{"id":"https://openalex.org/W7224079481","doi":"https://doi.org/10.3390/antibiotics15111077","title":"Acute Intravenous Tolerability of Antimicrobial Peptides Derived from the Human Cathelicidin LL-37 and Local Antibacterial Activity of Its FK-16 Fragment in A Methicillin-Resistant Staphylococcus epidermidis Rat Femoral Osteotomy Model","display_name":"Acute Intravenous Tolerability of Antimicrobial Peptides Derived from the Human Cathelicidin LL-37 and Local Antibacterial Activity of Its FK-16 Fragment in A Methicillin-Resistant Staphylococcus epidermidis Rat Femoral Osteotomy Model","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224079481","doi":"https://doi.org/10.3390/antibiotics15111077"},"language":"en","primary_location":{"id":"doi:10.3390/antibiotics15111077","doi":"https://doi.org/10.3390/antibiotics15111077","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antibiotics15111077","pdf_url":null,"source":{"id":"https://openalex.org/S2736332253","display_name":"Antibiotics","issn_l":"2079-6382","issn":["2079-6382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/antibiotics15111077","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010758415","display_name":"Vincenzo Pennone","orcid":"https://orcid.org/0000-0001-8752-3231","observed_orcids":["https://orcid.org/0000-0001-8752-3231"]},"institutions":[{"id":"https://openalex.org/I4210113215","display_name":"IRCCS Ospedale Galeazzi - Sant'Ambrogio","ror":"https://ror.org/01vyrje42","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113215","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Pennone","raw_affiliation_strings":["Cell and Tissue Engineering Laboratory, IRCCS Ospedale Galeazzi-Sant\u2019Ambrogio, 20157 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8752-3231","affiliations":[{"raw_affiliation_string":"Cell and Tissue Engineering Laboratory, IRCCS Ospedale Galeazzi-Sant\u2019Ambrogio, 20157 Milan, Italy","institution_ids":["https://openalex.org/I4210113215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011930545","display_name":"Stefania Mamberti","orcid":"https://orcid.org/0000-0001-9099-953X","observed_orcids":["https://orcid.org/0000-0001-9099-953X"]},"institutions":[{"id":"https://openalex.org/I4210113215","display_name":"IRCCS Ospedale Galeazzi - Sant'Ambrogio","ror":"https://ror.org/01vyrje42","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113215","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Mamberti","raw_affiliation_strings":["Cell and Tissue Engineering Laboratory, IRCCS Ospedale Galeazzi-Sant\u2019Ambrogio, 20157 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9099-953X","affiliations":[{"raw_affiliation_string":"Cell and Tissue Engineering Laboratory, IRCCS Ospedale Galeazzi-Sant\u2019Ambrogio, 20157 Milan, Italy","institution_ids":["https://openalex.org/I4210113215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141310897","display_name":"Giada Meogrossi","orcid":"https://orcid.org/0009-0005-2409-2784","observed_orcids":["https://orcid.org/0009-0005-2409-2784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giada Meogrossi","raw_affiliation_strings":["Fondazione Istituto Insubrico Ricerca per la Vita, 21040 Gerenzano, Italy"],"raw_orcid":"https://orcid.org/0009-0005-2409-2784","affiliations":[{"raw_affiliation_string":"Fondazione Istituto Insubrico Ricerca per la Vita, 21040 Gerenzano, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050613262","display_name":"Monica Abbondi","orcid":"https://orcid.org/0000-0002-8248-2861","observed_orcids":["https://orcid.org/0000-0002-8248-2861"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monica Abbondi","raw_affiliation_strings":["Fondazione Istituto Insubrico Ricerca per la Vita, 21040 Gerenzano, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8248-2861","affiliations":[{"raw_affiliation_string":"Fondazione Istituto Insubrico Ricerca per la Vita, 21040 Gerenzano, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046507576","display_name":"Barbara Canciani","orcid":"https://orcid.org/0000-0003-1942-1174","observed_orcids":["https://orcid.org/0000-0003-1942-1174"]},"institutions":[{"id":"https://openalex.org/I4210113215","display_name":"IRCCS Ospedale Galeazzi - Sant'Ambrogio","ror":"https://ror.org/01vyrje42","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113215","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Canciani","raw_affiliation_strings":["Tissue Engineering and Biomaterials Laboratory, IRCCS Ospedale Galeazzi-Sant\u2019Ambrogio, 20157 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1942-1174","affiliations":[{"raw_affiliation_string":"Tissue Engineering and Biomaterials Laboratory, IRCCS Ospedale Galeazzi-Sant\u2019Ambrogio, 20157 Milan, Italy","institution_ids":["https://openalex.org/I4210113215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090326151","display_name":"Camilla Recordati","orcid":"https://orcid.org/0000-0002-7172-9662","observed_orcids":["https://orcid.org/0000-0002-7172-9662"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Camilla Recordati","raw_affiliation_strings":["Department of Veterinary Medicine and Animal Sciences, University of Milan, 26900 Lodi, Italy","Mouse and Animal Pathology Laboratory, UNIMI Foundation, 20139 Milano, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7172-9662","affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine and Animal Sciences, University of Milan, 26900 Lodi, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Mouse and Animal Pathology Laboratory, UNIMI Foundation, 20139 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058389691","display_name":"David \u0160arlah","orcid":"https://orcid.org/0000-0002-8736-8953","observed_orcids":["https://orcid.org/0000-0002-8736-8953"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"David Sarlah","raw_affiliation_strings":["Department of Chemistry, Rice University, Houston, TX 77005, USA","Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA","Department of Chemistry, University of Pavia, 27100 Pavia, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8736-8953","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, TX 77005, USA","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Chemistry, University of Pavia, 27100 Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087225829","display_name":"Fabio Sangalli","orcid":"https://orcid.org/0000-0001-5912-0312","observed_orcids":["https://orcid.org/0000-0001-5912-0312"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Sangalli","raw_affiliation_strings":["Laboratory of Medical Imaging, Department of Biomedical Engineering, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, 24126 Bergamo, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5912-0312","affiliations":[{"raw_affiliation_string":"Laboratory of Medical Imaging, Department of Biomedical Engineering, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, 24126 Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087807280","display_name":"Elena De Vecchi","orcid":"https://orcid.org/0000-0001-9781-8607","observed_orcids":["https://orcid.org/0000-0001-9781-8607"]},"institutions":[{"id":"https://openalex.org/I4210113215","display_name":"IRCCS Ospedale Galeazzi - Sant'Ambrogio","ror":"https://ror.org/01vyrje42","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113215","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena De Vecchi","raw_affiliation_strings":["Laboratory of Clinical Chemistry and Microbiology, IRCCS Ospedale Galeazzi-Sant\u2019Ambrogio, 20157 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9781-8607","affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Chemistry and Microbiology, IRCCS Ospedale Galeazzi-Sant\u2019Ambrogio, 20157 Milan, Italy","institution_ids":["https://openalex.org/I4210113215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070245760","display_name":"Emanuela Galliera","orcid":"https://orcid.org/0000-0002-0764-3178","observed_orcids":["https://orcid.org/0000-0002-0764-3178"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210113215","display_name":"IRCCS Ospedale Galeazzi - Sant'Ambrogio","ror":"https://ror.org/01vyrje42","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113215","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuela Galliera","raw_affiliation_strings":["Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy","Osteoimmunology Unit, IRCCS Ospedale Galeazzi-Sant\u2019Ambrogio, 20157 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0764-3178","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Osteoimmunology Unit, IRCCS Ospedale Galeazzi-Sant\u2019Ambrogio, 20157 Milan, Italy","institution_ids":["https://openalex.org/I4210113215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068346827","display_name":"Arianna Barbara Lovati","orcid":"https://orcid.org/0000-0002-5230-9718","observed_orcids":["https://orcid.org/0000-0002-5230-9718"]},"institutions":[{"id":"https://openalex.org/I4210113215","display_name":"IRCCS Ospedale Galeazzi - Sant'Ambrogio","ror":"https://ror.org/01vyrje42","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113215","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Arianna Barbara Lovati","raw_affiliation_strings":["Cell and Tissue Engineering Laboratory, IRCCS Ospedale Galeazzi-Sant\u2019Ambrogio, 20157 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5230-9718","affiliations":[{"raw_affiliation_string":"Cell and Tissue Engineering Laboratory, IRCCS Ospedale Galeazzi-Sant\u2019Ambrogio, 20157 Milan, Italy","institution_ids":["https://openalex.org/I4210113215"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5068346827"],"corresponding_institution_ids":["https://openalex.org/I4210113215"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84958461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"11","first_page":"1077","last_page":"1077"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cathelicidin-ll-37","display_name":"cathelicidin LL-37","score":0.9390000104904175},{"id":"https://openalex.org/keywords/orthopedic-implant-associated-infection","display_name":"orthopedic implant-associated infection","score":0.8799999952316284},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-epidermidis","display_name":"methicillin-resistant Staphylococcus epidermidis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/femoral-nonunion","display_name":"femoral nonunion","score":0.7820000052452087},{"id":"https://openalex.org/keywords/osteomyelitis","display_name":"osteomyelitis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.5289999842643738},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/vancomycin-comparison","display_name":"vancomycin comparison","score":0.6140000224113464},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2777949923","wikidata":"https://www.wikidata.org/wiki/Q131915","display_name":"Staphylococcus epidermidis","level":4,"score":0.7827000021934509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6883000135421753},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5741000175476074},{"id":"https://openalex.org/C2777379352","wikidata":"https://www.wikidata.org/wiki/Q24739493","display_name":"Cathelicidin","level":4,"score":0.5534999966621399},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.5347999930381775},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5205000042915344},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.48330000042915344},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4332999885082245},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.43309998512268066},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.398499995470047},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.37540000677108765},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3271999955177307},{"id":"https://openalex.org/C2781467277","wikidata":"https://www.wikidata.org/wiki/Q375145","display_name":"Galactosamine","level":3,"score":0.3125999867916107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31119999289512634},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.31119999289512634},{"id":"https://openalex.org/C2779288629","wikidata":"https://www.wikidata.org/wiki/Q199695","display_name":"Staphylococcus","level":4,"score":0.30799999833106995},{"id":"https://openalex.org/C2775919214","wikidata":"https://www.wikidata.org/wiki/Q794072","display_name":"Azotemia","level":3,"score":0.29919999837875366},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2969000041484833},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.273499995470047},{"id":"https://openalex.org/C2780551157","wikidata":"https://www.wikidata.org/wiki/Q938983","display_name":"Osteomyelitis","level":2,"score":0.26989999413490295},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.26829999685287476},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2621999979019165},{"id":"https://openalex.org/C2775956843","wikidata":"https://www.wikidata.org/wiki/Q924421","display_name":"Septic arthritis","level":3,"score":0.2526000142097473},{"id":"https://openalex.org/C2777458120","wikidata":"https://www.wikidata.org/wiki/Q422273","display_name":"Clindamycin","level":3,"score":0.25189998745918274},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/antibiotics15111077","doi":"https://doi.org/10.3390/antibiotics15111077","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antibiotics15111077","pdf_url":null,"source":{"id":"https://openalex.org/S2736332253","display_name":"Antibiotics","issn_l":"2079-6382","issn":["2079-6382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/antibiotics15111077","doi":"https://doi.org/10.3390/antibiotics15111077","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antibiotics15111077","pdf_url":null,"source":{"id":"https://openalex.org/S2736332253","display_name":"Antibiotics","issn_l":"2079-6382","issn":["2079-6382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7213585205","https://openalex.org/W6958276587","https://openalex.org/W4413127805","https://openalex.org/W4313569758","https://openalex.org/W4401586206","https://openalex.org/W4392726527","https://openalex.org/W2740576992","https://openalex.org/W2135931091","https://openalex.org/W4392174584","https://openalex.org/W3045493040"],"abstract_inverted_index":{"Background:":[0],"Orthopedic":[1],"implant-associated":[2],"infections":[3],"are":[4,18],"difficult":[5],"to":[6,50,62,130,247],"eradicate":[7],"because":[8],"of":[9,23,30,43,68,81,241,245,250,346],"biofilm":[10],"formation":[11],"and":[12,16,34,61,94,109,112,121,152,162,187,196,201,226,266,300,318,339],"impaired":[13],"healing.":[14],"FK-16":[15,28,69,186,235,317,332],"GF-17":[17,39,101,191,319],"short":[19],"synthetic":[20],"antimicrobial":[21],"fragments":[22],"the":[24,37,41,64,242,281],"human":[25],"cathelicidin":[26],"LL-37;":[27],"consists":[29],"16":[31],"amino":[32],"acids":[33],"differs":[35],"from":[36,222,228],"17-amino-acid":[38],"by":[40,360],"absence":[42],"its":[44],"N-terminal":[45],"glycine.":[46],"This":[47],"study":[48],"aimed":[49],"assess":[51],"their":[52],"acute":[53,323],"tolerability":[54,324],"following":[55],"single-dose":[56],"intravenous":[57],"administration":[58],"in":[59,77,175,181],"mice":[60,91],"evaluate":[63],"local":[65],"antibacterial":[66,150,334],"efficacy":[67],"delivered":[70,331],"via":[71],"peptide-enriched":[72],"silk":[73],"fibroin":[74],"(PSF)":[75],"scaffolds":[76],"a":[78,131,205],"rat":[79],"model":[80],"methicillin-resistant":[82],"Staphylococcus":[83],"epidermidis":[84],"(MRSE)-associated":[85],"femoral":[86],"nonunion.":[87],"Methods:":[88],"Thirty-six":[89],"BALB/c":[90],"(18":[92],"males":[93],"18":[95],"females)":[96],"received":[97],"vehicle,":[98],"FK-16,":[99],"or":[100,103,135,144,170,233,356],"(0.1":[102],"1":[104,193],"mg/kg":[105],"for":[106],"each":[107],"peptide)":[108],"underwent":[110],"clinical":[111],"functional":[113],"assessments,":[114],"hemolysis":[115],"testing,":[116],"biochemical":[117],"analyses,":[118],"organ-weight":[119],"measurements,":[120],"histopathological":[122],"examination.":[123],"Thirty-two":[124],"male":[125],"Wistar":[126],"rats":[127],"were":[128,155,199,214],"assigned":[129],"noninfected":[132,305],"control":[133],"group":[134],"infected":[136],"groups":[137,309],"treated":[138,184,189,230,308],"with":[139,185,190,231,238,342],"unloaded":[140],"PSF,":[141,143],"vancomycin-loaded":[142],"FK-16-loaded":[145],"PSF.":[146],"On":[147],"day":[148,361],"56,":[149],"activity":[151],"bone":[153,267,354],"healing":[154,277,355],"evaluated":[156],"using":[157],"microbiological":[158],"culture,":[159],"micro-computed":[160,275],"tomography,":[161],"histopathology.":[163],"Results:":[164],"No":[165],"mortality,":[166],"persistent":[167],"neurobehavioral":[168],"abnormalities,":[169],"treatment-related":[171,211],"organ":[172,212],"lesions":[173,213],"occurred":[174,180],"mice.":[176],"Transient":[177],"hind-limb":[178],"paralysis":[179],"one":[182,188],"mouse":[183],"at":[192],"mg/kg.":[194],"Biochemical":[195],"hemolysis-related":[197],"changes":[198],"isolated":[200],"did":[202,349],"not":[203,350],"follow":[204],"consistent":[206],"dose\u2013response":[207],"pattern;":[208],"no":[209,273],"corresponding":[210],"observed.":[215],"In":[216],"rats,":[217],"viable":[218],"MRSE":[219],"was":[220,236,340],"recovered":[221],"3/4":[223],"untreated":[224],"specimens":[225],"none":[227],"those":[229],"vancomycin":[232],"FK-16.":[234],"associated":[237,341],"partial":[239],"normalization":[240],"circulating":[243],"ratio":[244],"osteoprotegerin":[246],"receptor":[248],"activator":[249],"nuclear":[251],"factor-\u03baB":[252],"ligand":[253],"without":[254],"significantly":[255,351],"reducing":[256],"early":[257],"systemic":[258],"inflammation.":[259],"Bone":[260],"mineral":[261,264],"density,":[262,265],"tissue":[263],"volume":[268],"fraction":[269],"increased":[270],"numerically,":[271],"but":[272,313,348],"quantitative":[274,353],"tomography":[276],"parameter":[278],"improved":[279],"significantly;":[280],"radiographic":[282],"osteomyelitis":[283,337],"score":[284],"decreased":[285],"significantly.":[286],"Untreated":[287],"PSF":[288],"showed":[289,310,320],"absent":[290],"bridging,":[291],"abundant":[292],"fibrovascular":[293],"tissue,":[294],"chronic":[295],"inflammation,":[296,347],"rare":[297],"Gram-positive":[298],"cocci,":[299],"higher":[301],"histological":[302,344],"scores":[303],"than":[304],"controls;":[306],"both":[307],"minimal":[311,343],"inflammation":[312],"incomplete":[314],"bridging.":[315],"Conclusions:":[316],"generally":[321],"acceptable":[322],"despite":[325],"transient":[326],"high-dose":[327],"neurological":[328],"effects.":[329],"Locally":[330],"demonstrated":[333],"activity,":[335],"reduced":[336],"severity,":[338],"evidence":[345],"improve":[352],"restore":[357],"complete":[358],"bridging":[359],"56.":[362]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-29T00:00:00"}