{"id":"https://openalex.org/W7223966352","doi":"https://doi.org/10.4274/gulhane.galenos.2026.29052","title":"The role of glutathione in modulating organ injury in a bleomycin, etoposide and cisplatin-induced fibrosis model","display_name":"The role of glutathione in modulating organ injury in a bleomycin, etoposide and cisplatin-induced fibrosis model","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7223966352","doi":"https://doi.org/10.4274/gulhane.galenos.2026.29052"},"language":"en","primary_location":{"id":"doi:10.4274/gulhane.galenos.2026.29052","doi":"https://doi.org/10.4274/gulhane.galenos.2026.29052","is_oa":true,"landing_page_url":"https://doi.org/10.4274/gulhane.galenos.2026.29052","pdf_url":"https://gulhanemedj.org/pdf/37eae217-e8b5-4f55-976f-35df98003e83/articles/gulhane.galenos.2026.29052/4-2026.29052.pdf","source":{"id":"https://openalex.org/S2764364248","display_name":"Gulhane Medical Journal","issn_l":"1302-0471","issn":["1302-0471","2146-8052"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gulhane Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://gulhanemedj.org/pdf/37eae217-e8b5-4f55-976f-35df98003e83/articles/gulhane.galenos.2026.29052/4-2026.29052.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060389330","display_name":"Hale Bayram","orcid":"https://orcid.org/0000-0002-6104-8820","observed_orcids":["https://orcid.org/0000-0002-6104-8820"]},"institutions":[{"id":"https://openalex.org/I44457188","display_name":"Maltepe University","ror":"https://ror.org/004dg2369","country_code":"TR","type":"education","lineage":["https://openalex.org/I44457188"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hale Bayram","raw_affiliation_strings":["Maltepe University Faculty of Medicine , Department of Histology and Embryology , \u0130stanbul , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maltepe University Faculty of Medicine , Department of Histology and Embryology , \u0130stanbul , T\u00fcrkiye","institution_ids":["https://openalex.org/I44457188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159926013","display_name":"Yaprak D\u00f6nmez \u00c7ak\u0131l","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44457188","display_name":"Maltepe University","ror":"https://ror.org/004dg2369","country_code":"TR","type":"education","lineage":["https://openalex.org/I44457188"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Yaprak D\u00f6nmez \u00c7ak\u0131l","raw_affiliation_strings":["Maltepe University Faculty of Medicine , Department of Medical Biology and Genetics , \u0130stanbul , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maltepe University Faculty of Medicine , Department of Medical Biology and Genetics , \u0130stanbul , T\u00fcrkiye","institution_ids":["https://openalex.org/I44457188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063908441","display_name":"Sevtap G\u00f6kalp","orcid":"https://orcid.org/0000-0002-8615-2448","observed_orcids":["https://orcid.org/0000-0002-8615-2448"]},"institutions":[{"id":"https://openalex.org/I44457188","display_name":"Maltepe University","ror":"https://ror.org/004dg2369","country_code":"TR","type":"education","lineage":["https://openalex.org/I44457188"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sevtap G\u00f6kalp","raw_affiliation_strings":["Maltepe University Faculty of Medicine , Department of Histology and Embryology , \u0130stanbul , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maltepe University Faculty of Medicine , Department of Histology and Embryology , \u0130stanbul , T\u00fcrkiye","institution_ids":["https://openalex.org/I44457188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033426835","display_name":"\u015e\u00fckr\u00fc Y\u0131ld\u0131r\u0131m","orcid":"https://orcid.org/0000-0001-6411-8460","observed_orcids":["https://orcid.org/0000-0001-6411-8460"]},"institutions":[{"id":"https://openalex.org/I44457188","display_name":"Maltepe University","ror":"https://ror.org/004dg2369","country_code":"TR","type":"education","lineage":["https://openalex.org/I44457188"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u015e\u00fckr\u00fc Y\u0131ld\u0131r\u0131m","raw_affiliation_strings":["Maltepe University Faculty of Medicine , Department of Medical Pathology , \u0130stanbul , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maltepe University Faculty of Medicine , Department of Medical Pathology , \u0130stanbul , T\u00fcrkiye","institution_ids":["https://openalex.org/I44457188"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084168559","display_name":"Mehmet C\u0131nc\u0131k","orcid":"https://orcid.org/0000-0002-0717-1756","observed_orcids":["https://orcid.org/0000-0002-0717-1756"]},"institutions":[{"id":"https://openalex.org/I44457188","display_name":"Maltepe University","ror":"https://ror.org/004dg2369","country_code":"TR","type":"education","lineage":["https://openalex.org/I44457188"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet C\u0131nc\u0131k","raw_affiliation_strings":["Maltepe University Faculty of Medicine , Department of Histology and Embryology , \u0130stanbul , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maltepe University Faculty of Medicine , Department of Histology and Embryology , \u0130stanbul , T\u00fcrkiye","institution_ids":["https://openalex.org/I44457188"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I44457188"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82200893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.5439000129699707,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.5439000129699707,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.16599999368190765,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.09809999912977219,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":1.0},{"id":"https://openalex.org/keywords/organ-damage","display_name":"organ damage","score":0.652999997138977},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.8629999756813049},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":1.0},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/drug-induced-fibrosis","display_name":"drug-induced fibrosis","score":0.6930000185966492},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.4690000116825104},{"id":"https://openalex.org/keywords/chemotherapeutic-nephrotoxicity","display_name":"chemotherapeutic nephrotoxicity","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9218000173568726},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.7882999777793884},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6764000058174133},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6326000094413757},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44600000977516174},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.353300005197525},{"id":"https://openalex.org/C3018799218","wikidata":"https://www.wikidata.org/wiki/Q188193","display_name":"Organ system","level":3,"score":0.3416000008583069},{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.3260999917984009},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28870001435279846},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.263700008392334}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4274/gulhane.galenos.2026.29052","doi":"https://doi.org/10.4274/gulhane.galenos.2026.29052","is_oa":true,"landing_page_url":"https://doi.org/10.4274/gulhane.galenos.2026.29052","pdf_url":"https://gulhanemedj.org/pdf/37eae217-e8b5-4f55-976f-35df98003e83/articles/gulhane.galenos.2026.29052/4-2026.29052.pdf","source":{"id":"https://openalex.org/S2764364248","display_name":"Gulhane Medical Journal","issn_l":"1302-0471","issn":["1302-0471","2146-8052"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gulhane Medical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4274/gulhane.galenos.2026.29052","doi":"https://doi.org/10.4274/gulhane.galenos.2026.29052","is_oa":true,"landing_page_url":"https://doi.org/10.4274/gulhane.galenos.2026.29052","pdf_url":"https://gulhanemedj.org/pdf/37eae217-e8b5-4f55-976f-35df98003e83/articles/gulhane.galenos.2026.29052/4-2026.29052.pdf","source":{"id":"https://openalex.org/S2764364248","display_name":"Gulhane Medical Journal","issn_l":"1302-0471","issn":["1302-0471","2146-8052"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gulhane Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223966352.pdf","grobid_xml":"https://content.openalex.org/works/W7223966352.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2383156296","https://openalex.org/W2997830182","https://openalex.org/W2034175804","https://openalex.org/W1970840747","https://openalex.org/W7029013992","https://openalex.org/W2407787859","https://openalex.org/W2498200363","https://openalex.org/W2613648901","https://openalex.org/W2365042595","https://openalex.org/W4235726360"],"abstract_inverted_index":{"Aims:":[0],"The":[1],"bleomycin,":[2],"etoposide,":[3],"and":[4,56,69,78,90,154,164,186,208,211,216,222,231,239],"cisplatin":[5],"(BEP)":[6],"regimen":[7],"is":[8],"associated":[9],"with":[10,123],"organ":[11,100],"fibrosis.In":[12],"this":[13,110],"study,":[14],"the":[15,20,57,74,118,124,157,174,180,194,235],"potential":[16],"beneficial":[17],"effect":[18],"of":[19],"antioxidant":[21],"glutathione":[22],"(GSH)":[23],"against":[24],"BEP-induced":[25,229],"fibrosis":[26,68,112,155,230],"was":[27,37,51],"investigated":[28],"in":[29,73,109,117,121,156,173,197,204,219,234],"a":[30,170],"rat":[31],"model.Methods:":[32],"This":[33],"randomized":[34],"controlled":[35],"study":[36],"performed":[38],"on":[39],"male":[40,104],"rats,":[41],"which":[42],"were":[43,66,93,107,114,202],"divided":[44],"into":[45],"control,":[46,220],"BEP,":[47,221],"or":[48],"BEP+GSH":[49,58,175,223],"groups.BEP":[50],"administered":[52],"for":[53,98],"nine":[54],"weeks,":[55],"group":[59,120,126,176],"received":[60],"concomitant":[61],"GSH":[62,148,225],"treatment.The":[63],"primary":[64],"endpoints":[65,97],"multi-organ":[67],"tissue":[70,152,232],"injury,":[71],"evaluated":[72],"liver,":[75,236],"lung,":[76,237],"kidney,":[77,238],"skin":[79,165],"using":[80],"histopathological":[81],"scoring":[82],"systems.Serum":[83],"aspartate":[84],"aminotransferase":[85,88],"(AST),":[86],"alanine":[87],"(ALT),":[89],"urea":[91,212],"levels":[92,168,213],"analyzed":[94],"as":[95],"secondary":[96],"functional":[99],"impairment.Results:":[101],"Twenty-four":[102],"12-week-old":[103],"Sprague-Dawley":[105],"rats":[106],"included":[108],"study.Histopathological":[111],"scores":[113],"significantly":[115,150],"increased":[116],"BEP":[119,187],"comparison":[122],"control":[125,181],"(Ishak":[127],"score":[128,131,135],"4.00\u00b10.00vs.":[129],"0.50\u00b10.53,Ashcroft":[130],"7.00\u00b10.76vs.":[132],"1.00\u00b11.41,renal":[133],"injury":[134,153,233],"5.50\u00b10.53":[136],"vs.":[137,141,183],"0.00\u00b10.00,dermal":[138],"thickness":[139],"241.82\u00b124.83":[140],"203.90\u00b126.83\u00b5m;":[142],"p<0.0001,":[143,144,145],"p<0.05,":[146],"respectively).Conversely,":[147],"co-administration":[149],"reduced":[151],"liver":[158],"(1.88\u00b10.83;p<0.0001),":[159],"lungs":[160],"(4.38\u00b10.92;p<0.0001),":[161],"kidneys":[162],"(3.7\u00b10.71;p<0.0001),":[163],"(193.64\u00b123.70\u00b5m;":[166],"p<0.01).AST":[167],"exhibited":[169],"slight":[171],"decrease":[172],"relative":[177],"to":[178],"both":[179],"(105.76\u00b114.71U/L":[182],"144.79\u00b125.81U/L;":[184],"p<0.01)":[185],"groups":[188],"(142.61\u00b18.31U/L;":[189],"p<0.01),":[190],"yet":[191],"remained":[192],"within":[193],"reference":[195],"range":[196],"all":[198],"groups.No":[199],"significant":[200],"differences":[201],"observed":[203],"ALT":[205],"(31.09\u00b13.93U/L,":[206],"29.49\u00b14.57U/L,":[207],"33.08\u00b14.46U/L,":[209],"respectively)":[210,218],"(13.11\u00b12.41mg/dL,":[214],"12.96\u00b11.60mg/dL,":[215],"13.20\u00b11.98mg/dL,":[217],"groups.Conclusions:":[224],"supplementation":[226],"may":[227],"attenuate":[228],"skin.":[240]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-10-28T00:00:00"}