{"id":"https://openalex.org/W7223835263","doi":"https://doi.org/10.12122/j.issn.1673-4254.2026.10.06","title":"[Role of Ddx56 gene associated with early-onset Parkinson disease in maintaining neural development and protecting against dopaminergic neuron apoptosis in zebrafish].","display_name":"[Role of Ddx56 gene associated with early-onset Parkinson disease in maintaining neural development and protecting against dopaminergic neuron apoptosis in zebrafish].","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223835263","doi":"https://doi.org/10.12122/j.issn.1673-4254.2026.10.06","pmid":"https://pubmed.ncbi.nlm.nih.gov/42934098","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13710987"},"language":"zh","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13710987","doi":"https://doi.org/10.12122/j.issn.1673-4254.2026.10.06","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710987/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710987/pdf/nfykdxxb-46-10-2357.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan Fang Yi Ke Da Xue Xue Bao","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710987/pdf/nfykdxxb-46-10-2357.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159960530","display_name":"Qian Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Xu","raw_affiliation_strings":["College of Integrative Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Integrative Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China","institution_ids":["https://openalex.org/I118783713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159895406","display_name":"Erqi Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Erqi Liu","raw_affiliation_strings":["College of Integrative Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Integrative Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China","institution_ids":["https://openalex.org/I118783713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021519314","display_name":"Qiaofeng Zhang","orcid":"https://orcid.org/0000-0002-9033-6696","observed_orcids":["https://orcid.org/0000-0002-9033-6696"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiaofeng Zhang","raw_affiliation_strings":["College of Integrative Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Integrative Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China","institution_ids":["https://openalex.org/I118783713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077559186","display_name":"Haixin Liu","orcid":"https://orcid.org/0000-0002-3172-5341","observed_orcids":["https://orcid.org/0000-0002-3172-5341"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haixin Liu","raw_affiliation_strings":["College of Integrative Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Integrative Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China","institution_ids":["https://openalex.org/I118783713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078298278","display_name":"Xinpei Lin","orcid":"https://orcid.org/0000-0001-5246-3558","observed_orcids":["https://orcid.org/0000-0001-5246-3558"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinpei Lin","raw_affiliation_strings":["College of Integrative Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Integrative Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China","institution_ids":["https://openalex.org/I118783713"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113968273","display_name":"Yao Lin","orcid":"https://orcid.org/0000-0002-2726-2911","observed_orcids":["https://orcid.org/0000-0002-2726-2911"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Lin","raw_affiliation_strings":["College of Integrative Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Integrative Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China","institution_ids":["https://openalex.org/I118783713"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I118783713"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81296808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"10","first_page":"2357","last_page":"2371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-onset-parkinson-disease","display_name":"early-onset Parkinson disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.9380000233650208},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/neural-development","display_name":"neural development","score":0.8769999742507935},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.9480000138282776},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.9490000009536743},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7129999995231628},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6764000058174133},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6678000092506409},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6166999936103821},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5878000259399414},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5575000047683716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5566999912261963},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5519000291824341},{"id":"https://openalex.org/C461258","wikidata":"https://www.wikidata.org/wiki/Q1345738","display_name":"Neural development","level":3,"score":0.5460000038146973},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.508899986743927},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4945000112056732},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4747999906539917},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4406999945640564},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.4239000082015991},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.41359999775886536},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.38960000872612},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3711000084877014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3601999878883362},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.3467999994754791},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3458999991416931},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.31029999256134033},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28360000252723694},{"id":"https://openalex.org/C2780427247","wikidata":"https://www.wikidata.org/wiki/Q409961","display_name":"LRRK2","level":4,"score":0.2676999866962433},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.25060001015663147}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017350","descriptor_name":"N-Acetylgalactosaminyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:13710987","doi":"https://doi.org/10.12122/j.issn.1673-4254.2026.10.06","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710987/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710987/pdf/nfykdxxb-46-10-2357.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan Fang Yi Ke Da Xue Xue Bao","raw_type":"Text"},{"id":"pmid:42934098","doi":"https://doi.org/10.12122/j.issn.1673-4254.2026.10.06","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42934098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University","raw_type":"English Abstract"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13710987","doi":"https://doi.org/10.12122/j.issn.1673-4254.2026.10.06","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710987/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710987/pdf/nfykdxxb-46-10-2357.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan Fang Yi Ke Da Xue Xue Bao","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223835263.pdf","grobid_xml":"https://content.openalex.org/works/W7223835263.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3140685673","https://openalex.org/W1980905317","https://openalex.org/W2165783038","https://openalex.org/W106368552","https://openalex.org/W4389439129","https://openalex.org/W1887176459","https://openalex.org/W2755007939","https://openalex.org/W953308654","https://openalex.org/W3055728959","https://openalex.org/W2952542498"],"abstract_inverted_index":{"OBJECTIVES:":[0],"associated":[1,38],"with":[2,39],"the":[3,27,49],"pathogenesis":[4],"of":[5,13,20,26,51,66,78],"early-onset":[6],"Parkinson":[7],"disease":[8],"(PD)":[9],"in":[10,23,46,48,58],"maintaining":[11],"survival":[12],"dopaminergic":[14],"(DA)":[15],"neurons":[16],"during":[17],"early":[18,24,76],"development":[19,25],"zebrafish.":[21],"METHODS:":[22],"nervous":[28],"system.":[29],"RESULTS:":[30],"knockdown.":[31],"These":[32],"differentially":[33],"expressed":[34],"genes":[35,62],"were":[36],"significantly":[37],"neurodegenerative":[40],"diseases,":[41],"and":[42,60,63],"their":[43],"alterations":[44],"resulted":[45],"changes":[47,57],"level":[50],"oxidative":[52],"phosphorylation.":[53],"CONCLUSIONS:":[54],"knockdown":[55],"causes":[56],"PD-":[59],"DA-associated":[61],"induces":[64],"apoptosis":[65],"DA":[67],"neurons,":[68],"suggesting":[69],"its":[70],"potential":[71],"as":[72],"a":[73],"biomarker":[74],"for":[75],"diagnosis":[77],"PD.":[79]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-28T00:00:00"}