{"id":"https://openalex.org/W7223700591","doi":"https://doi.org/10.1007/s00726-026-03565-7","title":"ZNF503-AS-Pep1 mitigates neuroinflammation and oxidative stress via HMGA2 in a microglia-mediated neuroinflammatory cell model","display_name":"ZNF503-AS-Pep1 mitigates neuroinflammation and oxidative stress via HMGA2 in a microglia-mediated neuroinflammatory cell model","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223700591","doi":"https://doi.org/10.1007/s00726-026-03565-7"},"language":"en","primary_location":{"id":"doi:10.1007/s00726-026-03565-7","doi":"https://doi.org/10.1007/s00726-026-03565-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00726-026-03565-7","pdf_url":null,"source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s00726-026-03565-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159700377","display_name":"Yatang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210135470","display_name":"Chongqing Emergency Medical Center","ror":"https://ror.org/03xhwyc44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135470"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yatang Chen","raw_affiliation_strings":["Chongqing Key Laboratory of Emergency Medical, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Emergency Medical, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210135470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159620953","display_name":"Yilin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yilin Liu","raw_affiliation_strings":["The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159577258","display_name":"Lei Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Yu","raw_affiliation_strings":["The Third People\u2019s Hospital of Qujing City, Qujing, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third People\u2019s Hospital of Qujing City, Qujing, Yunnan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159651815","display_name":"Yong Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Zeng","raw_affiliation_strings":["The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159621449","display_name":"Yongquan Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210135470","display_name":"Chongqing Emergency Medical Center","ror":"https://ror.org/03xhwyc44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135470"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongquan Lu","raw_affiliation_strings":["Chongqing Key Laboratory of Emergency Medical, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China","Clinical Laboratory, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Emergency Medical, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210135470"]},{"raw_affiliation_string":"Clinical Laboratory, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210135470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5159621449","https://openalex.org/A5159700377"],"corresponding_institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210135470"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77450697,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmga2","display_name":"HMGA2","score":0.8180000185966492},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.875},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.7730000019073486},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8668000102043152},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7929999828338623},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5511000156402588},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4957999885082245},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43140000104904175},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.375900000333786},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.3294999897480011},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3158999979496002},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3095000088214874},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3003999888896942},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2913999855518341},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.28060001134872437},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2784000039100647},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.2687999904155731},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s00726-026-03565-7","doi":"https://doi.org/10.1007/s00726-026-03565-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00726-026-03565-7","pdf_url":null,"source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s00726-026-03565-7","doi":"https://doi.org/10.1007/s00726-026-03565-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00726-026-03565-7","pdf_url":null,"source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7169733284","https://openalex.org/W1974521356","https://openalex.org/W4387630981","https://openalex.org/W7168283883","https://openalex.org/W7018740176","https://openalex.org/W2954722953","https://openalex.org/W2766265161","https://openalex.org/W1973589652","https://openalex.org/W4403046689","https://openalex.org/W3112030475"],"abstract_inverted_index":{"Neuroinflammation":[0],"and":[1,11,16,41,72,92,118,133,138,140,149,170,177,203,233,236,251,277],"oxidative":[2,178,226,252,278],"stress":[3,65,279],"are":[4],"critical":[5],"pathological":[6,191],"drivers":[7],"in":[8,32,36,39,180,247,257,280],"various":[9],"neurological":[10],"neuropsychiatric":[12],"disorders,":[13,282],"with":[14,103,111,205],"IL6":[15,86,98,113,168,211,220,249],"reactive":[17],"oxygen":[18],"species":[19],"(ROS)":[20],"as":[21,196,228,269],"key":[22,127,198],"factors.":[23],"This":[24],"study":[25],"investigated":[26],"the":[27,79,82,112,174,219],"lncRNA-derived":[28],"peptide":[29],"ZNF503-AS-Pep1\u2019s":[30],"role":[31,246],"modulating":[33,255],"these":[34,190],"pathways":[35],"cell":[37,57,260],"model":[38,58],"vitro":[40],"its":[42],"molecular":[43],"mechanism.":[44],"In":[45,240],"this":[46],"study,":[47],"HMC3":[48,182],"cells":[49],"were":[50,94,122,144,156],"used":[51,95],"to":[52,59,96,107,124,146],"construct":[53],"an":[54,258],"LPS-induced":[55],"inflammatory":[56,259],"simulate":[60],"a":[61,197,244,270],"neuroinflammatory":[62,281],"condition.":[63],"Oxidative":[64],"was":[66,105,194],"evaluated":[67],"by":[68,213,230,254],"measuring":[69],"ROS,":[70],"MDA,":[71],"SOD":[73,238],"levels.":[74],"Dual-luciferase":[75],"reporter":[76],"assays":[77],"assessed":[78],"impact":[80],"on":[81],"transcriptional":[83],"activity":[84],"of":[85,186,210],"promoter.":[87,221],"Enzyme-linked":[88],"immunosorbent":[89],"assay":[90],"(ELISA)":[91],"RT-qPCR":[93],"measure":[97],"level.":[99],"DNA":[100],"pull-down":[101],"combined":[102],"MS":[104],"utilized":[106,157],"identify":[108],"proteins":[109,130],"interacting":[110],"promoter":[114],"region.":[115],"Co-immunoprecipitation":[116],"(Co-IP)":[117],"Venn":[119],"diagram":[120],"analyses":[121],"employed":[123],"further":[125],"determine":[126],"intermediate":[128],"regulatory":[129],"between":[131],"ZNF503-AS-Pep1":[132,165,188,202,206,223,242,266],"IL6.":[134],"Chromatin":[135],"immunoprecipitation":[136],"(ChIP-PCR":[137],"ChIP-qPCR)":[139],"computational":[141],"structural":[142],"modeling":[143],"performed":[145],"elucidate":[147],"protein-DNA":[148],"peptide-protein":[150],"interactions,":[151],"while":[152],"antisense":[153],"oligonucleotides":[154],"(ASOs)":[155],"for":[158,274],"loss-of-function":[159],"validation.":[160],"The":[161],"results":[162],"showed":[163],"that":[164,265],"markedly":[166],"reduced":[167,231],"transcription":[169,212,250],"secretion,":[171],"effectively":[172],"mitigating":[173,275],"pro-inflammatory":[175],"state":[176],"damage":[179,253],"LPS-stimulated":[181],"cells,":[183],"whereas":[184],"knockdown":[185],"endogenous":[187],"exacerbated":[189],"phenotypes.":[192],"HMGA2":[193,216,256],"identified":[195],"intermediary":[199],"protein":[200],"connecting":[201],"IL6,":[204],"inhibiting":[207],"HMGA2\u2019s":[208],"enhancement":[209],"physically":[214],"hindering":[215],"occupancy":[217],"at":[218],"Additionally,":[222],"alleviated":[224],"HMGA2-induced":[225],"damage,":[227],"evidenced":[229],"ROS":[232],"MDA":[234],"levels":[235],"increased":[237],"activity.":[239],"conclusion,":[241],"exerted":[243],"protective":[245],"reducing":[248],"model.":[261],"These":[262],"findings":[263],"suggested":[264],"could":[267],"serve":[268],"promising":[271],"therapeutic":[272],"candidate":[273],"neuroinflammation":[276],"including":[283],"schizophrenia.":[284]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-27T00:00:00"}