{"id":"https://openalex.org/W7223928432","doi":"https://doi.org/10.1002/iid3.70569","title":"Allergen Immunotherapy and 36\u2010Month Allergic Respiratory Disease Trajectories: A Target\u2010Trial","display_name":"Allergen Immunotherapy and 36\u2010Month Allergic Respiratory Disease Trajectories: A Target\u2010Trial","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223928432","doi":"https://doi.org/10.1002/iid3.70569","pmid":"https://pubmed.ncbi.nlm.nih.gov/42934766","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13710663"},"language":"en","primary_location":{"id":"doi:10.1002/iid3.70569","doi":"https://doi.org/10.1002/iid3.70569","is_oa":true,"landing_page_url":"https://doi.org/10.1002/iid3.70569","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iid3.70569","source":{"id":"https://openalex.org/S2764380340","display_name":"Immunity Inflammation and Disease","issn_l":"2050-4527","issn":["2050-4527"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity, Inflammation and Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iid3.70569","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043138222","display_name":"V\u00edctor Gonz\u00e1lez-Uribe","orcid":"https://orcid.org/0000-0001-9053-7108","observed_orcids":["https://orcid.org/0000-0001-9053-7108"]},"institutions":[{"id":"https://openalex.org/I4210149727","display_name":"Universidad La Salle","ror":"https://ror.org/05c99rg80","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210149727"]},{"id":"https://openalex.org/I4405284794","display_name":"AlergiaMx","ror":"https://ror.org/04724ps82","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4405284794"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"V\u00edctor Gonzalez\u2010Uribe","raw_affiliation_strings":["AlergiaMx Mexico City Mexico","Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico"],"raw_orcid":"https://orcid.org/0000-0001-9053-7108","affiliations":[{"raw_affiliation_string":"AlergiaMx Mexico City Mexico","institution_ids":["https://openalex.org/I4405284794"]},{"raw_affiliation_string":"Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico","institution_ids":["https://openalex.org/I4210149727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147156317","display_name":"Sebastian Moreno\u2010Castro","orcid":"https://orcid.org/0009-0005-7705-6162","observed_orcids":["https://orcid.org/0009-0005-7705-6162"]},"institutions":[{"id":"https://openalex.org/I4210149727","display_name":"Universidad La Salle","ror":"https://ror.org/05c99rg80","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210149727"]},{"id":"https://openalex.org/I4405284794","display_name":"AlergiaMx","ror":"https://ror.org/04724ps82","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4405284794"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Sebastian Moreno\u2010Castro","raw_affiliation_strings":["AlergiaMx Mexico City Mexico","Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico"],"raw_orcid":"https://orcid.org/0009-0005-7705-6162","affiliations":[{"raw_affiliation_string":"AlergiaMx Mexico City Mexico","institution_ids":["https://openalex.org/I4405284794"]},{"raw_affiliation_string":"Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico","institution_ids":["https://openalex.org/I4210149727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119429476","display_name":"Viviana Cardoso-P\u00e9rez","orcid":"https://orcid.org/0009-0006-0710-4998","observed_orcids":["https://orcid.org/0009-0006-0710-4998"]},"institutions":[{"id":"https://openalex.org/I4210149727","display_name":"Universidad La Salle","ror":"https://ror.org/05c99rg80","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210149727"]},{"id":"https://openalex.org/I4405284794","display_name":"AlergiaMx","ror":"https://ror.org/04724ps82","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4405284794"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Viviana Cardoso\u2010Perez","raw_affiliation_strings":["AlergiaMx Mexico City Mexico","Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico"],"raw_orcid":"https://orcid.org/0009-0006-0710-4998","affiliations":[{"raw_affiliation_string":"AlergiaMx Mexico City Mexico","institution_ids":["https://openalex.org/I4405284794"]},{"raw_affiliation_string":"Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico","institution_ids":["https://openalex.org/I4210149727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159782946","display_name":"Diego A Mares\u2010Mateos","orcid":"https://orcid.org/0009-0002-8197-7077","observed_orcids":["https://orcid.org/0009-0002-8197-7077"]},"institutions":[{"id":"https://openalex.org/I4210149727","display_name":"Universidad La Salle","ror":"https://ror.org/05c99rg80","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210149727"]},{"id":"https://openalex.org/I4405284794","display_name":"AlergiaMx","ror":"https://ror.org/04724ps82","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4405284794"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Diego A Mares\u2010Mateos","raw_affiliation_strings":["AlergiaMx Mexico City Mexico","Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico"],"raw_orcid":"https://orcid.org/0009-0002-8197-7077","affiliations":[{"raw_affiliation_string":"AlergiaMx Mexico City Mexico","institution_ids":["https://openalex.org/I4405284794"]},{"raw_affiliation_string":"Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico","institution_ids":["https://openalex.org/I4210149727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159760787","display_name":"Mariel Paez\u2010Reyes","orcid":"https://orcid.org/0009-0006-7640-3860","observed_orcids":["https://orcid.org/0009-0006-7640-3860"]},"institutions":[{"id":"https://openalex.org/I4210149727","display_name":"Universidad La Salle","ror":"https://ror.org/05c99rg80","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210149727"]},{"id":"https://openalex.org/I4405284794","display_name":"AlergiaMx","ror":"https://ror.org/04724ps82","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4405284794"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mariel Paez\u2010Reyes","raw_affiliation_strings":["AlergiaMx Mexico City Mexico","Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico"],"raw_orcid":"https://orcid.org/0009-0006-7640-3860","affiliations":[{"raw_affiliation_string":"AlergiaMx Mexico City Mexico","institution_ids":["https://openalex.org/I4405284794"]},{"raw_affiliation_string":"Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico","institution_ids":["https://openalex.org/I4210149727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093325867","display_name":"Jimena Prieto-Gomez","orcid":"https://orcid.org/0009-0000-7455-002X","observed_orcids":["https://orcid.org/0009-0000-7455-002X"]},"institutions":[{"id":"https://openalex.org/I4210149727","display_name":"Universidad La Salle","ror":"https://ror.org/05c99rg80","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210149727"]},{"id":"https://openalex.org/I4405284794","display_name":"AlergiaMx","ror":"https://ror.org/04724ps82","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4405284794"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jimena Prieto\u2010Gomez","raw_affiliation_strings":["AlergiaMx Mexico City Mexico","Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico"],"raw_orcid":"https://orcid.org/0009-0000-7455-002X","affiliations":[{"raw_affiliation_string":"AlergiaMx Mexico City Mexico","institution_ids":["https://openalex.org/I4405284794"]},{"raw_affiliation_string":"Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico","institution_ids":["https://openalex.org/I4210149727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056682980","display_name":"Ricardo Mart\u00ednez-Tenopala","orcid":"https://orcid.org/0000-0001-5175-3828","observed_orcids":["https://orcid.org/0000-0001-5175-3828"]},"institutions":[{"id":"https://openalex.org/I4210149727","display_name":"Universidad La Salle","ror":"https://ror.org/05c99rg80","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210149727"]},{"id":"https://openalex.org/I4405284794","display_name":"AlergiaMx","ror":"https://ror.org/04724ps82","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4405284794"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ricardo Martinez\u2010Tenopala","raw_affiliation_strings":["AlergiaMx Mexico City Mexico","Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico"],"raw_orcid":"https://orcid.org/0000-0001-5175-3828","affiliations":[{"raw_affiliation_string":"AlergiaMx Mexico City Mexico","institution_ids":["https://openalex.org/I4405284794"]},{"raw_affiliation_string":"Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico","institution_ids":["https://openalex.org/I4210149727"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021734710","display_name":"Paola de Baro-\u00c1lvarez","orcid":"https://orcid.org/0009-0006-8519-2030","observed_orcids":["https://orcid.org/0009-0006-8519-2030"]},"institutions":[{"id":"https://openalex.org/I4210149727","display_name":"Universidad La Salle","ror":"https://ror.org/05c99rg80","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210149727"]},{"id":"https://openalex.org/I4405284794","display_name":"AlergiaMx","ror":"https://ror.org/04724ps82","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4405284794"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Paola de Baro Alvarez","raw_affiliation_strings":["AlergiaMx Mexico City Mexico","Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico"],"raw_orcid":"https://orcid.org/0009-0006-8519-2030","affiliations":[{"raw_affiliation_string":"AlergiaMx Mexico City Mexico","institution_ids":["https://openalex.org/I4405284794"]},{"raw_affiliation_string":"Facultad Mexicana de Medicina Universidad La Salle M\u00e9xico Mexico City Mexico","institution_ids":["https://openalex.org/I4210149727"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043138222"],"corresponding_institution_ids":["https://openalex.org/I4210149727","https://openalex.org/I4405284794"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81605738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergen-immunotherapy","display_name":"allergen immunotherapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sublingual-immunotherapy","display_name":"sublingual immunotherapy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/respiratory-allergic-diseases","display_name":"allergic respiratory diseases","score":0.9729999899864197},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.609000027179718},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8809999823570251},{"id":"https://openalex.org/keywords/clinical-remission","display_name":"clinical remission","score":0.8149999976158142},{"id":"https://openalex.org/keywords/asthma-control","display_name":"asthma control","score":0.6819999814033508},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9300000071525574},{"id":"https://openalex.org/keywords/exhaled-nitric-oxide","display_name":"exhaled nitric oxide","score":0.9950000047683716},{"id":"https://openalex.org/keywords/treatment-initiation","display_name":"treatment initiation","score":0.3659999966621399},{"id":"https://openalex.org/keywords/residual-confounding","display_name":"residual confounding","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9312999844551086},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.637499988079071},{"id":"https://openalex.org/C2779787640","wikidata":"https://www.wikidata.org/wiki/Q1641412","display_name":"Allergen immunotherapy","level":4,"score":0.6284999847412109},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5723000168800354},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5558000206947327},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5278000235557556},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.49779999256134033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48399999737739563},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4839000105857849},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.47380000352859497},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.3977999985218048},{"id":"https://openalex.org/C3020633164","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Allergic asthma","level":3,"score":0.3774000108242035},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37470000982284546},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.362199991941452},{"id":"https://openalex.org/C2781142857","wikidata":"https://www.wikidata.org/wiki/Q5420174","display_name":"Exhaled nitric oxide","level":4,"score":0.35179999470710754},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.3490000069141388},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3458999991416931},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.3458000123500824},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.2992999851703644},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.2955999970436096},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.2937999963760376},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.28380000591278076},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.28279998898506165},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2727999985218048}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003888","descriptor_name":"Desensitization, Immunologic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008800","descriptor_name":"Mexico","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063729","descriptor_name":"Sublingual Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/iid3.70569","doi":"https://doi.org/10.1002/iid3.70569","is_oa":true,"landing_page_url":"https://doi.org/10.1002/iid3.70569","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iid3.70569","source":{"id":"https://openalex.org/S2764380340","display_name":"Immunity Inflammation and Disease","issn_l":"2050-4527","issn":["2050-4527"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity, Inflammation and Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13710663","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710663/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710663/pdf/IID3-14-e70569.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immun Inflamm Dis","raw_type":"Text"},{"id":"pmid:42934766","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42934766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity, inflammation and disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f783574272a144baaa7432dd6745370e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f783574272a144baaa7432dd6745370e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Immunity, Inflammation and Disease, Vol 14, Iss 10, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/iid3.70569","doi":"https://doi.org/10.1002/iid3.70569","is_oa":true,"landing_page_url":"https://doi.org/10.1002/iid3.70569","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iid3.70569","source":{"id":"https://openalex.org/S2764380340","display_name":"Immunity Inflammation and Disease","issn_l":"2050-4527","issn":["2050-4527"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity, Inflammation and Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223928432.pdf","grobid_xml":"https://content.openalex.org/works/W7223928432.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2298338128","https://openalex.org/W2730224823","https://openalex.org/W2756993541","https://openalex.org/W2810415058","https://openalex.org/W2890503178","https://openalex.org/W2945085089","https://openalex.org/W3008150919","https://openalex.org/W3216914677","https://openalex.org/W4210353224","https://openalex.org/W4220948634","https://openalex.org/W4294992053","https://openalex.org/W4311204752","https://openalex.org/W4386516328","https://openalex.org/W4390229872","https://openalex.org/W4414702872","https://openalex.org/W7123606495","https://openalex.org/W7165043446","https://openalex.org/W7168784324"],"related_works":["https://openalex.org/W4372357767","https://openalex.org/W4390229872","https://openalex.org/W4416386154","https://openalex.org/W2040029779","https://openalex.org/W4294992053","https://openalex.org/W4392147022","https://openalex.org/W7215659790","https://openalex.org/W3169230151","https://openalex.org/W7165043446","https://openalex.org/W4285060875"],"abstract_inverted_index":{"BACKGROUND:":[0],"Allergen":[1],"immunotherapy":[2,48],"(AIT)":[3],"may":[4],"modify":[5],"allergic":[6],"respiratory":[7],"disease,":[8],"but":[9],"its":[10],"association":[11],"with":[12,55,158],"progression":[13,102],"and":[14,66,80,100,126,148,163,166,184],"remission":[15,116,128],"in":[16,29],"routine":[17],"practice":[18],"remains":[19],"uncertain.":[20],"MATERIALS":[21],"AND":[22],"METHODS:":[23],"We":[24,44],"emulated":[25],"a":[26,30,51,178],"target":[27],"trial":[28],"single-center":[31],"retrospective":[32],"cohort":[33],"at":[34],"AlergiaMx,":[35],"Mexico":[36],"City,":[37],"using":[38],"data":[39],"from":[40],"2020":[41],"to":[42,63],"2025.":[43],"compared":[45],"sublingual":[46],"allergen":[47],"initiation":[49,155],"within":[50],"14-day":[52],"grace":[53],"period":[54],"non-initiation":[56],"among":[57],"AIT-eligible":[58],"patients.":[59],"Follow-up":[60],"extended":[61],"up":[62],"36":[64,113,170],"months,":[65,114],"propensity-score":[67],"overlap":[68],"weighting":[69],"addressed":[70],"baseline":[71],"confounding.":[72],"RESULTS:":[73],"Among":[74],"2,713":[75],"patients,":[76],"1,971":[77],"initiated":[78],"AIT":[79,141,154],"742":[81],"did":[82],"not.":[83],"Weighted":[84],"disease":[85],"worsening":[86],"was":[87,103,117,129,156],"46.3%":[88],"versus":[89,105,119,131],"63.6%":[90],"(relative":[91],"risk":[92],"[RR]":[93],"0.73,":[94],"95%":[95,109,123,135],"confidence":[96],"interval":[97],"[CI]":[98],"0.65-0.82),":[99],"sustained":[101],"8.4%":[104],"17.0%":[106],"(RR":[107,121,133],"0.49,":[108],"CI":[110,124,136],"0.35-0.69).":[111],"At":[112],"clinical":[115,165],"47.0%":[118],"18.3%":[120],"2.57,":[122],"1.93-3.43),":[125],"treatment-associated":[127],"31.7%":[130],"5.8%":[132],"5.44,":[134],"3.23-9.16).":[137],"Longitudinal":[138],"differences":[139],"favored":[140],"for":[142],"asthma":[143],"control,":[144],"quality":[145],"of":[146],"life,":[147],"fractional":[149],"exhaled":[150],"nitric":[151],"oxide.":[152],"DISCUSSION:":[153],"associated":[157],"less":[159],"worsening,":[160],"greater":[161],"remission,":[162],"favorable":[164],"inflammatory":[167],"trajectories":[168],"over":[169],"months.":[171],"These":[172],"observational":[173],"findings":[174],"do":[175],"not":[176],"establish":[177],"causal":[179],"disease-modifying":[180],"effect;":[181],"residual":[182],"confounding":[183],"differential":[185],"follow-up":[186],"remain":[187],"possible.":[188]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-28T00:00:00"}