{"id":"https://openalex.org/W7224088123","doi":"https://doi.org/10.1007/s12672-026-06210-7","title":"Role of TPX2 in glycolytic activity and malignant progression of colorectal cancer","display_name":"Role of TPX2 in glycolytic activity and malignant progression of colorectal cancer","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224088123","doi":"https://doi.org/10.1007/s12672-026-06210-7"},"language":"en","primary_location":{"id":"doi:10.1007/s12672-026-06210-7","doi":"https://doi.org/10.1007/s12672-026-06210-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-026-06210-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s12672-026-06210-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159989647","display_name":"Yan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":["Department of Radiation Oncology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2019s Hospital, Quzhou, 324000, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2019s Hospital, Quzhou, 324000, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160049739","display_name":"Xiaohua Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohua Lin","raw_affiliation_strings":["Department of Gastroenterology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2019s Hospital, Quzhou, 324000, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2019s Hospital, Quzhou, 324000, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125615840","display_name":"Dajun Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dajun Chen","raw_affiliation_strings":["Department of Gastroenterology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2019s Hospital, Quzhou, 324000, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2019s Hospital, Quzhou, 324000, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126121170","display_name":"Fengping Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengping Wang","raw_affiliation_strings":["Department of Clinical Laboratory, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2019s Hospital, Quzhou, 324000, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2019s Hospital, Quzhou, 324000, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132712794","display_name":"Yu Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Lin","raw_affiliation_strings":["Health Management Center, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2019s Hospital, Quzhou, 324000, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Management Center, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2019s Hospital, Quzhou, 324000, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160039251","display_name":"Hongchun Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongchun Jia","raw_affiliation_strings":["Endoscopy Center, Quzhou People\u2019s Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endoscopy Center, Quzhou People\u2019s Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5135496899","display_name":"Huibin Weng","orcid":"https://orcid.org/0009-0008-2666-9323","observed_orcids":["https://orcid.org/0009-0008-2666-9323"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huibin Weng","raw_affiliation_strings":["Department of Gastroenterology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2019s Hospital, Quzhou, 324000, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2019s Hospital, Quzhou, 324000, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5135496899"],"corresponding_institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"],"apc_list":{"value":1690,"currency":"USD","value_usd":1690},"apc_paid":{"value":1690,"currency":"USD","value_usd":1690},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76814035,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tpx2","display_name":"TPX2","score":1.0},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pkm2","display_name":"PKM2","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5550000071525574},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.9079999923706055},{"id":"https://openalex.org/keywords/glut1","display_name":"GLUT1","score":0.8529999852180481},{"id":"https://openalex.org/keywords/ldha","display_name":"LDHA","score":0.9229999780654907},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.7922000288963318},{"id":"https://openalex.org/C10730799","wikidata":"https://www.wikidata.org/wiki/Q18030568","display_name":"PKM2","level":5,"score":0.6855999827384949},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6309999823570251},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.592199981212616},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4957999885082245},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.48969998955726624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47780001163482666},{"id":"https://openalex.org/C55885012","wikidata":"https://www.wikidata.org/wiki/Q4750801","display_name":"Anaerobic glycolysis","level":4,"score":0.4348999857902527},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4219000041484833},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.40950000286102295},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3882000148296356},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.36309999227523804},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3474000096321106},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.33869999647140503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33000001311302185},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3118000030517578},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3075999915599823},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2750999927520752},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C109156525","wikidata":"https://www.wikidata.org/wiki/Q56770304","display_name":"Warburg effect","level":4,"score":0.2605000138282776}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s12672-026-06210-7","doi":"https://doi.org/10.1007/s12672-026-06210-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-026-06210-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s12672-026-06210-7","doi":"https://doi.org/10.1007/s12672-026-06210-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-026-06210-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2912498466","https://openalex.org/W7138023923","https://openalex.org/W3137820182","https://openalex.org/W2024509852","https://openalex.org/W4408096309","https://openalex.org/W2079839199","https://openalex.org/W4387538496","https://openalex.org/W2423005099","https://openalex.org/W7172213743","https://openalex.org/W4396886324"],"abstract_inverted_index":{"Metabolic":[0],"reprogramming,":[1],"particularly":[2],"enhanced":[3],"glycolysis,":[4],"is":[5,15],"a":[6,60,129],"hallmark":[7],"of":[8,175,190,199,221,227,244,263],"colorectal":[9],"cancer":[10],"(CRC)":[11],"progression.":[12,272],"Although":[13],"TPX2":[14,56,69,83,125,146,200,207,245,253],"an":[16],"oncogene":[17],"implicated":[18],"in":[19,24,27,34,136,238],"multiple":[20],"cancers,":[21],"its":[22],"role":[23],"regulating":[25],"glycolysis":[26,94,203],"CRC":[28,35,80,137,150,210,271],"remains":[29,256],"unclear.":[30,257],"Differentially":[31],"expressed":[32],"genes":[33],"were":[36,95,113,180],"identified":[37,58,127],"using":[38,74,97,115],"GEO":[39],"datasets,":[40],"followed":[41],"by":[42,163,192,224],"functional":[43],"enrichment":[44],"analysis":[45],"and":[46,63,76,86,93,107,132,139,154,168,178,204,215,254,270],"protein\u2013protein":[47],"interaction":[48],"(PPI)":[49],"network":[50],"construction":[51],"to":[52,120,240],"screen":[53],"key":[54],"candidates.":[55],"was":[57,71,84,126,133,159],"as":[59,128,161],"hub":[61,130],"gene":[62,131],"selected":[64],"for":[65],"further":[66,72,261],"experimental":[67],"validation.":[68],"expression":[70,173],"validated":[73],"TIMER2.0":[75],"GEPIA2":[77],"databases.":[78],"In":[79,171],"cell":[81,89,140,151,211],"lines,":[82],"silenced,":[85],"effects":[87,198,223,243],"on":[88,202],"viability,":[90,152,212],"migration,":[91,153,213],"invasion,":[92,214],"assessed":[96],"CCK-8":[98],"assays,":[99],"extracellular":[100],"acidification":[101],"rate":[102],"(ECAR)":[103],"analysis,":[104],"glucose":[105,166],"uptake,":[106],"lactate":[108,169],"production":[109],"assays.":[110],"Rescue":[111],"experiments":[112],"performed":[114],"the":[116,122,196,241,248,264],"PKM2":[117,191,228,255],"activator":[118],"DASA-58":[119,193],"explore":[121],"potential":[123],"involvement.":[124],"significantly":[134,181],"upregulated":[135],"tissues":[138],"lines":[141],"(":[142,183],"P":[143,184],"<":[144,185],"0.05).":[145,186],"knockdown":[147],"markedly":[148],"inhibited":[149],"invasion.":[155],"Meanwhile,":[156],"glycolytic":[157,216,232,268],"activity":[158],"suppressed,":[160],"evidenced":[162],"reduced":[164],"ECAR,":[165],"consumption,":[167],"production.":[170],"addition,":[172],"levels":[174],"PKM2,":[176],"GLUT1,":[177],"LDHA":[179],"decreased":[182],"Notably,":[187],"pharmacological":[188,225],"activation":[189,226],"partially":[194],"reversed":[195],"inhibitory":[197],"silencing":[201,208],"malignant":[205],"phenotypes.":[206],"suppresses":[209],"activity.":[217],"The":[218],"partial":[219],"reversal":[220],"these":[222],"suggests":[229],"that":[230],"PKM2-associated":[231],"metabolism":[233],"may":[234],"contribute,":[235],"at":[236],"least":[237],"part,":[239],"observed":[242],"silencing.":[246],"However,":[247],"precise":[249],"molecular":[250],"relationship":[251],"between":[252,266],"These":[258],"findings":[259],"support":[260],"investigation":[262],"association":[265],"TPX2,":[267],"metabolism,":[269]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-10-29T00:00:00"}