{"id":"https://openalex.org/W7223971270","doi":"https://doi.org/10.2147/pgpm.s636883","title":"Personalized Nutrition for Immune Optimization: A Nutrigenetic Approach to the Peripheral Blood Mononuclear Cell Response","display_name":"Personalized Nutrition for Immune Optimization: A Nutrigenetic Approach to the Peripheral Blood Mononuclear Cell Response","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223971270","doi":"https://doi.org/10.2147/pgpm.s636883","pmid":"https://pubmed.ncbi.nlm.nih.gov/42967152","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13723227"},"language":"en","primary_location":{"id":"doi:10.2147/pgpm.s636883","doi":"https://doi.org/10.2147/pgpm.s636883","is_oa":true,"landing_page_url":"https://doi.org/10.2147/pgpm.s636883","pdf_url":"https://www.dovepress.com/article/download/121433","source":{"id":"https://openalex.org/S2764709116","display_name":"Pharmacogenomics and Personalized Medicine","issn_l":"1178-7066","issn":["1178-7066"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics and Personalized Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/121433","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119557613","display_name":"Akash Kishor Rokade","orcid":"https://orcid.org/0009-0008-7597-4834","observed_orcids":["https://orcid.org/0009-0008-7597-4834"]},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Akash Kishor Rokade","raw_affiliation_strings":["Laboratory of Pesticide and Environmental Toxicology, Department of Plant Pests and Diseases, Faculty of Agriculture, Universitas Padjadjaran, Jatinangor, West Java, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pesticide and Environmental Toxicology, Department of Plant Pests and Diseases, Faculty of Agriculture, Universitas Padjadjaran, Jatinangor, West Java, Indonesia","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051626660","display_name":"Anna Meiliana","orcid":"https://orcid.org/0000-0002-4430-5952","observed_orcids":["https://orcid.org/0000-0002-4430-5952"]},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Anna Meiliana","raw_affiliation_strings":["Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, Indonesia","Prodia Clinical Laboratory, Jakarta, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-4430-5952","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, Indonesia","institution_ids":["https://openalex.org/I91819753"]},{"raw_affiliation_string":"Prodia Clinical Laboratory, Jakarta, Indonesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040392133","display_name":"Vesara Ardhe Gatera","orcid":"https://orcid.org/0000-0002-2220-566X","observed_orcids":["https://orcid.org/0000-0002-2220-566X"]},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Vesara Ardhe Gatera","raw_affiliation_strings":["Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-2220-566X","affiliations":[{"raw_affiliation_string":"Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, Indonesia","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081908352","display_name":"Edmund Ui\u2010Hang Sim","orcid":"https://orcid.org/0000-0001-8652-8495","observed_orcids":["https://orcid.org/0000-0001-8652-8495"]},"institutions":[{"id":"https://openalex.org/I41461413","display_name":"Universiti Malaysia Sarawak","ror":"https://ror.org/05b307002","country_code":"MY","type":"education","lineage":["https://openalex.org/I41461413"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Edmund Ui-Hang Sim","raw_affiliation_strings":["Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia","institution_ids":["https://openalex.org/I41461413"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051626660"],"corresponding_institution_ids":["https://openalex.org/I91819753"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60356975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 19","issue":null,"first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13112","display_name":"Nutrition and Health Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/personalized-nutrition","display_name":"personalized nutrition","score":0.9440000057220459},{"id":"https://openalex.org/keywords/nutrigenomics","display_name":"nutrigenomics","score":0.9559999704360962},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.6919999718666077},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-diet-interaction","display_name":"gene-diet interaction","score":0.9200000166893005},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9340000152587891},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.984000027179718},{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptors","display_name":"peroxisome proliferator-activated receptors","score":0.8360000252723694},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.968999981880188},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.9660000205039978},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":1.0},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.9520000219345093},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":1.0},{"id":"https://openalex.org/keywords/cytokine-modulation","display_name":"cytokine modulation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.9150000214576721},{"id":"https://openalex.org/keywords/multi-omics","display_name":"multi-omics","score":0.7319999933242798},{"id":"https://openalex.org/keywords/functional-foods","display_name":"functional foods","score":0.652999997138977},{"id":"https://openalex.org/keywords/immune-resistance","display_name":"immune resistance","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7832000255584717},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6937999725341797},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5436000227928162},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5389000177383423},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.5346999764442444},{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.5105999708175659},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.46480000019073486},{"id":"https://openalex.org/C97633540","wikidata":"https://www.wikidata.org/wiki/Q4328195","display_name":"Nutrigenomics","level":3,"score":0.435699999332428},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41609999537467957},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3977999985218048},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.38999998569488525},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.3878999948501587},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.36469998955726624},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.296099990606308},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29499998688697815},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.2696000039577484},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.26840001344680786}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/pgpm.s636883","doi":"https://doi.org/10.2147/pgpm.s636883","is_oa":true,"landing_page_url":"https://doi.org/10.2147/pgpm.s636883","pdf_url":"https://www.dovepress.com/article/download/121433","source":{"id":"https://openalex.org/S2764709116","display_name":"Pharmacogenomics and Personalized Medicine","issn_l":"1178-7066","issn":["1178-7066"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics and Personalized Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13723227","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723227/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723227/pdf/PGPM-19-636883.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmgenomics Pers Med","raw_type":"Text"},{"id":"pmid:42967152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42967152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics and personalized medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0a4355e89f8647709e9334ae29dbc20a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0a4355e89f8647709e9334ae29dbc20a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pharmacogenomics and Personalized Medicine, Vol Volume 19, Iss Issue 1, Pp 1-16 (2026)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/121433","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/personalized-nutrition-for-immune-optimization-a-nutrigenetic-approach-peer-reviewed-fulltext-article-PGPM","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review"}],"best_oa_location":{"id":"doi:10.2147/pgpm.s636883","doi":"https://doi.org/10.2147/pgpm.s636883","is_oa":true,"landing_page_url":"https://doi.org/10.2147/pgpm.s636883","pdf_url":"https://www.dovepress.com/article/download/121433","source":{"id":"https://openalex.org/S2764709116","display_name":"Pharmacogenomics and Personalized Medicine","issn_l":"1178-7066","issn":["1178-7066"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics and Personalized Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G233117845","display_name":null,"funder_award_id":"RKT/HK.07.00/2025","funder_id":"https://openalex.org/F4320329092","funder_display_name":"Universitas Padjadjaran"},{"id":"https://openalex.org/G3068747324","display_name":null,"funder_award_id":"4303/ B3/DT.03.08/2025","funder_id":"https://openalex.org/F4320329092","funder_display_name":"Universitas Padjadjaran"},{"id":"https://openalex.org/G7937771343","display_name":null,"funder_award_id":"/UN6.3.1/PT.00/","funder_id":"https://openalex.org/F4320329092","funder_display_name":"Universitas Padjadjaran"}],"funders":[{"id":"https://openalex.org/F4320327264","display_name":"Ministrstvo za visoko \u0161olstvo, znanost in tehnologijo","ror":"https://ror.org/0452h9305"},{"id":"https://openalex.org/F4320328515","display_name":"Lembaga Pengelola Dana Pendidikan","ror":"https://ror.org/05p2xef58"},{"id":"https://openalex.org/F4320329092","display_name":"Universitas Padjadjaran","ror":"https://ror.org/00xqf8t64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223971270.pdf","grobid_xml":"https://content.openalex.org/works/W7223971270.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1872470270","https://openalex.org/W1970473725","https://openalex.org/W1980877353","https://openalex.org/W1989784608","https://openalex.org/W1989911164","https://openalex.org/W2006690432","https://openalex.org/W2012887294","https://openalex.org/W2025054234","https://openalex.org/W2040368181","https://openalex.org/W2053718891","https://openalex.org/W2055543393","https://openalex.org/W2080470582","https://openalex.org/W2129262211","https://openalex.org/W2162208431","https://openalex.org/W2298506252","https://openalex.org/W2516593410","https://openalex.org/W2554916781","https://openalex.org/W2587344758","https://openalex.org/W2808365741","https://openalex.org/W2993296725","https://openalex.org/W3036011462","https://openalex.org/W3083309812","https://openalex.org/W4214905414","https://openalex.org/W4220688734","https://openalex.org/W4224030493","https://openalex.org/W4303961983","https://openalex.org/W4319872942","https://openalex.org/W4385980653","https://openalex.org/W4385980720","https://openalex.org/W4386014819","https://openalex.org/W4390268219","https://openalex.org/W4393950436","https://openalex.org/W4396556648","https://openalex.org/W4402363529","https://openalex.org/W4403726837","https://openalex.org/W4406642058","https://openalex.org/W4409038337","https://openalex.org/W4410191441","https://openalex.org/W4414966769","https://openalex.org/W4415240010","https://openalex.org/W4416291244","https://openalex.org/W4416536671","https://openalex.org/W7117554752","https://openalex.org/W7165361486","https://openalex.org/W7216225037"],"related_works":["https://openalex.org/W1968474922","https://openalex.org/W4317212750","https://openalex.org/W2006690432","https://openalex.org/W3109456608","https://openalex.org/W7119059499","https://openalex.org/W7218103093","https://openalex.org/W7047489465","https://openalex.org/W4234013191","https://openalex.org/W4394907600","https://openalex.org/W4415000658"],"abstract_inverted_index":{"Abstract:":[0],"Personalized":[1],"nutrition,":[2,256],"guided":[3],"by":[4],"nutrigenetic":[5,222],"insights,":[6],"is":[7],"a":[8,30,113,225],"promising":[9],"strategy":[10],"for":[11,33,80,213],"optimizing":[12],"immune":[13,81,109,237],"function":[14],"through":[15],"targeted":[16],"dietary":[17,59],"interventions.":[18],"Peripheral":[19],"blood":[20],"mononuclear":[21],"cells":[22],"(PBMCs),":[23],"comprising":[24],"lymphocytes":[25],"and":[26,43,61,65,85,100,125,154,175,187,197,216,227,239,248],"monocytes,":[27],"serve":[28],"as":[29,106,108,192,224],"dynamic":[31],"model":[32],"investigating":[34],"gene\u2013diet":[35],"interactions":[36],"because":[37],"of":[38,70,76,164,194,203],"their":[39],"sensitivity":[40],"to":[41,49,90,132,166,206],"nutritional":[42,78],"genetic":[44,57,253],"influences.":[45],"This":[46],"review":[47],"aimed":[48],"synthesize":[50,91],"current":[51],"reports":[52],"on":[53,115,122],"the":[54,67,71,74,92,95,129,137,162],"interplay":[55],"between":[56,97],"variation,":[58],"components,":[60],"PBMC":[62],"molecular":[63,98,180],"responses":[64],"evaluate":[66],"clinical":[68,214],"applicability":[69],"interaction":[72],"in":[73,103,136,246],"development":[75],"individualized":[77],"strategies":[79],"optimization.":[82],"A":[83,117],"structured":[84],"narrative-focused":[86],"method":[87],"was":[88,120],"used":[89],"literature,":[93],"showing":[94],"relationship":[96],"knowledge":[99],"practical":[101],"solutions":[102],"personalized":[104,255],"nutrition":[105,209],"well":[107],"system":[110],"optimization,":[111],"with":[112],"focus":[114],"PBMCs.":[116],"thorough":[118],"search":[119],"performed":[121],"PubMed,":[123],"Scopus,":[124],"Google":[126],"Scholar,":[127],"encompassing":[128],"years":[130],"2006":[131],"2025.":[133],"Genetic":[134],"polymorphisms":[135],"vitamin":[138,169],"D":[139],"receptor":[140,146,156],"(":[141,151,158],"VDR":[142],"),":[143,153],"peroxisome":[144],"proliferator-activated":[145],"(PPAR),":[147],"superoxide":[148],"dismutase":[149],"2":[150],"SOD2":[152],"Toll-like":[155],"4":[157],"TLR4":[159],")":[160],"modulated":[161],"response":[163],"PBMCs":[165,191],"nutrients,":[167],"including":[168],"D,":[170],"omega-3":[171],"fatty":[172],"acids,":[173],"antioxidants,":[174],"polyphenols.":[176],"The":[177,201],"discussion":[178],"encompassed":[179],"pathways":[181],"involving":[182],"cytokine":[183],"modulation,":[184],"oxidative":[185],"stress,":[186],"epigenetic":[188],"alterations,":[189],"highlighting":[190],"indicators":[193],"immunological":[195],"resistance":[196],"chronic":[198],"disease":[199],"susceptibility.":[200],"exploration":[202],"multiomics":[204],"integration":[205],"achieve":[207],"precision":[208],"holds":[210],"significant":[211],"implications":[212],"practice":[215],"public":[217],"health.":[218],"By":[219],"using":[220],"PBMC-based":[221],"profiling":[223],"monitoring":[226],"stratification":[228],"tool,":[229],"future":[230],"interventions":[231],"may":[232],"move":[233],"toward":[234],"more":[235],"focused":[236],"optimization":[238],"improved":[240],"health":[241],"outcomes,":[242],"pending":[243],"further":[244],"validation":[245],"longitudinal":[247],"interventional":[249],"studies.":[250],"Keywords:":[251],"nutrigenomics,":[252],"polymorphism,":[254],"functional":[257],"foods":[258]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-28T00:00:00"}
