{"id":"https://openalex.org/W7223902145","doi":"https://doi.org/10.3389/fimmu.2026.1967436","title":"Huayu Wan induces ferroptosis and enhances anti-PD-1 efficacy in cisplatin-resistant esophageal squamous cell carcinoma","display_name":"Huayu Wan induces ferroptosis and enhances anti-PD-1 efficacy in cisplatin-resistant esophageal squamous cell carcinoma","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7223902145","doi":"https://doi.org/10.3389/fimmu.2026.1967436"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1967436","doi":"https://doi.org/10.3389/fimmu.2026.1967436","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1967436","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1967436/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1967436/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101933570","display_name":"Ting Zhu","orcid":"https://orcid.org/0000-0001-5619-4121","observed_orcids":["https://orcid.org/0000-0001-5619-4121"]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I4210160695","display_name":"Shaoxing People's Hospital","ror":"https://ror.org/05v58y004","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160695"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Zhu","raw_affiliation_strings":["Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University","institution_ids":["https://openalex.org/I192209268","https://openalex.org/I4210160695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159954158","display_name":"Bin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I4210160695","display_name":"Shaoxing People's Hospital","ror":"https://ror.org/05v58y004","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160695"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Wang","raw_affiliation_strings":["Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University","institution_ids":["https://openalex.org/I192209268","https://openalex.org/I4210160695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159966637","display_name":"Haiyong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I4210160695","display_name":"Shaoxing People's Hospital","ror":"https://ror.org/05v58y004","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160695"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyong Wang","raw_affiliation_strings":["Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University","institution_ids":["https://openalex.org/I192209268","https://openalex.org/I4210160695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044353882","display_name":"Jianyi Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I4210160695","display_name":"Shaoxing People's Hospital","ror":"https://ror.org/05v58y004","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160695"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianyi Ding","raw_affiliation_strings":["Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University","institution_ids":["https://openalex.org/I192209268","https://openalex.org/I4210160695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111263861","display_name":"Yangjun Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I4210160695","display_name":"Shaoxing People's Hospital","ror":"https://ror.org/05v58y004","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160695"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangjun Xu","raw_affiliation_strings":["Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University","institution_ids":["https://openalex.org/I192209268","https://openalex.org/I4210160695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159968049","display_name":"Jianfeng Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I4210160695","display_name":"Shaoxing People's Hospital","ror":"https://ror.org/05v58y004","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160695"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianfeng Xu","raw_affiliation_strings":["Department of Cardiac and Great Vascular Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac and Great Vascular Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University","institution_ids":["https://openalex.org/I192209268","https://openalex.org/I4210160695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038720412","display_name":"Lingjun Dong","orcid":"https://orcid.org/0000-0002-1565-6083","observed_orcids":["https://orcid.org/0000-0002-1565-6083"]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I4210160695","display_name":"Shaoxing People's Hospital","ror":"https://ror.org/05v58y004","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160695"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingjun Dong","raw_affiliation_strings":["Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University","institution_ids":["https://openalex.org/I192209268","https://openalex.org/I4210160695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159926822","display_name":"Xiang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I4210160695","display_name":"Shaoxing People's Hospital","ror":"https://ror.org/05v58y004","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160695"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Wang","raw_affiliation_strings":["Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University","institution_ids":["https://openalex.org/I192209268","https://openalex.org/I4210160695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015607655","display_name":"Guangmao Yu","orcid":"https://orcid.org/0000-0002-9446-429X","observed_orcids":["https://orcid.org/0000-0002-9446-429X"]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I4210160695","display_name":"Shaoxing People's Hospital","ror":"https://ror.org/05v58y004","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160695"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guangmao Yu","raw_affiliation_strings":["Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University","institution_ids":["https://openalex.org/I192209268","https://openalex.org/I4210160695"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159858455","display_name":"Zhupeng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I4210160695","display_name":"Shaoxing People's Hospital","ror":"https://ror.org/05v58y004","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160695"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhupeng Li","raw_affiliation_strings":["Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shaoxing People\u2019s Hospital, School of Medicine, Shaoxing University","institution_ids":["https://openalex.org/I192209268","https://openalex.org/I4210160695"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015607655","https://openalex.org/A5159858455"],"corresponding_institution_ids":["https://openalex.org/I192209268","https://openalex.org/I4210160695"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7648655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.9620000123977661},{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.8270000219345093},{"id":"https://openalex.org/keywords/immunogenic-cell-death","display_name":"immunogenic cell death","score":0.9589999914169312},{"id":"https://openalex.org/keywords/glutathione-metabolism","display_name":"glutathione metabolism","score":0.890999972820282},{"id":"https://openalex.org/keywords/ncoa4","display_name":"NCOA4","score":0.8289999961853027},{"id":"https://openalex.org/keywords/ferritinophagy","display_name":"ferritinophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/akt-mtor-signaling-pathway","display_name":"Akt/mTOR signaling","score":0.8029999732971191},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8399999737739563},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.796999990940094},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.9269999861717224},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.722000002861023},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.625}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6574000120162964},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5250999927520752},{"id":"https://openalex.org/C47450691","wikidata":"https://www.wikidata.org/wiki/Q634510","display_name":"Calreticulin","level":3,"score":0.5120999813079834},{"id":"https://openalex.org/C2777877232","wikidata":"https://www.wikidata.org/wiki/Q17144704","display_name":"Immunogenic cell death","level":4,"score":0.5055000185966492},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5004000067710876},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.462799996137619},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.45680001378059387},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.45089998841285706},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4429999887943268},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.43799999356269836},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.42579999566078186},{"id":"https://openalex.org/C2779881523","wikidata":"https://www.wikidata.org/wiki/Q18026129","display_name":"GCLC","level":4,"score":0.41359999775886536},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3869999945163727},{"id":"https://openalex.org/C158086472","wikidata":"https://www.wikidata.org/wiki/Q21103287","display_name":"GPX4","level":5,"score":0.35339999198913574},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.35280001163482666},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.32580000162124634},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.3188999891281128},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.3138999938964844},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.30720001459121704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2924000024795532},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.28999999165534973},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2784000039100647},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.266400009393692},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2662999927997589},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2603999972343445},{"id":"https://openalex.org/C2777476445","wikidata":"https://www.wikidata.org/wiki/Q5002519","display_name":"Buthionine sulfoximine","level":4,"score":0.25850000977516174}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fimmu.2026.1967436","doi":"https://doi.org/10.3389/fimmu.2026.1967436","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1967436","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1967436/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f44f29478bce454ba3248cea255bd4a6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f44f29478bce454ba3248cea255bd4a6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1967436","doi":"https://doi.org/10.3389/fimmu.2026.1967436","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1967436","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1967436/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324980","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223902145.pdf","grobid_xml":"https://content.openalex.org/works/W7223902145.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1937118646","https://openalex.org/W2067107606","https://openalex.org/W2514831411","https://openalex.org/W3010000625","https://openalex.org/W3036358233","https://openalex.org/W3043888701","https://openalex.org/W3134145478","https://openalex.org/W4210867925","https://openalex.org/W4224980565","https://openalex.org/W4318825421","https://openalex.org/W4324020810","https://openalex.org/W4376505785","https://openalex.org/W4379197415","https://openalex.org/W4385416772","https://openalex.org/W4386469199","https://openalex.org/W4388793929","https://openalex.org/W4391841886","https://openalex.org/W4392003475","https://openalex.org/W4392757206","https://openalex.org/W4392818320","https://openalex.org/W4394564046","https://openalex.org/W4395002388","https://openalex.org/W4399286806","https://openalex.org/W4400474662","https://openalex.org/W4402403788","https://openalex.org/W4404516352","https://openalex.org/W4404748956","https://openalex.org/W4406622755","https://openalex.org/W4407240778","https://openalex.org/W4409037312","https://openalex.org/W4409168480","https://openalex.org/W4409762039","https://openalex.org/W4410983795","https://openalex.org/W4411402028","https://openalex.org/W4412901661","https://openalex.org/W4414082867","https://openalex.org/W4414473158","https://openalex.org/W4414753514","https://openalex.org/W7126170132","https://openalex.org/W7140208890","https://openalex.org/W7171843612"],"related_works":["https://openalex.org/W4392003475","https://openalex.org/W7122542185","https://openalex.org/W4387032972","https://openalex.org/W7204637405","https://openalex.org/W4396891232","https://openalex.org/W4415427558","https://openalex.org/W2502375831","https://openalex.org/W4399972138","https://openalex.org/W2481771380","https://openalex.org/W7127373916"],"abstract_inverted_index":{"Cisplatin":[0],"resistance":[1],"remains":[2],"a":[3,44],"major":[4],"therapeutic":[5],"challenge":[6],"in":[7,26,207],"esophageal":[8],"squamous":[9],"cell":[10,73,109],"carcinoma":[11],"(ESCC).":[12],"Here,":[13],"we":[14],"investigated":[15],"the":[16,32,93],"antitumor":[17,181,204],"effects":[18,182],"and":[19,38,42,60,79,82,91,101,108,117,126,128,136,142,160,167,199],"underlying":[20],"mechanisms":[21],"of":[22,34,134,196],"Huayu":[23],"Wan":[24],"(HYW)":[25],"cisplatin-resistant":[27,35,146,208],"ESCC.":[28,209],"HYW":[29,69,87,113,149,174,190],"markedly":[30],"inhibited":[31],"growth":[33,152],"human":[36],"KYSE150":[37],"murine":[39],"mEC25":[40],"cells":[41],"induced":[43],"ferroptotic":[45],"phenotype":[46],"characterized":[47],"by":[48,123],"reactive":[49],"oxygen":[50],"species":[51],"accumulation,":[52],"increased":[53,88,124,168],"intracellular":[54],"iron,":[55],"glutathione":[56,197],"depletion,":[57],"lipid":[58],"peroxidation,":[59],"reduced":[61,164],"GPX4":[62],"expression.":[63,131],"Ferrostatin-1":[64],"partially":[65,104],"reversed":[66],"HYW-induced":[67,143],"cytotoxicity.":[68,144],"also":[70],"promoted":[71,118],"immunogenic":[72,161],"death-associated":[74],"changes,":[75,163],"including":[76],"extracellular":[77],"ATP":[78],"HMGB1":[80],"release":[81],"cell-surface":[83],"calreticulin":[84],"exposure.":[85],"Mechanistically,":[86],"p53":[89],"expression":[90],"impaired":[92],"SLC7A11/GCLC-dependent":[94],"cystine\u2013glutathione":[95],"antioxidant":[96],"system,":[97],"whereas":[98],"GCLC":[99],"overexpression":[100],"P53":[102],"inhibition":[103,133],"restored":[105],"redox":[106],"homeostasis":[107],"survival.":[110],"In":[111,145],"parallel,":[112],"suppressed":[114,150],"AKT\u2013mTOR":[115],"signaling":[116],"NCOA4-associated":[119,200],"ferritinophagy,":[120],"as":[121],"evidenced":[122],"NCOA4":[125,137],"LC3-II":[127],"decreased":[129],"FTH":[130],"Pharmacological":[132],"autophagy":[135],"knockdown":[138],"attenuated":[139],"iron":[140],"accumulation":[141],"syngeneic":[147],"tumors,":[148],"tumor":[151],"with":[153,176],"generally":[154],"acceptable":[155],"systemic":[156],"tolerability,":[157],"enhanced":[158],"ferroptosis-":[159],"stress-associated":[162],"PD-L1":[165],"expression,":[166],"CD8":[169],"+":[170],"T-cell":[171],"infiltration.":[172],"Moreover,":[173],"combined":[175],"anti-PD-1":[177],"treatment":[178],"produced":[179],"greater":[180],"than":[183],"either":[184],"monotherapy.":[185],"These":[186],"findings":[187],"suggest":[188],"that":[189],"promotes":[191],"ferroptosis":[192],"through":[193],"coordinated":[194],"disruption":[195],"metabolism":[198],"ferritinophagy":[201],"while":[202],"enhancing":[203],"immune":[205],"responses":[206]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-10-28T00:00:00"}