{"id":"https://openalex.org/W7224018762","doi":"https://doi.org/10.1038/s42003-026-11046-6","title":"SQSTM1/p62-LC3A\u2013mediated autophagic clearance of stress granules prevents apoptosis under hyperosmotic stress","display_name":"SQSTM1/p62-LC3A\u2013mediated autophagic clearance of stress granules prevents apoptosis under hyperosmotic stress","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7224018762","doi":"https://doi.org/10.1038/s42003-026-11046-6"},"language":"en","primary_location":{"id":"doi:10.1038/s42003-026-11046-6","doi":"https://doi.org/10.1038/s42003-026-11046-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11046-6","pdf_url":"https://www.nature.com/articles/s42003-026-11046-6_reference.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s42003-026-11046-6_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159891654","display_name":"Qianqian Yi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianqian Yi","raw_affiliation_strings":["School of Life Science and Technology, ShanghaiTech University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075184818","display_name":"Chen'ang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen\u2019ang Zhang","raw_affiliation_strings":["School of Life Science and Technology, ShanghaiTech University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159771615","display_name":"Shuyao Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuyao Hu","raw_affiliation_strings":["School of Life Science and Technology, ShanghaiTech University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034685694","display_name":"Zhangshun Wang","orcid":"https://orcid.org/0009-0007-6862-015X","observed_orcids":["https://orcid.org/0009-0007-6862-015X"]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhangshun Wang","raw_affiliation_strings":["School of Life Science and Technology, ShanghaiTech University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159934852","display_name":"Liang He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang He","raw_affiliation_strings":["School of Life Science and Technology, ShanghaiTech University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159917855","display_name":"Man Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Man Zhang","raw_affiliation_strings":["School of Life Science and Technology, ShanghaiTech University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159849987","display_name":"Zhi Man","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi Man","raw_affiliation_strings":["School of Life Science and Technology, ShanghaiTech University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003878253","display_name":"Yun Bai","orcid":"https://orcid.org/0000-0002-5441-9777","observed_orcids":["https://orcid.org/0000-0002-5441-9777"]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yun Bai","raw_affiliation_strings":["School of Life Science and Technology, ShanghaiTech University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-5441-9777","affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101945324","display_name":"Yanfen Liu","orcid":"https://orcid.org/0000-0002-1192-8328","observed_orcids":["https://orcid.org/0000-0002-1192-8328"]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanfen Liu","raw_affiliation_strings":["School of Life Science and Technology, ShanghaiTech University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-1192-8328","affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003878253","https://openalex.org/A5101945324"],"corresponding_institution_ids":["https://openalex.org/I30809798"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8709082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lc3a","display_name":"LC3A","score":0.9819999933242798},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.968999981880188},{"id":"https://openalex.org/keywords/stress-granules","display_name":"stress granules","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hyperosmotic-stress","display_name":"hyperosmotic stress","score":0.9369999766349792},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.6610000133514404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6597999930381775},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6381999850273132},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6075000166893005},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.5235999822616577},{"id":"https://openalex.org/C129900496","wikidata":"https://www.wikidata.org/wiki/Q643555","display_name":"Osmotic concentration","level":2,"score":0.5008000135421753},{"id":"https://openalex.org/C168529131","wikidata":"https://www.wikidata.org/wiki/Q13656562","display_name":"Osmotic shock","level":3,"score":0.4544999897480011},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.40049999952316284},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.29440000653266907},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.29420000314712524},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.2854999899864197},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.2671000063419342}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s42003-026-11046-6","doi":"https://doi.org/10.1038/s42003-026-11046-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11046-6","pdf_url":"https://www.nature.com/articles/s42003-026-11046-6_reference.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s42003-026-11046-6","doi":"https://doi.org/10.1038/s42003-026-11046-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11046-6","pdf_url":"https://www.nature.com/articles/s42003-026-11046-6_reference.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4395181090","display_name":null,"funder_award_id":"32070697","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8311434185","display_name":null,"funder_award_id":"2016YFA0500901","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320327675","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224018762.pdf","grobid_xml":"https://content.openalex.org/works/W7224018762.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2962342072","https://openalex.org/W7207852746","https://openalex.org/W6982578527","https://openalex.org/W7019743845","https://openalex.org/W4283378115","https://openalex.org/W7128280203","https://openalex.org/W2788513142","https://openalex.org/W2772196626","https://openalex.org/W7221198615","https://openalex.org/W7147006669"],"abstract_inverted_index":{"Stress":[0],"granules":[1],"(SGs)":[2],"are":[3,96],"transient,":[4],"membraneless":[5],"assemblies":[6],"that":[7,31],"form":[8],"in":[9,37,87,92,99,139],"response":[10],"to":[11,25,111],"cellular":[12],"stress":[13,18,116],"and":[14,56,101,119,142],"typically":[15],"disassemble":[16],"when":[17],"resolves.":[19],"Their":[20],"persistence":[21],"has":[22,33],"been":[23],"linked":[24,110],"neurodegenerative":[26],"disease.":[27],"Here":[28],"we":[29],"show":[30],"LC3A":[32,59,63],"a":[34],"selective":[35],"role":[36,91,134],"the":[38,83,132,136],"autophagic":[39],"clearance":[40,66],"of":[41,58,67,82,135],"SGs":[42,95],"formed":[43],"during":[44],"hyperosmotic":[45],"stress.":[46,147],"LC3A,":[47],"but":[48],"not":[49],"LC3B":[50],"or":[51,72],"LC3C,":[52],"associates":[53],"with":[54,105],"SGs,":[55,88],"depletion":[57],"impairs":[60],"their":[61],"removal.":[62],"also":[64,97],"promotes":[65,120],"pathogenic":[68],"inclusions":[69],"containing":[70],"TDP-43":[71],"poly(GR)":[73],"dipeptides":[74],"from":[75],"C9orf72":[76],"expansions.":[77],"Proteomic":[78],"analysis":[79],"reveals":[80],"enrichment":[81],"autophagy":[84],"receptor":[85],"SQSTM1/p62":[86],"supporting":[89],"its":[90],"SG":[93,127,140],"degradation.":[94],"enriched":[98],"mitochondrial":[100,112],"apoptosis-related":[102],"proteins,":[103],"consistent":[104],"an":[106],"anti-apoptotic":[107],"function":[108],"potentially":[109],"proximity.":[113],"However,":[114],"prolonged":[115],"activates":[117],"CASP3":[118],"apoptosis,":[121],"which":[122],"is":[123],"exacerbated":[124],"by":[125],"defective":[126],"clearance.":[128],"These":[129],"findings":[130],"highlight":[131],"critical":[133],"SQSTM1\u2013LC3A":[137],"axis":[138],"turnover":[141],"cell":[143],"survival":[144],"under":[145],"chronic":[146]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-10-28T00:00:00"}
