{"id":"https://openalex.org/W7224084099","doi":"https://doi.org/10.3389/fmicb.2026.1961106","title":"Bakuchiol perturbs purine metabolism and ABC transporter pathways in Streptococcus agalactiae, possibly affecting S. agalactiae-induced mastitis","display_name":"Bakuchiol perturbs purine metabolism and ABC transporter pathways in Streptococcus agalactiae, possibly affecting S. agalactiae-induced mastitis","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224084099","doi":"https://doi.org/10.3389/fmicb.2026.1961106"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2026.1961106","doi":"https://doi.org/10.3389/fmicb.2026.1961106","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1961106","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1961106/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1961106/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160022646","display_name":"Rui Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66883779","display_name":"Weifang University","ror":"https://ror.org/01frp7483","country_code":"CN","type":"education","lineage":["https://openalex.org/I66883779"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rui Wang","raw_affiliation_strings":["Key Laboratory of Biochemistry and Molecular Biology in Universities of Shandong Province, Weifang University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Biochemistry and Molecular Biology in Universities of Shandong Province, Weifang University","institution_ids":["https://openalex.org/I66883779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108996471","display_name":"Ya\u2010Rui Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya-Rui Jin","raw_affiliation_strings":["School of Pharmacy, Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Lanzhou University","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057833091","display_name":"Wei\u2010Qi Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-Qi Jiang","raw_affiliation_strings":["School of Pharmacy, Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Lanzhou University","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081245223","display_name":"Jun\u2010Xia An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-Xia An","raw_affiliation_strings":["School of Pharmacy, Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Lanzhou University","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106462827","display_name":"Guo\u2010Liang Mou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guo-Liang Mou","raw_affiliation_strings":["School of Pharmacy, Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Lanzhou University","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100627183","display_name":"Lijing Zhang","orcid":"https://orcid.org/0000-0003-0649-5078","observed_orcids":["https://orcid.org/0000-0003-0649-5078"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Jing Zhang","raw_affiliation_strings":["School of Pharmacy, Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Lanzhou University","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054518606","display_name":"Ying\u2010Qian Liu","orcid":"https://orcid.org/0000-0001-5040-2516","observed_orcids":["https://orcid.org/0000-0001-5040-2516","https://orcid.org/0000-0001-5600-0913","https://orcid.org/0000-0002-2347-3949","https://orcid.org/0000-0001-7384-4763"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying-Qian Liu","raw_affiliation_strings":["School of Pharmacy, Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Lanzhou University","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160042188","display_name":"Zhi-Jun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Jun Zhang","raw_affiliation_strings":["School of Pharmacy, Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Lanzhou University","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160027243","display_name":"Shao-Yong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018263800","display_name":"Huzhou Normal University","ror":"https://ror.org/04mvpxy20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3018263800"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shao-Yong Zhang","raw_affiliation_strings":["Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University","institution_ids":["https://openalex.org/I3018263800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054518606","https://openalex.org/A5160022646"],"corresponding_institution_ids":["https://openalex.org/I66883779","https://openalex.org/I76214153"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82979596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11226","display_name":"Milk Quality and Mastitis in Dairy Cows","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11226","display_name":"Milk Quality and Mastitis in Dairy Cows","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.10520000010728836,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.026499999687075615,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bakuchiol","display_name":"bakuchiol","score":0.996999979019165},{"id":"https://openalex.org/keywords/streptococcus-agalactiae","display_name":"Streptococcus agalactiae","score":1.0},{"id":"https://openalex.org/keywords/bacterial-mastitis","display_name":"bacterial mastitis","score":0.7509999871253967},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.9200000166893005},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.9940000176429749},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.7680000066757202},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.6779999732971191},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8539999723434448},{"id":"https://openalex.org/keywords/mouse-mastitis-model","display_name":"mouse mastitis model","score":0.828000009059906},{"id":"https://openalex.org/keywords/low-toxicity","display_name":"low toxicity","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C2777860557","wikidata":"https://www.wikidata.org/wiki/Q132949","display_name":"Streptococcus agalactiae","level":4,"score":0.9041000008583069},{"id":"https://openalex.org/C2776344049","wikidata":"https://www.wikidata.org/wiki/Q835061","display_name":"Mastitis","level":2,"score":0.7648000121116638},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.7441999912261963},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7229999899864197},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.5809000134468079},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5774999856948853},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5091999769210815},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.44999998807907104},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.4228000044822693},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.38690000772476196},{"id":"https://openalex.org/C169586020","wikidata":"https://www.wikidata.org/wiki/Q3780159","display_name":"Purine metabolism","level":3,"score":0.36890000104904175},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3587000072002411},{"id":"https://openalex.org/C2778276568","wikidata":"https://www.wikidata.org/wiki/Q190161","display_name":"Streptococcus","level":3,"score":0.35690000653266907},{"id":"https://openalex.org/C14225744","wikidata":"https://www.wikidata.org/wiki/Q770530","display_name":"Antibiosis","level":3,"score":0.3440000116825104},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.3336000144481659},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.32199999690055847},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.30169999599456787},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.30070000886917114},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.2969000041484833},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2946000099182129},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.2840000092983246},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.25099998712539673}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fmicb.2026.1961106","doi":"https://doi.org/10.3389/fmicb.2026.1961106","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1961106","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1961106/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:353c5e184d2b4af7985b7887b85b8817","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/353c5e184d2b4af7985b7887b85b8817","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2026.1961106","doi":"https://doi.org/10.3389/fmicb.2026.1961106","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1961106","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1961106/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224084099.pdf","grobid_xml":"https://content.openalex.org/works/W7224084099.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1967377218","https://openalex.org/W2000969439","https://openalex.org/W2014526984","https://openalex.org/W2040831929","https://openalex.org/W2049210029","https://openalex.org/W2061856163","https://openalex.org/W2116496714","https://openalex.org/W2520115479","https://openalex.org/W2606049286","https://openalex.org/W2769668997","https://openalex.org/W2784085354","https://openalex.org/W2808381977","https://openalex.org/W2886414402","https://openalex.org/W2894131129","https://openalex.org/W2896129158","https://openalex.org/W2898008780","https://openalex.org/W2969217144","https://openalex.org/W2983789406","https://openalex.org/W3005718707","https://openalex.org/W3092413229","https://openalex.org/W3134086379","https://openalex.org/W3137200117","https://openalex.org/W3157993535","https://openalex.org/W3186594593","https://openalex.org/W3194977041","https://openalex.org/W3210489033","https://openalex.org/W3217240365","https://openalex.org/W4200339903","https://openalex.org/W4206945683","https://openalex.org/W4284690807","https://openalex.org/W4311789543","https://openalex.org/W4312054632","https://openalex.org/W4313332773","https://openalex.org/W4320920718","https://openalex.org/W4324095548","https://openalex.org/W4366992983","https://openalex.org/W4368357821","https://openalex.org/W4383100558","https://openalex.org/W4387233867","https://openalex.org/W4388924359","https://openalex.org/W4398221165","https://openalex.org/W4399673406","https://openalex.org/W4402566426","https://openalex.org/W4403620184","https://openalex.org/W4403975945","https://openalex.org/W4403997683","https://openalex.org/W4408221102","https://openalex.org/W4408870980","https://openalex.org/W4410379881","https://openalex.org/W4411919007","https://openalex.org/W4412977531","https://openalex.org/W4413232909","https://openalex.org/W4413627867","https://openalex.org/W4414572146","https://openalex.org/W7134855067","https://openalex.org/W7171559982"],"related_works":["https://openalex.org/W7204831729","https://openalex.org/W4312054632","https://openalex.org/W7213319039","https://openalex.org/W4416506014","https://openalex.org/W4281397038","https://openalex.org/W1837725395","https://openalex.org/W4384400792","https://openalex.org/W4409526377","https://openalex.org/W4220794357","https://openalex.org/W7163152169"],"abstract_inverted_index":{"Objective":[0],"To":[1],"evaluate":[2],"the":[3,56,67,128,134],"bacteriostatic":[4],"effect":[5],"of":[6,60,69,96,130,136,172],"Bakuchiol":[7],"(Bak)":[8],"against":[9,117],"Streptococcus":[10,118],"agalactiae":[11,45,76,119,182,215],",":[12,19],"explored":[13],"its":[14,22,40,84],"antibacterial":[15,115,167],"mechanism":[16,59],"in":[17,26,87,180],"vitro":[18],"and":[20,50,83,94,102,133,151,155,175,206],"investigated":[21],"in-vivo":[23],"therapeutic":[24,85,226],"activity":[25,42,116,168],"a":[27,194,218,224],"mouse":[28,78,195],"mastitis":[29,79,196,201],"model.":[30],"Methods":[31],"The":[32],"Oxford":[33],"cup":[34],"assay":[35],"was":[36,63,81,89],"performed":[37],"to":[38,54,65],"test":[39],"inhibitory":[41],"on":[43,71],"S.":[44,75,181,214],".":[46,120,183],"Scanning":[47],"electron":[48],"microscopy":[49],"qPCR":[51],"were":[52],"employed":[53],"unravel":[55],"in-vitro":[57],"molecular":[58],"Bak.":[61],"Metabolomics":[62],"conducted":[64],"assess":[66],"impact":[68],"Bak":[70,112,125,164,189,198,212],"bacterial":[72,229],"metabolites.":[73],"A":[74],"-induced":[77],"model":[80],"constructed,":[82],"efficacy":[86],"mice":[88],"evaluated":[90],"via":[91],"histopathological":[92],"sections":[93],"detection":[95],"inflammatory":[97],"cytokine":[98,209],"(IL-6,":[99],"IL-8,":[100],"IL-1\u03b2":[101],"TNF-\u03b1)":[103],"expression.":[104],"Results":[105],"Among":[106],"24":[107],"natural":[108],"small-molecule":[109],"phenolic":[110],"compounds,":[111],"exhibited":[113,190],"favorable":[114],"Mechanistic":[121],"studies":[122,186],"revealed":[123,162],"that":[124,163,188],"significantly":[126,199],"inhibited":[127],"production":[129],"virulence":[131,137],"factors":[132],"expression":[135],"genes.":[138],"Notably,":[139],"it":[140,222],"suppressed":[141],"biofilm":[142,153],"formation":[143],"by":[144,202],"disrupting":[145],"initial":[146],"adhesion,":[147],"eliminating":[148],"mature":[149],"biofilms,":[150],"reducing":[152],"metabolism":[154,174],"extracellular":[156],"polymer":[157],"production.":[158],"Untargeted":[159],"metabolomics":[160],"analysis":[161],"might":[165],"produce":[166],"through":[169,217],"significant":[170],"disruption":[171],"purine":[173],"ABC":[176],"transport-associated":[177],"metabolic":[178],"pathways":[179],"Acute":[184],"toxicity":[185],"indicated":[187],"low":[191],"toxicity.":[192],"In":[193],"model,":[197],"improved":[200],"mitigating":[203],"tissue":[204],"damage,":[205],"downregulating":[207],"pro-inflammatory":[208],"levels.":[210],"Conclusion":[211],"attenuated":[213],"pathogenicity":[216],"multi-target":[219],"mechanism,":[220],"positioning":[221],"as":[223],"potential":[225],"candidate":[227],"for":[228],"mastitis.":[230]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-29T00:00:00"}
