-kompetitiven":[207],"Inhibitors":[208],"Malariamedikament.":[210],"Zusammen":[211],"verbessern":[212],"diese":[213],"Beitr\u00e4ge":[214],"quantitative":[216],"Verst\u00e4ndnis":[217],"Infektionsdynamik":[219],"Lipidstoffwechsels":[222],"liefern":[227],"Grundlagen":[228],"Entwicklung":[231],"Malariamedikamenten":[233],"n\u00e4chsten":[235],"Generation.":[236]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-10-29T00:00:00"}