{"id":"https://openalex.org/W7224076763","doi":"https://doi.org/10.64898/2026.10.27.762262","title":"An aged human bone marrow mesenchymal niche causes impaired function of human hematopoietic stem cells under regeneration-induced stress","display_name":"An aged human bone marrow mesenchymal niche causes impaired function of human hematopoietic stem cells under regeneration-induced stress","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224076763","doi":"https://doi.org/10.64898/2026.10.27.762262"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.27.762262","doi":"https://doi.org/10.64898/2026.10.27.762262","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.27.762262","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.10.27.762262","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103052234","display_name":"Ani Grigoryan","orcid":"https://orcid.org/0000-0003-2757-7021","observed_orcids":["https://orcid.org/0000-0003-2757-7021"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE","SE"],"is_corresponding":true,"raw_author_name":"Ani Grigoryan","raw_affiliation_strings":["Bone Organ Modeling and Regeneration Laboratory, Department of Clinical Sciences Lund, Lund University, Lund 22362, Sweden","Stem Cell Niche and Aging Laboratory, Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany","Wallenberg Centre for Molecular Medicine, Lund Stem Cell Centre, Lund University Cancer Centre, Lund University, Lund 22362, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-2757-7021","affiliations":[{"raw_affiliation_string":"Bone Organ Modeling and Regeneration Laboratory, Department of Clinical Sciences Lund, Lund University, Lund 22362, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Stem Cell Niche and Aging Laboratory, Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Wallenberg Centre for Molecular Medicine, Lund Stem Cell Centre, Lund University Cancer Centre, Lund University, Lund 22362, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160030856","display_name":"Ruba Abdelrahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ruba Abdelrahman","raw_affiliation_strings":["Stem Cell Niche and Aging Laboratory, Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Niche and Aging Laboratory, Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160061824","display_name":"Wong Sik Seo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wong Sik Seo","raw_affiliation_strings":["Stem Cell Niche and Aging Laboratory, Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Niche and Aging Laboratory, Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159996864","display_name":"Alejandro Gracia-Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Alejandro Garcia-Garcia","raw_affiliation_strings":["Bone Organ Modeling and Regeneration Laboratory, Department of Clinical Sciences Lund, Lund University, Lund 22362, Sweden","Wallenberg Centre for Molecular Medicine, Lund Stem Cell Centre, Lund University Cancer Centre, Lund University, Lund 22362, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Organ Modeling and Regeneration Laboratory, Department of Clinical Sciences Lund, Lund University, Lund 22362, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Wallenberg Centre for Molecular Medicine, Lund Stem Cell Centre, Lund University Cancer Centre, Lund University, Lund 22362, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067463217","display_name":"Vadim Sakk","orcid":"https://orcid.org/0000-0001-5797-5851","observed_orcids":["https://orcid.org/0000-0001-5797-5851"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vadim Sakk","raw_affiliation_strings":["Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160017030","display_name":"Antigoni Karavelaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Antigone Karavelaki","raw_affiliation_strings":["Stem Cell Niche and Aging Laboratory, Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Niche and Aging Laboratory, Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160009839","display_name":"Karin Maria Danzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210140058","display_name":"University and Rehabilitation Clinics Ulm","ror":"https://ror.org/043yx1v14","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210140058","https://openalex.org/I4210155144"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karin M Danzer","raw_affiliation_strings":["Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany","German Center for Neurodegenerative Diseases (DZNE), University of Ulm, 89075 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I4210140058","https://openalex.org/I4210155144"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), University of Ulm, 89075 Ulm, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113742678","display_name":"Christian Haupt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Haupt","raw_affiliation_strings":["Institute of Protein Biochemistry, University of Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Protein Biochemistry, University of Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068469918","display_name":"Hubert Schrezenmeier","orcid":"https://orcid.org/0000-0003-1222-6659","observed_orcids":["https://orcid.org/0000-0003-1222-6659"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I2801931480","display_name":"German Red Cross","ror":"https://ror.org/02y3dtg29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801931480"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hubert Schrezenmeier","raw_affiliation_strings":["Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden W\u00fcrttemberg-Hessen and University Hospital Ulm, 89081 Ulm, Germany","Institute of Transfusion Medicine, University of Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden W\u00fcrttemberg-Hessen and University Hospital Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I2801931480","https://openalex.org/I4210155144"]},{"raw_affiliation_string":"Institute of Transfusion Medicine, University of Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020181771","display_name":"Moritz Oltmanns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Moritz Oltmanns","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022406137","display_name":"Heiko Reichel","orcid":"https://orcid.org/0000-0001-6096-9890","observed_orcids":["https://orcid.org/0000-0001-6096-9890"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heiko Reichel","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009491648","display_name":"Hartmut Geiger","orcid":"https://orcid.org/0000-0002-5794-5430","observed_orcids":["https://orcid.org/0000-0002-5794-5430","https://orcid.org/0000-0001-7314-9891"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hartmut Geiger","raw_affiliation_strings":["Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006777098","display_name":"Paul Emile Bourgine","orcid":"https://orcid.org/0000-0002-7639-6844","observed_orcids":["https://orcid.org/0000-0002-7639-6844"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Paul E Bourgine","raw_affiliation_strings":["Bone Organ Modeling and Regeneration Laboratory, Department of Clinical Sciences Lund, Lund University, Lund 22362, Sweden","Wallenberg Centre for Molecular Medicine, Lund Stem Cell Centre, Lund University Cancer Centre, Lund University, Lund 22362, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Organ Modeling and Regeneration Laboratory, Department of Clinical Sciences Lund, Lund University, Lund 22362, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Wallenberg Centre for Molecular Medicine, Lund Stem Cell Centre, Lund University Cancer Centre, Lund University, Lund 22362, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5103052234"],"corresponding_institution_ids":["https://openalex.org/I187531555","https://openalex.org/I196349391"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.8880000114440918},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/human-bone-marrow","display_name":"human bone marrow","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7662000060081482},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7652999758720398},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.6875},{"id":"https://openalex.org/C2993373878","wikidata":"https://www.wikidata.org/wiki/Q9621","display_name":"Human bone","level":3,"score":0.6754999756813049},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6571999788284302},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6510999798774719},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6200000047683716},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5885000228881836},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5685999989509583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5608999729156494},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47999998927116394},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.4740000069141388},{"id":"https://openalex.org/C143441281","wikidata":"https://www.wikidata.org/wiki/Q5133858","display_name":"Clinical uses of mesenchymal stem cells","level":5,"score":0.3474999964237213},{"id":"https://openalex.org/C2779979121","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Blood cell","level":2,"score":0.32659998536109924},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.32179999351501465},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.3068000078201294},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30630001425743103},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.2906000018119812},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C13685319","wikidata":"https://www.wikidata.org/wiki/Q7607302","display_name":"Stem cell transplantation for articular cartilage repair","level":5,"score":0.2678999900817871}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.27.762262","doi":"https://doi.org/10.64898/2026.10.27.762262","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.27.762262","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.27.762262","doi":"https://doi.org/10.64898/2026.10.27.762262","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.27.762262","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1972222251","https://openalex.org/W1982202983","https://openalex.org/W1985688738","https://openalex.org/W1985905343","https://openalex.org/W1996626693","https://openalex.org/W2013158306","https://openalex.org/W2023039165","https://openalex.org/W2028815852","https://openalex.org/W2033548186","https://openalex.org/W2042932723","https://openalex.org/W2046053349","https://openalex.org/W2053737668","https://openalex.org/W2065544737","https://openalex.org/W2069332674","https://openalex.org/W2078489918","https://openalex.org/W2080620471","https://openalex.org/W2089878334","https://openalex.org/W2093679515","https://openalex.org/W2096467350","https://openalex.org/W2114514472","https://openalex.org/W2125868380","https://openalex.org/W2294874864","https://openalex.org/W2337668972","https://openalex.org/W2406237471","https://openalex.org/W2469412979","https://openalex.org/W2474073575","https://openalex.org/W2530300223","https://openalex.org/W2532126664","https://openalex.org/W2569978261","https://openalex.org/W2579192651","https://openalex.org/W2595342131","https://openalex.org/W2609515808","https://openalex.org/W2743713570","https://openalex.org/W2792055257","https://openalex.org/W2892605399","https://openalex.org/W2965096513","https://openalex.org/W2998362353","https://openalex.org/W3009185135","https://openalex.org/W3040944400","https://openalex.org/W3083915579","https://openalex.org/W3112309061","https://openalex.org/W3114696276","https://openalex.org/W3136484732","https://openalex.org/W3166197489","https://openalex.org/W3191830829","https://openalex.org/W3197904176","https://openalex.org/W4304809085","https://openalex.org/W4315620741","https://openalex.org/W4323531466","https://openalex.org/W4362635502","https://openalex.org/W4381436691","https://openalex.org/W7119717035"],"related_works":["https://openalex.org/W3037441864","https://openalex.org/W3159630024","https://openalex.org/W3110162347","https://openalex.org/W2888276373","https://openalex.org/W4407694074","https://openalex.org/W2552151938","https://openalex.org/W2091184152","https://openalex.org/W2995203578","https://openalex.org/W2895234480","https://openalex.org/W4407261795"],"abstract_inverted_index":{"Abstract":[0],"Hematopoietic":[1],"stem":[2],"cells":[3,86],"(HSCs)":[4],"reside":[5],"in":[6,32,111],"the":[7,43,69,74,99],"bone":[8,45],"marrow":[9,46],"(BM)":[10],"and":[11,71],"are":[12],"responsible":[13],"for":[14],"blood":[15],"formation":[16],"throughout":[17],"life.":[18],"With":[19],"advancing":[20],"age,":[21],"HSCs":[22,34],"show":[23],"reduced":[24],"functional":[25],"capacity.":[26],"While":[27],"clear":[28],"intrinsic":[29],"cellular":[30],"changes":[31],"human":[33,44],"(hHSCs)":[35],"occur":[36],"during":[37,114],"aging,":[38],"it":[39],"remains":[40],"unclear":[41],"how":[42],"(hBM)":[47],"niche":[48,91],"contributes":[49],"to":[50,59,98],"hHSC":[51,94],"dysfunction.":[52],"This":[53,78],"research":[54],"gap":[55],"is":[56,123],"largely":[57],"due":[58],"a":[60,108],"lack":[61],"of":[62,67,73,93,102,121],"suitable":[63],"experimental":[64],"models":[65],"capable":[66],"replicating":[68],"organization":[70],"function":[72,95,120],"aged":[75,82],"hBM":[76,83],"environment.":[77],"study":[79],"demonstrates":[80],"that":[81],"mesenchymal":[84],"stromal":[85],"(hBMSCs)":[87],"act":[88],"as":[89],"important":[90],"regulators":[92],"by":[96],"contributing":[97],"myeloid-biased":[100],"differentiation":[101],"young":[103],"hHSCs.":[104],"Furthermore,":[105],"hBMSCs":[106,122],"play":[107],"crucial":[109],"role":[110],"protecting":[112],"hHSCs":[113],"regeneration-induced":[115],"stress":[116],"while":[117],"this":[118],"protective":[119],"impaired":[124],"with":[125],"age.":[126]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}