{"id":"https://openalex.org/W7223969463","doi":"https://doi.org/10.3390/ijms27219606","title":"Deciphering Cancer-Specific H3K27ac Landscapes Through Systematic Multi-Omics Integration and Development of Open-Access Genomic Annotation Platform","display_name":"Deciphering Cancer-Specific H3K27ac Landscapes Through Systematic Multi-Omics Integration and Development of Open-Access Genomic Annotation Platform","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7223969463","doi":"https://doi.org/10.3390/ijms27219606"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27219606","doi":"https://doi.org/10.3390/ijms27219606","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219606","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27219606","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159759890","display_name":"Yu-Shuo Zhuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Shuo Zhuang","raw_affiliation_strings":["Inner Mongolia Key Laboratory of Biophysics and Bioinformatics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Key Laboratory of Biophysics and Bioinformatics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159966761","display_name":"Yuan-Yuan Gao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan-Yuan Gao","raw_affiliation_strings":["Inner Mongolia Traditional Chinese & Mongolian Medical Research Institute, Hohhot 010020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Traditional Chinese & Mongolian Medical Research Institute, Hohhot 010020, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073409235","display_name":"Zhao\u2010Yue Zhang","orcid":"https://orcid.org/0000-0002-4619-247X","observed_orcids":["https://orcid.org/0000-0002-4619-247X"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhao-Yue Zhang","raw_affiliation_strings":["School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159887641","display_name":"Zhe-Peng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe-Peng Wang","raw_affiliation_strings":["Inner Mongolia Key Laboratory of Biophysics and Bioinformatics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Key Laboratory of Biophysics and Bioinformatics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349131","display_name":"Jun-Jie Liu","orcid":"https://orcid.org/0000-0002-7610-1399","observed_orcids":["https://orcid.org/0000-0002-7610-1399"]},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-Jie Liu","raw_affiliation_strings":["Inner Mongolia Key Laboratory of Biophysics and Bioinformatics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Key Laboratory of Biophysics and Bioinformatics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114734351","display_name":"Lirong Zhang","orcid":"https://orcid.org/0000-0001-5366-4837","observed_orcids":["https://orcid.org/0000-0001-5366-4837"]},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Rong Zhang","raw_affiliation_strings":["Inner Mongolia Key Laboratory of Biophysics and Bioinformatics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China"],"raw_orcid":"https://orcid.org/0000-0001-5366-4837","affiliations":[{"raw_affiliation_string":"Inner Mongolia Key Laboratory of Biophysics and Bioinformatics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052107668","display_name":"Siqin Bateer","orcid":"https://orcid.org/0000-0001-8828-9141","observed_orcids":["https://orcid.org/0000-0001-8828-9141"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Siqin Bateer","raw_affiliation_strings":["Inner Mongolia Traditional Chinese & Mongolian Medical Research Institute, Hohhot 010020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Traditional Chinese & Mongolian Medical Research Institute, Hohhot 010020, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082604057","display_name":"Lu-Qiang Zhang","orcid":"https://orcid.org/0000-0003-1236-957X","observed_orcids":["https://orcid.org/0000-0003-1236-957X"]},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lu-Qiang Zhang","raw_affiliation_strings":["Inner Mongolia Key Laboratory of Biophysics and Bioinformatics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Key Laboratory of Biophysics and Bioinformatics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China","institution_ids":["https://openalex.org/I2722730"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052107668","https://openalex.org/A5082604057"],"corresponding_institution_ids":["https://openalex.org/I2722730"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73558848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"21","first_page":"9606","last_page":"9606"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.18359999358654022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.08709999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h3k27ac","display_name":"H3K27ac","score":0.9599999785423279},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cancer-epigenetics","display_name":"cancer epigenetics","score":0.8460000157356262},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.7749999761581421},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7269999980926514},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.6570000052452087},{"id":"https://openalex.org/keywords/gata1","display_name":"GATA-1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tal1","display_name":"TAL1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/noncoding-regions","display_name":"non-coding regions","score":0.746999979019165},{"id":"https://openalex.org/keywords/chromatin-interactions","display_name":"chromatin interactions","score":0.7549999952316284},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8237000107765198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6593000292778015},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6151000261306763},{"id":"https://openalex.org/C2778760011","wikidata":"https://www.wikidata.org/wiki/Q21163346","display_name":"CTCF","level":5,"score":0.5992000102996826},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5807999968528748},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5236999988555908},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4496999979019165},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4481000006198883},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.42570000886917114},{"id":"https://openalex.org/C176504155","wikidata":"https://www.wikidata.org/wiki/Q4943254","display_name":"Bookmarking","level":2,"score":0.41990000009536743},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3937999904155731},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.36890000104904175},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.3587999939918518},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3521000146865845},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.34119999408721924},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.33820000290870667},{"id":"https://openalex.org/C67258246","wikidata":"https://www.wikidata.org/wiki/Q5065897","display_name":"ChIA-PET","level":5,"score":0.3181000053882599},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3043999969959259},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.30309998989105225},{"id":"https://openalex.org/C56952853","wikidata":"https://www.wikidata.org/wiki/Q5773144","display_name":"Histone-modifying enzymes","level":5,"score":0.29159998893737793},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.28999999165534973},{"id":"https://openalex.org/C137338518","wikidata":"https://www.wikidata.org/wiki/Q4919210","display_name":"Bivalent chromatin","level":5,"score":0.2888000011444092},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.28279998898506165}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/ijms27219606","doi":"https://doi.org/10.3390/ijms27219606","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219606","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/ijms27219606","doi":"https://doi.org/10.3390/ijms27219606","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219606","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322868","display_name":"Natural Science Foundation of Inner Mongolia","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W883478816","https://openalex.org/W1945410182","https://openalex.org/W1966116114","https://openalex.org/W1990636453","https://openalex.org/W2076513103","https://openalex.org/W2093146349","https://openalex.org/W2102619694","https://openalex.org/W2108234281","https://openalex.org/W2110065044","https://openalex.org/W2119180969","https://openalex.org/W2124114530","https://openalex.org/W2170219300","https://openalex.org/W2170551349","https://openalex.org/W2481029670","https://openalex.org/W2507399124","https://openalex.org/W2592811885","https://openalex.org/W2604214647","https://openalex.org/W2767826728","https://openalex.org/W2794318873","https://openalex.org/W2884862390","https://openalex.org/W2908255744","https://openalex.org/W2946657092","https://openalex.org/W2952990620","https://openalex.org/W2963537251","https://openalex.org/W2985045444","https://openalex.org/W3012964494","https://openalex.org/W3014716126","https://openalex.org/W3033842668","https://openalex.org/W3070230487","https://openalex.org/W3087158721","https://openalex.org/W3101477379","https://openalex.org/W3119209549","https://openalex.org/W3122477661","https://openalex.org/W3134945914","https://openalex.org/W3192642190","https://openalex.org/W4205212055","https://openalex.org/W4284885524","https://openalex.org/W4302774050","https://openalex.org/W4362507076","https://openalex.org/W4362736454","https://openalex.org/W4377242448","https://openalex.org/W4379537746","https://openalex.org/W4389315539","https://openalex.org/W4390501506","https://openalex.org/W4392462844","https://openalex.org/W4392763741","https://openalex.org/W4393374890","https://openalex.org/W4394853923","https://openalex.org/W7171940685"],"related_works":["https://openalex.org/W4407845563","https://openalex.org/W3161977826","https://openalex.org/W7164121872","https://openalex.org/W4388007365","https://openalex.org/W2024499475","https://openalex.org/W2164230507","https://openalex.org/W4311098277","https://openalex.org/W2002525399","https://openalex.org/W2519607943","https://openalex.org/W1504602997"],"abstract_inverted_index":{"H3K27ac":[0,15,25,32,53,58,78,110,135,195],"epigenetically":[1],"modulates":[2],"gene":[3,152],"expression":[4],"and":[5,38,47,70,94,116,121,147,208],"serves":[6],"as":[7,199],"an":[8,179,210],"indicator":[9],"of":[10,23,51,100,149,174,193,204,217],"cancer":[11,219],"status.":[12],"Although":[13],"aberrant":[14],"has":[16],"been":[17],"widely":[18],"studied,":[19],"a":[20,48,138,163,190,200],"comprehensive":[21,191],"landscape":[22,192],"cancer-specific":[24,52,57,77,109,194],"patterns":[26],"remains":[27],"lacking.":[28],"By":[29],"integrating":[30],"209":[31],"ChIP-seq":[33],"datasets":[34],"across":[35,62],"48":[36],"tissues":[37],"cell":[39],"types,":[40],"we":[41,177],"defined":[42],"3612":[43],"universally":[44],"conserved":[45],"regions":[46],"vast":[49],"repertoire":[50],"alterations.":[54],"Strikingly,":[55],"while":[56],"gains":[59,79,136],"were":[60,73,80,88],"pervasive":[61],"leukemia,":[63],"hepatocellular":[64],"carcinoma,":[65],"breast":[66],"cancer,":[67],"lung":[68],"adenocarcinoma,":[69],"lymphoma,":[71],"losses":[72,111],"remarkably":[74],"rare.":[75],"These":[76],"predominantly":[81],"enriched":[82],"in":[83,114,127,168],"non-coding":[84],"regions,":[85],"where":[86],"they":[87],"associated":[89],"with":[90,118,161],"increased":[91,159],"chromatin":[92,95,119,140,206],"accessibility":[93],"interactions,":[96],"enabling":[97],"the":[98,215,218],"recruitment":[99],"oncogenic":[101,144,205],"transcription":[102],"factors":[103],"to":[104],"activate":[105],"target":[106,151],"genes.":[107],"Conversely,":[108],"preferentially":[112],"occurred":[113],"promoters":[115],"correlated":[117],"compaction":[120],"transcriptional":[122],"repression.":[123],"Mechanistic":[124],"multi-omics":[125],"analyses":[126],"leukemia":[128],"further":[129],"demonstrated":[130],"this":[131,155],"epigenetic-structural":[132],"coupling.":[133],"Leukemia-specific":[134],"established":[137],"permissive":[139],"environment":[141],"that":[142],"facilitated":[143],"GATA1":[145],"binding":[146],"activation":[148],"its":[150],"TAL1.":[153],"Within":[154],"context,":[156],"TAL1":[157],"exhibited":[158],"interaction":[160],"STIL,":[162],"well-known":[164],"fusion":[165],"partner":[166],"implicated":[167],"leukemogenesis.":[169],"To":[170],"enable":[171],"broader":[172],"application":[173],"these":[175],"findings,":[176],"developed":[178],"open-access":[180],"web":[181],"server":[182],"for":[183,213],"genomic":[184],"annotation.":[185],"Collectively,":[186],"our":[187],"study":[188],"provides":[189],"modifications,":[196],"defining":[197],"them":[198],"functional":[201],"epigenetic":[202],"signature":[203],"remodeling":[207],"offering":[209],"annotation":[211],"resource":[212],"understanding":[214],"regulation":[216],"genome.":[220]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-28T00:00:00"}
