{"id":"https://openalex.org/W7224089547","doi":"https://doi.org/10.21037/tcr-2026-1922","title":"Molecular subtyping, prognostic evaluation, and tumor immune microenvironment heterogeneity in intrahepatic cholangiocarcinoma based on epithelial-mesenchymal transition and mitophagy-related genes","display_name":"Molecular subtyping, prognostic evaluation, and tumor immune microenvironment heterogeneity in intrahepatic cholangiocarcinoma based on epithelial-mesenchymal transition and mitophagy-related genes","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7224089547","doi":"https://doi.org/10.21037/tcr-2026-1922","pmid":"https://pubmed.ncbi.nlm.nih.gov/42997913","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13743237"},"language":"en","primary_location":{"id":"doi:10.21037/tcr-2026-1922","doi":"https://doi.org/10.21037/tcr-2026-1922","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-2026-1922","pdf_url":null,"source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/tcr-2026-1922","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020292516","display_name":"Yecheng Wang","orcid":"https://orcid.org/0000-0003-3567-944X","observed_orcids":["https://orcid.org/0000-0003-3567-944X"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yecheng Wang","raw_affiliation_strings":["Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210094218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160039750","display_name":"Dongbin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dongbin Liu","raw_affiliation_strings":["Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210094218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160039343","display_name":"Kuo Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kuo Liang","raw_affiliation_strings":["Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210094218"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049319348","display_name":"Zhenshun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenshun Wang","raw_affiliation_strings":["Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210094218"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5160039750"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210094218"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85082171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"10","first_page":"751","last_page":"751"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.968999981880188},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/molecular-subtyping","display_name":"molecular subtyping","score":0.9789999723434448},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.8510000109672546},{"id":"https://openalex.org/keywords/pygb","display_name":"PYGB","score":0.9480000138282776},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neuregulin-1","display_name":"neuregulin-1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/plod2","display_name":"PLOD2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.6970000267028809},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/memory-cd4-t-cells","display_name":"memory CD4+ T cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.5899999737739563},{"id":"https://openalex.org/keywords/erbb-signaling-pathway","display_name":"ErbB signaling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.859000027179718},{"id":"https://openalex.org/keywords/staurosporine","display_name":"staurosporine","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5453000068664551},{"id":"https://openalex.org/C2909135397","wikidata":"https://www.wikidata.org/wiki/Q124292","display_name":"Intrahepatic Cholangiocarcinoma","level":2,"score":0.5415999889373779},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4999000132083893},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48510000109672546},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48350000381469727},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.45649999380111694},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.41769999265670776},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.40310001373291016},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.35690000653266907},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.33869999647140503},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3163999915122986},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.314300000667572},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31060001254081726},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.30630001425743103},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.2782999873161316},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.2768999934196472},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2720000147819519},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.27149999141693115},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.26499998569488525},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.26330000162124634},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.258899986743927}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21037/tcr-2026-1922","doi":"https://doi.org/10.21037/tcr-2026-1922","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-2026-1922","pdf_url":null,"source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},{"id":"pmid:42997913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42997913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/tcr-2026-1922","doi":"https://doi.org/10.21037/tcr-2026-1922","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-2026-1922","pdf_url":null,"source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4399787047","https://openalex.org/W7137364494","https://openalex.org/W1979728979","https://openalex.org/W4411572378","https://openalex.org/W4385554101","https://openalex.org/W3217621138","https://openalex.org/W7172335227","https://openalex.org/W4327895854","https://openalex.org/W4327919457","https://openalex.org/W7148749604"],"abstract_inverted_index":{"Background:":[0],"Intrahepatic":[1],"cholangiocarcinoma":[2],"(ICC)":[3],"is":[4],"a":[5,10,60,282],"highly":[6],"aggressive":[7],"malignancy":[8],"with":[9,92,179,239,259],"dismal":[11],"prognosis,":[12,93],"yet":[13],"effective":[14],"prognostic":[15,64,131,211,287],"biomarkers":[16],"and":[17,26,34,55,63,80,95,137,147,161,176,205,220,275,286,294,301,309,316],"therapeutic":[18,149,319],"targets":[19,311],"remain":[20],"scarce.":[21],"Both":[22],"epithelial-mesenchymal":[23],"transition":[24],"(EMT)":[25],"mitophagy":[27,96,162],"are":[28],"known":[29],"to":[30,52,58,106,120,142,159,273],"drive":[31],"tumor":[32],"progression":[33],"therapy":[35],"resistance,":[36],"but":[37],"their":[38],"synergistic":[39],"regulatory":[40],"network":[41,116,190],"in":[42,230,246],"ICC":[43,108,168,290,314],"has":[44],"not":[45],"been":[46],"systematically":[47],"characterized.":[48],"This":[49,278],"study":[50],"aims":[51],"integrate":[53],"EMT-":[54,293],"mitophagy-related":[56,295],"genes":[57,89,300],"establish":[59],"molecular":[61,111,284],"subtyping":[62,285],"evaluation":[65],"system":[66],"for":[67,129,289,312],"ICC.":[68],"Methods:":[69],"Transcriptomic":[70],"data":[71],"were":[72,97,140,163,207],"obtained":[73],"from":[74],"the":[75,256],"Gene":[76],"Expression":[77],"Omnibus":[78],"(GEO)":[79],"The":[81,297],"Cancer":[82],"Genome":[83],"Atlas":[84],"(TCGA)":[85],"repositories.":[86],"Differentially":[87],"expressed":[88],"(DEGs)":[90],"associated":[91],"EMT,":[94],"screened":[98],"using":[99],"bioinformatics":[100],"approaches.":[101],"Consensus":[102,165],"clustering":[103,166],"was":[104,118,270],"applied":[105],"stratify":[107],"patients":[109,169],"into":[110,170],"subtypes.":[112],"Protein-protein":[113],"interaction":[114],"(PPI)":[115],"analysis":[117,191,280],"performed":[119],"identify":[121],"hub":[122,195,299],"genes,":[123,196],"followed":[124],"by":[125],"Cox":[126],"regression":[127],"validation":[128],"independent":[130,210],"predictors.":[132,212],"Functional":[133,213],"enrichment,":[134],"immune":[135],"infiltration,":[136],"drug-sensitivity":[138],"analyses":[139],"conducted":[141],"explore":[143],"underlying":[144],"biological":[145],"mechanisms":[146],"subtype-specific":[148,302],"vulnerabilities.":[150],"Results:":[151],"A":[152],"total":[153],"of":[154],"18":[155],"prognosis-related":[156],"DEGs":[157],"linked":[158],"EMT":[160],"identified.":[164],"divided":[167],"two":[171],"distinct":[172],"subtypes":[173],"(Cluster":[174],"1":[175,181,269],"Cluster":[177,180,231,247,268],"2),":[178],"showing":[182],"significantly":[183],"poorer":[184],"overall":[185],"survival":[186],"(OS)":[187],"(P=0.009).":[188],"PPI":[189],"revealed":[192],"nine":[193],"core":[194],"among":[197],"which":[198],"PYGB":[199],",":[200,202,204],"IGF1":[201],"NRG1":[203],"PLOD2":[206],"validated":[208],"as":[209],"enrichment":[214],"highlighted":[215],"microRNA-mediated":[216],"regulation,":[217],"ErbB":[218],"signaling,":[219],"endocrine":[221],"resistance.":[222],"Immune":[223],"infiltration":[224],"uncovered":[225],"marked":[226],"heterogeneity":[227],"between":[228],"subtypes:":[229],"1,":[232],"activated":[233,249,260],"mast":[234],"cells":[235,243,254,262],"correlated":[236],"most":[237],"strongly":[238],"resting":[240],"natural":[241],"killer":[242],"(r=0.78),":[244],"whereas":[245],"2,":[248],"CD4":[250],"+":[251],"memory":[252],"T":[253],"showed":[255],"strongest":[257],"correlation":[258],"dendritic":[261],"(r=0.46).":[263],"Drug-sensitivity":[264],"predictions":[265],"indicated":[266],"that":[267],"more":[271],"sensitive":[272],"UMI-77":[274],"staurosporine.":[276],"Conclusions:":[277],"integrative":[279],"establishes":[281],"novel":[283],"framework":[288],"based":[291],"on":[292],"genes.":[296],"identified":[298],"immune/drug":[303],"profiles":[304],"provide":[305],"new":[306],"theoretical":[307],"insights":[308],"candidate":[310],"understanding":[313],"pathogenesis":[315],"developing":[317],"personalized":[318],"strategies.":[320]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-29T00:00:00"}