{"id":"https://openalex.org/W7224079986","doi":"https://doi.org/10.3389/fneur.2026.1984962","title":"Hemodynamic characteristics at rupture sites of middle cerebral artery aneurysms: a CFD study with intraoperative correlation","display_name":"Hemodynamic characteristics at rupture sites of middle cerebral artery aneurysms: a CFD study with intraoperative correlation","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224079986","doi":"https://doi.org/10.3389/fneur.2026.1984962"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2026.1984962","doi":"https://doi.org/10.3389/fneur.2026.1984962","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1984962","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1984962/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1984962/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159991678","display_name":"Mingmei Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405280210","display_name":"University of Health and Rehabilitation Sciences","ror":"https://ror.org/02kjtx631","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280210"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingmei Zhao","raw_affiliation_strings":["Qingdao Central Hospital, University of Health and Rehabilitation Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Central Hospital, University of Health and Rehabilitation Sciences","institution_ids":["https://openalex.org/I4405280210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160053997","display_name":"Shaoyong Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405280210","display_name":"University of Health and Rehabilitation Sciences","ror":"https://ror.org/02kjtx631","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280210"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaoyong Yuan","raw_affiliation_strings":["Qingdao Central Hospital, University of Health and Rehabilitation Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Central Hospital, University of Health and Rehabilitation Sciences","institution_ids":["https://openalex.org/I4405280210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049062155","display_name":"\u9648\u7476\u521a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405280210","display_name":"University of Health and Rehabilitation Sciences","ror":"https://ror.org/02kjtx631","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280210"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaogang Chen","raw_affiliation_strings":["Qingdao Central Hospital, University of Health and Rehabilitation Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Central Hospital, University of Health and Rehabilitation Sciences","institution_ids":["https://openalex.org/I4405280210"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044492121","display_name":"\u738b\u5c0f\u540c","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaotong Wang","raw_affiliation_strings":["Qingdao University Affiliated Qingdao Third People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao University Affiliated Qingdao Third People\u2019s Hospital","institution_ids":["https://openalex.org/I108688024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044492121"],"corresponding_institution_ids":["https://openalex.org/I108688024"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82215852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12747","display_name":"Moyamoya disease diagnosis and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/middle-cerebral-artery-aneurysm","display_name":"middle cerebral artery aneurysm","score":0.9399999976158142},{"id":"https://openalex.org/keywords/intracranial-aneurysm-rupture","display_name":"intracranial aneurysm rupture","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.7680000066757202},{"id":"https://openalex.org/keywords/wall-shear-stress","display_name":"wall shear stress","score":0.9210000038146973},{"id":"https://openalex.org/keywords/oscillatory-shear-index","display_name":"oscillatory shear index","score":0.9929999709129333},{"id":"https://openalex.org/keywords/aneurysm-sac","display_name":"aneurysm sac","score":0.8050000071525574},{"id":"https://openalex.org/keywords/parent-artery","display_name":"parent artery","score":0.7039999961853027},{"id":"https://openalex.org/keywords/computational-fluid-dynamics","display_name":"computational fluid dynamics","score":0.7200000286102295},{"id":"https://openalex.org/keywords/ct-angiography","display_name":"CT angiography","score":0.8519999980926514},{"id":"https://openalex.org/keywords/intraoperative-correlation","display_name":"intraoperative correlation","score":0.5709999799728394},{"id":"https://openalex.org/keywords/aneurysm-treatment-planning","display_name":"aneurysm treatment planning","score":0.5019999742507935},{"id":"https://openalex.org/keywords/endovascular-treatment","display_name":"endovascular treatment","score":0.37700000405311584},{"id":"https://openalex.org/keywords/surgical-planning","display_name":"surgical planning","score":0.4169999957084656},{"id":"https://openalex.org/keywords/aneurysm-sac-pressure","display_name":"aneurysm sac pressure","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7455000281333923},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.7098000049591064},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5896999835968018},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5559999942779541},{"id":"https://openalex.org/C2775841333","wikidata":"https://www.wikidata.org/wiki/Q498179","display_name":"Middle cerebral artery","level":3,"score":0.4853000044822693},{"id":"https://openalex.org/C2780643987","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Angiography","level":2,"score":0.46149998903274536},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.460099995136261},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44830000400543213},{"id":"https://openalex.org/C2781347138","wikidata":"https://www.wikidata.org/wiki/Q1024492","display_name":"Computed tomography angiography","level":3,"score":0.37689998745918274},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.3621000051498413},{"id":"https://openalex.org/C2778749279","wikidata":"https://www.wikidata.org/wiki/Q5064095","display_name":"Cerebral angiography","level":3,"score":0.3481000065803528},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3296000063419342},{"id":"https://openalex.org/C21141959","wikidata":"https://www.wikidata.org/wiki/Q657936","display_name":"Shear stress","level":2,"score":0.3102000057697296},{"id":"https://openalex.org/C2777604165","wikidata":"https://www.wikidata.org/wiki/Q503643","display_name":"Brachial artery","level":3,"score":0.3098999857902527},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.28780001401901245},{"id":"https://openalex.org/C2777202286","wikidata":"https://www.wikidata.org/wiki/Q9609","display_name":"Vein","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C55138121","wikidata":"https://www.wikidata.org/wiki/Q7370320","display_name":"Rotational angiography","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C2776619873","wikidata":"https://www.wikidata.org/wiki/Q3623006","display_name":"Arterial tree","level":2,"score":0.2667999863624573},{"id":"https://openalex.org/C171614378","wikidata":"https://www.wikidata.org/wiki/Q5064093","display_name":"Cerebral arteries","level":2,"score":0.2628999948501587}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fneur.2026.1984962","doi":"https://doi.org/10.3389/fneur.2026.1984962","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1984962","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1984962/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f76e1bb691de44b2a3f263ebe6ccf72c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f76e1bb691de44b2a3f263ebe6ccf72c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2026.1984962","doi":"https://doi.org/10.3389/fneur.2026.1984962","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1984962","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1984962/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224079986.pdf","grobid_xml":"https://content.openalex.org/works/W7224079986.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1967625137","https://openalex.org/W2017733968","https://openalex.org/W2031955337","https://openalex.org/W2034878216","https://openalex.org/W2036109722","https://openalex.org/W2050970791","https://openalex.org/W2066061468","https://openalex.org/W2073851508","https://openalex.org/W2096227551","https://openalex.org/W2101569050","https://openalex.org/W2113713760","https://openalex.org/W2150027450","https://openalex.org/W2156152931","https://openalex.org/W2172066222","https://openalex.org/W2185602086","https://openalex.org/W2315137743","https://openalex.org/W2594834811","https://openalex.org/W2811501961","https://openalex.org/W2887755085","https://openalex.org/W2889008666","https://openalex.org/W2890539449","https://openalex.org/W2936762674","https://openalex.org/W2999276141","https://openalex.org/W3038057459","https://openalex.org/W3137503028","https://openalex.org/W4224221103","https://openalex.org/W4398145406","https://openalex.org/W4399370575","https://openalex.org/W4400260556","https://openalex.org/W4416539472","https://openalex.org/W7128540383"],"related_works":["https://openalex.org/W2036109722","https://openalex.org/W2551007810","https://openalex.org/W2034878216","https://openalex.org/W2886176933","https://openalex.org/W3215510372","https://openalex.org/W3206578320","https://openalex.org/W1511389619","https://openalex.org/W2743550661","https://openalex.org/W4284960760","https://openalex.org/W2943086340"],"abstract_inverted_index":{"Objective":[0],"To":[1],"characterise":[2],"the":[3,7,14,91,102,106,126,133,141,155,160,176,187,191,196,210,243,249,284,287,291,302,306,321],"hemodynamic":[4],"environment":[5],"at":[6,96,154,159,186,195],"intraoperatively":[8],"confirmed":[9],"rupture":[10,142,156,188,238,285,303,322],"point,":[11],"relative":[12],"to":[13,61,132,140],"aneurysm":[15,134,161,192,288,307],"sac":[16,135,162,193,256,267],"and":[17,35,58,73,109,138,163,170,190,203,245,263,281,290,295,305,313],"parent":[18,127,164,197,292],"artery,":[19],"in":[20,48,258,269,279],"middle":[21],"cerebral":[22],"artery":[23,128,165,198],"aneurysms":[24],"(MCAAs),":[25],"using":[26,105],"CT":[27],"angiography":[28],"(CTA)-based":[29],"computational":[30],"fluid":[31],"dynamics":[32],"(CFD).":[33],"Materials":[34],"methods":[36],"Preoperative":[37],"CTA":[38,93],"data":[39],"from":[40,125],"15":[41,261],"patients":[42],"with":[43,114,172,242],"ruptured":[44],"MCAAs":[45],"were":[46,54,78,99,219],"reconstructed":[47],"three":[49,103,223],"dimensions.":[50],"Transient":[51],"CFD":[52,275],"simulations":[53],"run":[55],"under":[56],"rigid-wall":[57],"Newtonian-fluid":[59],"assumptions":[60],"compute":[62],"time-averaged":[63],"wall":[64],"shear":[65,69],"stress":[66],"(TAWSS),":[67],"oscillatory":[68],"index":[70],"(OSI),":[71],"pressure,":[72,299],"flow":[74],"streamlines.":[75],"Rupture":[76],"regions":[77],"identified":[79,89],"intraoperatively.":[80],"No":[81],"daughter":[82],"sac,":[83,289,308],"bleb,":[84],"or":[85,95],"secondary":[86],"lobulation":[87],"was":[88,152,184,253],"on":[90],"preoperative":[92],"reconstructions":[94],"surgery.":[97],"Parameters":[98],"compared":[100],"across":[101],"locations":[104],"Friedman":[107,217],"test":[108],"pairwise":[110,147],"Wilcoxon":[111],"signed-rank":[112],"tests":[113,218],"Bonferroni":[115],"correction":[116],"(":[117,166,179,199,213],"p":[118,148,167,180,200,214,226,230,234],"<":[119,227],"0.0167).":[120],"Results":[121],"TAWSS":[122,252,257,280,294,312],"decreased":[123],"monotonically":[124],"(median":[129],"9.97":[130],"Pa)":[131,137],"(4.58":[136],"then":[139],"point":[143,157,189,304],"(2.14":[144],"Pa;":[145],"all":[146,222],"\u2264":[149],"0.003).":[150],"OSI":[151,265,268,282,315],"higher":[153,185],"than":[158,194,255,317],"=":[168,181,201,215,231,235],"0.0003":[169],"0.0002),":[171],"no":[173],"difference":[174],"between":[175,209,283,301],"latter":[177],"two":[178,212],"0.252).":[182],"Pressure":[183],"0.005":[202],"0.009)":[204],"but":[205,297],"did":[206],"not":[207,298],"differ":[208],"first":[211],"0.027).":[216],"significant":[220],"for":[221],"parameters":[224],"(TAWSS:":[225],"0.0001;":[228],"OSI:":[229],"0.0004;":[232],"pressure:":[233],"0.0011).":[236],"The":[237],"region":[239],"coincided":[240],"spatially":[241],"low-TAWSS":[244],"high-OSI":[246],"areas":[247],"of":[248,260,271],"sac:":[250],"rupture-point":[251,264],"lower":[254],"14":[259],"patients,":[262],"exceeded":[266],"13":[270],"15.":[272],"Conclusion":[273],"CTA-based":[274],"resolved":[276],"region-level":[277],"differences":[278],"region,":[286],"artery.":[293],"OSI,":[296],"differed":[300],"indicating":[309],"that":[310],"low":[311],"high":[314],"rather":[316],"elevated":[318],"pressure":[319],"characterize":[320],"point.":[323]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}
