{"id":"https://openalex.org/W7223878874","doi":"https://doi.org/10.3389/fgene.2026.1899719","title":"Prenatal diagnostic outcomes and positive predictive values in 1,326 pregnancies with high-risk non-invasive prenatal testing results","display_name":"Prenatal diagnostic outcomes and positive predictive values in 1,326 pregnancies with high-risk non-invasive prenatal testing results","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7223878874","doi":"https://doi.org/10.3389/fgene.2026.1899719","pmid":"https://pubmed.ncbi.nlm.nih.gov/42985402","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13732125"},"language":"en","primary_location":{"id":"doi:10.3389/fgene.2026.1899719","doi":"https://doi.org/10.3389/fgene.2026.1899719","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2026.1899719","pdf_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1899719/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1899719/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014651641","display_name":"Runxuan Du","orcid":"https://orcid.org/0000-0002-9776-8862","observed_orcids":["https://orcid.org/0000-0002-9776-8862"]},"institutions":[{"id":"https://openalex.org/I4210110525","display_name":"Hebei General Hospital","ror":"https://ror.org/01nv7k942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110525"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runxuan Du","raw_affiliation_strings":["Department of Reproductive Genetics, Hebei General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Reproductive Genetics, Hebei General Hospital","institution_ids":["https://openalex.org/I4210110525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005355520","display_name":"Bingyi Zhao","orcid":"https://orcid.org/0000-0001-5794-2662","observed_orcids":["https://orcid.org/0000-0001-5794-2662"]},"institutions":[{"id":"https://openalex.org/I4210110525","display_name":"Hebei General Hospital","ror":"https://ror.org/01nv7k942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110525"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingyi Zhao","raw_affiliation_strings":["Department of Reproductive Genetics, Hebei General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Reproductive Genetics, Hebei General Hospital","institution_ids":["https://openalex.org/I4210110525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111088117","display_name":"Xuedong Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110525","display_name":"Hebei General Hospital","ror":"https://ror.org/01nv7k942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110525"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuedong Shi","raw_affiliation_strings":["Department of Reproductive Genetics, Hebei General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Reproductive Genetics, Hebei General Hospital","institution_ids":["https://openalex.org/I4210110525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159820955","display_name":"Yingjie Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110525","display_name":"Hebei General Hospital","ror":"https://ror.org/01nv7k942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110525"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingjie Gao","raw_affiliation_strings":["Department of Reproductive Genetics, Hebei General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Reproductive Genetics, Hebei General Hospital","institution_ids":["https://openalex.org/I4210110525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052197445","display_name":"\u674e\u4e9a\u4e3d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110525","display_name":"Hebei General Hospital","ror":"https://ror.org/01nv7k942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110525"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yali Li","raw_affiliation_strings":["Department of Reproductive Genetics, Hebei General Hospital","Hebei Clinical Research Center for Birth Defects"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Reproductive Genetics, Hebei General Hospital","institution_ids":["https://openalex.org/I4210110525"]},{"raw_affiliation_string":"Hebei Clinical Research Center for Birth Defects","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025722777","display_name":"\u90b1\u6ce2","orcid":"https://orcid.org/0009-0009-8829-8764","observed_orcids":["https://orcid.org/0009-0009-8829-8764"]},"institutions":[{"id":"https://openalex.org/I4210110525","display_name":"Hebei General Hospital","ror":"https://ror.org/01nv7k942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110525"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Qiu","raw_affiliation_strings":["Department of Pharmacy, Hebei General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Hebei General Hospital","institution_ids":["https://openalex.org/I4210110525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052197445"],"corresponding_institution_ids":["https://openalex.org/I4210110525"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.87063151,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1899719","last_page":"1899719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-invasive-prenatal-testing","display_name":"non-invasive prenatal testing","score":0.9919999837875366},{"id":"https://openalex.org/keywords/positive-predictive-value","display_name":"positive predictive value","score":0.9200000166893005},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.7910000085830688},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/trisomy-18","display_name":"trisomy 18","score":0.9990000128746033},{"id":"https://openalex.org/keywords/trisomy-13","display_name":"trisomy 13","score":1.0},{"id":"https://openalex.org/keywords/sex-chromosome-abnormalities","display_name":"sex chromosome abnormalities","score":0.9940000176429749},{"id":"https://openalex.org/keywords/advanced-maternal-age","display_name":"advanced maternal age","score":0.7699999809265137},{"id":"https://openalex.org/keywords/z-score","display_name":"Z-score","score":0.781000018119812},{"id":"https://openalex.org/keywords/genetic-counseling","display_name":"genetic counseling","score":0.6190000176429749},{"id":"https://openalex.org/keywords/prenatal-diagnosis","display_name":"prenatal diagnosis","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C2776229224","wikidata":"https://www.wikidata.org/wiki/Q844903","display_name":"Trisomy","level":2,"score":0.7918000221252441},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7218000292778015},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.6330000162124634},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.5835000276565552},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4977000057697296},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.4668000042438507},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.46299999952316284},{"id":"https://openalex.org/C2776352029","wikidata":"https://www.wikidata.org/wiki/Q4686351","display_name":"Advanced maternal age","level":4,"score":0.4544000029563904},{"id":"https://openalex.org/C2779954681","wikidata":"https://www.wikidata.org/wiki/Q47715","display_name":"Down syndrome","level":2,"score":0.4027000069618225},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.40149998664855957},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.3716999888420105},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3714999854564667},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.35440000891685486},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.3483000099658966},{"id":"https://openalex.org/C53789813","wikidata":"https://www.wikidata.org/wiki/Q3553769","display_name":"Positive predicative value","level":3,"score":0.3481999933719635},{"id":"https://openalex.org/C152110520","wikidata":"https://www.wikidata.org/wiki/Q14225730","display_name":"Cell-free fetal DNA","level":5,"score":0.3395000100135803},{"id":"https://openalex.org/C2992422692","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal screening","level":5,"score":0.33570000529289246},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.3255999982357025},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.3156999945640564},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.31459999084472656},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.30799999833106995},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.303600013256073},{"id":"https://openalex.org/C2780246931","wikidata":"https://www.wikidata.org/wiki/Q202771","display_name":"Y chromosome","level":3,"score":0.2969000041484833},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C80227256","wikidata":"https://www.wikidata.org/wiki/Q1124169","display_name":"Genetic counseling","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C3018956284","wikidata":"https://www.wikidata.org/wiki/Q2642447","display_name":"Prenatal ultrasound","level":5,"score":0.2734000086784363},{"id":"https://openalex.org/C82157600","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic test","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.25679999589920044},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.25369998812675476}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3389/fgene.2026.1899719","doi":"https://doi.org/10.3389/fgene.2026.1899719","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2026.1899719","pdf_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1899719/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},{"id":"pmid:42985402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42985402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in genetics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6c20c650888040c6a62e9d0e1cd362cf","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6c20c650888040c6a62e9d0e1cd362cf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Genetics, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fgene.2026.1899719","doi":"https://doi.org/10.3389/fgene.2026.1899719","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2026.1899719","pdf_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1899719/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223878874.pdf","grobid_xml":"https://content.openalex.org/works/W7223878874.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W2100977485","https://openalex.org/W2887336438","https://openalex.org/W2952356519","https://openalex.org/W3161799708","https://openalex.org/W4281930456","https://openalex.org/W4292679480","https://openalex.org/W4318395107","https://openalex.org/W4378672735","https://openalex.org/W4390598341","https://openalex.org/W4396621948","https://openalex.org/W4403295484","https://openalex.org/W4406794307","https://openalex.org/W4407560522","https://openalex.org/W4407593901","https://openalex.org/W4409316428","https://openalex.org/W4410826565","https://openalex.org/W4412424946","https://openalex.org/W4413313916","https://openalex.org/W4414555199","https://openalex.org/W4414671021","https://openalex.org/W7117537878","https://openalex.org/W7119536923","https://openalex.org/W7150784672"],"related_works":["https://openalex.org/W4284894311","https://openalex.org/W3187760360","https://openalex.org/W7202179433","https://openalex.org/W3086841949","https://openalex.org/W4407762885","https://openalex.org/W4413259516","https://openalex.org/W3039478859","https://openalex.org/W4411394754","https://openalex.org/W4296095754","https://openalex.org/W4295427557"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"investigate":[2],"the":[3,22,66,73,125,132,140,144,156,185],"prenatal":[4,13,236],"diagnostic":[5,42,237],"outcomes":[6],"of":[7,27,50,65,90,139,223],"pregnant":[8],"women":[9],"with":[10,76,166,216],"high-risk":[11,77,224],"non-invasive":[12],"testing":[14],"(NIPT)":[15],"results":[16,226],"and":[17,60,62,104,113,149,169,208,212,234,244],"to":[18,239],"explore":[19],"factors":[20],"influencing":[21],"positive":[23],"predictive":[24],"value":[25],"(PPV)":[26],"NIPT.":[28],"Methods:":[29],"hybridization":[30],"(FISH),":[31],"and/or":[32],"copy":[33],"number":[34],"variation":[35],"sequencing":[36],"(CNV-seq)":[37],"were":[38,45,81,109,122,170,181,214],"used":[39],"as":[40,83],"confirmatory":[41,235],"methods.":[43],"PPVs":[44,93,117,145,164],"compared":[46],"across":[47],"different":[48],"types":[49],"chromosomal":[51],"abnormalities,":[52],"maternal":[53,127,134,229],"age":[54,128,135],"groups,":[55],"Z-score":[56],"categories,":[57],"ultrasound":[58,175,232],"findings,":[59],"before":[61],"after":[63],"implementation":[64,138],"free":[67,141],"NIPT":[68,78,201,225],"screening":[69,142,204],"policy.":[70],"Results:":[71],"Among":[72,183],"1,326":[74],"pregnancies":[75],"results,":[79],"648":[80],"confirmed":[82],"true":[84],"positives,":[85],"yielding":[86],"an":[87],"overall":[88],"PPV":[89,186],"48.87%.":[91],"The":[92,116],"for":[94,118,146,187,196,206],"trisomy":[95,98,101],"21":[96],"(T21),":[97],"18":[99],"(T18),":[100],"13":[102],"(T13),":[103],"sex":[105,188,197],"chromosome":[106,189,198],"abnormalities":[107],"(SCAs)":[108],"78.61%,":[110],"56.36%,":[111],"10.53%,":[112],"47.11%,":[114],"respectively.":[115],"common":[119],"autosomal":[120],"trisomies":[121],"higher":[123,167,193],"in":[124,131],"advanced":[126],"group":[129],"than":[130,194],"non-advanced":[133],"group.":[136],"After":[137],"program,":[143],"T21,":[147],"T18,":[148,209],"T13":[150,211],"showed":[151],"a":[152],"slight":[153],"numerical":[154],"increase,":[155],"difference":[157],"between":[158],"groups":[159],"was":[160,191],"not":[161],"statistically":[162],"significant.":[163],"increased":[165],"Z-scores":[168],"further":[171],"elevated":[172],"when":[173],"multiple":[174],"soft":[176],"markers":[177],"or":[178],"structural":[179],"anomalies":[180],"present.":[182],"SCAs,":[184],"gains":[190],"significantly":[192],"that":[195],"losses.":[199],"Conclusion:":[200],"demonstrated":[202],"high":[203,218],"performance":[205],"T21":[207],"whereas":[210],"SCAs":[213],"associated":[215],"relatively":[217],"false-positive":[219],"risks.":[220],"Clinical":[221],"interpretation":[222],"should":[227],"integrate":[228],"age,":[230],"Z-score,":[231],"phenotype,":[233],"findings":[238],"facilitate":[240],"stratified":[241],"genetic":[242],"counseling":[243],"optimize":[245],"pregnancy":[246],"management.":[247]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-28T00:00:00"}