{"id":"https://openalex.org/W7223687900","doi":"https://doi.org/10.12956/tjpd.2026.1269","title":"Evaluation of neutrophil-to-lymphocyte, platelet-to-lymphocyte and eosinophil-to-lymphocyte ratios in childhood atopic dermatitis: Association with disease severity and treatment response","display_name":"Evaluation of neutrophil-to-lymphocyte, platelet-to-lymphocyte and eosinophil-to-lymphocyte ratios in childhood atopic dermatitis: Association with disease severity and treatment response","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223687900","doi":"https://doi.org/10.12956/tjpd.2026.1269"},"language":"en","primary_location":{"id":"doi:10.12956/tjpd.2026.1269","doi":"https://doi.org/10.12956/tjpd.2026.1269","is_oa":true,"landing_page_url":"https://doi.org/10.12956/tjpd.2026.1269","pdf_url":"https://turkjpediatrdis.org/article/download/1269/1305","source":{"id":"https://openalex.org/S4210229845","display_name":"Turkish Journal of Pediatric Disease","issn_l":"1307-4490","issn":["1307-4490","2148-3566"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Pediatric Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://turkjpediatrdis.org/article/download/1269/1305","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159613945","display_name":"P\u0131nar Y\u0131lmaz","orcid":"https://orcid.org/0009-0007-7610-1106","observed_orcids":["https://orcid.org/0009-0007-7610-1106"]},"institutions":[{"id":"https://openalex.org/I4399598363","display_name":"Ankara Bilkent City Hospital","ror":"https://ror.org/033fqnp11","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4399598363"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"P\u0131nar Y\u0131lmaz","raw_affiliation_strings":["Ankara Bilkent \u015eehir Hastanesi"],"raw_orcid":"https://orcid.org/0009-0007-7610-1106","affiliations":[{"raw_affiliation_string":"Ankara Bilkent \u015eehir Hastanesi","institution_ids":["https://openalex.org/I4399598363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017851428","display_name":"Zeynep \u015eeng\u00fcl Emeksiz","orcid":"https://orcid.org/0000-0001-7648-0352","observed_orcids":["https://orcid.org/0000-0001-7648-0352"]},"institutions":[{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]},{"id":"https://openalex.org/I4399598363","display_name":"Ankara Bilkent City Hospital","ror":"https://ror.org/033fqnp11","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4399598363"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zeynep \u015eeng\u00fcl Emeksiz","raw_affiliation_strings":["Sa\u011fl\u0131k Bilimleri \u00dcniversitesi, Ankara Bilkent \u015eehir Hastanesi"],"raw_orcid":"https://orcid.org/0000-0001-7648-0352","affiliations":[{"raw_affiliation_string":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi, Ankara Bilkent \u015eehir Hastanesi","institution_ids":["https://openalex.org/I4210128276","https://openalex.org/I4399598363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065192331","display_name":"Ahmet Selmano\u011flu","orcid":"https://orcid.org/0000-0002-6748-7330","observed_orcids":["https://orcid.org/0000-0002-6748-7330"]},"institutions":[{"id":"https://openalex.org/I4399598363","display_name":"Ankara Bilkent City Hospital","ror":"https://ror.org/033fqnp11","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4399598363"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ahmet Selmanoglu","raw_affiliation_strings":["Ankara Bilkent \u015eehir Hastanesi"],"raw_orcid":"https://orcid.org/0000-0002-6748-7330","affiliations":[{"raw_affiliation_string":"Ankara Bilkent \u015eehir Hastanesi","institution_ids":["https://openalex.org/I4399598363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069005637","display_name":"M\u00fcge Toyran","orcid":"https://orcid.org/0000-0002-2490-0551","observed_orcids":["https://orcid.org/0000-0002-2490-0551"]},"institutions":[{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]},{"id":"https://openalex.org/I4399598363","display_name":"Ankara Bilkent City Hospital","ror":"https://ror.org/033fqnp11","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4399598363"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Muge Toyran","raw_affiliation_strings":["Sa\u011fl\u0131k Bilimleri \u00dcniversitesi, Ankara Bilkent \u015eehir Hastanesi"],"raw_orcid":"https://orcid.org/0000-0002-2490-0551","affiliations":[{"raw_affiliation_string":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi, Ankara Bilkent \u015eehir Hastanesi","institution_ids":["https://openalex.org/I4210128276","https://openalex.org/I4399598363"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020470808","display_name":"Emine Dibek M\u0131s\u0131rl\u0131o\u011flu","orcid":"https://orcid.org/0000-0002-3241-2005","observed_orcids":["https://orcid.org/0000-0002-3241-2005","https://orcid.org/0000-0001-7648-0352"]},"institutions":[{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]},{"id":"https://openalex.org/I4399598363","display_name":"Ankara Bilkent City Hospital","ror":"https://ror.org/033fqnp11","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4399598363"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Eminde Dibek M\u0131s\u0131rl\u0131o\u011flu","raw_affiliation_strings":["Sa\u011fl\u0131k Bilimleri \u00dcniversitesi, Ankara Bilkent \u015eehir Hastanesi"],"raw_orcid":"https://orcid.org/0000-0002-3241-2005","affiliations":[{"raw_affiliation_string":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi, Ankara Bilkent \u015eehir Hastanesi","institution_ids":["https://openalex.org/I4210128276","https://openalex.org/I4399598363"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85641044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pediatric-atopic-dermatitis","display_name":"pediatric atopic dermatitis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":1.0},{"id":"https://openalex.org/keywords/platelet-to-lymphocyte-ratio","display_name":"platelet-to-lymphocyte ratio","score":1.0},{"id":"https://openalex.org/keywords/eosinophil-to-lymphocyte-ratio","display_name":"eosinophil-to-lymphocyte ratio","score":1.0},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.9419999718666077},{"id":"https://openalex.org/keywords/eczema-area-and-severity-index","display_name":"Eczema Area and Severity Index","score":0.9120000004768372},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.7839999794960022},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.8690000176429749},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9470000267028809},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6488999724388123},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.611299991607666},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5526999831199646},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5422999858856201},{"id":"https://openalex.org/C2780699399","wikidata":"https://www.wikidata.org/wiki/Q20708049","display_name":"Eczema Area and Severity Index","level":3,"score":0.5094000101089478},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4966999888420105},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.4948999881744385},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4652999937534332},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4521999955177307},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.4361000061035156},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.4050999879837036},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.33169999718666077},{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.3046000003814697},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.26989999413490295},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2572999894618988},{"id":"https://openalex.org/C2776173921","wikidata":"https://www.wikidata.org/wiki/Q25326609","display_name":"Dermatology Life Quality Index","level":3,"score":0.257099986076355}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.12956/tjpd.2026.1269","doi":"https://doi.org/10.12956/tjpd.2026.1269","is_oa":true,"landing_page_url":"https://doi.org/10.12956/tjpd.2026.1269","pdf_url":"https://turkjpediatrdis.org/article/download/1269/1305","source":{"id":"https://openalex.org/S4210229845","display_name":"Turkish Journal of Pediatric Disease","issn_l":"1307-4490","issn":["1307-4490","2148-3566"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Pediatric Disease","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.12956/tjpd.2026.1269","doi":"https://doi.org/10.12956/tjpd.2026.1269","is_oa":true,"landing_page_url":"https://doi.org/10.12956/tjpd.2026.1269","pdf_url":"https://turkjpediatrdis.org/article/download/1269/1305","source":{"id":"https://openalex.org/S4210229845","display_name":"Turkish Journal of Pediatric Disease","issn_l":"1307-4490","issn":["1307-4490","2148-3566"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Pediatric Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223687900.pdf","grobid_xml":"https://content.openalex.org/works/W7223687900.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1526387844","https://openalex.org/W1973874699","https://openalex.org/W2022137053","https://openalex.org/W2089853915","https://openalex.org/W2117359358","https://openalex.org/W2117983771","https://openalex.org/W2783471118","https://openalex.org/W2848123689","https://openalex.org/W2970991985","https://openalex.org/W3026414117","https://openalex.org/W4377115449","https://openalex.org/W4378173064","https://openalex.org/W4404386272","https://openalex.org/W4405191522"],"related_works":["https://openalex.org/W4399063610","https://openalex.org/W2595264342","https://openalex.org/W6960657160","https://openalex.org/W2783471118","https://openalex.org/W2964674903","https://openalex.org/W4413288350","https://openalex.org/W4385969815","https://openalex.org/W4411397280","https://openalex.org/W7149029316","https://openalex.org/W7166510340"],"abstract_inverted_index":{"Objective:":[0],"Atopic":[1],"dermatitis":[2],"(AD)":[3],"is":[4,234],"a":[5,235],"common":[6],"chronic,":[7],"inflammatory":[8,39,61,86,165],"skin":[9],"disease":[10,74,179,246],"in":[11,59,104,170,208,251,262],"childhood,":[12],"characterized":[13],"by":[14,77],"pruritus":[15],"and":[16,24,32,49,81,85,90,92,101,109,132,151,238,248,265],"recurrent":[17],"exacerbations.":[18],"AD":[19,120],"may":[20,243,259],"impair":[21],"daily":[22],"functioning":[23],"negatively":[25],"affect":[26],"quality":[27,133],"of":[28,65,134],"life,":[29],"psychosocial":[30],"status,":[31],"personal":[33],"development.":[34],"In":[35],"recent":[36],"years,":[37],"hematologic":[38,164],"indices":[40],"such":[41],"as":[42,56],"neutrophil-to-lymphocyte":[43,198],"ratio":[44,47,51,199],"(NLR),":[45],"platelet-to-lymphocyte":[46],"(PLR),":[48],"eosinophil-to-lymphocyte":[50],"(ELR)":[52],"have":[53],"been":[54],"investigated":[55],"potential":[57],"biomarkers":[58,87],"chronic":[60,178],"diseases.":[62],"The":[63,186,224],"aim":[64],"this":[66],"study":[67,114],"was":[68,189,230],"to":[69,93,161],"evaluate":[70],"the":[71,78,197],"relationship":[72],"between":[73],"severity":[75],"assessed":[76],"Eczema":[79],"Area":[80],"Severity":[82],"Index":[83],"(EASI)":[84],"(NLR,":[88],"PLR,":[89],"ELR),":[91],"determine":[94,162],"whether":[95,163],"these":[96],"markers":[97],"can":[98],"predict":[99,245],"prognosis":[100,247],"treatment":[102,249,267],"response":[103,250],"children":[105],"with":[106,119],"AD.":[107,253],"Materials":[108],"Methods:":[110],"This":[111],"prospective":[112],"observational":[113],"included":[115],"pediatric":[116,252],"patients":[117,175,203],"diagnosed":[118],"based":[121],"on":[122],"standard":[123],"diagnostic":[124],"criteria.":[125],"Demographic":[126],"characteristics,":[127],"clinical":[128],"findings,":[129],"laboratory":[130],"parameters,":[131],"life":[135],"scores":[136,146],"(Infants\u2019":[137],"Dermatitis":[138],"Life":[139],"Quality":[140],"Index,":[141],"IDLQI)":[142],"were":[143,147,159,180,184],"recorded.":[144],"EASI":[145,171,209],"calculated":[148],"at":[149],"diagnosis":[150],"after":[152],"treatment.":[153],"Receiver":[154],"operating":[155],"characteristic":[156],"(ROC)":[157],"analyses":[158],"performed":[160],"parameters":[166],"predicted":[167],"\u226550%":[168,206],"improvement":[169],"score.":[172],"Results:":[173],"Seventy":[174],"without":[176],"additional":[177],"included;":[181],"41":[182],"(58.6%)":[183],"boys.":[185],"mean":[187],"age":[188],"9.4":[190],"\u00b114.4":[191],"months.":[192],"ROC":[193],"analysis":[194],"demonstrated":[195],"that":[196,242],"(NLR)":[200],"significantly":[201],"differentiated":[202],"who":[204,213],"achieved":[205],"reduction":[207],"score":[210],"from":[211],"those":[212],"did":[214],"not":[215],"(AUC":[216],"=":[217],"0.648,":[218],"p":[219],"=0.041;":[220],"95%":[221],"CI:":[222],"0.50\u20130.70).":[223],"optimal":[225],"cutoff":[226],"value":[227],"for":[228],"NLR":[229,233,255],"0.3.":[231],"Conclusion:":[232],"rapid,":[236],"inexpensive,":[237],"widely":[239],"accessible":[240],"biomarker":[241],"help":[244],"Incorporating":[254],"into":[256],"routine":[257],"follow-up":[258],"assist":[260],"clinicians":[261],"monitoring":[263],"inflammation":[264],"optimizing":[266],"strategies.":[268]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-27T00:00:00"}
