{"id":"https://openalex.org/W7224078767","doi":"https://doi.org/10.3389/fragi.2026.1887671","title":"Maternal age-related thyroid changes during pregnancy: implications for isolated hypothyroxinemia patterns","display_name":"Maternal age-related thyroid changes during pregnancy: implications for isolated hypothyroxinemia patterns","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224078767","doi":"https://doi.org/10.3389/fragi.2026.1887671"},"language":"en","primary_location":{"id":"doi:10.3389/fragi.2026.1887671","doi":"https://doi.org/10.3389/fragi.2026.1887671","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fragi.2026.1887671","pdf_url":"https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1887671/pdf","source":{"id":"https://openalex.org/S4210191507","display_name":"Frontiers in Aging","issn_l":"2673-6217","issn":["2673-6217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1887671/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160001866","display_name":"Saifeng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210108664","display_name":"International Peace Maternity & Child Health Hospital","ror":"https://ror.org/01byttc20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108664"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Saifeng Wang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University","Shanghai Key Laboratory of Embryo Original Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210108664"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Embryo Original Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159778590","display_name":"Yili Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210108664","display_name":"International Peace Maternity & Child Health Hospital","ror":"https://ror.org/01byttc20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108664"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yili Zhang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University","Shanghai Key Laboratory of Embryo Original Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210108664"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Embryo Original Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160060958","display_name":"Ailin Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210108664","display_name":"International Peace Maternity & Child Health Hospital","ror":"https://ror.org/01byttc20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108664"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ailin Zhu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University","Shanghai Key Laboratory of Embryo Original Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210108664"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Embryo Original Diseases","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160048549","display_name":"Yu Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210108664","display_name":"International Peace Maternity & Child Health Hospital","ror":"https://ror.org/01byttc20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108664"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu Meng","raw_affiliation_strings":["Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University","Shanghai Key Laboratory of Embryo Original Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210108664"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Embryo Original Diseases","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5160048549","https://openalex.org/A5160060958"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210108664"],"apc_list":{"value":2550,"currency":"CHF","value_usd":3077},"apc_paid":{"value":2550,"currency":"CHF","value_usd":3077},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85519535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-age","display_name":"maternal age","score":0.9990000128746033},{"id":"https://openalex.org/keywords/isolated-hypothyroxinemia","display_name":"isolated hypothyroxinemia","score":0.9319999814033508},{"id":"https://openalex.org/keywords/thyroid-function-in-pregnancy","display_name":"thyroid function in pregnancy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.9950000047683716},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.8510000109672546},{"id":"https://openalex.org/keywords/macrosomia","display_name":"macrosomia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/low-birth-weight","display_name":"low birth weight","score":0.996999979019165},{"id":"https://openalex.org/keywords/adverse-pregnancy-outcomes","display_name":"adverse pregnancy outcomes","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7384999990463257},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6528000235557556},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.5996000170707703},{"id":"https://openalex.org/C117354338","wikidata":"https://www.wikidata.org/wiki/Q1165112","display_name":"Singleton","level":3,"score":0.5598000288009644},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5472999811172485},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.447299987077713},{"id":"https://openalex.org/C2778840127","wikidata":"https://www.wikidata.org/wiki/Q712838","display_name":"Thyroid function tests","level":3,"score":0.4275999963283539},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3986999988555908},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3919999897480011},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3833000063896179},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.37279999256134033},{"id":"https://openalex.org/C2776352029","wikidata":"https://www.wikidata.org/wiki/Q4686351","display_name":"Advanced maternal age","level":4,"score":0.36910000443458557},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.36469998955726624},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.35600000619888306},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.35510000586509705},{"id":"https://openalex.org/C2993737852","wikidata":"https://www.wikidata.org/wiki/Q712838","display_name":"Free thyroxine","level":4,"score":0.3375000059604645},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C66322754","wikidata":"https://www.wikidata.org/wiki/Q4128476","display_name":"Birth weight","level":3,"score":0.3343000113964081},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33329999446868896},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.32409998774528503},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3061000108718872},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30480000376701355},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.2858000099658966},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C2779083892","wikidata":"https://www.wikidata.org/wiki/Q6692979","display_name":"Low birth weight","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C2777886399","wikidata":"https://www.wikidata.org/wiki/Q211544","display_name":"Thyroid-stimulating hormone","level":3,"score":0.26159998774528503},{"id":"https://openalex.org/C87227347","wikidata":"https://www.wikidata.org/wiki/Q7100713","display_name":"Ordered logit","level":2,"score":0.25780001282691956},{"id":"https://openalex.org/C2780176905","wikidata":"https://www.wikidata.org/wiki/Q6673122","display_name":"Thyroid disease","level":3,"score":0.25270000100135803}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fragi.2026.1887671","doi":"https://doi.org/10.3389/fragi.2026.1887671","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fragi.2026.1887671","pdf_url":"https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1887671/pdf","source":{"id":"https://openalex.org/S4210191507","display_name":"Frontiers in Aging","issn_l":"2673-6217","issn":["2673-6217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:4709a550cfd9498380b6575ee0681485","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4709a550cfd9498380b6575ee0681485","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Aging, Vol 7 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fragi.2026.1887671","doi":"https://doi.org/10.3389/fragi.2026.1887671","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fragi.2026.1887671","pdf_url":"https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1887671/pdf","source":{"id":"https://openalex.org/S4210191507","display_name":"Frontiers in Aging","issn_l":"2673-6217","issn":["2673-6217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224078767.pdf","grobid_xml":"https://content.openalex.org/works/W7224078767.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1523732577","https://openalex.org/W1968156993","https://openalex.org/W1977677577","https://openalex.org/W1989691662","https://openalex.org/W2047159776","https://openalex.org/W2064744222","https://openalex.org/W2088816242","https://openalex.org/W2123931921","https://openalex.org/W2124173888","https://openalex.org/W2179042909","https://openalex.org/W2294573042","https://openalex.org/W2394582105","https://openalex.org/W2766388580","https://openalex.org/W2784256256","https://openalex.org/W2884255175","https://openalex.org/W2886095109","https://openalex.org/W2888728671","https://openalex.org/W2944208557","https://openalex.org/W2981958174","https://openalex.org/W3211959597","https://openalex.org/W4210493444","https://openalex.org/W4211148596","https://openalex.org/W4211170880","https://openalex.org/W4233259059","https://openalex.org/W4285792670","https://openalex.org/W4320856437","https://openalex.org/W4381470518","https://openalex.org/W4386726992","https://openalex.org/W4387675613","https://openalex.org/W4387935976","https://openalex.org/W4393082002","https://openalex.org/W4393278834","https://openalex.org/W4394581520","https://openalex.org/W4401466944","https://openalex.org/W4402582282","https://openalex.org/W4405534819","https://openalex.org/W4410980567","https://openalex.org/W4417328881","https://openalex.org/W7116719113","https://openalex.org/W7121432953"],"related_works":["https://openalex.org/W4414751350","https://openalex.org/W4223456589","https://openalex.org/W4407081776","https://openalex.org/W2387336596","https://openalex.org/W4383745950","https://openalex.org/W2795678112","https://openalex.org/W2046792534","https://openalex.org/W2924840314","https://openalex.org/W2136182294","https://openalex.org/W1990132542"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,25,30,103,114,117,156],"associations":[4,82,140],"between":[5,105,116],"maternal":[6,106],"age":[7,28,107,135,151,211,222],"and":[8,13,51,60,73,83,93,108,119,128,144,178,195],"thyroid":[9],"function":[10],"in":[11,58,161],"early":[12,59],"late":[14,61],"pregnancy,":[15,62],"as":[16,18,111,113],"well":[17,112],"their":[19,65,145],"changes,":[20],"with":[21,44,64,141,148,155,166,225],"a":[22,162,226,237],"focus":[23],"on":[24,29],"impact":[26],"of":[27,33,158,187,192,229,240],"longitudinal":[31],"patterns":[32,118,203],"isolated":[34,159,189,231],"hypothyroxinemia.":[35,190],"Methods":[36],"This":[37],"retrospective":[38],"cohort":[39],"study":[40],"included":[41],"43,545":[42],"women":[43,167],"singleton":[45],"pregnancies.":[46],"Serum":[47],"free":[48],"thyroxine":[49],"(FT4)":[50],"thyroid-stimulating":[52],"hormone":[53],"(TSH)":[54],"levels":[55,143],"were":[56,77],"measured":[57],"along":[63],"changes.":[66],"Linear":[67],"regression,":[68],"restricted":[69],"cubic":[70],"spline":[71],"(RCS),":[72],"piecewise":[74],"linear":[75],"regression":[76,98],"used":[78,100],"to":[79,101,201,236],"assess":[80],"non-linear":[81],"threshold":[84],"effects.":[85],"Isolated":[86],"hypothyroxinemia":[87,160],"was":[88,99,152],"categorized":[89],"into":[90],"euthyroid,":[91],"transient,":[92],"persistent":[94,188,202,230],"patterns.":[95],"Ordinal":[96],"logistic":[97],"examine":[102],"association":[104],"these":[109],"patterns,":[110],"relationships":[115],"adverse":[120,241],"pregnancy":[121,219,242],"outcomes,":[122],"including":[123],"preeclampsia,":[124,193],"preterm":[125],"birth,":[126],"macrosomia,":[127,194],"low":[129],"birth":[130],"weight":[131],"(LBW).":[132],"Results":[133],"Maternal":[134,150,210],"showed":[136],"significantly":[137],"stronger":[138],"negative":[139],"FT4":[142,217],"changes":[146],"than":[147],"TSH.":[149],"positively":[153],"associated":[154,224],"risk":[157],"dose\u2013response":[163],"manner.":[164],"Compared":[165],"aged":[168,172],"18\u201324":[169],"years,":[170],"those":[171],"35\u201339":[173],"years":[174,180],"(OR":[175,181],"=":[176,182],"1.89)":[177],"40\u201349":[179],"3.01)":[183],"had":[184],"higher":[185,227],"risks":[186],"Risks":[191],"LBW":[196],"increased":[197],"progressively":[198],"from":[199],"transient":[200],"(all":[204],"P":[205],"for":[206],"trend":[207],"<0.01).":[208],"Conclusion":[209],"is":[212,223,234],"an":[213],"important":[214],"factor":[215],"influencing":[216],"during":[218],".":[220],"Increasing":[221],"likelihood":[228],"hypothyroxinemia,":[232],"which":[233],"linked":[235],"broader":[238],"range":[239],"outcomes.":[243]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}
