{"id":"https://openalex.org/W7224006248","doi":"https://doi.org/10.1159/pat/aehag005","title":"A unique case of thymic indolent T-lymphoblastic proliferation: Redefining the extrathymic boundaries","display_name":"A unique case of thymic indolent T-lymphoblastic proliferation: Redefining the extrathymic boundaries","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7224006248","doi":"https://doi.org/10.1159/pat/aehag005","pmid":"https://pubmed.ncbi.nlm.nih.gov/42945444"},"language":"en","primary_location":{"id":"doi:10.1159/pat/aehag005","doi":"https://doi.org/10.1159/pat/aehag005","is_oa":true,"landing_page_url":"https://doi.org/10.1159/pat/aehag005","pdf_url":"https://karger.com/pat/article-pdf/doi/10.1159/pat/aehag005/4599232/000555058.pdf","source":{"id":"https://openalex.org/S18964055","display_name":"Pathobiology","issn_l":"1015-2008","issn":["1015-2008","1423-0291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathobiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://karger.com/pat/article-pdf/doi/10.1159/pat/aehag005/4599232/000555058.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006714671","display_name":"Chandler B. Sy","orcid":"https://orcid.org/0000-0002-8739-561X","observed_orcids":["https://orcid.org/0000-0002-8739-561X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chandler B. Sy","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085033553","display_name":"Liming Bao","orcid":"https://orcid.org/0000-0001-9400-734X","observed_orcids":["https://orcid.org/0000-0001-9400-734X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liming Bao","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073388235","display_name":"Paul Dylan Barone","orcid":"https://orcid.org/0000-0002-7756-6091","observed_orcids":["https://orcid.org/0000-0002-7756-6091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul D Barone","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064702056","display_name":"Amy Chadburn","orcid":"https://orcid.org/0000-0002-9499-8638","observed_orcids":["https://orcid.org/0000-0002-9499-8638"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy Chadburn","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011192154","display_name":"Manju Harshan","orcid":"https://orcid.org/0009-0006-0970-4452","observed_orcids":["https://orcid.org/0009-0006-0970-4452"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manju Harshan","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000475484","display_name":"Uqba Khan","orcid":"https://orcid.org/0000-0002-4740-2256","observed_orcids":["https://orcid.org/0000-0002-4740-2256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uqba Khan","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103048248","display_name":"Anna S. Nam","orcid":"https://orcid.org/0000-0003-4192-8916","observed_orcids":["https://orcid.org/0000-0003-4192-8916"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna S. Nam","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050722674","display_name":"Madhu Micheal Ouseph","orcid":"https://orcid.org/0000-0002-3422-1675","observed_orcids":["https://orcid.org/0000-0002-3422-1675"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madhu M. Ouseph","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022791013","display_name":"Madhulatha Pantrangi","orcid":"https://orcid.org/0009-0003-1013-1717","observed_orcids":["https://orcid.org/0009-0003-1013-1717"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madhulatha Pantrangi","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127784591","display_name":"Sanjay Patel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanjay Patel","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158461060","display_name":"James Solomon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Solomon","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043668902","display_name":"Julia Turbiner Geyer","orcid":"https://orcid.org/0000-0002-4424-6139","observed_orcids":["https://orcid.org/0000-0002-4424-6139"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia T. Geyer","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006714671"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84354367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.0649000033736229,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.06030000001192093,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymus","display_name":"thymus","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mediastinal-mass","display_name":"mediastinal mass","score":0.8080000281333923},{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/t-lymphoblastic-leukemia-lymphoma","display_name":"T lymphoblastic leukemia/lymphoma","score":0.9049999713897705},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6697999835014343},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5713000297546387},{"id":"https://openalex.org/C3018156656","wikidata":"https://www.wikidata.org/wiki/Q5376560","display_name":"Disease entity","level":3,"score":0.5590000152587891},{"id":"https://openalex.org/C2777179996","wikidata":"https://www.wikidata.org/wiki/Q911222","display_name":"Mistake","level":2,"score":0.5171999931335449},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47780001163482666},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4293000102043152},{"id":"https://openalex.org/C3018028637","wikidata":"https://www.wikidata.org/wiki/Q4271422","display_name":"Mediastinal mass","level":2,"score":0.3853999972343445},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3555999994277954},{"id":"https://openalex.org/C2779701055","wikidata":"https://www.wikidata.org/wiki/Q929833","display_name":"Rare disease","level":3,"score":0.32190001010894775},{"id":"https://openalex.org/C2910722220","wikidata":"https://www.wikidata.org/wiki/Q1429863","display_name":"Thymus Neoplasm","level":3,"score":0.3215999901294708},{"id":"https://openalex.org/C2779159893","wikidata":"https://www.wikidata.org/wiki/Q1429863","display_name":"Thymoma","level":2,"score":0.31310001015663147},{"id":"https://openalex.org/C113842279","wikidata":"https://www.wikidata.org/wiki/Q1873857","display_name":"Lymphoblast","level":3,"score":0.3003000020980835},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.26739999651908875},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.2660999894142151}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1159/pat/aehag005","doi":"https://doi.org/10.1159/pat/aehag005","is_oa":true,"landing_page_url":"https://doi.org/10.1159/pat/aehag005","pdf_url":"https://karger.com/pat/article-pdf/doi/10.1159/pat/aehag005/4599232/000555058.pdf","source":{"id":"https://openalex.org/S18964055","display_name":"Pathobiology","issn_l":"1015-2008","issn":["1015-2008","1423-0291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathobiology","raw_type":"journal-article"},{"id":"pmid:42945444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42945444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathobiology : journal of immunopathology, molecular and cellular biology","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1159/pat/aehag005","doi":"https://doi.org/10.1159/pat/aehag005","is_oa":true,"landing_page_url":"https://doi.org/10.1159/pat/aehag005","pdf_url":"https://karger.com/pat/article-pdf/doi/10.1159/pat/aehag005/4599232/000555058.pdf","source":{"id":"https://openalex.org/S18964055","display_name":"Pathobiology","issn_l":"1015-2008","issn":["1015-2008","1423-0291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathobiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332513","display_name":"Weill Cornell Medical College","ror":"https://ror.org/02r109517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224006248.pdf","grobid_xml":"https://content.openalex.org/works/W7224006248.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1980408998","https://openalex.org/W3197692317","https://openalex.org/W4280496500","https://openalex.org/W2769207806","https://openalex.org/W4384471081","https://openalex.org/W2325088022","https://openalex.org/W2793498261","https://openalex.org/W2313635349","https://openalex.org/W2329800921","https://openalex.org/W3136772129"],"abstract_inverted_index":{"Per":[0],"the":[1,105,112,121,127,145,157],"WHO":[2],"Classification":[3],"of":[4,20,72,107,116,126,129],"Haematolymphoid":[5],"Tumours":[6],"(5th":[7],"edition),":[8],"indolent":[9,59,74],"T-lymphoblastic":[10,40,75],"proliferation":[11,19,76],"(iT-LBP)":[12],"is":[13,57,111,133],"defined":[14],"as":[15,26,83],"an":[16,30,35,43,58,73,117,124],"extrathymic":[17],"non-clonal":[18],"T":[21],"lymphoblasts":[22],"that":[23,61,140],"typically":[24],"presents":[25],"isolated":[27,31],"lymphadenopathy":[28],"or":[29],"tumor":[32],"mass":[33,86],"in":[34,87,120,160],"otherwise":[36,90],"healthy":[37,91],"individual.":[38],"Unlike":[39],"leukemia/lymphoma":[41],"(T-ALL/LBL),":[42],"aggressive":[44],"hematologic":[45],"malignancy":[46],"characterized":[47],"by":[48],"monoclonal":[49],"T-lymphoblasts":[50],"and":[51,147,162],"requiring":[52],"treatment":[53],"with":[54,77,94],"chemotherapy,":[55],"iT-LBP":[56],"process":[60],"does":[62],"not":[63,148],"require":[64],"any":[65],"specific":[66],"treatment.":[67],"We":[68],"report":[69],"a":[70,84,88,100],"case":[71,115],"subsequently":[78],"diagnosed":[79],"Graves'":[80],"disease":[81],"presenting":[82],"mediastinal":[85],"young,":[89],"woman.":[92],"Consistent":[93],"this":[95,110,141],"diagnosis,":[96],"she":[97],"has":[98],"had":[99],"benign":[101],"clinical":[102],"course.":[103],"To":[104],"best":[106],"our":[108],"knowledge,":[109],"first":[113],"reported":[114],"iT-LBP-like":[118],"entity":[119,142],"thymus,":[122],"suggesting":[123],"expansion":[125],"definition":[128],"iT-LBP.":[130],"Therefore,":[131],"it":[132,150],"critical":[134],"for":[135,151],"pathologists":[136],"to":[137],"be":[138],"aware":[139],"can":[143],"involve":[144],"thymus":[146],"mistake":[149],"other":[152],"malignancies,":[153],"especially":[154],"T-ALL/LBL,":[155],"given":[156],"significant":[158],"differences":[159],"prognosis":[161],"management.":[163]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-28T00:00:00"}