{"id":"https://openalex.org/W7223953458","doi":"https://doi.org/10.1172/jci.insight.208926","title":"AVIL is dispensable for baseline neurobehavioral and somatosensory function in mice","display_name":"AVIL is dispensable for baseline neurobehavioral and somatosensory function in mice","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7223953458","doi":"https://doi.org/10.1172/jci.insight.208926","pmid":"https://pubmed.ncbi.nlm.nih.gov/42944752"},"language":"en","primary_location":{"id":"doi:10.1172/jci.insight.208926","doi":"https://doi.org/10.1172/jci.insight.208926","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.208926","pdf_url":"http://insight.jci.org/articles/view/208926/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://insight.jci.org/articles/view/208926/files/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078428022","display_name":"Sarah A. Lynch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah A. Lynch","raw_affiliation_strings":["Department of Pathology, School of Medicine, University of Virginia, Charlottesville, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, University of Virginia, Charlottesville, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124081681","display_name":"Martyna Glowczyk-Gluc","orcid":"https://orcid.org/0009-0006-2222-0604","observed_orcids":["https://orcid.org/0009-0006-2222-0604"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martyna Glowczyk-Gluc","raw_affiliation_strings":["Department of Pathology, School of Medicine, University of Virginia, Charlottesville, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, University of Virginia, Charlottesville, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123358879","display_name":"Yiwei Wang","orcid":"https://orcid.org/0009-0005-5697-2276","observed_orcids":["https://orcid.org/0009-0005-5697-2276"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiwei Wang","raw_affiliation_strings":["Department of Pathology, School of Medicine, University of Virginia, Charlottesville, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, University of Virginia, Charlottesville, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045831304","display_name":"Summer Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Summer Johnson","raw_affiliation_strings":["Department of Pathology, School of Medicine, University of Virginia, Charlottesville, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, University of Virginia, Charlottesville, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124068114","display_name":"Xinrui Shi","orcid":"https://orcid.org/0009-0003-1739-8895","observed_orcids":["https://orcid.org/0009-0003-1739-8895"]},"institutions":[{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinrui Shi","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, United States of America","institution_ids":["https://openalex.org/I4210134211","https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138875648","display_name":"Abdul-Salam Gidado","orcid":"https://orcid.org/0009-0000-0054-3724","observed_orcids":["https://orcid.org/0009-0000-0054-3724"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdul-Salam Gidado","raw_affiliation_strings":["Department of Pathology, School of Medicine, University of Virginia, Charlottesville, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, University of Virginia, Charlottesville, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062269455","display_name":"Alexis M. Johnson","orcid":"https://orcid.org/0000-0003-2943-6847","observed_orcids":["https://orcid.org/0000-0003-2943-6847"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis Johnson","raw_affiliation_strings":["Department of Neuroscience, University of Virginia, Charlottesville, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2943-6847","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Virginia, Charlottesville, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026328537","display_name":"Christopher D. Deppmann","orcid":"https://orcid.org/0000-0002-6591-1767","observed_orcids":["https://orcid.org/0000-0002-6591-1767"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Deppmann","raw_affiliation_strings":["Department of Biology, University of Virginia, Charlottesville, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6591-1767","affiliations":[{"raw_affiliation_string":"Department of Biology, University of Virginia, Charlottesville, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071448130","display_name":"John R. Lukens","orcid":"https://orcid.org/0000-0002-6795-0866","observed_orcids":["https://orcid.org/0000-0002-6795-0866"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Lukens","raw_affiliation_strings":["Department of Neuroscience, University of Virginia, Charlottesville, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6795-0866","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Virginia, Charlottesville, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100634516","display_name":"Hui Li","orcid":"https://orcid.org/0000-0002-7879-1792","observed_orcids":["https://orcid.org/0000-0002-7879-1792"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Li","raw_affiliation_strings":["Department of Pathology, School of Medicine, University of Virginia, Charlottesville, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7879-1792","affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, University of Virginia, Charlottesville, United States of America","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81141518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.14900000393390656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.14900000393390656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.10830000042915344,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.10440000146627426,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurobehavioral-functioning","display_name":"neurobehavioral function","score":0.7009999752044678},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.7459999918937683},{"id":"https://openalex.org/keywords/exploratory-behavior","display_name":"exploratory behavior","score":0.8889999985694885},{"id":"https://openalex.org/keywords/motor-coordination","display_name":"motor coordination","score":0.9399999976158142},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.8479999899864197},{"id":"https://openalex.org/keywords/emotional-responses","display_name":"emotional responses","score":0.7239999771118164},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tactile-sensitivity","display_name":"tactile sensitivity","score":0.890999972820282},{"id":"https://openalex.org/keywords/peripheral-sensory-neurons","display_name":"peripheral sensory neurons","score":0.8500000238418579},{"id":"https://openalex.org/keywords/merkel-cells","display_name":"Merkel cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/low-grade-glioma","display_name":"low-grade glioma","score":0.7129999995231628},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/rhabdomyosarcoma","display_name":"rhabdomyosarcoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.6079999804496765},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C172497186","wikidata":"https://www.wikidata.org/wiki/Q328835","display_name":"Somatosensory system","level":2,"score":0.8546000123023987},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.7440999746322632},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.6728000044822693},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6496000289916992},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5769000053405762},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5116999745368958},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.48539999127388},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.48240000009536743},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.3610999882221222},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.3610999882221222},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3569999933242798},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.31369999051094055},{"id":"https://openalex.org/C2909026353","wikidata":"https://www.wikidata.org/wiki/Q2712836","display_name":"Quantitative sensory testing","level":3,"score":0.3057999908924103},{"id":"https://openalex.org/C49409089","wikidata":"https://www.wikidata.org/wiki/Q7674137","display_name":"Tactile discrimination","level":3,"score":0.30550000071525574},{"id":"https://openalex.org/C113062710","wikidata":"https://www.wikidata.org/wiki/Q2463100","display_name":"Motor coordination","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.29280000925064087},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.29109999537467957},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.2881999909877777},{"id":"https://openalex.org/C110235638","wikidata":"https://www.wikidata.org/wiki/Q17119820","display_name":"Sensory threshold","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C164659718","wikidata":"https://www.wikidata.org/wiki/Q5159266","display_name":"Conditional gene knockout","level":4,"score":0.2669000029563904},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.25679999589920044},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25270000100135803},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25189998745918274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.251800000667572}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1172/jci.insight.208926","doi":"https://doi.org/10.1172/jci.insight.208926","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.208926","pdf_url":"http://insight.jci.org/articles/view/208926/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},{"id":"pmid:42944752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42944752","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI insight","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci.insight.208926","doi":"https://doi.org/10.1172/jci.insight.208926","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.208926","pdf_url":"http://insight.jci.org/articles/view/208926/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317351","display_name":"UVA Cancer Center","ror":"https://ror.org/04w75nz84"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223953458.pdf","grobid_xml":"https://content.openalex.org/works/W7223953458.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2753084136"],"related_works":["https://openalex.org/W3089139789","https://openalex.org/W4414740867","https://openalex.org/W3041602947","https://openalex.org/W2937773127","https://openalex.org/W1970073314","https://openalex.org/W2093696471","https://openalex.org/W4255316986","https://openalex.org/W2153968156","https://openalex.org/W2041683834","https://openalex.org/W4386524538"],"abstract_inverted_index":{"Advillin":[0],"(AVIL)":[1],"is":[2],"an":[3,36],"actin-binding":[4],"protein":[5],"expressed":[6],"in":[7,17,66,119,197],"peripheral":[8,108,154],"sensory":[9,100,171],"neurons":[10],"and":[11,24,29,44,56,63,69,78,86,93,95,98,126,135,138,157,170],"Merkel":[12],"cells,":[13],"but":[14],"aberrantly":[15],"upregulated":[16],"several":[18],"malignancies,":[19],"including":[20],"low-grade":[21],"glioma,":[22],"glioblastoma,":[23],"rhabdomyosarcoma.":[25],"AVIL's":[26],"oncogenic":[27],"activity":[28],"restricted":[30],"adult":[31],"tissue":[32],"expression":[33],"make":[34],"it":[35],"attractive":[37],"therapeutic":[38,195],"target;":[39],"however,":[40],"its":[41],"physiological":[42],"function":[43,101],"the":[45,186],"safety":[46],"of":[47,59,107,144,180],"AVIL":[48,115,190],"inhibition":[49,143,184],"remain":[50],"incompletely":[51],"understood.":[52],"We":[53],"evaluated":[54,103],"genetic":[55],"pharmacologic":[57,142,183],"targeting":[58],"Avil":[60,71,175],"using":[61],"neurobehavioral":[62],"somatosensory":[64],"assays":[65],"vivo.":[67,120],"Constitutive":[68],"conditional":[70],"knockout":[72],"mice,":[73],"generated":[74],"by":[75],"exons":[76],"7":[77],"8":[79],"deletion,":[80],"underwent":[81],"behavioral":[82,169],"testing":[83],"assessing":[84],"anxiety-related":[85,127],"exploratory":[87,125],"behaviors,":[88],"motor":[89,130],"coordination,":[90,131],"affective":[91,133],"responses,":[92,134],"learning":[94,137],"memory.":[96,139],"Nociceptive":[97],"tactile":[99,151],"were":[102,160],"alongside":[104],"histologic":[105,158],"analysis":[106],"mechanosensory":[109,155],"architecture.":[110],"In":[111],"parallel,":[112],"a":[113,192],"first-in-class":[114],"inhibitor":[116],"was":[117],"assessed":[118],"Avil-deficient":[121],"mice":[122],"exhibited":[123],"normal":[124],"behavior,":[128],"intact":[129],"preserved":[132,167],"unaltered":[136],"Loss":[140],"or":[141,153],"advillin":[145],"did":[146],"not":[147,161],"impair":[148],"nociceptive":[149],"processing,":[150],"sensitivity,":[152],"architecture,":[156],"abnormalities":[159],"detected.":[162],"Together,":[163],"these":[164],"findings":[165],"show":[166],"baseline":[168],"outcomes":[172],"following":[173,182],"lifelong":[174],"loss,":[176],"with":[177],"complementary":[178],"evidence":[179],"tolerability":[181],"under":[185],"conditions":[187],"tested,":[188],"supporting":[189],"as":[191],"potentially":[193],"well-tolerated":[194],"target":[196],"cancer.":[198]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-28T00:00:00"}