{"id":"https://openalex.org/W7223936619","doi":"https://doi.org/10.1093/jahafs/vsag015","title":"Gas bubble disease in the upside-down jellyfish Cassiopea sp.: Experimental induction and histopathological characterization","display_name":"Gas bubble disease in the upside-down jellyfish Cassiopea sp.: Experimental induction and histopathological characterization","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7223936619","doi":"https://doi.org/10.1093/jahafs/vsag015","pmid":"https://pubmed.ncbi.nlm.nih.gov/42937189"},"language":"en","primary_location":{"id":"doi:10.1093/jahafs/vsag015","doi":"https://doi.org/10.1093/jahafs/vsag015","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jahafs/vsag015","pdf_url":null,"source":{"id":"https://openalex.org/S194317145","display_name":"Journal of Aquatic Animal Health","issn_l":"0899-7659","issn":["0899-7659","1548-8667"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Aquatic Animal Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/jahafs/vsag015","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001518775","display_name":"Young Jin Ryu","orcid":"https://orcid.org/0000-0001-5222-3749","observed_orcids":["https://orcid.org/0000-0001-5222-3749","https://orcid.org/0009-0001-4862-7270"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Jin Ryu","raw_affiliation_strings":["College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University , Chuncheon ,"],"raw_orcid":"https://orcid.org/0009-0001-4862-7270","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University , Chuncheon ,","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101752899","display_name":"Ji\u2010Hyung Park","orcid":"https://orcid.org/0000-0002-8210-3198","observed_orcids":["https://orcid.org/0000-0002-8210-3198"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Hyung Park","raw_affiliation_strings":["College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University , Chuncheon ,"],"raw_orcid":"https://orcid.org/0000-0002-8210-3198","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University , Chuncheon ,","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060951283","display_name":"Seung Hyeok Seok","orcid":"https://orcid.org/0000-0002-4315-0688","observed_orcids":["https://orcid.org/0000-0002-4315-0688"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seung Hyeok Seok","raw_affiliation_strings":["Cancer Research Institute, Seoul National University , Seoul ,","Department of Biomedical Sciences, Seoul National University College of Medicine , Seoul ,","Institute of Endemic Diseases, Seoul National University Medical Research Center , Seoul ,","Macrophage Lab, Department of Microbiology and Immunology, and Institute of Endemic Disease, College of Medicine, Seoul\u00a0National University , Seoul ,"],"raw_orcid":"https://orcid.org/0000-0002-4315-0688","affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University , Seoul ,","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Seoul National University College of Medicine , Seoul ,","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Institute of Endemic Diseases, Seoul National University Medical Research Center , Seoul ,","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Macrophage Lab, Department of Microbiology and Immunology, and Institute of Endemic Disease, College of Medicine, Seoul\u00a0National University , Seoul ,","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102918972","display_name":"Sang Wha Kim","orcid":"https://orcid.org/0000-0001-7205-7741","observed_orcids":["https://orcid.org/0000-0001-7205-7741"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang Wha Kim","raw_affiliation_strings":["College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University , Chuncheon ,"],"raw_orcid":"https://orcid.org/0000-0001-7205-7741","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University , Chuncheon ,","institution_ids":["https://openalex.org/I165507594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060951283","https://openalex.org/A5102918972"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I165507594"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82146855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1911","display_name":"Paleontology"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1911","display_name":"Paleontology"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11401","display_name":"Minerals Flotation and Separation Techniques","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gas-bubble-disease","display_name":"gas bubble disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cassiopea","display_name":"Cassiopea","score":0.9430000185966492},{"id":"https://openalex.org/keywords/upside-down-jellyfish","display_name":"upside-down jellyfish","score":0.984000027179718},{"id":"https://openalex.org/keywords/microbubbles","display_name":"microbubbles","score":0.9520000219345093},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.8009999990463257},{"id":"https://openalex.org/keywords/gas-supersaturation","display_name":"gas supersaturation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/behavior-change","display_name":"behavior change","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C2779735984","wikidata":"https://www.wikidata.org/wiki/Q30178","display_name":"Jellyfish","level":2,"score":0.9843999743461609},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6389999985694885},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.4586000144481659},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.4187999963760376},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.4162999987602234},{"id":"https://openalex.org/C2776927070","wikidata":"https://www.wikidata.org/wiki/Q26864","display_name":"Aurelia aurita","level":3,"score":0.40689998865127563},{"id":"https://openalex.org/C2777807006","wikidata":"https://www.wikidata.org/wiki/Q5530379","display_name":"Gelatinous zooplankton","level":3,"score":0.38040000200271606},{"id":"https://openalex.org/C88676905","wikidata":"https://www.wikidata.org/wiki/Q75794","display_name":"Liquid bubble","level":3,"score":0.337799996137619},{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.31459999084472656},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.29510000348091125},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2703000009059906}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/jahafs/vsag015","doi":"https://doi.org/10.1093/jahafs/vsag015","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jahafs/vsag015","pdf_url":null,"source":{"id":"https://openalex.org/S194317145","display_name":"Journal of Aquatic Animal Health","issn_l":"0899-7659","issn":["0899-7659","1548-8667"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Aquatic Animal Health","raw_type":"journal-article"},{"id":"pmid:42937189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42937189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of aquatic animal health","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/jahafs/vsag015","doi":"https://doi.org/10.1093/jahafs/vsag015","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jahafs/vsag015","pdf_url":null,"source":{"id":"https://openalex.org/S194317145","display_name":"Journal of Aquatic Animal Health","issn_l":"0899-7659","issn":["0899-7659","1548-8667"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Aquatic Animal Health","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1971317451","https://openalex.org/W1976926002","https://openalex.org/W1982072122","https://openalex.org/W1987172009","https://openalex.org/W2038279349","https://openalex.org/W2044921680","https://openalex.org/W2047535992","https://openalex.org/W2048509743","https://openalex.org/W2083716121","https://openalex.org/W2111389637","https://openalex.org/W2151187256","https://openalex.org/W2511942253","https://openalex.org/W2591720094","https://openalex.org/W2886174005","https://openalex.org/W2889799106","https://openalex.org/W2982116934","https://openalex.org/W3159972119","https://openalex.org/W3170712261","https://openalex.org/W4210495802","https://openalex.org/W4292231176","https://openalex.org/W4295094412","https://openalex.org/W4296332279","https://openalex.org/W4323359620","https://openalex.org/W4392284073","https://openalex.org/W4404937730"],"related_works":["https://openalex.org/W4414743531","https://openalex.org/W2736233703","https://openalex.org/W2919737842","https://openalex.org/W2038279349","https://openalex.org/W1733496951","https://openalex.org/W7217101349","https://openalex.org/W2055689546","https://openalex.org/W223375406","https://openalex.org/W2024145818","https://openalex.org/W4404937730"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Jellyfish":[1],"are":[2],"known":[3,13],"to":[4,8,44,59,77,111,152],"be":[5,78],"difficult":[6],"species":[7],"breed,":[9],"yet":[10],"little":[11],"is":[12],"about":[14],"the":[15,23,60,71,81,90,150],"diseases":[16],"that":[17,128,137],"affect":[18],"them.":[19],"This":[20,134],"study":[21,135],"investigated":[22],"behavioral":[24],"and":[25,46,103,120,148],"histopathological":[26],"changes":[27],"caused":[28],"by":[29,64],"gas":[30,154],"bubble":[31],"disease":[32],"(GBD)":[33],"in":[34,70,89,145],"upside-down":[35,86,146],"jellyfish":[36,41,87,147,157],"Cassiopea":[37],"sp.":[38],"METHODS:":[39],"Upside-down":[40],"were":[42,57,99,123],"assigned":[43],"control":[45],"microbubble-exposed":[47,91],"tanks":[48],"(n":[49],"=":[50],"7":[51],"each;":[52],"36":[53],"L":[54],"size).":[55],"Microbubbles":[56],"supplied":[58],"experimental":[61],"group":[62],"tank":[63,92],"inducing":[65],"an":[66],"insufficient":[67],"water":[68],"level":[69],"sump":[72],"tank,":[73],"which":[74,109],"allowed":[75],"air":[76],"entrained":[79],"into":[80],"return":[82],"pump.":[83],"RESULT:":[84],"All":[85],"maintained":[88],"exhibited":[93],"signs":[94],"of":[95,118],"GBD.":[96,132],"Gas":[97],"bubbles":[98],"observed":[100],"both":[101],"grossly":[102],"histologically,":[104],"along":[105],"with":[106],"chronic":[107],"lesions,":[108],"progressed":[110],"bell":[112],"ulceration.":[113],"Behavioral":[114],"changes,":[115],"including":[116],"loss":[117],"equilibrium":[119],"abnormal":[121],"pulsation,":[122],"observed.":[124],"These":[125],"results":[126],"demonstrate":[127],"excessive":[129,138],"microbubbles":[130],"induce":[131,143],"CONCLUSION:":[133],"demonstrates":[136],"microbubble":[139],"exposure":[140],"can":[141],"experimentally":[142],"GBD":[144],"highlights":[149],"need":[151],"monitor":[153],"supersaturation":[155],"during":[156],"rearing.":[158]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-28T00:00:00"}