{"id":"https://openalex.org/W7224082630","doi":"https://doi.org/10.1021/acsabm.6c01833","title":"Phenolic Hydroxyl-Containing Lipid Nanoparticles Enable Codelivery of HPV Peptide Antigens and Manganese Adjuvant for Cancer Immunotherapy","display_name":"Phenolic Hydroxyl-Containing Lipid Nanoparticles Enable Codelivery of HPV Peptide Antigens and Manganese Adjuvant for Cancer Immunotherapy","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224082630","doi":"https://doi.org/10.1021/acsabm.6c01833","pmid":"https://pubmed.ncbi.nlm.nih.gov/42947624"},"language":"en","primary_location":{"id":"doi:10.1021/acsabm.6c01833","doi":"https://doi.org/10.1021/acsabm.6c01833","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsabm.6c01833","pdf_url":null,"source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080719636","display_name":"Shuang Hou","orcid":"https://orcid.org/0000-0001-5487-2427","observed_orcids":["https://orcid.org/0000-0001-5487-2427"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Hou","raw_affiliation_strings":["College of Chemistry and Molecular Sciences, Henan University , , ,","Henan University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular Sciences, Henan University , , ,","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Henan University , , ,","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147448764","display_name":"Deling Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Deling Zhou","raw_affiliation_strings":["College of Chemistry and Molecular Sciences, Henan University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular Sciences, Henan University , , ,","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159990788","display_name":"Yi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Henan University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan University , , ,","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160052113","display_name":"Youming Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youming Li","raw_affiliation_strings":["College of Chemistry and Molecular Sciences, Henan University , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular Sciences, Henan University , ,","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000840123","display_name":"Dang Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dang Fan","raw_affiliation_strings":["College of Chemistry and Molecular Sciences, Henan University , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular Sciences, Henan University , ,","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100568337","display_name":"Yeqin Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yeqin Hu","raw_affiliation_strings":["MAXVAX Bio-tech Co., Ltd. , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MAXVAX Bio-tech Co., Ltd. , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147115326","display_name":"Liyan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyan Li","raw_affiliation_strings":["Henan University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan University , , ,","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101696030","display_name":"Changjiang Qin","orcid":"https://orcid.org/0000-0003-4295-4964","observed_orcids":["https://orcid.org/0000-0003-4295-4964"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changjiang Qin","raw_affiliation_strings":["Huaihe Hospital of Henan University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huaihe Hospital of Henan University , , ,","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086661699","display_name":"Mingxue Li","orcid":"https://orcid.org/0000-0003-2760-2020","observed_orcids":["https://orcid.org/0000-0003-2760-2020"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingxue Li","raw_affiliation_strings":["College of Chemistry and Molecular Sciences, Henan University , ,","Huaihe Hospital, Henan University , , ,"],"raw_orcid":"https://orcid.org/0000-0003-2760-2020","affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular Sciences, Henan University , ,","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Huaihe Hospital, Henan University , , ,","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159993860","display_name":"Ming Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming Li","raw_affiliation_strings":["College of Chemistry and Molecular Sciences, Henan University , ,","Huaihe Hospital, Henan University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular Sciences, Henan University , ,","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Huaihe Hospital, Henan University , , ,","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410345","display_name":"Hong Liu","orcid":"https://orcid.org/0000-0003-0350-7475","observed_orcids":["https://orcid.org/0000-0003-0350-7475"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hong Liu","raw_affiliation_strings":["Henan University , , ,"],"raw_orcid":"https://orcid.org/0000-0003-0350-7475","affiliations":[{"raw_affiliation_string":"Henan University , , ,","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100428820","display_name":"Yongming Chen","orcid":"https://orcid.org/0000-0003-2843-5543","observed_orcids":["https://orcid.org/0000-0003-2843-5543"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongming Chen","raw_affiliation_strings":["College of Chemistry and Molecular Sciences, Henan University , ,","Henan University , , ,"],"raw_orcid":"https://orcid.org/0000-0003-2843-5543","affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular Sciences, Henan University , ,","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Henan University , , ,","institution_ids":["https://openalex.org/I173899330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086661699","https://openalex.org/A5100410345","https://openalex.org/A5101696030","https://openalex.org/A5159993860"],"corresponding_institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76617797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.06530000269412994,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.9380000233650208},{"id":"https://openalex.org/keywords/phenolic-hydroxyl-groups","display_name":"phenolic hydroxyl groups","score":0.8820000290870667},{"id":"https://openalex.org/keywords/peptide-vaccine","display_name":"peptide vaccine","score":0.5410000085830688},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8360000252723694},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/sting-signaling","display_name":"STING signaling","score":0.9819999933242798},{"id":"https://openalex.org/keywords/innate-immune-activation","display_name":"innate immune activation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.796999990940094},{"id":"https://openalex.org/keywords/hpv-associated-cancers","display_name":"HPV-associated cancers","score":0.7279999852180481},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.7020999789237976},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.6973999738693237},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6715999841690063},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6506999731063843},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.633400022983551},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.6062999963760376},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5425000190734863},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5228000283241272},{"id":"https://openalex.org/C2911179620","wikidata":"https://www.wikidata.org/wiki/Q901656","display_name":"Immunopotentiator","level":3,"score":0.5170000195503235},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5019999742507935},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.3589000105857849},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.35260000824928284},{"id":"https://openalex.org/C2909935589","wikidata":"https://www.wikidata.org/wiki/Q967453","display_name":"Immunoadjuvant","level":3,"score":0.33480000495910645},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.33070001006126404},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3222000002861023},{"id":"https://openalex.org/C2776929087","wikidata":"https://www.wikidata.org/wiki/Q189096","display_name":"Cell-penetrating peptide","level":3,"score":0.31790000200271606},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.313400000333786},{"id":"https://openalex.org/C2776662205","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor antigen","level":4,"score":0.3127000033855438},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.29899999499320984},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C2778378633","wikidata":"https://www.wikidata.org/wiki/Q2378309","display_name":"Cancer vaccine","level":4,"score":0.29600000381469727},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28999999165534973},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.2892000079154968},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.2888000011444092},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.28450000286102295},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.2822999954223633},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26420000195503235},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2623000144958496},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2612000107765198},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2524999976158142}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acsabm.6c01833","doi":"https://doi.org/10.1021/acsabm.6c01833","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsabm.6c01833","pdf_url":null,"source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},{"id":"pmid:42947624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42947624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied bio materials","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320336593","display_name":"Henan Provincial Science and Technology Research Project","ror":null},{"id":"https://openalex.org/F4320336613","display_name":"Science and Technology Innovation Talents in Universities of Henan Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W2253488282","https://openalex.org/W2336353704","https://openalex.org/W2512657324","https://openalex.org/W2600400434","https://openalex.org/W2833167137","https://openalex.org/W2914084076","https://openalex.org/W2973037624","https://openalex.org/W2995702491","https://openalex.org/W3004878730","https://openalex.org/W3119877504","https://openalex.org/W3127944141","https://openalex.org/W3137897437","https://openalex.org/W3209735640","https://openalex.org/W4200148704","https://openalex.org/W4213413021","https://openalex.org/W4283803576","https://openalex.org/W4294904099","https://openalex.org/W4312019855","https://openalex.org/W4362705340","https://openalex.org/W4385611967","https://openalex.org/W4389537757","https://openalex.org/W4402279057","https://openalex.org/W4402468964","https://openalex.org/W4403690208","https://openalex.org/W4404200215","https://openalex.org/W4405596838","https://openalex.org/W4406795175","https://openalex.org/W4410695735","https://openalex.org/W4410718805","https://openalex.org/W4410916278","https://openalex.org/W4412673241","https://openalex.org/W4413109062","https://openalex.org/W4413178155","https://openalex.org/W4414905090","https://openalex.org/W4416066410","https://openalex.org/W7122711964","https://openalex.org/W7123918121","https://openalex.org/W7125007151","https://openalex.org/W7201881752"],"related_works":["https://openalex.org/W2099478058","https://openalex.org/W7163341100","https://openalex.org/W4400079678","https://openalex.org/W4414772615","https://openalex.org/W2281375963","https://openalex.org/W2108989990","https://openalex.org/W2346292891","https://openalex.org/W2752787803","https://openalex.org/W3122063492","https://openalex.org/W2921406742"],"abstract_inverted_index":{"Therapeutic":[0],"peptide":[1,36,57,183],"vaccines":[2],"against":[3,199],"HPV-associated":[4,200],"cancers":[5],"are":[6],"often":[7],"limited":[8],"by":[9,108,115,153],"insufficient":[10],"immunogenicity":[11],"and":[12,38,56,74,89,102,121,133,158,192],"inefficient":[13],"intracellular":[14],"delivery.":[15],"Here,":[16],"we":[17],"develop":[18],"a":[19,26,94,141,177,190],"phenolic":[20,53,72],"hydroxyl-containing":[21],"lipid":[22],"nanoparticle":[23],"(EMT@LNP)":[24],"as":[25,113],"nanomedicine":[27],"platform":[28,195],"for":[29,196],"the":[30,77],"coordinated":[31],"codelivery":[32],"of":[33,62,80,110,118],"HPV16":[34],"E6/E7":[35],"antigens":[37],"manganese":[39],"(Mn2+)":[40],"adjuvant.":[41],"Distinct":[42],"from":[43],"conventional":[44],"electrostatic":[45],"loading":[46,61,184],"strategies,":[47],"EMT@LNP":[48,98,125,146],"exploits":[49],"hydrogen-bonding":[50],"interactions":[51,70],"between":[52,71],"hydroxyl":[54],"groups":[55],"antigens,":[58],"enabling":[59],"charge-independent":[60,182],"peptides":[63],"with":[64,185],"diverse":[65],"physicochemical":[66],"properties,":[67],"while":[68],"coordination":[69],"moieties":[73],"Mn2+":[75],"allow":[76],"simultaneous":[78],"incorporation":[79],"immunostimulatory":[81],"adjuvants.":[82],"This":[83],"dual-interaction-driven":[84],"design":[85],"integrates":[86],"antigen":[87,100,135],"delivery":[88,128],"innate":[90],"immune":[91,150,187],"activation":[92,109],"within":[93],"single":[95],"nanostructure.":[96],"Functionally,":[97],"enhances":[99],"uptake":[101],"promotes":[103],"dendritic":[104],"cell":[105,161],"maturation,":[106],"accompanied":[107],"STING-associated":[111],"signaling,":[112],"indicated":[114],"increased":[116],"phosphorylation":[117],"STING,":[119],"TBK1,":[120],"IRF3.":[122],"In":[123,140],"vivo,":[124],"facilitates":[126],"efficient":[127],"to":[129,164],"draining":[130],"lymph":[131],"nodes":[132],"prolongs":[134],"retention":[136],"following":[137],"intramuscular":[138],"administration.":[139],"therapeutic":[142,197],"TC-1":[143],"tumor":[144,166],"model,":[145],"elicits":[147],"potent":[148],"antitumor":[149],"responses,":[151],"characterized":[152],"enhanced":[154],"CD8+":[155],"T-cell":[156],"infiltration":[157],"reduced":[159],"immunosuppressive":[160],"populations,":[162],"leading":[163],"significant":[165],"growth":[167],"inhibition":[168],"without":[169],"observable":[170],"systemic":[171],"toxicity.":[172],"Collectively,":[173],"this":[174],"study":[175],"presents":[176],"nanobiotechnology":[178],"strategy":[179],"that":[180],"combines":[181],"metal-ion-mediated":[186],"activation,":[188],"providing":[189],"versatile":[191],"potentially":[193],"translatable":[194],"vaccination":[198],"malignancies.":[201]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-29T00:00:00"}
