{"id":"https://openalex.org/W7223937652","doi":"https://doi.org/10.3791/72614","title":"Analgesic and Sedative Effect of Acupuncture Combined with Medicine on Patients Undergoing Cardiac Surgery","display_name":"Analgesic and Sedative Effect of Acupuncture Combined with Medicine on Patients Undergoing Cardiac Surgery","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7223937652","doi":"https://doi.org/10.3791/72614","pmid":"https://pubmed.ncbi.nlm.nih.gov/42949155"},"language":"en","primary_location":{"id":"doi:10.3791/72614","doi":"https://doi.org/10.3791/72614","is_oa":false,"landing_page_url":"https://doi.org/10.3791/72614","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159919960","display_name":"Bixia Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bixia Huang","raw_affiliation_strings":["Department of Critical Care Medicine, Xinchang County Hospital of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Xinchang County Hospital of Traditional Chinese Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159849387","display_name":"Hailong Ding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hailong Ding","raw_affiliation_strings":["Department of Critical Care Medicine, Xinchang County Hospital of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Xinchang County Hospital of Traditional Chinese Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159905460","display_name":"Wei Liang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Liang","raw_affiliation_strings":["Department of Critical Care Medicine, Xinchang County Hospital of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Xinchang County Hospital of Traditional Chinese Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159808780","display_name":"Lingen Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingen Xu","raw_affiliation_strings":["Department of Critical Care Medicine, Xinchang County Hospital of Traditional Chinese Medicine; xlger@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Xinchang County Hospital of Traditional Chinese Medicine; xlger@163.com","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.89144591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"236","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acupuncture","display_name":"acupuncture","score":0.9850000143051147},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.890999972820282},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiac-surgery","display_name":"cardiac surgery","score":0.9739999771118164},{"id":"https://openalex.org/keywords/perioperative-pain","display_name":"perioperative pain","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8845999836921692},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7299000024795532},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.7279000282287598},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.6211000084877014},{"id":"https://openalex.org/C2777602617","wikidata":"https://www.wikidata.org/wiki/Q847705","display_name":"Sedative","level":2,"score":0.6140999794006348},{"id":"https://openalex.org/C56837625","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture","level":3,"score":0.5139999985694885},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3474000096321106},{"id":"https://openalex.org/C2910179533","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture analgesia","level":5,"score":0.34389999508857727},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.3212999999523163},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.28119999170303345},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.25949999690055847}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003964","descriptor_name":"Diaphragm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003964","descriptor_name":"Diaphragm","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006348","descriptor_name":"Cardiac Surgical Procedures","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015667","descriptor_name":"Acupuncture Analgesia","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015670","descriptor_name":"Acupuncture Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3791/72614","doi":"https://doi.org/10.3791/72614","is_oa":false,"landing_page_url":"https://doi.org/10.3791/72614","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},{"id":"pmid:42949155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42949155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of visualized experiments : JoVE","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2463014814","https://openalex.org/W4300933524","https://openalex.org/W3024389060","https://openalex.org/W2417418394","https://openalex.org/W2139178283","https://openalex.org/W2409138569","https://openalex.org/W2411154783","https://openalex.org/W2468278296","https://openalex.org/W2402496812","https://openalex.org/W2421841795"],"abstract_inverted_index":{"Acupuncture":[0],"(AP)":[1],"has":[2],"been":[3],"reported":[4],"to":[5,54],"modulate":[6],"inflammation":[7],"and":[8,41,56,62,64,79,97,109,124,162,166,171,185,189,193,211,230,235,238],"oxidative":[9,98,172,190],"stress,":[10],"but":[11],"whether":[12,34],"it":[13],"can":[14],"reduce":[15],"dexmedetomidine":[16],"(Dex)":[17],"requirements":[18,234],"or":[19],"protect":[20],"against":[21],"Dex-induced":[22,239],"diaphragm":[23,160,183,240],"toxicity":[24],"during":[25],"mechanical":[26],"ventilation":[27],"(MV)":[28],"remains":[29],"unknown.":[30],"This":[31],"study":[32],"investigated":[33],"AP":[35,60,127,181,215,227],"could":[36],"alleviate":[37],"Dex-aggravated":[38],"diaphragmatic":[39],"dysfunction":[40,241],"explored":[42],"its":[43,224],"underlying":[44],"mechanisms,":[45],"focusing":[46],"on":[47],"autophagy.":[48,247],"Female":[49],"Sprague-Dawley":[50],"rats":[51,243],"were":[52,82,116],"subjected":[53],"MV":[55,146,158,192,194],"treated":[57],"with":[58],"Dex,":[59],"(Baihui":[61],"Yintang),":[63],"the":[65,119,129,145],"autophagy":[66],"inducer":[67],"rapamycin":[68],"(RAPA).":[69],"Arterial":[70],"blood":[71,76],"gas":[72],"parameters,":[73,179],"vital":[74],"signs,":[75],"cell":[77],"counts,":[78],"sedative":[80],"dosage":[81,132],"recorded.":[83],"Diaphragm":[84],"function":[85,184],"was":[86],"evaluated":[87],"by":[88,133,203,244],"measuring":[89],"contractile":[90],"force,":[91],"muscle":[92],"fiber":[93],"cross-sectional":[94,164],"area,":[95],"apoptosis,":[96,170,188],"stress":[99,173],"markers,":[100],"including":[101],"superoxide":[102],"dismutase":[103],"(SOD),":[104],"catalase":[105],"(CAT),":[106],"malondialdehyde":[107],"(MDA),":[108],"angiotensin":[110],"II":[111],"(ANG":[112],"II).":[113],"Autophagy":[114],"levels":[115],"assessed":[117],"using":[118],"LC3-II/LC3-I":[120,209],"ratio,":[121,210],"p62":[122,213],"expression,":[123,169],"autophagosome":[125],"accumulation.":[126],"reduced":[128,232],"total":[130],"Dex":[131,148,175,196,233],"54.7%":[134],"(0.102":[135],"\u00b1":[136,141],"0.005":[137],"mg":[138,143],"vs.":[139],"0.225":[140],"0.009":[142],"in":[144,242],"+":[147,195],"group,":[149],"p":[150],"<":[151],"0.001)":[152],"while":[153,220],"maintaining":[154],"stable":[155],"physiological":[156],"parameters.":[157],"decreased":[159,212],"contractility":[161],"myofiber":[163],"area":[165],"increased":[167,208],"MAFbx":[168],"markers.":[174],"further":[176],"worsened":[177],"these":[178,217],"whereas":[180],"improved":[182],"attenuated":[186],"atrophy,":[187],"stress.":[191],"groups":[197],"exhibited":[198],"excessive":[199,246],"autophagy,":[200],"as":[201],"shown":[202],"autophagic":[204,218],"vacuole":[205],"accumulation,":[206],"an":[207],"expression.":[214],"inhibited":[216],"changes,":[219],"RAPA":[221],"partially":[222],"reversed":[223],"protective":[225],"effects.":[226],"at":[228],"Baihui":[229],"Yintang":[231],"alleviated":[236],"MV-":[237],"inhibiting":[245]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-28T00:00:00"}