{"id":"https://openalex.org/W7223885408","doi":"https://doi.org/10.64898/2026.10.23.760958","title":"A transporter essential for apical secretory organelles homeostasis in Toxoplasma gondii","display_name":"A transporter essential for apical secretory organelles homeostasis in Toxoplasma gondii","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7223885408","doi":"https://doi.org/10.64898/2026.10.23.760958"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.23.760958","doi":"https://doi.org/10.64898/2026.10.23.760958","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.23.760958","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/27/2026.10.23.760958.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/27/2026.10.23.760958.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068849669","display_name":"Alessandro Bonavoglia","orcid":"https://orcid.org/0009-0009-0031-8362","observed_orcids":["https://orcid.org/0009-0009-0031-8362"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alessandro Bonavoglia","raw_affiliation_strings":["Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0009-0009-0031-8362","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063715025","display_name":"Rachel Humann","orcid":"https://orcid.org/0000-0001-5631-7494","observed_orcids":["https://orcid.org/0000-0001-5631-7494"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Rachel Humann","raw_affiliation_strings":["Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-5631-7494","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006249493","display_name":"Oscar Vadas","orcid":"https://orcid.org/0000-0003-3511-6479","observed_orcids":["https://orcid.org/0000-0003-3511-6479"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Oscar Vadas","raw_affiliation_strings":["Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3511-6479","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056179612","display_name":"Isabel Meister","orcid":"https://orcid.org/0000-0001-9063-0492","observed_orcids":["https://orcid.org/0000-0001-9063-0492"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Isabel Meister","raw_affiliation_strings":["School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-9063-0492","affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009224552","display_name":"Bohumil Maco","orcid":"https://orcid.org/0000-0001-8444-313X","observed_orcids":["https://orcid.org/0000-0001-8444-313X"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bohumil Maco","raw_affiliation_strings":["Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8444-313X","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050919940","display_name":"David J. Dubois","orcid":"https://orcid.org/0000-0001-9814-1677","observed_orcids":["https://orcid.org/0000-0001-9814-1677"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"David J Dubois","raw_affiliation_strings":["Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002955450","display_name":"Dominique Soldati\u2010Favre","orcid":"https://orcid.org/0000-0003-4156-2109","observed_orcids":["https://orcid.org/0000-0003-4156-2109"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dominique Soldati-Favre","raw_affiliation_strings":["Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4156-2109","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074691238","display_name":"Syrian G. Sanchez","orcid":"https://orcid.org/0009-0007-7995-1560","observed_orcids":["https://orcid.org/0009-0007-7995-1560"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Syrian G Sanchez","raw_affiliation_strings":["Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0009-0007-7995-1560","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074691238"],"corresponding_institution_ids":["https://openalex.org/I114457229"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12691","display_name":"Coccidia and coccidiosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxoplasma-gondii","display_name":"Toxoplasma gondii","score":1.0},{"id":"https://openalex.org/keywords/major-facilitator-superfamily","display_name":"major facilitator superfamily","score":0.9190000295639038},{"id":"https://openalex.org/keywords/rhoptry","display_name":"rhoptry","score":0.8270000219345093},{"id":"https://openalex.org/keywords/micronemes","display_name":"micronemes","score":0.921999990940094},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.656000018119812},{"id":"https://openalex.org/keywords/lipid-homeostasis","display_name":"lipid homeostasis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.5389999747276306},{"id":"https://openalex.org/keywords/parasite-virulence","display_name":"parasite virulence","score":0.7419999837875366},{"id":"https://openalex.org/keywords/apicomplexa","display_name":"Apicomplexa","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C40602308","wikidata":"https://www.wikidata.org/wiki/Q7321455","display_name":"Rhoptry","level":5,"score":0.960099995136261},{"id":"https://openalex.org/C2779934537","wikidata":"https://www.wikidata.org/wiki/Q2655487","display_name":"Microneme","level":5,"score":0.9508000016212463},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.8029000163078308},{"id":"https://openalex.org/C2778128430","wikidata":"https://www.wikidata.org/wiki/Q131003","display_name":"Toxoplasma gondii","level":3,"score":0.791100025177002},{"id":"https://openalex.org/C2775855988","wikidata":"https://www.wikidata.org/wiki/Q1825478","display_name":"Apicoplast","level":5,"score":0.775600016117096},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7222999930381775},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7045000195503235},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5419999957084656},{"id":"https://openalex.org/C62465871","wikidata":"https://www.wikidata.org/wiki/Q1886097","display_name":"Major facilitator superfamily","level":4,"score":0.5012999773025513},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4408999979496002},{"id":"https://openalex.org/C2781023229","wikidata":"https://www.wikidata.org/wiki/Q193030","display_name":"Apicomplexa","level":4,"score":0.4343999922275543},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.4083000123500824},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.35899999737739563},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.353300005197525},{"id":"https://openalex.org/C6492254","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory pathway","level":4,"score":0.3488999903202057},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3160000145435333},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C155432671","wikidata":"https://www.wikidata.org/wiki/Q17073362","display_name":"Organelle biogenesis","level":4,"score":0.2831999957561493},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28279998898506165},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.27790001034736633},{"id":"https://openalex.org/C174626541","wikidata":"https://www.wikidata.org/wiki/Q1884420","display_name":"Magnetosome","level":3,"score":0.2750999927520752},{"id":"https://openalex.org/C10858879","wikidata":"https://www.wikidata.org/wiki/Q899790","display_name":"Signal peptide","level":4,"score":0.2718999981880188},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.25440001487731934},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.2522999942302704},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.23.760958","doi":"https://doi.org/10.64898/2026.10.23.760958","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.23.760958","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/27/2026.10.23.760958.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.23.760958","doi":"https://doi.org/10.64898/2026.10.23.760958","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.23.760958","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/27/2026.10.23.760958.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5051104502","display_name":null,"funder_award_id":"HUG RC09-18","funder_id":"https://openalex.org/F4320323829","funder_display_name":"H\u00f4pitaux Universitaires de Gen\u00e8ve"}],"funders":[{"id":"https://openalex.org/F3751039985","display_name":"Fondation priv\u00e9e des H\u00f4pitaux universitaires de Gen\u00e8ve","ror":null},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320323829","display_name":"H\u00f4pitaux Universitaires de Gen\u00e8ve","ror":"https://ror.org/01m1pv723"},{"id":"https://openalex.org/F4320323830","display_name":"Universit\u00e9 de Gen\u00e8ve","ror":"https://ror.org/01swzsf04"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223885408.pdf","grobid_xml":"https://content.openalex.org/works/W7223885408.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2801949382","https://openalex.org/W3180899738","https://openalex.org/W4366819513","https://openalex.org/W4409634034","https://openalex.org/W4413026428","https://openalex.org/W4412396480","https://openalex.org/W7055145020","https://openalex.org/W2606473477","https://openalex.org/W7125937490","https://openalex.org/W4411887108"],"abstract_inverted_index":{"ABSTRACT":[0],"Apicomplexan":[1],"parasites":[2],"rely":[3],"on":[4,66,191],"the":[5,24,81,87,114,175,211,225,245,261,295],"rhoptries":[6],"and":[7,13,62,68,89,128,134,203,248,268,271,276,297,303],"micronemes":[8],"to":[9,60,144,184,244],"coordinate":[10],"egress,":[11,275],"motility,":[12,274],"host":[14,200,277],"cell":[15,201,278],"invasion.":[16],"In":[17],"Toxoplasma":[18,222],"gondii":[19,37,223],",":[20,224],"mechanistic":[21],"insights":[22],"into":[23],"control":[25],"of":[26,95,106,117,177,227,299],"these":[27,162,216],"organelles\u2019":[28],"lipid":[29,146,156,171,229,256,292],"composition":[30,157],"remain":[31,45],"sparse.":[32],"Although":[33],"nearly":[34],"60":[35],"T.":[36],"Major":[38],"Facilitator":[39],"Superfamily":[40],"(MFS)":[41],"are":[42,218],"predicted,":[43],"many":[44],"functionally":[46],"uncharacterized.":[47],"The":[48,188],"MFS":[49,107],"protein":[50,58],"HAP12":[51,74],"was":[52],"previously":[53],"annotated":[54],"as":[55,238,306],"an":[56,239],"apicoplast":[57],"contributing":[59,183],"invasion":[61,202,279],"organelle":[63],"inheritance.":[64],"Based":[65],"localization":[67],"phylogenetic":[69],"analyses,":[70],"we":[71,235],"show":[72],"that":[73,139],"(renamed":[75],"TFP5),":[76],"is":[77,141],"predominantly":[78],"associated":[79],"with":[80,83,103,251],"Golgi,":[82],"additional":[84],"signal":[85],"in":[86,113,124,131,154,167,221,254,294],"ELC":[88],"apical":[90,119,178,197,300],"compartments,":[91],"without":[92,280],"convincing":[93],"evidence":[94],"a":[96,104,165,252,287,307],"major":[97],"apicoplast-associated":[98],"pool.":[99],"Furthermore,":[100],"TFP5":[101,121,140,159,169,237,258,305],"clusters":[102],"subgroup":[105],"transporter":[108,242],"facilitator":[109],"proteins":[110],"(TFPs)":[111],"involved":[112],"morphological":[115],"integrity":[116],"secretory":[118,179,301],"organelles.":[120],"depletion":[122,259],"results":[123],"defective":[125],"microneme":[126,266],"secretion":[127,194,267],"pronounced":[129],"alterations":[130],"rhoptry":[132,269],"morphology":[133],"positioning.":[135],"Structural":[136],"analyses":[137,150],"revealed":[138],"strongly":[142],"similar":[143],"MFSD2-like":[145,241],"transporters,":[147],"while":[148],"lipidomic":[149],"showed":[151],"substantial":[152],"changes":[153],"parasite":[155,185,262],"following":[158],"depletion.":[160],"Together,":[161],"findings":[163,285],"support":[164],"model":[166],"which":[168],"regulates":[170],"homeostasis":[172,293],"required":[173],"for":[174,199,208,290],"function":[176,298],"organelles,":[180],"thereby":[181],"critically":[182],"virulence.":[186],"IMPORTANCE":[187],"Apicomplexa":[189],"relies":[190],"tightly":[192],"regulated":[193],"from":[195],"specialized":[196],"organelles":[198,217,302],"intracellular":[204,282],"proliferation,":[205],"processes":[206],"essential":[207],"pathogenicity.":[209],"While":[210],"membrane":[212,228,255,291],"trafficking":[213],"pathways":[214],"controlling":[215],"well":[219],"characterized":[220],"contribution":[226],"transporters":[230],"remains":[231],"poorly":[232],"understood.":[233],"Here,":[234],"identify":[236,304],"Alveolata-conserved":[240],"localized":[243],"endomembrane":[246],"system":[247],"micronemes.":[249],"Consistent":[250],"role":[253,289],"homeostasis,":[257],"alters":[260],"lipidome,":[263],"severely":[264],"impairs":[265],"morphology,":[270],"consequently":[272],"disrupts":[273],"affecting":[281],"replication.":[283],"These":[284],"reveal":[286],"critical":[288],"organization":[296],"potential":[308],"therapeutic":[309],"target":[310],"against":[311],"apicomplexan":[312],"parasites.":[313]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-28T00:00:00"}