{"id":"https://openalex.org/W7223699343","doi":"https://doi.org/10.1503/cmaj.261004","title":"Estradiol for persistent vasomotor symptoms after surgical menopause in a transgender man","display_name":"Estradiol for persistent vasomotor symptoms after surgical menopause in a transgender man","publication_year":2026,"publication_date":"2026-10-25","ids":{"openalex":"https://openalex.org/W7223699343","doi":"https://doi.org/10.1503/cmaj.261004","pmid":"https://pubmed.ncbi.nlm.nih.gov/42933800","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13719283"},"language":"en","primary_location":{"id":"doi:10.1503/cmaj.261004","doi":"https://doi.org/10.1503/cmaj.261004","is_oa":true,"landing_page_url":"https://doi.org/10.1503/cmaj.261004","pdf_url":"https://www.cmaj.ca/content/cmaj/198/37/E1439.full.pdf","source":{"id":"https://openalex.org/S4362743","display_name":"Canadian Medical Association Journal","issn_l":"0820-3946","issn":["0820-3946","1488-2329"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320072","host_organization_name":"Canadian Medical Association","host_organization_lineage":["https://openalex.org/P4310320072"],"host_organization_lineage_names":["Canadian Medical Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Medical Association Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cmaj.ca/content/cmaj/198/37/E1439.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094295236","display_name":"Macie Narbonne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I4210129503","display_name":"William Osler Health System","ror":"https://ror.org/03d1xjg58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210129503"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Macie Narbonne","raw_affiliation_strings":["Division of General Internal Medicine (Narbonne), Division of Endocrinology (Ahmad), and Department of Obstetrics and Gynaecology (Jacobson), University of Toronto, Toronto, Ont.; Department of Obstetrics and Gynecology (Jacobson), William Osler Health System, Ont.; Division of Endocrinology (Ahmad), Department of Medicine, Toronto Western Hospital-University Health Network, Toronto, Ont. macie.narbonne@mail.utoronto.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine (Narbonne), Division of Endocrinology (Ahmad), and Department of Obstetrics and Gynaecology (Jacobson), University of Toronto, Toronto, Ont.; Department of Obstetrics and Gynecology (Jacobson), William Osler Health System, Ont.; Division of Endocrinology (Ahmad), Department of Medicine, Toronto Western Hospital-University Health Network, Toronto, Ont. macie.narbonne@mail.utoronto.ca","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2799337515","https://openalex.org/I4210129503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108748577","display_name":"Michelle R. Jacobson","orcid":"https://orcid.org/0000-0002-2458-1909","observed_orcids":["https://orcid.org/0000-0002-2458-1909"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I4210129503","display_name":"William Osler Health System","ror":"https://ror.org/03d1xjg58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210129503"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michelle Jacobson","raw_affiliation_strings":["Division of General Internal Medicine (Narbonne), Division of Endocrinology (Ahmad), and Department of Obstetrics and Gynaecology (Jacobson), University of Toronto, Toronto, Ont.; Department of Obstetrics and Gynecology (Jacobson), William Osler Health System, Ont.; Division of Endocrinology (Ahmad), Department of Medicine, Toronto Western Hospital-University Health Network, Toronto, Ont"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine (Narbonne), Division of Endocrinology (Ahmad), and Department of Obstetrics and Gynaecology (Jacobson), University of Toronto, Toronto, Ont.; Department of Obstetrics and Gynecology (Jacobson), William Osler Health System, Ont.; Division of Endocrinology (Ahmad), Department of Medicine, Toronto Western Hospital-University Health Network, Toronto, Ont","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2799337515","https://openalex.org/I4210129503"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046145052","display_name":"Tehmina Ahmad","orcid":"https://orcid.org/0000-0002-7185-1131","observed_orcids":["https://orcid.org/0000-0002-7185-1131"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I4210129503","display_name":"William Osler Health System","ror":"https://ror.org/03d1xjg58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210129503"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tehmina Ahmad","raw_affiliation_strings":["Division of General Internal Medicine (Narbonne), Division of Endocrinology (Ahmad), and Department of Obstetrics and Gynaecology (Jacobson), University of Toronto, Toronto, Ont.; Department of Obstetrics and Gynecology (Jacobson), William Osler Health System, Ont.; Division of Endocrinology (Ahmad), Department of Medicine, Toronto Western Hospital-University Health Network, Toronto, Ont"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine (Narbonne), Division of Endocrinology (Ahmad), and Department of Obstetrics and Gynaecology (Jacobson), University of Toronto, Toronto, Ont.; Department of Obstetrics and Gynecology (Jacobson), William Osler Health System, Ont.; Division of Endocrinology (Ahmad), Department of Medicine, Toronto Western Hospital-University Health Network, Toronto, Ont","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2799337515","https://openalex.org/I4210129503"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5094295236"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2799337515","https://openalex.org/I4210129503"],"apc_list":{"value":3500,"currency":"CAD","value_usd":2553},"apc_paid":{"value":3500,"currency":"CAD","value_usd":2553},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83055224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"198","issue":"37","first_page":"E1439","last_page":"E1442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10156","display_name":"LGBTQ Health, Identity, and Policy","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8980000019073486},{"id":"https://openalex.org/keywords/vasomotor-symptoms","display_name":"vasomotor symptoms","score":0.9419999718666077},{"id":"https://openalex.org/keywords/surgical-menopause","display_name":"surgical menopause","score":0.7680000066757202},{"id":"https://openalex.org/keywords/trans-men","display_name":"transgender men","score":0.7990000247955322},{"id":"https://openalex.org/keywords/oophorectomy","display_name":"oophorectomy","score":0.9700000286102295},{"id":"https://openalex.org/keywords/estrogen-deficiency","display_name":"estrogen deficiency","score":0.9890000224113464},{"id":"https://openalex.org/keywords/testosterone-replacement-therapy","display_name":"testosterone replacement therapy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C2776214587","wikidata":"https://www.wikidata.org/wiki/Q3430227","display_name":"Vasomotor","level":2,"score":0.8634999990463257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8210999965667725},{"id":"https://openalex.org/C2779671885","wikidata":"https://www.wikidata.org/wiki/Q189125","display_name":"Transgender","level":2,"score":0.7117000222206116},{"id":"https://openalex.org/C2910687382","wikidata":"https://www.wikidata.org/wiki/Q189125","display_name":"Transgender Person","level":3,"score":0.6579999923706055},{"id":"https://openalex.org/C2777696064","wikidata":"https://www.wikidata.org/wiki/Q1751597","display_name":"Oophorectomy","level":3,"score":0.621999979019165},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.6194999814033508},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5453000068664551},{"id":"https://openalex.org/C2910557164","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Surgical Menopause","level":3,"score":0.45249998569488525},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4259999990463257},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3456000089645386},{"id":"https://openalex.org/C3020211606","wikidata":"https://www.wikidata.org/wiki/Q3354346","display_name":"Estrogen replacement therapy","level":3,"score":0.3440999984741211},{"id":"https://openalex.org/C2910401296","wikidata":"https://www.wikidata.org/wiki/Q2062354","display_name":"Transgender people","level":3,"score":0.34380000829696655},{"id":"https://openalex.org/C3020302352","wikidata":"https://www.wikidata.org/wiki/Q1052281","display_name":"Transgender women","level":5,"score":0.33980000019073486},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.27709999680519104},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C2777656388","wikidata":"https://www.wikidata.org/wiki/Q1049021","display_name":"Gender dysphoria","level":3,"score":0.2572000026702881}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1503/cmaj.261004","doi":"https://doi.org/10.1503/cmaj.261004","is_oa":true,"landing_page_url":"https://doi.org/10.1503/cmaj.261004","pdf_url":"https://www.cmaj.ca/content/cmaj/198/37/E1439.full.pdf","source":{"id":"https://openalex.org/S4362743","display_name":"Canadian Medical Association Journal","issn_l":"0820-3946","issn":["0820-3946","1488-2329"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320072","host_organization_name":"Canadian Medical Association","host_organization_lineage":["https://openalex.org/P4310320072"],"host_organization_lineage_names":["Canadian Medical Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Medical Association Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13719283","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13719283/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13719283/pdf/198e1439.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CMAJ","raw_type":"Text"},{"id":"pmid:42933800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42933800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1503/cmaj.261004","doi":"https://doi.org/10.1503/cmaj.261004","is_oa":true,"landing_page_url":"https://doi.org/10.1503/cmaj.261004","pdf_url":"https://www.cmaj.ca/content/cmaj/198/37/E1439.full.pdf","source":{"id":"https://openalex.org/S4362743","display_name":"Canadian Medical Association Journal","issn_l":"0820-3946","issn":["0820-3946","1488-2329"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320072","host_organization_name":"Canadian Medical Association","host_organization_lineage":["https://openalex.org/P4310320072"],"host_organization_lineage_names":["Canadian Medical Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Medical Association Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223699343.pdf","grobid_xml":"https://content.openalex.org/works/W7223699343.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2911596552","https://openalex.org/W3202709749","https://openalex.org/W1975535219","https://openalex.org/W2099666397","https://openalex.org/W1498014128","https://openalex.org/W2434509691","https://openalex.org/W2944278081","https://openalex.org/W2776943939","https://openalex.org/W2433011740","https://openalex.org/W4295559956"],"abstract_inverted_index":{"Key":[0],"points":[1],"\u2022Persistent":[2],"vasomotor":[3],"symptoms":[4],"after":[5],"oophorectomy":[6],"should":[7],"prompt":[8],"evaluation":[9],"for":[10],"hypoestrogenemia,":[11],"even":[12],"in":[13],"transgender":[14],"men":[15],"receiving":[16],"adequate":[17],"testosterone":[18],"therapy.":[19]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2026-10-27T00:00:00"}
