{"id":"https://openalex.org/W7223870409","doi":"https://doi.org/10.20944/preprints202610.2562.v1","title":"The Evolving Role of Frailty Assessment in Systemic Light Chain (AL) Amyloidosis and Multiple Myeloma \u2014 Bridging Gaps","display_name":"The Evolving Role of Frailty Assessment in Systemic Light Chain (AL) Amyloidosis and Multiple Myeloma \u2014 Bridging Gaps","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7223870409","doi":"https://doi.org/10.20944/preprints202610.2562.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202610.2562.v1","doi":"https://doi.org/10.20944/preprints202610.2562.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.2562.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.20944/preprints202610.2562.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101595710","display_name":"Rafael R\u00edos","orcid":"https://orcid.org/0000-0001-8193-1402","observed_orcids":["https://orcid.org/0000-0001-8193-1402"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rafael R\u00edos-Tamayo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101595710"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.6025000214576721,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.6025000214576721,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.3009999990463257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.07999999821186066,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/frailty-assessment","display_name":"frailty assessment","score":0.984000027179718},{"id":"https://openalex.org/keywords/systemic-light-chain-amyloidosis","display_name":"systemic light chain amyloidosis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/frailty-score","display_name":"frailty score","score":0.7089999914169312},{"id":"https://openalex.org/keywords/prognostic-impact","display_name":"prognostic impact","score":0.8289999961853027},{"id":"https://openalex.org/keywords/monoclonal-gammopathy","display_name":"monoclonal gammopathy","score":0.8500000238418579},{"id":"https://openalex.org/keywords/plasma-cell-dyscrasia","display_name":"plasma cell dyscrasia","score":0.48899999260902405},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.5220000147819519},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.8050000071525574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7440999746322632},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.5569000244140625},{"id":"https://openalex.org/C174348530","wikidata":"https://www.wikidata.org/wiki/Q188635","display_name":"Bridging (networking)","level":2,"score":0.5522000193595886},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5472999811172485},{"id":"https://openalex.org/C2779551797","wikidata":"https://www.wikidata.org/wiki/Q4652470","display_name":"AL amyloidosis","level":4,"score":0.5016999840736389},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4887000024318695},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.4812999963760376},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4352000057697296},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.4269999861717224},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.42289999127388},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4027000069618225},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.39309999346733093},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.3903000056743622},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.3887999951839447},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.36570000648498535},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31679999828338623},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31360000371932983},{"id":"https://openalex.org/C2776396001","wikidata":"https://www.wikidata.org/wiki/Q250694","display_name":"Plasma cell","level":3,"score":0.3093000054359436},{"id":"https://openalex.org/C2781098529","wikidata":"https://www.wikidata.org/wiki/Q20948663","display_name":"Ixazomib","level":5,"score":0.3091999888420105},{"id":"https://openalex.org/C2776063141","wikidata":"https://www.wikidata.org/wiki/Q425681","display_name":"Lenalidomide","level":3,"score":0.27970001101493835},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C2908937092","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Plasma Cell Myeloma","level":3,"score":0.2721000015735626}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202610.2562.v1","doi":"https://doi.org/10.20944/preprints202610.2562.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.2562.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202610.2562.v1","doi":"https://doi.org/10.20944/preprints202610.2562.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.2562.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4323347487","https://openalex.org/W3015070914","https://openalex.org/W2954483077","https://openalex.org/W7134046698","https://openalex.org/W2804788884","https://openalex.org/W4407781063","https://openalex.org/W4395676414","https://openalex.org/W2606036544","https://openalex.org/W4403290393","https://openalex.org/W4403844943"],"abstract_inverted_index":{"Systemic":[0],"light-chain":[1],"(AL)":[2],"amyloidosis":[3],"and":[4,20,38,57,75,82,100,105,112,137,155,160,186],"multiple":[5],"myeloma":[6],"are":[7,15,44,196],"two":[8],"separated":[9],"but":[10],"closely":[11],"related":[12],"entities.":[13],"Both":[14,23],"chronic,":[16],"complex,":[17],"challenging,":[18],"heterogeneous,":[19],"incurable":[21],"diseases.":[22],"belong":[24],"to":[25,77,80,95,150,163,182,202],"the":[26,47,143,153,172,193],"broad":[27],"group":[28],"of":[29,41,49,122,130,158,174,189],"monoclonal":[30],"gammopathies,":[31],"with":[32,114],"a":[33,50,65,88,128,183],"peak":[34],"incidence":[35],"between":[36],"60":[37],"70":[39],"years":[40],"age.":[42],"They":[43],"characterized":[45],"by":[46,71],"presence":[48],"bone":[51],"marrow":[52],"clonal":[53],"plasma":[54],"cell":[55],"infiltration,":[56],"they":[58],"share":[59],"similar":[60],"anti-clonal":[61],"therapy.":[62],"Frailty":[63],"is":[64],"dynamic,":[66,185],"multidimensional,":[67],"age-related":[68],"syndrome,":[69],"defined":[70],"reduced":[72],"physiological":[73],"reserve":[74],"resistance":[76],"stressors,":[78],"leading":[79],"vulnerability":[81],"poor":[83],"outcomes.":[84],"Therefore,":[85],"frailty":[86,126,165,190],"plays":[87],"crucial":[89],"role":[90],"in":[91,132,166,171,178,192],"clinical":[92,168,175],"decision":[93],"making":[94],"tailor":[96],"therapy,":[97],"minimizing":[98],"toxicity":[99],"optimizing":[101],"outcome.":[102],"A":[103,119],"systematic":[104],"comprehensive":[106],"English":[107],"PubMed":[108],"search":[109],"was":[110],"undertaken":[111],"complemented":[113],"other":[115],"parallel":[116],"search\u2019":[117],"strategies.":[118],"growing":[120],"body":[121],"evidence":[123],"supports":[124],"including":[125],"as":[127,198,200],"standard":[129],"care":[131],"these":[133],"diseases,":[134],"at":[135,139],"baseline":[136],"dynamically":[138],"selected":[140],"moments":[141],"through":[142],"evolutive":[144],"course.":[145],"This":[146],"narrative":[147],"review":[148],"aims":[149],"critically":[151],"analyze":[152],"efficiency":[154],"prognostic":[156],"impact":[157],"tools":[159],"scores":[161],"used":[162],"assess":[164],"both":[167],"scenarios,":[169],"whether":[170],"context":[173],"trials":[176],"or":[177],"real":[179,194],"life.":[180],"Barriers":[181],"widely,":[184],"standardized":[187],"use":[188],"assessment":[191],"world":[195],"analyzed":[197],"well":[199],"strategies":[201],"overcome":[203],"them.":[204]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-28T00:00:00"}