{"id":"https://openalex.org/W7223847565","doi":"https://doi.org/10.12122/j.issn.1673-4254.2026.10.12","title":"[Sphingomyelin phosphodiesterase 1 knockdown promotes exogenous dihomo-\u03b3-linolenic acid-induced ferroptosis in acute myeloid leukemia cells].","display_name":"[Sphingomyelin phosphodiesterase 1 knockdown promotes exogenous dihomo-\u03b3-linolenic acid-induced ferroptosis in acute myeloid leukemia cells].","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223847565","doi":"https://doi.org/10.12122/j.issn.1673-4254.2026.10.12","pmid":"https://pubmed.ncbi.nlm.nih.gov/42934104","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13711005"},"language":"zh","primary_location":{"id":"pmid:42934104","doi":"https://doi.org/10.12122/j.issn.1673-4254.2026.10.12","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42934104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13711005/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137156930","display_name":"Yingying Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingying Huang","raw_affiliation_strings":["School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China","Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159775687","display_name":"Wei Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wu","raw_affiliation_strings":["School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China","Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150034044","display_name":"Xiaoying Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoying Hong","raw_affiliation_strings":["School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China","Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042884708","display_name":"Xiandong Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiandong Jiang","raw_affiliation_strings":["School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China","Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050510686","display_name":"Xue Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Xue","raw_affiliation_strings":["School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China","Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159860126","display_name":"Donghong Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Donghong Lin","raw_affiliation_strings":["School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China","Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129708740"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86660282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"10","first_page":"2424","last_page":"2433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smpd1","display_name":"SMPD1","score":0.8050000071525574},{"id":"https://openalex.org/keywords/dihomo-gamma-linolenic-acid","display_name":"dihomo-gamma-linolenic acid","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.7360000014305115},{"id":"https://openalex.org/keywords/slc7a11","display_name":"SLC7A11","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8119999766349792},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.8569999933242798},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.656000018119812},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.7850000262260437},{"id":"https://openalex.org/keywords/transferrin-receptor-1","display_name":"transferrin receptor 1","score":0.9509999752044678}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8083000183105469},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6942999958992004},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6861000061035156},{"id":"https://openalex.org/C158086472","wikidata":"https://www.wikidata.org/wiki/Q21103287","display_name":"GPX4","level":5,"score":0.6363999843597412},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5637999773025513},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.44830000400543213},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4117000102996826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4075999855995178},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.397599995136261},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38989999890327454},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3882000148296356},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36820000410079956},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3677000105381012},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3628000020980835},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.3409999907016754},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.31040000915527344},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.29840001463890076},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.29490000009536743},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27720001339912415},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2651999890804291}],"mesh":[{"descriptor_ui":"D000074084","descriptor_name":"THP-1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015126","descriptor_name":"8,11,14-Eicosatrienoic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:42934104","doi":"https://doi.org/10.12122/j.issn.1673-4254.2026.10.12","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42934104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University","raw_type":"English Abstract"},{"id":"pmh:oai:pubmedcentral.nih.gov:13711005","doi":"https://doi.org/10.12122/j.issn.1673-4254.2026.10.12","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13711005/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan Fang Yi Ke Da Xue Xue Bao","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13711005","doi":"https://doi.org/10.12122/j.issn.1673-4254.2026.10.12","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13711005/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan Fang Yi Ke Da Xue Xue Bao","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400585655","https://openalex.org/W4413790956","https://openalex.org/W4405041492","https://openalex.org/W4403002130","https://openalex.org/W4391961510","https://openalex.org/W7119524083","https://openalex.org/W4372299061","https://openalex.org/W4389233520","https://openalex.org/W4310108213","https://openalex.org/W4411929607"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"identify":[2],"the":[3,9,35,42,48,79,104,131,153,156,165],"potential":[4],"target":[5],"genes":[6],"involved":[7],"in":[8,16,28,88],"regulation":[10],"of":[11,55,60,72,86,123,126,155,168],"dihomo\u2011\u03b3\u2011linolenic":[12],"acid":[13],"(DGLA)-induced":[14],"ferroptosis":[15,56],"acute":[17],"myeloid":[18],"leukemia":[19],"(AML)":[20],"cells":[21,50,90,96,139],"and":[22,45,47,63,65,68,74,111,116,128,149,151,162,164,170],"to":[23],"investigate":[24],"their":[25],"functional":[26],"role":[27],"this":[29],"process..":[30],"METHODS:":[31],".":[32,173],"RESULTS:":[33],"In":[34,94,130],"tumor-bearing":[36],"mice,":[37],"DGLA":[38,100,143],"treatment":[39,101,144],"markedly":[40],"reduced":[41,103],"tumor":[43,49,147],"volume":[44,148],"weight,":[46],"showed":[51],"typical":[52],"ultrastructural":[53],"changes":[54],"with":[57,78,91,97,140],"upregulated":[58],"levels":[59,71,125,167],"ROS,":[61,114,161],"MDA,":[62],"Fe\u00b2\u207a":[64,117],"increased":[66,112,152],"mRNA":[67],"protein":[69,124,166],"expression":[70],"TfR1":[73,169],"PTGS2.":[75,171],"RNA-seq":[76],"combined":[77],"FerrDb":[80],"database":[81],"analysis":[82],"revealed":[83],"significant":[84,121],"upregulation":[85],"SMPD1":[87,98,141],"AML":[89],"DGLA-induced":[92],"ferroptosis.":[93],"THP-1":[95,138],"knockdown,":[99,142],"significantly":[102,145],"cell":[105],"viability,":[106],"aggravated":[107],"mitochondrial":[108],"ferroptotic":[109],"injury,":[110],"intracellular":[113],"MDA":[115],"levels,":[118],"causing":[119],"also":[120],"reductions":[122],"GPX4":[127],"SLC7A11.":[129],"mouse":[132],"models":[133],"bearing":[134],"xenografts":[135],"derived":[136],"from":[137],"decreased":[146],"weight":[150],"expressions":[154],"lipid":[157],"peroxidation":[158],"markers":[159],"(MDA,":[160],"Fe\u00b2\u207a)":[163],"CONCLUSIONS:":[172]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-28T00:00:00"}