{"id":"https://openalex.org/W7224014170","doi":"https://doi.org/10.64898/2026.10.23.761403","title":"Tumor SETDB1 expression predicts worse overall survival for bladder cancer patients","display_name":"Tumor SETDB1 expression predicts worse overall survival for bladder cancer patients","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7224014170","doi":"https://doi.org/10.64898/2026.10.23.761403","pmid":"https://pubmed.ncbi.nlm.nih.gov/42990198","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13733746"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.23.761403","doi":"https://doi.org/10.64898/2026.10.23.761403","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.23.761403","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/27/2026.10.23.761403.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/27/2026.10.23.761403.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065771961","display_name":"Sarah R. Athans","orcid":"https://orcid.org/0000-0003-1079-0010","observed_orcids":["https://orcid.org/0000-0003-1079-0010"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Athans","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center"],"raw_orcid":"https://orcid.org/0000-0003-1079-0010","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014084715","display_name":"Meegan Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meegan Young","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159929080","display_name":"Han Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Han Yu","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081472044","display_name":"Bhavisha Doshi","orcid":"https://orcid.org/0000-0003-3411-4770","observed_orcids":["https://orcid.org/0000-0003-3411-4770"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhavisha Doshi","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center"],"raw_orcid":"https://orcid.org/0000-0003-3411-4770","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063338223","display_name":"Ellen Karasik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Karasik","raw_affiliation_strings":["Department of Animal Resources, Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Resources, Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001641824","display_name":"Shuhei Ueshima","orcid":"https://orcid.org/0000-0001-6223-2403","observed_orcids":["https://orcid.org/0000-0001-6223-2403"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuhei Ueshima","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center"],"raw_orcid":"https://orcid.org/0000-0001-6223-2403","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101748588","display_name":"Jia Fang","orcid":"https://orcid.org/0000-0001-8583-1652","observed_orcids":["https://orcid.org/0000-0001-8583-1652"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia Fang","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center"],"raw_orcid":"https://orcid.org/0000-0001-8583-1652","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069975901","display_name":"Anna Woloszynska\u2010Read","orcid":"https://orcid.org/0000-0001-5279-9414","observed_orcids":["https://orcid.org/0000-0001-5279-9414"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Woloszynska","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center"],"raw_orcid":"https://orcid.org/0000-0001-5279-9414","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1292894508"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/setdb1","display_name":"SETDB1","score":1.0},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7599999904632568},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9549999833106995},{"id":"https://openalex.org/keywords/protein-expression","display_name":"protein expression","score":0.6570000052452087},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.7210000157356262},{"id":"https://openalex.org/keywords/sarcomatoid-differentiation","display_name":"sarcomatoid differentiation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6990000009536743},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.7185999751091003},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.694599986076355},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.6406000256538391},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5443000197410583},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5249999761581421},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5121999979019165},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.46399998664855957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.460999995470047},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.447299987077713},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42890000343322754},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4106999933719635},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.40860000252723694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.397599995136261},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.3824000060558319},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.382099986076355},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.3808000087738037},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3666999936103821},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35830000042915344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3425000011920929},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.32589998841285706},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3163999915122986},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.3140999972820282},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.3109000027179718},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30809998512268066},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.2985999882221222},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.28700000047683716},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.2842000126838684},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.28200000524520874},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.2639999985694885},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.257099986076355}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.23.761403","doi":"https://doi.org/10.64898/2026.10.23.761403","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.23.761403","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/27/2026.10.23.761403.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13733746","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13733746/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13733746/pdf/nihpp-2026.10.23.761403v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42990198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42990198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.10.23.761403","doi":"https://doi.org/10.64898/2026.10.23.761403","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.23.761403","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/27/2026.10.23.761403.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G9000866055","display_name":"Summer Research Experiences in Quantitative Cancer Sciences and Emerging Technologies","funder_award_id":"R25CA181003","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000888465","display_name":"Roswell Park Cancer Center Support Grant","funder_award_id":"P30CA016056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224014170.pdf","grobid_xml":"https://content.openalex.org/works/W7224014170.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3016411890","https://openalex.org/W2599553746","https://openalex.org/W2059876640","https://openalex.org/W2356652930","https://openalex.org/W3081959733","https://openalex.org/W2062304932","https://openalex.org/W2155877820","https://openalex.org/W3160243615","https://openalex.org/W2895559825","https://openalex.org/W7117649186"],"abstract_inverted_index":{"Aberrant":[0],"activity":[1],"of":[2,14,213],"histone":[3,20],"methyltransferases":[4],"promotes":[5],"tumorigenesis":[6],"across":[7],"multiple":[8],"cancer":[9,28,70],"types,":[10],"making":[11],"this":[12],"class":[13],"enzymes":[15],"attractive":[16],"therapeutic":[17],"targets.":[18],"The":[19],"methyltransferase":[21],"SETDB1":[22,39,55,83,89,121,145,206,218],"is":[23,42],"frequently":[24],"amplified":[25],"in":[26,33,50,58,63],"bladder":[27,51,69,221],"and":[29,47,109,115,144,185],"has":[30],"been":[31],"implicated":[32],"chemotherapy":[34],"resistance.":[35],"We":[36],"examine":[37],"whether":[38],"protein":[40,56,84],"expression":[41,57,85,111,122,146],"associated":[43,149,195,204],"with":[44,72,119,150,177,196,205],"overall":[45,127,151],"survival":[46,128,135,152],"tumor":[48,105],"characteristics":[49],"cancer.":[52,222],"To":[53],"assess":[54],"patients,":[59],"we":[60,103],"performed":[61],"immunohistochemistry":[62],"tissue":[64],"microarrays":[65],"(TMAs)":[66],"containing":[67],"350":[68],"cases":[71],"well-annotated":[73],"clinical":[74,107],"information.":[75],"Digital":[76],"image":[77],"analysis":[78,157],"was":[79,147],"used":[80],"to":[81,86,130,175],"quantify":[82],"produce":[87],"a":[88],"H-score,":[90],"from":[91],"which":[92,193,217],"patients":[93,133,171],"were":[94,172],"categorized":[95],"as":[96],"SETDB1-high":[97,114,170],"or":[98],"SETDB1-low.":[99],"Using":[100],"these":[101],"categories,":[102],"compared":[104,129],"characteristics,":[106],"outcomes,":[108],"gene":[110],"profiles":[112],"between":[113],"SETDB1-low":[116,131],"patients.":[117],"Patients":[118],"high":[120],"(n=143)":[123],"had":[124],"significantly":[125],"shorter":[126],"(n=125)":[132],"(median":[134],"months:":[136],"SETDB1-high,":[137],"30.09;":[138],"SETDB1-low,":[139],"87.85;":[140],"p":[141,167,182],"=":[142,159,163,168,183],"0.0006),":[143],"independently":[148],"upon":[153],"multivariate":[154],"cox":[155],"regression":[156],"(HR":[158],"1.93,":[160],"95%":[161],"CI":[162],"1.08":[164],"-":[165],"3.45,":[166],"0.026).":[169],"more":[173],"likely":[174],"present":[176],"squamous":[178],"(35%":[179],"vs":[180,188],"20%,":[181],"0.026)":[184],"sarcomatoid":[186],"(11%":[187],"3.6%,":[189],"p=0.049)":[190],"differentiation":[191],"features,":[192],"are":[194],"poorer":[197],"prognosis.":[198],"Exploratory":[199],"analyses":[200],"identified":[201],"transcriptional":[202],"differences":[203],"expression,":[207],"providing":[208],"rationale":[209],"for":[210],"further":[211],"exploration":[212],"the":[214],"mechanisms":[215],"by":[216],"may":[219],"promote":[220]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-28T00:00:00"}