{"id":"https://openalex.org/W7224021233","doi":"https://doi.org/10.1186/s12872-026-06936-w","title":"Associations of serum glutathione S-transferase pi 1 with NYHA functional class and emergency department disposition in decompensated heart failure: a prospective observational study","display_name":"Associations of serum glutathione S-transferase pi 1 with NYHA functional class and emergency department disposition in decompensated heart failure: a prospective observational study","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7224021233","doi":"https://doi.org/10.1186/s12872-026-06936-w"},"language":"en","primary_location":{"id":"doi:10.1186/s12872-026-06936-w","doi":"https://doi.org/10.1186/s12872-026-06936-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12872-026-06936-w","pdf_url":null,"source":{"id":"https://openalex.org/S206686666","display_name":"BMC Cardiovascular Disorders","issn_l":"1471-2261","issn":["1471-2261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovascular Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12872-026-06936-w","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159861848","display_name":"Elif Kahveci K\u00fc\u00e7\u00fck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Elif Kahveci K\u00fc\u00e7\u00fck","raw_affiliation_strings":["Department of Emergency Medicine, Trakya University Faculty of Medicine, Edirne, T\u00fcrkiye, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Trakya University Faculty of Medicine, Edirne, T\u00fcrkiye, Turkey","institution_ids":["https://openalex.org/I12387023"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070175078","display_name":"Eray \u00c7elikt\u00fcrk","orcid":"https://orcid.org/0000-0002-1183-6511","observed_orcids":["https://orcid.org/0000-0002-1183-6511"]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Eray \u00c7elikt\u00fcrk","raw_affiliation_strings":["Department of Emergency Medicine, Trakya University Faculty of Medicine, Edirne, T\u00fcrkiye, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Trakya University Faculty of Medicine, Edirne, T\u00fcrkiye, Turkey","institution_ids":["https://openalex.org/I12387023"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039598959","display_name":"Mustafa Burak Sayhan","orcid":"https://orcid.org/0000-0002-1156-5424","observed_orcids":["https://orcid.org/0000-0002-1156-5424","https://orcid.org/0000-0001-9335-9001"]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Burak Sayhan","raw_affiliation_strings":["Department of Emergency Medicine, Trakya University Faculty of Medicine, Edirne, T\u00fcrkiye, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Trakya University Faculty of Medicine, Edirne, T\u00fcrkiye, Turkey","institution_ids":["https://openalex.org/I12387023"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067180889","display_name":"Murat G\u00f6k","orcid":"https://orcid.org/0000-0003-3118-9064","observed_orcids":["https://orcid.org/0000-0003-3118-9064"]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Murat G\u00f6k","raw_affiliation_strings":["Department of Cardiology, Trakya University Faculty of Medicine, Edirne, T\u00fcrkiye, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Trakya University Faculty of Medicine, Edirne, T\u00fcrkiye, Turkey","institution_ids":["https://openalex.org/I12387023"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095942554","display_name":"Satuk Bu\u011fra Han Bozatl\u0131","orcid":"https://orcid.org/0000-0002-7695-9969","observed_orcids":["https://orcid.org/0000-0002-7695-9969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satuk Bu\u011fra Han Bozatl\u0131","raw_affiliation_strings":["Emergency Department, Edirne Sultan 1st Murat State Hospital, Edirne, T\u00fcrkiye, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Department, Edirne Sultan 1st Murat State Hospital, Edirne, T\u00fcrkiye, Turkey","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114536331","display_name":"Sinem \u00c7al\u0131n","orcid":"https://orcid.org/0009-0007-3274-0096","observed_orcids":["https://orcid.org/0009-0007-3274-0096"]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sinem \u00c7al\u0131n","raw_affiliation_strings":["Department of Medical Biochemistry, Trakya University Faculty of Medicine, Edirne, T\u00fcrkiye, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Trakya University Faculty of Medicine, Edirne, T\u00fcrkiye, Turkey","institution_ids":["https://openalex.org/I12387023"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070175078"],"corresponding_institution_ids":["https://openalex.org/I12387023"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85284273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-s-transferase-pi-1","display_name":"glutathione S-transferase pi 1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gstp1","display_name":"GSTP1","score":0.8299999833106995},{"id":"https://openalex.org/keywords/acute-decompensated-heart-failure","display_name":"acute decompensated heart failure","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nyha-functional-class","display_name":"NYHA functional class","score":0.9959999918937683},{"id":"https://openalex.org/keywords/emergency-department-disposition","display_name":"emergency department disposition","score":0.9940000176429749},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7889999747276306},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9106000065803528},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.7921000123023987},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.7567999958992004},{"id":"https://openalex.org/C555175668","wikidata":"https://www.wikidata.org/wiki/Q539690","display_name":"Angiology","level":2,"score":0.6658999919891357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6432999968528748},{"id":"https://openalex.org/C38022665","wikidata":"https://www.wikidata.org/wiki/Q1149305","display_name":"Disposition","level":2,"score":0.5663999915122986},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4966999888420105},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.4406000077724457},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.43320000171661377},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.41499999165534973},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3276999890804291},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.32600000500679016},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2883000075817108}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12872-026-06936-w","doi":"https://doi.org/10.1186/s12872-026-06936-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12872-026-06936-w","pdf_url":null,"source":{"id":"https://openalex.org/S206686666","display_name":"BMC Cardiovascular Disorders","issn_l":"1471-2261","issn":["1471-2261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovascular Disorders","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12872-026-06936-w","doi":"https://doi.org/10.1186/s12872-026-06936-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12872-026-06936-w","pdf_url":null,"source":{"id":"https://openalex.org/S206686666","display_name":"BMC Cardiovascular Disorders","issn_l":"1471-2261","issn":["1471-2261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovascular Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4414311306","https://openalex.org/W2025696765","https://openalex.org/W2147160663","https://openalex.org/W2330863306","https://openalex.org/W2051972092","https://openalex.org/W2991912917","https://openalex.org/W2418686560","https://openalex.org/W2015883041","https://openalex.org/W2007929239","https://openalex.org/W1925606942"],"abstract_inverted_index":{"Glutathione":[0],"S-transferase":[1],"pi":[2],"1":[3],"(GSTP-1)":[4],"participates":[5],"in":[6,19,121,140,223,293,321],"glutathione-dependent":[7],"detoxification":[8],"and":[9,98,109,149,175,191,202,208,243,266,286,329],"stress":[10],"signalling,":[11],"but":[12],"its":[13,39],"relationship":[14],"with":[15,41,54,129,143,227,281,289],"pre-presentation":[16,282],"functional":[17,35,284],"limitation":[18],"decompensated":[20,55,95],"heart":[21,56,66],"failure":[22],"is":[23,332],"uncertain.":[24],"We":[25],"evaluated":[26],"serum":[27],"GSTP-1":[28,126,164,195,224,245,276],"across":[29,198],"New":[30],"York":[31],"Heart":[32],"Association":[33],"(NYHA)":[34],"classes":[36],"and,":[37],"secondarily,":[38],"association":[40,280],"emergency":[42,290],"department":[43,291],"disposition.":[44],"This":[45],"single-centre":[46],"prospective":[47],"observational":[48],"study":[49],"enrolled":[50,82],"120":[51,123],"adults":[52],"presenting":[53],"failure,":[57,67],"either":[58],"de":[59],"novo":[60],"or":[61,317],"as":[62],"worsening":[63],"of":[64,72,101,230,272,311],"pre-existing":[65],"using":[68,151,325],"a":[69,93,130,152,159,278],"prespecified":[70],"quota":[71,88,264],"30":[73],"participants":[74],"per":[75],"NYHA":[76,134,168,283],"class.":[77],"Eligible":[78],"consenting":[79],"patients":[80,142],"were":[81,146,189,193,258],"consecutively":[83],"while":[84],"the":[85,118,216,312],"relevant":[86],"class":[87,285],"remained":[89],"open.":[90],"Eligibility":[91],"required":[92],"compatible":[94],"clinical":[96,161,315],"syndrome":[97],"objective":[99],"evidence":[100],"congestion.":[102],"B-type":[103],"natriuretic":[104],"peptide,":[105],"posteroanterior":[106],"chest":[107],"radiography,":[108],"transthoracic":[110],"echocardiography":[111,114],"informed":[112],"diagnosis;":[113],"was":[115,127,136,183,225,287],"performed":[116],"during":[117],"index":[119,313],"presentation":[120],"all":[122],"patients.":[124],"Serum":[125,275],"measured":[128],"research-use-only":[131],"ELISA.":[132],"The":[133,297],"comparison":[135],"prespecified;":[137],"admission":[138,205,231,298],"analyses":[139],"119":[141,186],"known":[144],"disposition":[145,292],"post":[147],"hoc":[148],"exploratory,":[150],"selected":[153],"four-variable":[154],"reference":[155],"model":[156],"rather":[157],"than":[158],"validated":[160,327],"prediction":[162],"model.":[163],"increased":[165,197],"stepwise":[166],"from":[167],"I":[169],"to":[170],"IV":[171],"(26.70,":[172],"62.44,":[173],"85.98,":[174],"126.25":[176],"ng/mL;":[177,210],"overall":[178,211],"p":[179,212,240,253],"<":[180,213,241,254],"0.001).":[181,214,255],"Disposition":[182],"available":[184],"for":[185],"patients:":[187],"36":[188],"discharged":[190],"83":[192],"admitted.":[194],"also":[196],"discharge,":[199],"ward":[200],"admission,":[201],"intensive":[203],"care":[204],"(51.10,":[206],"66.18,":[207],"94.65":[209],"In":[215],"exploratory":[217],"selected-variable":[218],"model,":[219],"each":[220],"10-ng/mL":[221],"increase":[222],"associated":[226,288],"higher":[228],"odds":[229,233],"(adjusted":[232],"ratio":[234],"1.36,":[235],"95%":[236],"confidence":[237],"interval":[238],"1.14\u20131.63;":[239],"0.001),":[242],"adding":[244],"improved":[246],"nested-model":[247],"fit":[248],"(likelihood-ratio":[249],"\u03c7\u00b2":[250],"=":[251],"14.47,":[252],"NYHA-adjusted":[256],"estimates":[257],"considered":[259],"consistency":[260],"checks":[261],"only":[262],"because":[263],"construction":[265],"sparse":[267],"within-class":[268],"outcomes":[269],"precluded":[270],"separation":[271],"residual":[273],"confounding.":[274],"showed":[277],"graded":[279],"this":[294],"quota-constructed":[295],"cohort.":[296],"findings":[299],"provide":[300],"hypothesis-generating,":[301],"cohort-conditional":[302],"statistical":[303],"information;":[304],"they":[305],"do":[306],"not":[307],"establish":[308],"haemodynamic":[309],"severity":[310],"decompensation,":[314],"prediction,":[316],"decision-making":[318],"utility.":[319],"Confirmation":[320],"unselected":[322],"multicentre":[323],"cohorts":[324],"clinically":[326],"assays":[328],"serial":[330],"sampling":[331],"needed.":[333]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-10-28T00:00:00"}
