{"id":"https://openalex.org/W7223845848","doi":"https://doi.org/10.1186/s12883-026-05539-4","title":"Digital mobility outcomes showed responsiveness and clinical convergence without sample size advantage in Parkinson disease","display_name":"Digital mobility outcomes showed responsiveness and clinical convergence without sample size advantage in Parkinson disease","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7223845848","doi":"https://doi.org/10.1186/s12883-026-05539-4"},"language":"en","primary_location":{"id":"doi:10.1186/s12883-026-05539-4","doi":"https://doi.org/10.1186/s12883-026-05539-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12883-026-05539-4","pdf_url":null,"source":{"id":"https://openalex.org/S120289491","display_name":"BMC Neurology","issn_l":"1471-2377","issn":["1471-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12883-026-05539-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029156913","display_name":"Weihang Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weihang Guo","raw_affiliation_strings":["Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]},{"raw_affiliation_string":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138418508","display_name":"Jingyue Liu","orcid":"https://orcid.org/0000-0002-7143-7213","observed_orcids":["https://orcid.org/0000-0002-7143-7213"]},"institutions":[{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyue Liu","raw_affiliation_strings":["Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]},{"raw_affiliation_string":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108964401","display_name":"Zhiyue Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyue Wu","raw_affiliation_strings":["Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]},{"raw_affiliation_string":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159880314","display_name":"Xitong Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xitong Xu","raw_affiliation_strings":["Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]},{"raw_affiliation_string":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124301956","display_name":"Zheng Ruan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Ruan","raw_affiliation_strings":["Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]},{"raw_affiliation_string":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133237312","display_name":"Anqi Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anqi Huang","raw_affiliation_strings":["Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]},{"raw_affiliation_string":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042636700","display_name":"Erhe Xu","orcid":"https://orcid.org/0000-0003-2026-5914","observed_orcids":["https://orcid.org/0000-0003-2026-5914"]},"institutions":[{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Erhe Xu","raw_affiliation_strings":["Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]},{"raw_affiliation_string":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013606717","display_name":"Wei Mao","orcid":"https://orcid.org/0000-0002-7690-9013","observed_orcids":["https://orcid.org/0000-0002-7690-9013"]},"institutions":[{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Mao","raw_affiliation_strings":["Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]},{"raw_affiliation_string":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113568150","display_name":"Piu Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Piu Chan","raw_affiliation_strings":["Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]},{"raw_affiliation_string":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050112775","display_name":"Piu Chan","orcid":"https://orcid.org/0000-0002-4620-1268","observed_orcids":["https://orcid.org/0000-0002-4620-1268"]},"institutions":[{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Piu Chan","raw_affiliation_strings":["Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-4620-1268","affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]},{"raw_affiliation_string":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I4210094218"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050112775","https://openalex.org/A5113568150"],"corresponding_institution_ids":["https://openalex.org/I4210094218"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88410399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10114","display_name":"Balance, Gait, and Falls Prevention","score":0.5034000277519226,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10114","display_name":"Balance, Gait, and Falls Prevention","score":0.5034000277519226,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.2363000065088272,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/walking-speed","display_name":"walking speed","score":0.7099999785423279},{"id":"https://openalex.org/keywords/wearable-sensors","display_name":"wearable sensors","score":0.42800000309944153},{"id":"https://openalex.org/keywords/sample-size-calculation","display_name":"sample size determination","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mds-updrs","display_name":"MDS-UPDRS","score":0.8550000190734863},{"id":"https://openalex.org/keywords/late-life-function-and-disability-instrument","display_name":"Late-Life Function and Disability Instrument","score":0.7879999876022339},{"id":"https://openalex.org/keywords/stride-length","display_name":"stride length","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7484999895095825},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.6014999747276306},{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.5910999774932861},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5885000228881836},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.5552999973297119},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5390999913215637},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.5317000150680542},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5246000289916992},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.4788999855518341},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4336000084877014},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.40939998626708984},{"id":"https://openalex.org/C70770792","wikidata":"https://www.wikidata.org/wiki/Q7239848","display_name":"Preferred walking speed","level":2,"score":0.37770000100135803},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.3695000112056732},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.35839998722076416},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C18007350","wikidata":"https://www.wikidata.org/wiki/Q7394815","display_name":"STRIDE","level":2,"score":0.35420000553131104},{"id":"https://openalex.org/C2779517570","wikidata":"https://www.wikidata.org/wiki/Q7144954","display_name":"Patient-reported outcome","level":3,"score":0.2955999970436096},{"id":"https://openalex.org/C12770488","wikidata":"https://www.wikidata.org/wiki/Q188449","display_name":"Neurosurgery","level":2,"score":0.28040000796318054},{"id":"https://openalex.org/C89337504","wikidata":"https://www.wikidata.org/wiki/Q4828276","display_name":"Average treatment effect","level":3,"score":0.2777000069618225},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2721000015735626},{"id":"https://openalex.org/C2778111679","wikidata":"https://www.wikidata.org/wiki/Q5155639","display_name":"Comparative effectiveness research","level":3,"score":0.2702000141143799},{"id":"https://openalex.org/C111278954","wikidata":"https://www.wikidata.org/wiki/Q17069312","display_name":"Minimal clinically important difference","level":3,"score":0.2680000066757202},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2671999931335449},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2596000134944916},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C2780218827","wikidata":"https://www.wikidata.org/wiki/Q4199597","display_name":"Goal Attainment Scaling","level":3,"score":0.2538999915122986}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12883-026-05539-4","doi":"https://doi.org/10.1186/s12883-026-05539-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12883-026-05539-4","pdf_url":null,"source":{"id":"https://openalex.org/S120289491","display_name":"BMC Neurology","issn_l":"1471-2377","issn":["1471-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Neurology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12883-026-05539-4","doi":"https://doi.org/10.1186/s12883-026-05539-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12883-026-05539-4","pdf_url":null,"source":{"id":"https://openalex.org/S120289491","display_name":"BMC Neurology","issn_l":"1471-2377","issn":["1471-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7221859193","https://openalex.org/W7128057399","https://openalex.org/W7127943304","https://openalex.org/W4414659093","https://openalex.org/W4409227168","https://openalex.org/W7127194859","https://openalex.org/W7220363497","https://openalex.org/W6893230608","https://openalex.org/W7048990758","https://openalex.org/W4390341959"],"abstract_inverted_index":{"A":[0,116],"digital":[1],"mobility":[2],"outcome":[3,52,94,182],"can":[4],"change":[5],"over":[6,47,230],"time":[7],"without":[8],"representing":[9],"a":[10,68,133,171,176,227],"meaningful":[11],"treatment":[12,222],"benefit":[13],"or":[14,226],"reducing":[15],"trial":[16],"sample-size":[17,228],"requirements.":[18],"We":[19,28],"examined":[20,201],"these":[21],"distinct":[22],"properties":[23],"in":[24,62,126,136,209],"ambulatory":[25,211],"Parkinson":[26,212],"disease.":[27,213],"analysed":[29],"524":[30],"participants":[31,147,186],"from":[32],"the":[33,54,71,149,156,180,244],"observational":[34],"Mobilise-D":[35,236],"Clinical":[36,237],"Validation":[37,238],"Study,":[38],"with":[39,190,243],"up":[40],"to":[41,104],"five":[42],"seven-day":[43],"lower-back":[44,202],"sensor":[45],"assessments":[46],"24":[48,144],"months.":[49],"The":[50,92,200,234],"primary":[51,93,150,181],"was":[53,89,240],"weekly":[55],"90th":[56],"percentile":[57],"(P90)":[58],"of":[59,70,74],"walking":[60],"speed":[61,119],"bouts":[63],"longer":[64],"than":[65],"30":[66],"s,":[67],"measure":[69],"faster":[72],"end":[73],"real-world":[75],"walking.":[76],"Mixed":[77],"models":[78,83],"assessed":[79,84],"longitudinal":[80],"change;":[81],"within-participant":[82,118],"clinical":[85,217,232],"co-change.":[86],"Sample-size":[87],"planning":[88],"post":[90],"hoc.":[91],"declined":[95],"by":[96],"\u2212":[97,102,105],"0.0164":[98],"m/s/year":[99],"(95%":[100],"CI":[101],"0.0226":[103],"0.0103;":[106],"2,081":[107],"observations).":[108],"Walking-bout":[109],"steps":[110],"and":[111,123,130,132,139,195,216],"stride":[112],"length":[113],"also":[114],"declined.":[115],"one-baseline-SD":[117],"reduction":[120,135],"accompanied":[121],"1.10-point":[122],"1.79-point":[124],"worsening":[125],"MDS-UPDRS":[127,193],"Parts":[128],"II":[129,194],"III":[131],"0.92-point":[134],"Late-Life":[137],"Function":[138],"Disability":[140],"Instrument":[141],"function.":[142],"At":[143],"months,":[145],"359":[146],"had":[148],"outcome.":[151],"Missing-not-at-random":[152],"sensitivity":[153],"scenarios":[154],"preserved":[155],"decline":[157],"direction":[158],"when":[159],"unobserved":[160],"values":[161],"were":[162],"assumed":[163],"worse,":[164],"but":[165],"its":[166],"magnitude":[167],"remained":[168],"uncertain.":[169],"Under":[170],"24-month,":[172],"80%-power":[173],"scenario":[174],"targeting":[175],"30%":[177],"slope":[178],"reduction,":[179],"required":[183],"approximately":[184],"3,450":[185],"per":[187],"arm,":[188],"compared":[189],"2,150":[191],"for":[192,197],"2,550":[196],"Part":[198],"III.":[199],"sensor-derived":[203],"outcomes":[204],"captured":[205],"small":[206],"group-level":[207],"changes":[208],"mild-to-moderate":[210],"Longitudinal":[214],"responsiveness":[215],"convergence":[218],"did":[219],"not":[220],"establish":[221],"responsiveness,":[223],"patient-perceived":[224],"benefit,":[225],"advantage":[229],"both":[231],"comparators.":[233],"parent":[235],"Study":[239],"prospectively":[241],"registered":[242],"ISRCTN":[245],"registry":[246],"(ISRCTN12051706)":[247],"on":[248],"10":[249],"December":[250],"2020.":[251]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-28T00:00:00"}