{"id":"https://openalex.org/W7223788902","doi":"https://doi.org/10.21203/rs.3.rs-11490262/v1","title":"Heptyl prodigiosin from estuarine Zooshikella sp. RANM57 induces caspase-dependent apoptosis and suppresses clonogenic survival in androgen-independent prostate cancer cells","display_name":"Heptyl prodigiosin from estuarine Zooshikella sp. RANM57 induces caspase-dependent apoptosis and suppresses clonogenic survival in androgen-independent prostate cancer cells","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7223788902","doi":"https://doi.org/10.21203/rs.3.rs-11490262/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11490262/v1","doi":"https://doi.org/10.21203/rs.3.rs-11490262/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11490262/v1","pdf_url":"https://www.researchsquare.com/article/rs-11490262/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11490262/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057711238","display_name":"Royston Stephen Madtha","orcid":"https://orcid.org/0000-0002-7798-9107","observed_orcids":["https://orcid.org/0000-0002-7798-9107"]},"institutions":[{"id":"https://openalex.org/I4403928307","display_name":"St. Aloysius (Deemed to Be University)","ror":"https://ror.org/05aba1p21","country_code":"IN","type":"education","lineage":["https://openalex.org/I4403928307"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Royston Stephen Madtha","raw_affiliation_strings":["St. Aloysius (Deemed to Be University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Aloysius (Deemed to Be University)","institution_ids":["https://openalex.org/I4403928307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112617848","display_name":"Kedeke Balakrishna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4401726862","display_name":"St. Xavier's College (Autonomous)","ror":"https://ror.org/0316y5a96","country_code":"IN","type":"education","lineage":["https://openalex.org/I4401726862"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kedeke Balakrishna","raw_affiliation_strings":["St Xavier's College, Palayamkottai, Tirunelveli, Tamil Nadu - 627002"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Xavier's College, Palayamkottai, Tirunelveli, Tamil Nadu - 627002","institution_ids":["https://openalex.org/I4401726862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093622667","display_name":"KhansabRazak Deen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4401726862","display_name":"St. Xavier's College (Autonomous)","ror":"https://ror.org/0316y5a96","country_code":"IN","type":"education","lineage":["https://openalex.org/I4401726862"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Khansab Razak Deen","raw_affiliation_strings":["St Xavier's College, Palayamkottai, Tirunelveli, Tamil Nadu - 627002"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Xavier's College, Palayamkottai, Tirunelveli, Tamil Nadu - 627002","institution_ids":["https://openalex.org/I4401726862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159860535","display_name":"Selvam Rithick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4401726862","display_name":"St. Xavier's College (Autonomous)","ror":"https://ror.org/0316y5a96","country_code":"IN","type":"education","lineage":["https://openalex.org/I4401726862"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Selvam Rithick","raw_affiliation_strings":["St Xavier's College, Palayamkottai, Tirunelveli, Tamil Nadu - 627002"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Xavier's College, Palayamkottai, Tirunelveli, Tamil Nadu - 627002","institution_ids":["https://openalex.org/I4401726862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035477778","display_name":"Savarimuthu Ignacimuthu S.J.","orcid":"https://orcid.org/0000-0002-8467-789X","observed_orcids":["https://orcid.org/0000-0002-8467-789X"]},"institutions":[{"id":"https://openalex.org/I4401726862","display_name":"St. Xavier's College (Autonomous)","ror":"https://ror.org/0316y5a96","country_code":"IN","type":"education","lineage":["https://openalex.org/I4401726862"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Savarimuthu Ignacimuthu","raw_affiliation_strings":["St Xavier's College, Palayamkottai, Tirunelveli, Tamil Nadu - 627002"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Xavier's College, Palayamkottai, Tirunelveli, Tamil Nadu - 627002","institution_ids":["https://openalex.org/I4401726862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024809059","display_name":"P. Pandikumar","orcid":"https://orcid.org/0000-0002-1643-7325","observed_orcids":["https://orcid.org/0000-0002-1643-7325"]},"institutions":[{"id":"https://openalex.org/I4210115345","display_name":"Sri Balaji Vidyapeeth University","ror":"https://ror.org/02avh2k34","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210115345"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Perumal Pandikumar","raw_affiliation_strings":["Sri Balaji Vidyapeeth (Deemed to be University), Pillayarkuppam, Puducherry \u2013 607 403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sri Balaji Vidyapeeth (Deemed to be University), Pillayarkuppam, Puducherry \u2013 607 403","institution_ids":["https://openalex.org/I4210115345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028583291","display_name":"Sreejesh Pilakkavil Chirakkara","orcid":"https://orcid.org/0000-0003-1012-9054","observed_orcids":["https://orcid.org/0000-0003-1012-9054"]},"institutions":[{"id":"https://openalex.org/I4403928307","display_name":"St. Aloysius (Deemed to Be University)","ror":"https://ror.org/05aba1p21","country_code":"IN","type":"education","lineage":["https://openalex.org/I4403928307"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sreejesh Pilakkavil Chirakkara","raw_affiliation_strings":["St. Aloysius (Deemed to Be University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Aloysius (Deemed to Be University)","institution_ids":["https://openalex.org/I4403928307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101727587","display_name":"Asha Abraham","orcid":"https://orcid.org/0000-0002-1710-7440","observed_orcids":["https://orcid.org/0000-0002-1710-7440"]},"institutions":[{"id":"https://openalex.org/I4403928307","display_name":"St. Aloysius (Deemed to Be University)","ror":"https://ror.org/05aba1p21","country_code":"IN","type":"education","lineage":["https://openalex.org/I4403928307"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Asha Abraham","raw_affiliation_strings":["St. Aloysius (Deemed to Be University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Aloysius (Deemed to Be University)","institution_ids":["https://openalex.org/I4403928307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estuarine-bacteria","display_name":"estuarine bacteria","score":0.8040000200271606},{"id":"https://openalex.org/keywords/prodiginines","display_name":"prodiginines","score":0.7609999775886536},{"id":"https://openalex.org/keywords/caspase-dependent-apoptosis","display_name":"caspase-dependent apoptosis","score":0.7879999876022339},{"id":"https://openalex.org/keywords/caspase-3-activation","display_name":"caspase-3 activation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9620000123977661},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/clonogenic-survival","display_name":"clonogenic survival","score":0.8050000071525574},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7749999761581421},{"id":"https://openalex.org/keywords/red-pigment","display_name":"red pigment","score":0.44699999690055847},{"id":"https://openalex.org/keywords/natural-product-discovery","display_name":"natural product discovery","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2779337610","wikidata":"https://www.wikidata.org/wiki/Q415663","display_name":"Prodigiosin","level":5,"score":0.6643000245094299},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6172999739646912},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5996000170707703},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.5892000198364258},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.5812000036239624},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5450999736785889},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.4794999957084656},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.4296000003814697},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4000999927520752},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3779999911785126},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3752000033855438},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.37369999289512634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36890000104904175},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3630000054836273},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.34790000319480896},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3450999855995178},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.33480000495910645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.325300008058548},{"id":"https://openalex.org/C2781160685","wikidata":"https://www.wikidata.org/wiki/Q5276420","display_name":"Dihydroartemisinin","level":5,"score":0.3239000141620636},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.3212999999523163},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C11957725","wikidata":"https://www.wikidata.org/wiki/Q5533590","display_name":"Gentamicin protection assay","level":4,"score":0.26100000739097595},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C2777002184","wikidata":"https://www.wikidata.org/wiki/Q63370","display_name":"Pheophorbide A","level":3,"score":0.25600001215934753},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.2549000084400177}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11490262/v1","doi":"https://doi.org/10.21203/rs.3.rs-11490262/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11490262/v1","pdf_url":"https://www.researchsquare.com/article/rs-11490262/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11490262/v1","doi":"https://doi.org/10.21203/rs.3.rs-11490262/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11490262/v1","pdf_url":"https://www.researchsquare.com/article/rs-11490262/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223788902.pdf","grobid_xml":"https://content.openalex.org/works/W7223788902.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1570782805","https://openalex.org/W2021400214","https://openalex.org/W2054644182","https://openalex.org/W2080737199","https://openalex.org/W2126534544","https://openalex.org/W2139906780","https://openalex.org/W2172027841","https://openalex.org/W2432801886","https://openalex.org/W2469217345","https://openalex.org/W2586242710","https://openalex.org/W2615534223","https://openalex.org/W2898615169","https://openalex.org/W2899118326","https://openalex.org/W2951276669","https://openalex.org/W3007301053","https://openalex.org/W3015773090","https://openalex.org/W3081592218","https://openalex.org/W3114190434","https://openalex.org/W3134744159","https://openalex.org/W3215339314","https://openalex.org/W4224797220","https://openalex.org/W4283326387","https://openalex.org/W4386932901","https://openalex.org/W4386933789","https://openalex.org/W4387270727","https://openalex.org/W4399356092","https://openalex.org/W4405112500","https://openalex.org/W4405499276","https://openalex.org/W4408261620","https://openalex.org/W4409088123","https://openalex.org/W4409528835","https://openalex.org/W4411404580","https://openalex.org/W4414156982","https://openalex.org/W4414483399","https://openalex.org/W7052896800","https://openalex.org/W7078080449","https://openalex.org/W7125541043","https://openalex.org/W7155541219"],"related_works":["https://openalex.org/W1967273521","https://openalex.org/W2899118326","https://openalex.org/W3093789578","https://openalex.org/W3007301053","https://openalex.org/W2298571091","https://openalex.org/W1991119899","https://openalex.org/W7120770871","https://openalex.org/W7020664444","https://openalex.org/W7172135616","https://openalex.org/W2263927274"],"abstract_inverted_index":{"Abstract":[0],"Estuarine":[1],"microbiomes":[2],"are":[3],"rich":[4],"ecological":[5],"niches":[6],"for":[7,247],"discovering":[8],"novel":[9],"secondary":[10],"metabolites":[11],"with":[12,128],"therapeutic":[13],"applications.":[14],"This":[15],"study":[16],"focuses":[17],"on":[18,119],"the":[19,44,61,113,213,227],"isolation,":[20],"purification,":[21],"structural":[22],"elucidation,":[23],"and":[24,56,69,74,89,104,123,178,197,203],"antineoplastic":[25],"evaluation":[26],"of":[27,205,215,235],"a":[28,32,231,243],"red":[29],"pigment":[30,63,109],"from":[31,43,208],"marine":[33],"microbial":[34],"isolate.":[35],"The":[36,92,107,200],"bacterium":[37],"Zooshikella":[38,209],"sp.":[39,210],"RANM57":[40,211],"was":[41,49,64,79,96,110],"isolated":[42],"Netravathi":[45],"River":[46],"estuary.":[47],"Biomass":[48],"recovered":[50],"using":[51,72,87,98],"an":[52,163],"alum-induced":[53],"flocculation":[54],"technique":[55],"solvent":[57],"extraction,":[58],"after":[59,193],"which":[60],"primary":[62,185],"purified":[65,108],"via":[66,162],"flash":[67],"chromatography":[68],"structurally":[70],"characterized":[71],"HRLCMS-QTOF":[73],"NMR":[75,125],"spectroscopy.":[76],"Anticancer":[77],"potential":[78],"evaluated":[80],"against":[81,139],"human":[82],"PC-3":[83,140],"prostate":[84],"cancer":[85],"cells":[86,141],"MTT":[88],"clonogenic":[90,191],"assays.":[91,106],"underlying":[93],"apoptotic":[94,165],"mechanism":[95],"delineated":[97],"Annexin":[99],"V/PI":[100],"staining,":[101],"Caspase-3":[102,175],"quantification,":[103],"TUNEL":[105],"identified":[111],"as":[112,167,230,242],"tripyrrole":[114,240],"alkaloid":[115],"heptyl":[116,206],"prodigiosin":[117,207],"based":[118],"HRLCMS-QTOF,":[120],"UV-Vis/FT-IR":[121],"profiling,":[122],"1D":[124],"spectral":[126],"concordance":[127],"reported":[129],"prodiginine":[130],"features.":[131],"In":[132],"vitro":[133],"evaluations":[134,224],"revealed":[135],"significant":[136,170],"dose-dependent":[137],"cytotoxicity":[138],"(IC":[142],"50":[143],"=":[144],"9.00":[145],"\u00b5g/mL),":[146],"demonstrating":[147],"high":[148],"anticancer":[149,249],"efficacy":[150],"relative":[151],"to":[152],"cisplatin.":[153],"Mechanistic":[154],"profiling":[155],"confirmed":[156],"that":[157,226],"cell":[158],"death":[159],"occurred":[160],"exclusively":[161],"intrinsic":[164],"cascade,":[166],"evidenced":[168],"by":[169],"phosphatidylserine":[171],"externalization":[172],"(17.60%),":[173],"executioner":[174],"activation":[176],"(52.45%),":[177],"terminal":[179],"DNA":[180],"fragmentation":[181],"(21.25%),":[182],"without":[183],"inducing":[184],"necrosis.":[186],"Furthermore,":[187],"treatment":[188],"also":[189],"reduced":[190],"survival":[192],"24":[194],"h":[195],"exposure":[196],"8-day":[198],"outgrowth.":[199],"successful":[201],"isolation":[202],"characterization":[204],"underscores":[212],"value":[214],"estuarine":[216],"bacteria":[217],"in":[218],"natural":[219],"product":[220],"discovery.":[221],"Our":[222],"biological":[223],"demonstrate":[225],"compound":[228],"functions":[229],"precise,":[232],"potent":[233],"inducer":[234],"caspase-associated":[236],"apoptosis,":[237],"positioning":[238],"this":[239],"scaffold":[241],"highly":[244],"promising":[245],"candidate":[246],"further":[248],"pharmacological":[250],"development.":[251]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-28T00:00:00"}
