{"id":"https://openalex.org/W7223965358","doi":"https://doi.org/10.1016/j.foodhyd.2026.113518","title":"Using state diagrams to understand salt-dependent aggregation of \u03b2-lactoglobulin nanogel particle dispersions for conditions relevant to ultra-high temperature treatment","display_name":"Using state diagrams to understand salt-dependent aggregation of \u03b2-lactoglobulin nanogel particle dispersions for conditions relevant to ultra-high temperature treatment","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7223965358","doi":"https://doi.org/10.1016/j.foodhyd.2026.113518"},"language":"en","primary_location":{"id":"doi:10.1016/j.foodhyd.2026.113518","doi":"https://doi.org/10.1016/j.foodhyd.2026.113518","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.foodhyd.2026.113518","pdf_url":null,"source":{"id":"https://openalex.org/S168584722","display_name":"Food Hydrocolloids","issn_l":"0268-005X","issn":["0268-005X","1873-7137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Hydrocolloids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.foodhyd.2026.113518","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148417686","display_name":"Pernille Koch","orcid":"https://orcid.org/0009-0002-1944-2135","observed_orcids":["https://orcid.org/0009-0002-1944-2135"]},"institutions":[{"id":"https://openalex.org/I4210104415","display_name":"Arla Foods (Denmark)","ror":"https://ror.org/01hgxez56","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210104415"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Pernille Koch","raw_affiliation_strings":["Arla Foods Ingredients Group P/S - Product Discovery R&D, S\u00f8nderupvej 26, Videb\u00e6k, 6920, Denmark"],"raw_orcid":"https://orcid.org/0009-0002-1944-2135","affiliations":[{"raw_affiliation_string":"Arla Foods Ingredients Group P/S - Product Discovery R&D, S\u00f8nderupvej 26, Videb\u00e6k, 6920, Denmark","institution_ids":["https://openalex.org/I4210104415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037681348","display_name":"Jos\u00e9 C. Bonilla","orcid":"https://orcid.org/0000-0001-8200-4918","observed_orcids":["https://orcid.org/0000-0001-8200-4918"]},"institutions":[{"id":"https://openalex.org/I4210104415","display_name":"Arla Foods (Denmark)","ror":"https://ror.org/01hgxez56","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210104415"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 C. Bonilla","raw_affiliation_strings":["Arla Foods Ingredients Group P/S - Product Discovery R&D, S\u00f8nderupvej 26, Videb\u00e6k, 6920, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arla Foods Ingredients Group P/S - Product Discovery R&D, S\u00f8nderupvej 26, Videb\u00e6k, 6920, Denmark","institution_ids":["https://openalex.org/I4210104415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129320963","display_name":"Frans W.J. van den Berg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frans W.J. van den Berg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045251552","display_name":"Anni Bygvr\u00e5 Hougaard","orcid":"https://orcid.org/0000-0001-9767-4092","observed_orcids":["https://orcid.org/0000-0001-9767-4092"]},"institutions":[{"id":"https://openalex.org/I4210104415","display_name":"Arla Foods (Denmark)","ror":"https://ror.org/01hgxez56","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210104415"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anni Bygvr\u00e5 Hougaard","raw_affiliation_strings":["Arla Foods Ingredients Group P/S - Product Discovery R&D, S\u00f8nderupvej 26, Videb\u00e6k, 6920, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arla Foods Ingredients Group P/S - Product Discovery R&D, S\u00f8nderupvej 26, Videb\u00e6k, 6920, Denmark","institution_ids":["https://openalex.org/I4210104415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080189005","display_name":"Katarzyna Kaczynska","orcid":"https://orcid.org/0000-0001-8843-0344","observed_orcids":["https://orcid.org/0000-0001-8843-0344"]},"institutions":[{"id":"https://openalex.org/I4210104415","display_name":"Arla Foods (Denmark)","ror":"https://ror.org/01hgxez56","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210104415"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Katarzyna Kaczynska","raw_affiliation_strings":["Arla Foods Ingredients Group P/S - Product Discovery R&D, S\u00f8nderupvej 26, Videb\u00e6k, 6920, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arla Foods Ingredients Group P/S - Product Discovery R&D, S\u00f8nderupvej 26, Videb\u00e6k, 6920, Denmark","institution_ids":["https://openalex.org/I4210104415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159973421","display_name":"S\u00f8ren Bang Nielsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104415","display_name":"Arla Foods (Denmark)","ror":"https://ror.org/01hgxez56","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210104415"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S\u00f8ren Bang Nielsen","raw_affiliation_strings":["Arla Foods Ingredients Group P/S - Product Discovery R&D, S\u00f8nderupvej 26, Videb\u00e6k, 6920, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arla Foods Ingredients Group P/S - Product Discovery R&D, S\u00f8nderupvej 26, Videb\u00e6k, 6920, Denmark","institution_ids":["https://openalex.org/I4210104415"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039774549","display_name":"Serafim Bakalis","orcid":"https://orcid.org/0000-0002-5593-4498","observed_orcids":["https://orcid.org/0000-0002-5593-4498"]},"institutions":[{"id":"https://openalex.org/I4210104415","display_name":"Arla Foods (Denmark)","ror":"https://ror.org/01hgxez56","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210104415"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Serafim Bakalis","raw_affiliation_strings":["Arla Foods Ingredients Group P/S - Product Discovery R&D, S\u00f8nderupvej 26, Videb\u00e6k, 6920, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arla Foods Ingredients Group P/S - Product Discovery R&D, S\u00f8nderupvej 26, Videb\u00e6k, 6920, Denmark","institution_ids":["https://openalex.org/I4210104415"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5148417686"],"corresponding_institution_ids":["https://openalex.org/I4210104415"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"185","issue":null,"first_page":"113518","last_page":"113518"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12048","display_name":"Microencapsulation and Drying Processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-lactoglobulin","display_name":"\u03b2-lactoglobulin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ultra-high-temperature-treatment","display_name":"ultra-high temperature treatment","score":0.871999979019165},{"id":"https://openalex.org/keywords/state-transition-diagrams","display_name":"state diagrams","score":0.949999988079071},{"id":"https://openalex.org/keywords/calcium-chloride","display_name":"calcium chloride","score":0.49399998784065247},{"id":"https://openalex.org/keywords/sodium-chloride","display_name":"sodium chloride","score":0.8230000138282776},{"id":"https://openalex.org/keywords/potassium-chloride","display_name":"potassium chloride","score":0.9079999923706055},{"id":"https://openalex.org/keywords/sodium-citrate","display_name":"sodium citrate","score":0.9580000042915344},{"id":"https://openalex.org/keywords/sodium-phosphate","display_name":"sodium phosphate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/high-protein-beverages","display_name":"high-protein beverages","score":0.6880000233650208},{"id":"https://openalex.org/keywords/isoelectric-point","display_name":"isoelectric point","score":0.7670000195503235},{"id":"https://openalex.org/keywords/ph-effect","display_name":"pH effect","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C134424308","wikidata":"https://www.wikidata.org/wiki/Q4119000","display_name":"Nanogel","level":3,"score":0.9232000112533569},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6154000163078308},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.5601000189781189},{"id":"https://openalex.org/C2778207910","wikidata":"https://www.wikidata.org/wiki/Q397610","display_name":"Agr\u00e9gation","level":3,"score":0.41370001435279846},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.4050999879837036},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3582000136375427},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.34950000047683716},{"id":"https://openalex.org/C85906118","wikidata":"https://www.wikidata.org/wiki/Q186693","display_name":"Phase diagram","level":3,"score":0.3483999967575073},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.34709998965263367},{"id":"https://openalex.org/C16671368","wikidata":"https://www.wikidata.org/wiki/Q230885","display_name":"State diagram","level":3,"score":0.31850001215934753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3073999881744385},{"id":"https://openalex.org/C107814960","wikidata":"https://www.wikidata.org/wiki/Q611957","display_name":"Solid-state","level":2,"score":0.295199990272522},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C96087396","wikidata":"https://www.wikidata.org/wiki/Q393340","display_name":"Particle aggregation","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.2533999979496002},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.25270000100135803}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.foodhyd.2026.113518","doi":"https://doi.org/10.1016/j.foodhyd.2026.113518","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.foodhyd.2026.113518","pdf_url":null,"source":{"id":"https://openalex.org/S168584722","display_name":"Food Hydrocolloids","issn_l":"0268-005X","issn":["0268-005X","1873-7137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Hydrocolloids","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.foodhyd.2026.113518","doi":"https://doi.org/10.1016/j.foodhyd.2026.113518","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.foodhyd.2026.113518","pdf_url":null,"source":{"id":"https://openalex.org/S168584722","display_name":"Food Hydrocolloids","issn_l":"0268-005X","issn":["0268-005X","1873-7137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Hydrocolloids","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317418","display_name":"Arla Foods Ingredients Group","ror":"https://ror.org/01hgxez56"},{"id":"https://openalex.org/F4320320945","display_name":"K\u00f8benhavns Universitet","ror":"https://ror.org/035b05819"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1969259546","https://openalex.org/W1991104045","https://openalex.org/W2000576914","https://openalex.org/W2022392453","https://openalex.org/W2044801367","https://openalex.org/W2049921027","https://openalex.org/W2050592424","https://openalex.org/W2054937814","https://openalex.org/W2065874912","https://openalex.org/W2070018868","https://openalex.org/W2075426319","https://openalex.org/W2079781585","https://openalex.org/W2088042539","https://openalex.org/W2091128117","https://openalex.org/W2149145061","https://openalex.org/W2164225438","https://openalex.org/W2167279371","https://openalex.org/W2168461973","https://openalex.org/W2279819020","https://openalex.org/W2315835335","https://openalex.org/W2319727106","https://openalex.org/W2319870402","https://openalex.org/W2573724744","https://openalex.org/W2610291929","https://openalex.org/W2809202362","https://openalex.org/W2889500241","https://openalex.org/W2907890673","https://openalex.org/W2916338083","https://openalex.org/W2941345785","https://openalex.org/W3048354009","https://openalex.org/W3140098542","https://openalex.org/W3174513467","https://openalex.org/W3177402451","https://openalex.org/W4205470110","https://openalex.org/W4236995618","https://openalex.org/W4288969567","https://openalex.org/W4296640368","https://openalex.org/W4301368872","https://openalex.org/W4386602600","https://openalex.org/W4403660279"],"related_works":["https://openalex.org/W2221715301","https://openalex.org/W7212270515","https://openalex.org/W2235129069","https://openalex.org/W7008615201","https://openalex.org/W2518735141","https://openalex.org/W2792192785","https://openalex.org/W1595960784","https://openalex.org/W3002777747","https://openalex.org/W4294570140","https://openalex.org/W6987691441"],"abstract_inverted_index":{"Formulating":[0],"shelf-stable,":[1],"high-protein":[2,242],"nutritional":[3],"beverages":[4,243],"at":[5,176,197],"neutral":[6],"pH":[7,208],"requires":[8],"controlling":[9],"protein":[10,19,80,108,148,157],"aggregation":[11,51],"and":[12,48,52,83,98,109,123,154,238],"gelation":[13,53,172,189,226],"during":[14,63],"heat":[15,247],"treatment,":[16],"where":[17],"whey":[18],"nanogel":[20,60],"particles":[21,31],"are":[22],"a":[23,105,232],"promising":[24],"solution.":[25],"However,":[26],"our":[27],"understanding":[28],"of":[29,43,54,107,142,194,241],"these":[30],"is":[32],"limited,":[33],"especially":[34],"above":[35],"130":[36],"\u00b0C.":[37],"This":[38],"study":[39],"investigated":[40],"the":[41,136,140,160,167,212,225],"influence":[42],"sodium,":[44],"potassium,":[45],"calcium,":[46],"chloride":[47,205],"phosphorus":[49],"on":[50,133],"\u03b2":[55,58],"-lactoglobulin":[56],"(":[57],"-lg)":[59],"particle":[61],"dispersions":[62,77],"ultra-high":[64],"temperature":[65],"(UHT)":[66],"treatment.":[67],"Gelation":[68,144],"was":[69,145],"assessed":[70],"after":[71],"UHT-mimicking":[72],"treatment":[73,103],"by":[74,92,147],"visually":[75],"classifying":[76],"with":[78,180],"varying":[79],"(1\u201310":[81],"wt%)":[82],"salt":[84,110,161,168,192,216],"(0\u2013500":[85],"mM)":[86],"concentrations":[87,158,193],"as":[88,104],"liquid":[89,97],"or":[90,185,206],"gel":[91,99],"inversion.":[93],"State":[94],"diagrams,":[95],"separating":[96],"regions":[100],"following":[101],"UHT":[102],"function":[106],"concentration,":[111,149],"were":[112],"constructed":[113],"for":[114,163,171,183,204,234],"sodium":[115,121,124,184],"chloride,":[116,118,120],"potassium":[117],"calcium":[119],"citrate":[122],"phosphate":[125],"using":[126],"an":[127],"optimized":[128],"sequential":[129],"sampling":[130],"algorithm":[131],"focused":[132],"experiments":[134],"near":[135],"liquid-gel":[137],"boundary,":[138],"minimizing":[139],"number":[141],"experiments.":[143],"governed":[146],"salt-to-protein":[150],"ratio,":[151],"ion":[152],"type,":[153],"pH.":[155],"Higher":[156],"lowered":[159],"threshold":[162],"gelation.":[164,219],"Calcium":[165],"reduced":[166],"concentration":[169],"required":[170],"to":[173,190,201,245],"0.8":[174],"mM":[175,182,196,203],"1%":[177,198],"protein,":[178,199],"compared":[179],"15":[181,202],"potassium.":[186],"Citrate":[187],"shifted":[188],"higher":[191],"60":[195],"relative":[200],"phosphate.":[207],"values":[209],"further":[210],"from":[211],"isoelectric":[213],"point":[214],"increased":[215],"tolerance":[217],"before":[218],"Aggregation":[220],"could":[221],"be":[222],"observed":[223],"below":[224],"threshold.":[227],"The":[228],"state":[229],"diagrams":[230],"provide":[231],"framework":[233],"predicting":[235],"heat-induced":[236],"structuring":[237],"support":[239],"formulation":[240],"subjected":[244],"preservative":[246],"treatments.":[248]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-28T00:00:00"}