{"id":"https://openalex.org/W7224088635","doi":"https://doi.org/10.5281/zenodo.23742168","title":"Unsupervised AI-platform for Virus-Agnostic Therapeutic Targets Discovery from Multi-Omics Datasets","display_name":"Unsupervised AI-platform for Virus-Agnostic Therapeutic Targets Discovery from Multi-Omics Datasets","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224088635","doi":"https://doi.org/10.5281/zenodo.23742168"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23742168","doi":"https://doi.org/10.5281/zenodo.23742168","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23742168","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23742168","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077017629","display_name":"Sofiya Micheva\u2010Viteva","orcid":"https://orcid.org/0000-0002-2693-4333","observed_orcids":["https://orcid.org/0000-0002-2693-4333"]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Micheva-Viteva, Sofiya","raw_affiliation_strings":["Los Alamos National Laboratory"],"raw_orcid":"https://orcid.org/0000-0002-2693-4333","affiliations":[{"raw_affiliation_string":"Los Alamos National Laboratory","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066261993","display_name":"Maksim E. Eren","orcid":"https://orcid.org/0000-0002-4362-0256","observed_orcids":["https://orcid.org/0000-0002-4362-0256"]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eren, Maksim","raw_affiliation_strings":["Los Alamos National Laboratory"],"raw_orcid":"https://orcid.org/0000-0002-4362-0256","affiliations":[{"raw_affiliation_string":"Los Alamos National Laboratory","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087166268","display_name":"Migun Shakya","orcid":"https://orcid.org/0000-0003-3876-691X","observed_orcids":["https://orcid.org/0000-0003-3876-691X"]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shakya, Migun","raw_affiliation_strings":["Los Alamos National Laboratory"],"raw_orcid":"https://orcid.org/0000-0003-3876-691X","affiliations":[{"raw_affiliation_string":"Los Alamos National Laboratory","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049643407","display_name":"Alison M. Kell","orcid":"https://orcid.org/0000-0001-5550-1038","observed_orcids":["https://orcid.org/0000-0001-5550-1038"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kell, Alison","raw_affiliation_strings":["University of New Mexico School of Medicine"],"raw_orcid":"https://orcid.org/0000-0001-5550-1038","affiliations":[{"raw_affiliation_string":"University of New Mexico School of Medicine","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059931302","display_name":"Steven B. Bradfute","orcid":"https://orcid.org/0000-0002-1985-751X","observed_orcids":["https://orcid.org/0000-0002-1985-751X"]},"institutions":[{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradfute, Steven","raw_affiliation_strings":["University of New Mexico Health Sciences Center"],"raw_orcid":"https://orcid.org/0000-0002-1985-751X","affiliations":[{"raw_affiliation_string":"University of New Mexico Health Sciences Center","institution_ids":["https://openalex.org/I4405255059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079029372","display_name":"Boian S. Alexandrov","orcid":"https://orcid.org/0000-0001-8636-4603","observed_orcids":["https://orcid.org/0000-0001-8636-4603"]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandrov, Boian","raw_affiliation_strings":["Los Alamos National Laboratory"],"raw_orcid":"https://orcid.org/0000-0001-8636-4603","affiliations":[{"raw_affiliation_string":"Los Alamos National Laboratory","institution_ids":["https://openalex.org/I1343871089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76722413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7592999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7592999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.05900000035762787,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.8009999990463257},{"id":"https://openalex.org/keywords/non-negative-matrix-factorization","display_name":"non-negative matrix factorization","score":0.7570000290870667},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.8169999718666077},{"id":"https://openalex.org/keywords/viral-rna-dependent-rna-polymerase","display_name":"viral RNA-dependent RNA polymerase","score":0.5},{"id":"https://openalex.org/keywords/host-dependency","display_name":"host dependency","score":0.4090000092983246},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9330000281333923},{"id":"https://openalex.org/keywords/ebola-virus","display_name":"Ebola virus","score":0.9639999866485596},{"id":"https://openalex.org/keywords/influenza-virus","display_name":"influenza virus","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hantaan-virus","display_name":"Hantaan virus","score":0.6779999732971191},{"id":"https://openalex.org/keywords/vaccinia-virus","display_name":"vaccinia virus","score":0.8830000162124634},{"id":"https://openalex.org/keywords/endosomal-trafficking","display_name":"endosomal trafficking","score":0.7409999966621399},{"id":"https://openalex.org/keywords/gap-junction-signaling","display_name":"gap junction signaling","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7129999995231628},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6485000252723694},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5382000207901001},{"id":"https://openalex.org/C2910208175","wikidata":"https://www.wikidata.org/wiki/Q29001073","display_name":"Hantavirus Infection","level":4,"score":0.37700000405311584},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.36320000886917114},{"id":"https://openalex.org/C20850961","wikidata":"https://www.wikidata.org/wiki/Q478216","display_name":"Virus classification","level":4,"score":0.35420000553131104},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3188000023365021},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C151810110","wikidata":"https://www.wikidata.org/wiki/Q7307074","display_name":"RefSeq","level":4,"score":0.3059999942779541},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.290800005197525},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.27790001034736633},{"id":"https://openalex.org/C190743605","wikidata":"https://www.wikidata.org/wiki/Q17027885","display_name":"Human virome","level":4,"score":0.26969999074935913},{"id":"https://openalex.org/C2776844884","wikidata":"https://www.wikidata.org/wiki/Q1134583","display_name":"Coronaviridae","level":5,"score":0.26579999923706055},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.2639999985694885},{"id":"https://openalex.org/C2911029443","wikidata":"https://www.wikidata.org/wiki/Q21296145","display_name":"Human proteins","level":3,"score":0.2623000144958496},{"id":"https://openalex.org/C143876685","wikidata":"https://www.wikidata.org/wiki/Q22327705","display_name":"ESCRT","level":4,"score":0.2554999887943268},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.2506999969482422}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23742168","doi":"https://doi.org/10.5281/zenodo.23742168","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23742168","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5281/zenodo.23742169","doi":"https://doi.org/10.5281/zenodo.23742169","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23742169","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23742168","doi":"https://doi.org/10.5281/zenodo.23742168","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23742168","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7159968212","https://openalex.org/W4214858683","https://openalex.org/W7151049797","https://openalex.org/W3209130934","https://openalex.org/W2922427996","https://openalex.org/W7130740824","https://openalex.org/W7203793536","https://openalex.org/W7162641785","https://openalex.org/W7161560332","https://openalex.org/W2614884487"],"abstract_inverted_index":{"Here,":[0],"we":[1],"developed":[2],"ViralTensors,":[3],"an":[4,162],"unsupervised":[5],"artificial":[6],"intelligence":[7],"(AI)":[8],"platform":[9],"that":[10,33],"employs":[11],"Nonnegative":[12],"Matrix":[13],"Factorization":[14],"(NMF)":[15],"and":[16,25,41,70,77,90,121,129,174],"Weighted":[17],"NMF":[18],"(WNMF)":[19],"for":[20,165,184],"integration":[21],"of":[22,27,60,96,113,137,148,178,187],"multidimensional":[23],"datasets":[24,52],"extraction":[26],"interpretable":[28],"latent":[29],"features.":[30],"We":[31],"demonstrate":[32,175],"ViralTensors":[34,160],"extracts":[35],"biologically":[36],"relevant":[37],"host":[38,75,99,150,168,181],"regulatory":[39],"programs":[40,183],"previously":[42],"unrecognized":[43],"associations":[44],"within":[45],"complex":[46],"virus\u2013host":[47,54],"interactions":[48],"from":[49],"global":[50,134],"transcriptomic":[51],"with":[53,80,127],"protein":[55,151],"interaction":[56],"data.":[57],"Systems-level":[58],"analysis":[59,136],"viruses":[61,126,173],"representing":[62,125],"three":[63],"distinct":[64],"taxonomic":[65],"families\u2014Coronaviridae":[66],"(SARS-CoV-2),":[67],"Filoviridae":[68],"(Ebolavirus),":[69],"Orthomyxoviridae":[71],"(Influenza":[72],"virus)\u2014revealed":[73],"conserved":[74,167],"pathways":[76],"targets":[78,100],"associated":[79],"diverse":[81,172],"cellular":[82,182],"functions,":[83],"including":[84],"endosomal":[85],"trafficking,":[86],"gap":[87],"junction":[88],"signaling,":[89],"cholesterol":[91],"biosynthesis.":[92],"The":[93],"functional":[94],"relevance":[95,147],"these":[97,157],"predicted":[98],"was":[101],"validated":[102],"in":[103],"cell-based":[104],"infection":[105],"assays":[106],"using":[107],"FDA-approved":[108],"therapeutics":[109],"to":[110,153],"inhibit":[111],"replication":[112],"human":[114,141],"coronavirus":[115],"229E":[116],"(HCoV-229E),":[117],"vaccinia":[118],"virus":[119,123],"(VACV-WR),":[120],"Hantaan":[122],"(HTNV),":[124],"RNA":[128],"DNA":[130],"genomes.":[131],"Furthermore,":[132],"quantitative":[133],"proteomic":[135],"Seoul":[138],"hantavirus":[139],"infected":[140],"endothelial":[142],"cells":[143],"independently":[144],"supported":[145],"the":[146,176,185],"AI-predicted":[149],"networks":[152],"viral":[154],"replication.":[155],"Collectively,":[156],"findings":[158],"establish":[159],"as":[161],"analytical":[163],"framework":[164],"identifying":[166],"dependencies":[169],"across":[170],"taxonomically":[171],"potential":[177],"targeting":[179],"shared":[180],"development":[186],"broad-spectrum":[188],"antiviral":[189],"therapeutics.":[190]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-10-29T00:00:00"}