{"id":"https://openalex.org/W7223688089","doi":"https://doi.org/10.3389/fphar.2026.1979114","title":"Cross-organ translation of antifibrotic strategies from skin and lung fibrosis to glaucoma filtration surgery","display_name":"Cross-organ translation of antifibrotic strategies from skin and lung fibrosis to glaucoma filtration surgery","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223688089","doi":"https://doi.org/10.3389/fphar.2026.1979114"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1979114","doi":"https://doi.org/10.3389/fphar.2026.1979114","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1979114","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1979114/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1979114/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5128285679","display_name":"Xiaolu Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolu Zhong","raw_affiliation_strings":["The First Clinical College, Guangdong Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical College, Guangdong Medical University","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070033208","display_name":"\u8d75\u6842\u73b2","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guiling Zhao","raw_affiliation_strings":["Department of Ophthalmology, Affiliated Hospital of Guangdong Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Affiliated Hospital of Guangdong Medical University","institution_ids":["https://openalex.org/I176834541"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070033208"],"corresponding_institution_ids":["https://openalex.org/I176834541"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.89819418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glaucoma-filtering-surgery","display_name":"glaucoma filtration surgery","score":0.9850000143051147},{"id":"https://openalex.org/keywords/filtering-bleb-scarring","display_name":"filtering bleb scarring","score":0.9580000042915344},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/skin-fibrosis","display_name":"skin fibrosis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.7940000295639038},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.9309999942779541},{"id":"https://openalex.org/keywords/fibroblast-activation","display_name":"fibroblast activation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.9169999957084656},{"id":"https://openalex.org/keywords/local-drug-delivery","display_name":"local drug delivery","score":0.6859999895095825},{"id":"https://openalex.org/keywords/lysyl-oxidase","display_name":"lysyl oxidase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.6840000152587891},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6710000038146973},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8036999702453613},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.6668999791145325},{"id":"https://openalex.org/C2776228307","wikidata":"https://www.wikidata.org/wiki/Q4925763","display_name":"Bleb (medicine)","level":4,"score":0.5879999995231628},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.57669997215271},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.47940000891685486},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.4562999904155731},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4108000099658966},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.40310001373291016},{"id":"https://openalex.org/C2776766258","wikidata":"https://www.wikidata.org/wiki/Q5567291","display_name":"Glaucoma surgery","level":3,"score":0.39430001378059387},{"id":"https://openalex.org/C2777824320","wikidata":"https://www.wikidata.org/wiki/Q3177088","display_name":"Trabeculectomy","level":3,"score":0.3808000087738037},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37560001015663147},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3601999878883362},{"id":"https://openalex.org/C162264550","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Translational medicine","level":2,"score":0.3479999899864197},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.34439998865127563},{"id":"https://openalex.org/C193143273","wikidata":"https://www.wikidata.org/wiki/Q419389","display_name":"Lysyl oxidase","level":3,"score":0.3400999903678894},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.33730000257492065},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3264999985694885},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.323199987411499},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3231000006198883},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.320499986410141},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3147999942302704},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.3057999908924103},{"id":"https://openalex.org/C2777350992","wikidata":"https://www.wikidata.org/wiki/Q18035329","display_name":"KLF2","level":4,"score":0.3028999865055084},{"id":"https://openalex.org/C2908744134","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Lung fibrosis","level":4,"score":0.3027999997138977},{"id":"https://openalex.org/C2778698245","wikidata":"https://www.wikidata.org/wiki/Q1641147","display_name":"Hypertrophic scar","level":2,"score":0.2919999957084656},{"id":"https://openalex.org/C2778005187","wikidata":"https://www.wikidata.org/wiki/Q5262669","display_name":"Dermal fibroblast","level":4,"score":0.2865999937057495},{"id":"https://openalex.org/C2780404050","wikidata":"https://www.wikidata.org/wiki/Q416331","display_name":"Pentoxifylline","level":2,"score":0.2863999903202057},{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.2858000099658966},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C2779832356","wikidata":"https://www.wikidata.org/wiki/Q2060696","display_name":"Pirfenidone","level":4,"score":0.27799999713897705},{"id":"https://openalex.org/C2780299668","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Tropoelastin","level":3,"score":0.27799999713897705},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2768000066280365},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.27639999985694885},{"id":"https://openalex.org/C2777872592","wikidata":"https://www.wikidata.org/wiki/Q349185","display_name":"Wrinkle","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.25279998779296875},{"id":"https://openalex.org/C2778190193","wikidata":"https://www.wikidata.org/wiki/Q577377","display_name":"Brimonidine","level":3,"score":0.2524000108242035}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fphar.2026.1979114","doi":"https://doi.org/10.3389/fphar.2026.1979114","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1979114","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1979114/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:bcbde66d42b6413a8cbfc9304d49415f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bcbde66d42b6413a8cbfc9304d49415f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1979114","doi":"https://doi.org/10.3389/fphar.2026.1979114","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1979114","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1979114/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223688089.pdf","grobid_xml":"https://content.openalex.org/works/W7223688089.grobid-xml"},"referenced_works_count":120,"referenced_works":["https://openalex.org/W95012892","https://openalex.org/W123239899","https://openalex.org/W235216389","https://openalex.org/W594993882","https://openalex.org/W1183482596","https://openalex.org/W1993287053","https://openalex.org/W2024098656","https://openalex.org/W2027855264","https://openalex.org/W2058029601","https://openalex.org/W2062879793","https://openalex.org/W2133485412","https://openalex.org/W2160959025","https://openalex.org/W2338029131","https://openalex.org/W2742591033","https://openalex.org/W2757469257","https://openalex.org/W2884278586","https://openalex.org/W2888213689","https://openalex.org/W2903052513","https://openalex.org/W2914421535","https://openalex.org/W2928656056","https://openalex.org/W2942015005","https://openalex.org/W2972284911","https://openalex.org/W2986499003","https://openalex.org/W3011655170","https://openalex.org/W3028104192","https://openalex.org/W3033940483","https://openalex.org/W3090365611","https://openalex.org/W3105077348","https://openalex.org/W3115137350","https://openalex.org/W3118566702","https://openalex.org/W3120325987","https://openalex.org/W3120770418","https://openalex.org/W3121789561","https://openalex.org/W3159041271","https://openalex.org/W3161152772","https://openalex.org/W3164909090","https://openalex.org/W3166067883","https://openalex.org/W3167963024","https://openalex.org/W3187333782","https://openalex.org/W3209891406","https://openalex.org/W3211628450","https://openalex.org/W4206711402","https://openalex.org/W4212922872","https://openalex.org/W4214555582","https://openalex.org/W4214828299","https://openalex.org/W4220986712","https://openalex.org/W4223484562","https://openalex.org/W4224289969","https://openalex.org/W4283747664","https://openalex.org/W4285034857","https://openalex.org/W4286448996","https://openalex.org/W4286697932","https://openalex.org/W4294276876","https://openalex.org/W4296963810","https://openalex.org/W4304757178","https://openalex.org/W4307339500","https://openalex.org/W4308294079","https://openalex.org/W4310549220","https://openalex.org/W4313392342","https://openalex.org/W4313489005","https://openalex.org/W4315620168","https://openalex.org/W4316672739","https://openalex.org/W4319656491","https://openalex.org/W4319663107","https://openalex.org/W4320857476","https://openalex.org/W4322766271","https://openalex.org/W4366261646","https://openalex.org/W4372058898","https://openalex.org/W4377246025","https://openalex.org/W4378374067","https://openalex.org/W4378450726","https://openalex.org/W4378746122","https://openalex.org/W4382369714","https://openalex.org/W4382468838","https://openalex.org/W4384523433","https://openalex.org/W4384525350","https://openalex.org/W4386602536","https://openalex.org/W4386886942","https://openalex.org/W4387494731","https://openalex.org/W4387617374","https://openalex.org/W4387693584","https://openalex.org/W4390418587","https://openalex.org/W4390674546","https://openalex.org/W4391607884","https://openalex.org/W4391766892","https://openalex.org/W4394770533","https://openalex.org/W4396509875","https://openalex.org/W4396873760","https://openalex.org/W4397289033","https://openalex.org/W4398191354","https://openalex.org/W4400205241","https://openalex.org/W4400700863","https://openalex.org/W4401172861","https://openalex.org/W4401803517","https://openalex.org/W4401970825","https://openalex.org/W4402630338","https://openalex.org/W4402826052","https://openalex.org/W4405234436","https://openalex.org/W4406994591","https://openalex.org/W4407596211","https://openalex.org/W4408217629","https://openalex.org/W4409001054","https://openalex.org/W4409245856","https://openalex.org/W4409994330","https://openalex.org/W4410243731","https://openalex.org/W4410530711","https://openalex.org/W4410855836","https://openalex.org/W4410932204","https://openalex.org/W4411989529","https://openalex.org/W4412807945","https://openalex.org/W4413354018","https://openalex.org/W4414168730","https://openalex.org/W4414184987","https://openalex.org/W4416396250","https://openalex.org/W4416859942","https://openalex.org/W7125430088","https://openalex.org/W7126264232","https://openalex.org/W7127068768","https://openalex.org/W7130508224","https://openalex.org/W7161267140"],"related_works":["https://openalex.org/W4408217629","https://openalex.org/W4321495591","https://openalex.org/W3031691034","https://openalex.org/W4413062773","https://openalex.org/W2319397046","https://openalex.org/W3031003731","https://openalex.org/W393784782","https://openalex.org/W7039983532","https://openalex.org/W2105963014","https://openalex.org/W6310631"],"abstract_inverted_index":{"Filtering":[0],"bleb":[1],"scarring":[2],"after":[3],"glaucoma":[4],"filtration":[5],"surgery":[6],"(GFS)":[7],"remains":[8],"the":[9,143,186],"leading":[10],"cause":[11],"of":[12,54,146,190],"surgical":[13],"failure,":[14],"and":[15,31,41,57,93,111,120,142,166],"current":[16],"antimetabolites":[17],"are":[18],"limited":[19],"by":[20],"non-selective":[21],"cytotoxicity":[22],"that":[23,159],"restricts":[24],"their":[25],"long-term":[26,187],"use.":[27],"Research":[28],"on":[29,102,154,171],"skin":[30,92],"lung":[32,94],"fibrosis":[33,95],"has":[34],"accumulated":[35],"extensive":[36],"experience":[37],"in":[38,87,150],"antifibrotic":[39,72,89],"mechanisms":[40],"therapeutic":[42],"approaches.":[43],"These":[44],"tissues":[45],"share":[46],"a":[47,67,77],"common":[48],"transforming":[49],"growth":[50],"factor-beta":[51],"(TGF-\u03b2)-driven":[52],"program":[53],"fibroblast":[55],"activation":[56],"extracellular":[58],"matrix":[59],"(ECM)":[60],"remodeling":[61],"with":[62,133],"Tenon":[63],"capsule":[64],"fibroblasts,":[65],"providing":[66],"theoretical":[68],"basis":[69],"for":[70,99,184],"translating":[71,88],"strategies":[73,169],"across":[74],"organs.":[75],"From":[76],"cross-organ":[78],"translational":[79,122,144],"medicine":[80],"perspective,":[81],"this":[82,155],"review":[83],"systematically":[84],"summarizes":[85],"progress":[86],"research":[90],"from":[91],"to":[96],"antiscarring":[97,168],"therapy":[98],"GFS,":[100],"focusing":[101],"four":[103],"aspects:":[104],"shared":[105],"fibrotic":[106],"mechanisms;":[107],"repurposed":[108],"approved":[109],"drugs":[110],"emerging":[112],"molecular":[113],"targets;":[114],"local":[115,147,164],"drug":[116],"delivery":[117,149],"systems":[118],"(DDS);":[119],"ophthalmology-specific":[121],"challenges.":[123],"It":[124],"also":[125],"highlights":[126],"mechanotransduction":[127],"via":[128],"Yes-associated":[129],"protein":[130],"(YAP)/transcriptional":[131],"co-activator":[132],"PDZ-binding":[134],"motif":[135],"(TAZ),":[136],"lysyl":[137],"oxidase":[138],"(LOX)-mediated":[139],"ECM":[140],"crosslinking,":[141],"potential":[145],"sustained-release":[148],"filtering":[151],"blebs.":[152],"Building":[153],"foundation,":[156],"we":[157],"propose":[158],"multi-target":[160],"combination":[161],"therapy,":[162],"precision":[163],"delivery,":[165],"individualized":[167],"based":[170],"biomarkers":[172],"such":[173],"as":[174],"aqueous":[175],"humor":[176],"TGF-\u03b2":[177],"2":[178],"may":[179],"represent":[180],"important":[181],"future":[182],"directions":[183],"improving":[185],"success":[188],"rate":[189],"GFS.":[191]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-27T00:00:00"}