{"id":"https://openalex.org/W7223689869","doi":"https://doi.org/10.2147/ijn.s639450","title":"Extracellular Vesicles and Choline Metabolism in Neonatal Bronchopulmonary Dysplasia: A Systems-Pharmacology Framework for Regenerative Therapy","display_name":"Extracellular Vesicles and Choline Metabolism in Neonatal Bronchopulmonary Dysplasia: A Systems-Pharmacology Framework for Regenerative Therapy","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223689869","doi":"https://doi.org/10.2147/ijn.s639450","pmid":"https://pubmed.ncbi.nlm.nih.gov/42965167","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13722048"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s639450","doi":"https://doi.org/10.2147/ijn.s639450","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s639450","pdf_url":"https://www.dovepress.com/article/download/121378","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/121378","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123986457","display_name":"Radhika Joshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102117144","display_name":"Banasthali University","ror":"https://ror.org/05ycegt40","country_code":"IN","type":"education","lineage":["https://openalex.org/I102117144"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Radhika Joshi","raw_affiliation_strings":["Department of Bioscience & Biotechnology, Banasthali Vidyapith, Banasthali, Rajasthan, India","Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience & Biotechnology, Banasthali Vidyapith, Banasthali, Rajasthan, India","institution_ids":["https://openalex.org/I102117144"]},{"raw_affiliation_string":"Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India","institution_ids":["https://openalex.org/I102117144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159581961","display_name":"Aarti Deshwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102117144","display_name":"Banasthali University","ror":"https://ror.org/05ycegt40","country_code":"IN","type":"education","lineage":["https://openalex.org/I102117144"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aarti Deshwal","raw_affiliation_strings":["Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India","institution_ids":["https://openalex.org/I102117144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159646104","display_name":"Hitisha Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102117144","display_name":"Banasthali University","ror":"https://ror.org/05ycegt40","country_code":"IN","type":"education","lineage":["https://openalex.org/I102117144"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hitisha Sharma","raw_affiliation_strings":["Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India","institution_ids":["https://openalex.org/I102117144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152025782","display_name":"Manshi Kesharwani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102117144","display_name":"Banasthali University","ror":"https://ror.org/05ycegt40","country_code":"IN","type":"education","lineage":["https://openalex.org/I102117144"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manshi Kesharwani","raw_affiliation_strings":["Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India","institution_ids":["https://openalex.org/I102117144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019393394","display_name":"Swati Paliwal","orcid":"https://orcid.org/0000-0001-8498-6310","observed_orcids":["https://orcid.org/0000-0001-8498-6310"]},"institutions":[{"id":"https://openalex.org/I102117144","display_name":"Banasthali University","ror":"https://ror.org/05ycegt40","country_code":"IN","type":"education","lineage":["https://openalex.org/I102117144"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Swati Paliwal","raw_affiliation_strings":["Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India","institution_ids":["https://openalex.org/I102117144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031625375","display_name":"Devesh U. Kapoor","orcid":"https://orcid.org/0000-0003-4085-8936","observed_orcids":["https://orcid.org/0000-0003-4085-8936"]},"institutions":[{"id":"https://openalex.org/I4405255592","display_name":"Dr. Dayaram Patel Pharmacy College","ror":"https://ror.org/036dmex16","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405255592"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Devesh U Kapoor","raw_affiliation_strings":["Department of Pharmacy, Dr. Dayaram Patel Pharmacy College, Surat, Gujrat, India"],"raw_orcid":"https://orcid.org/0000-0003-4085-8936","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Dr. Dayaram Patel Pharmacy College, Surat, Gujrat, India","institution_ids":["https://openalex.org/I4405255592"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159714613","display_name":"Swapnil Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102117144","display_name":"Banasthali University","ror":"https://ror.org/05ycegt40","country_code":"IN","type":"education","lineage":["https://openalex.org/I102117144"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Swapnil Sharma","raw_affiliation_strings":["Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India","institution_ids":["https://openalex.org/I102117144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031625375","https://openalex.org/A5159714613"],"corresponding_institution_ids":["https://openalex.org/I102117144","https://openalex.org/I4405255592"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61538462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 21","issue":null,"first_page":"1","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.19539999961853027,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bronchopulmonary-dysplasia","display_name":"bronchopulmonary dysplasia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9890000224113464},{"id":"https://openalex.org/keywords/choline-metabolism","display_name":"choline metabolism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/systems-pharmacology","display_name":"systems pharmacology","score":0.7459999918937683},{"id":"https://openalex.org/keywords/regenerative-therapy","display_name":"regenerative therapy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/phosphatidylcholine-biosynthesis","display_name":"phosphatidylcholine synthesis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/s-adenosylmethionine","display_name":"S-adenosylmethionine","score":0.9779999852180481},{"id":"https://openalex.org/keywords/one-carbon-metabolism","display_name":"one-carbon metabolism","score":0.9300000071525574},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/lung-brain-axis","display_name":"lung-brain axis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/endothelial-barrier","display_name":"endothelial barrier","score":0.8330000042915344},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7509999871253967},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6060000061988831},{"id":"https://openalex.org/keywords/neonatal-lung-development","display_name":"neonatal lung development","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2778721537","wikidata":"https://www.wikidata.org/wiki/Q922640","display_name":"Bronchopulmonary dysplasia","level":4,"score":0.8863000273704529},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.7128000259399414},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6208000183105469},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5443000197410583},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48649999499320984},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.4860000014305115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44029998779296875},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.4239000082015991},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4052000045776367},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.39149999618530273},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.38760000467300415},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.357699990272522},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.3472999930381775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3424000144004822},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3287999927997589},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.29820001125335693},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.2939999997615814},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.29179999232292175},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2904999852180481},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2865999937057495},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.2540000081062317}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001997","descriptor_name":"Bronchopulmonary Dysplasia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001997","descriptor_name":"Bronchopulmonary Dysplasia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2147/ijn.s639450","doi":"https://doi.org/10.2147/ijn.s639450","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s639450","pdf_url":"https://www.dovepress.com/article/download/121378","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmid:42965167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42965167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13722048","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722048/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:98178bdfbc774a3584242f6407062b87","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/98178bdfbc774a3584242f6407062b87","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol Volume 21, Iss Issue 1, Pp 1-34 (2026)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/121378","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/extracellular-vesicles-and-choline-metabolism-in-neonatal-bronchopulmo-peer-reviewed-fulltext-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review"}],"best_oa_location":{"id":"doi:10.2147/ijn.s639450","doi":"https://doi.org/10.2147/ijn.s639450","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s639450","pdf_url":"https://www.dovepress.com/article/download/121378","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223689869.pdf","grobid_xml":"https://content.openalex.org/works/W7223689869.grobid-xml"},"referenced_works_count":122,"referenced_works":["https://openalex.org/W86318757","https://openalex.org/W1840268501","https://openalex.org/W1981203180","https://openalex.org/W1986852088","https://openalex.org/W1989970156","https://openalex.org/W1994147703","https://openalex.org/W2026146003","https://openalex.org/W2027167191","https://openalex.org/W2045363444","https://openalex.org/W2046948130","https://openalex.org/W2061136308","https://openalex.org/W2066550198","https://openalex.org/W2069620520","https://openalex.org/W2072167135","https://openalex.org/W2090278635","https://openalex.org/W2099930946","https://openalex.org/W2121030618","https://openalex.org/W2122602360","https://openalex.org/W2123240447","https://openalex.org/W2136005557","https://openalex.org/W2139123746","https://openalex.org/W2162931487","https://openalex.org/W2176161034","https://openalex.org/W2184895054","https://openalex.org/W2302291950","https://openalex.org/W2322232338","https://openalex.org/W2401235024","https://openalex.org/W2471010858","https://openalex.org/W2510118245","https://openalex.org/W2587852293","https://openalex.org/W2591561423","https://openalex.org/W2622879993","https://openalex.org/W2755388963","https://openalex.org/W2760010828","https://openalex.org/W2781751290","https://openalex.org/W2811208517","https://openalex.org/W2889393211","https://openalex.org/W2893429695","https://openalex.org/W2904010299","https://openalex.org/W2904668262","https://openalex.org/W2966841399","https://openalex.org/W2967808696","https://openalex.org/W2973039076","https://openalex.org/W2996664610","https://openalex.org/W3009868920","https://openalex.org/W3034196829","https://openalex.org/W3036037610","https://openalex.org/W3043682330","https://openalex.org/W3046668398","https://openalex.org/W3108455023","https://openalex.org/W3125812806","https://openalex.org/W3134865517","https://openalex.org/W3147674260","https://openalex.org/W3165561827","https://openalex.org/W3166192697","https://openalex.org/W3172612204","https://openalex.org/W3176504956","https://openalex.org/W3184755963","https://openalex.org/W3185635035","https://openalex.org/W3194730254","https://openalex.org/W3208263134","https://openalex.org/W4211175539","https://openalex.org/W4213013094","https://openalex.org/W4223919531","https://openalex.org/W4229375124","https://openalex.org/W4231816767","https://openalex.org/W4282934402","https://openalex.org/W4284687823","https://openalex.org/W4285795314","https://openalex.org/W4290614464","https://openalex.org/W4292756584","https://openalex.org/W4297094104","https://openalex.org/W4303650461","https://openalex.org/W4309467168","https://openalex.org/W4312172553","https://openalex.org/W4316362877","https://openalex.org/W4317941334","https://openalex.org/W4318026418","https://openalex.org/W4321495943","https://openalex.org/W4327611085","https://openalex.org/W4365452630","https://openalex.org/W4367320835","https://openalex.org/W4378348497","https://openalex.org/W4384264172","https://openalex.org/W4385330162","https://openalex.org/W4388001265","https://openalex.org/W4388288803","https://openalex.org/W4389613530","https://openalex.org/W4390792201","https://openalex.org/W4391449343","https://openalex.org/W4392201174","https://openalex.org/W4392356214","https://openalex.org/W4393187882","https://openalex.org/W4393988739","https://openalex.org/W4396801956","https://openalex.org/W4397010723","https://openalex.org/W4398184520","https://openalex.org/W4399070604","https://openalex.org/W4399817304","https://openalex.org/W4400585907","https://openalex.org/W4401699763","https://openalex.org/W4404480929","https://openalex.org/W4406178696","https://openalex.org/W4406593571","https://openalex.org/W4407343752","https://openalex.org/W4407512254","https://openalex.org/W4408187080","https://openalex.org/W4408221422","https://openalex.org/W4408304383","https://openalex.org/W4408877315","https://openalex.org/W4410218257","https://openalex.org/W4410374805","https://openalex.org/W4410405550","https://openalex.org/W4410765143","https://openalex.org/W4411483024","https://openalex.org/W4411612521","https://openalex.org/W4411920748","https://openalex.org/W4412441374","https://openalex.org/W4412767055","https://openalex.org/W4413835074","https://openalex.org/W4415001616","https://openalex.org/W4415172635"],"related_works":["https://openalex.org/W7166344490","https://openalex.org/W4392710898","https://openalex.org/W7084291041","https://openalex.org/W4225512328","https://openalex.org/W7117556911","https://openalex.org/W7161553365","https://openalex.org/W4402361947","https://openalex.org/W3017368542","https://openalex.org/W4308698184","https://openalex.org/W3033712741"],"abstract_inverted_index":{"Bronchopulmonary":[0],"dysplasia":[1],"(BPD)":[2],"affects":[3],"not":[4,30],"only":[5],"the":[6,10,25,32,52,80,84,133,137,154],"lungs":[7],"but":[8,28],"also":[9],"lung-brain":[11,155],"axis,":[12],"leading":[13],"to":[14,47,59,72,75,96,149],"neuroinflammation":[15],"and":[16,56,70,78,88,93,101,110,113,123,139,146,152],"white":[17],"matter":[18],"dysmaturation.":[19],"Current":[20],"therapies":[21],"for":[22,37],"BPD":[23,49,151],"treat":[24,48,150],"lung":[26],"manifestations":[27],"do":[29],"address":[31],"multi-organistic":[33],"signaling":[34,109],"network":[35],"essential":[36],"neonatal":[38],"development.":[39],"Here,":[40],"we":[41],"describe":[42],"a":[43,143],"regenerative":[44],"medicine-based":[45],"approach":[46],"by":[50,128],"employing":[51],"extracellular":[53],"vesicle":[54],"(EV)":[55],"choline":[57,87,140],"pathways":[58,125,141],"restore":[60],"developmental":[61],"homeostasis.":[62],"Mesenchymal":[63],"cell-derived":[64],"EVs":[65],"transport":[66],"bioactive":[67],"lipids,":[68],"proteins,":[69],"microRNAs":[71],"target":[73],"cells":[74],"resolve":[76],"inflammation":[77],"stabilize":[79],"endothelial":[81],"barrier.":[82],"At":[83],"same":[85],"time,":[86],"its":[89],"derivatives":[90],"regulate":[91],"phosphatidylcholine":[92],"S-adenosylmethionine":[94],"synthesis":[95],"preserve":[97],"cellular":[98],"membrane":[99],"integrity":[100],"epigenetic":[102],"marks.":[103],"The":[104],"systems-pharmacology":[105],"hypothesis":[106],"that":[107],"EV-mediated":[108],"choline-dependent":[111],"phospholipid":[112],"one-carbon":[114],"metabolism":[115],"may":[116],"have":[117],"complementary":[118],"effects":[119],"on":[120],"inflammatory,":[121],"vascular,":[122],"neurodevelopmental":[124],"is":[126],"supported":[127],"available":[129],"mechanistic":[130],"evidence.":[131],"Thus,":[132],"combined":[134],"effect":[135],"of":[136],"EV":[138],"represents":[142],"highly":[144],"translational":[145],"network-based":[147],"therapy":[148],"protect":[153],"axis.":[156]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-27T00:00:00"}
