{"id":"https://openalex.org/W7223684584","doi":"https://doi.org/10.1155/crcc/6794847","title":"Case Report: Sepsis With Multisystemic Amyloid Light\u2010Chain Amyloidosis","display_name":"Case Report: Sepsis With Multisystemic Amyloid Light\u2010Chain Amyloidosis","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7223684584","doi":"https://doi.org/10.1155/crcc/6794847","pmid":"https://pubmed.ncbi.nlm.nih.gov/42936115","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13700113"},"language":"en","primary_location":{"id":"doi:10.1155/crcc/6794847","doi":"https://doi.org/10.1155/crcc/6794847","is_oa":true,"landing_page_url":"https://doi.org/10.1155/crcc/6794847","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/crcc/6794847","source":{"id":"https://openalex.org/S2764546890","display_name":"Case Reports in Critical Care","issn_l":"2090-6420","issn":["2090-6420","2090-6439"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Case Reports in Critical Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/crcc/6794847","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020871236","display_name":"Mehtap Sel\u00e7uk","orcid":"https://orcid.org/0000-0003-4653-641X","observed_orcids":["https://orcid.org/0000-0003-4653-641X"]},"institutions":[{"id":"https://openalex.org/I322491407","display_name":"Ac\u0131badem University","ror":"https://ror.org/01rp2a061","country_code":"TR","type":"education","lineage":["https://openalex.org/I322491407"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehtap Sel\u00e7uk","raw_affiliation_strings":["Ac\u0131badem Ata\u015fehir Hospital  Istanbul Turkey"],"raw_orcid":"https://orcid.org/0000-0003-4653-641X","affiliations":[{"raw_affiliation_string":"Ac\u0131badem Ata\u015fehir Hospital  Istanbul Turkey","institution_ids":["https://openalex.org/I322491407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159580058","display_name":"Galip Emre K\u0131l\u0131\u00e7aslan","orcid":"https://orcid.org/0000-0002-8217-5730","observed_orcids":["https://orcid.org/0000-0002-8217-5730"]},"institutions":[{"id":"https://openalex.org/I322491407","display_name":"Ac\u0131badem University","ror":"https://ror.org/01rp2a061","country_code":"TR","type":"education","lineage":["https://openalex.org/I322491407"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Galip Emre K\u0131l\u0131\u00e7aslan","raw_affiliation_strings":["Department of Anesthesiology and Reanimation Department of Intensive Care Ac\u0131badem University Medical Faculty  Istanbul Turkey  acibadem.edu.tr"],"raw_orcid":"https://orcid.org/0000-0002-8217-5730","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Reanimation Department of Intensive Care Ac\u0131badem University Medical Faculty  Istanbul Turkey  acibadem.edu.tr","institution_ids":["https://openalex.org/I322491407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120190556","display_name":"Sinem Keskin Kayalar","orcid":"https://orcid.org/0009-0002-3789-2674","observed_orcids":["https://orcid.org/0009-0002-3789-2674"]},"institutions":[{"id":"https://openalex.org/I322491407","display_name":"Ac\u0131badem University","ror":"https://ror.org/01rp2a061","country_code":"TR","type":"education","lineage":["https://openalex.org/I322491407"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sinem Keskin Kayalar","raw_affiliation_strings":["Ac\u0131badem Ata\u015fehir Hospital  Istanbul Turkey"],"raw_orcid":"https://orcid.org/0009-0002-3789-2674","affiliations":[{"raw_affiliation_string":"Ac\u0131badem Ata\u015fehir Hospital  Istanbul Turkey","institution_ids":["https://openalex.org/I322491407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008310786","display_name":"\u0130smail Cinel","orcid":"https://orcid.org/0000-0002-7595-1295","observed_orcids":["https://orcid.org/0000-0002-7595-1295"]},"institutions":[{"id":"https://openalex.org/I322491407","display_name":"Ac\u0131badem University","ror":"https://ror.org/01rp2a061","country_code":"TR","type":"education","lineage":["https://openalex.org/I322491407"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ismail Cinel","raw_affiliation_strings":["Department of Anesthesiology and Reanimation Department of Intensive Care Ac\u0131badem University Medical Faculty  Istanbul Turkey  acibadem.edu.tr"],"raw_orcid":"https://orcid.org/0000-0002-7595-1295","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Reanimation Department of Intensive Care Ac\u0131badem University Medical Faculty  Istanbul Turkey  acibadem.edu.tr","institution_ids":["https://openalex.org/I322491407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008310786"],"corresponding_institution_ids":["https://openalex.org/I322491407"],"apc_list":{"value":790,"currency":"USD","value_usd":790},"apc_paid":{"value":790,"currency":"USD","value_usd":790},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85298913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2026","issue":"1","first_page":"6794847","last_page":"6794847"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-light-chain-amyloidosis","display_name":"systemic light chain amyloidosis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9739999771118164},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cardiac-involvement","display_name":"cardiac involvement","score":0.7369999885559082},{"id":"https://openalex.org/keywords/renal-involvement","display_name":"renal involvement","score":0.9710000157356262},{"id":"https://openalex.org/keywords/ascites","display_name":"ascites","score":0.7850000262260437},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/implantable-cardioverter-defibrillator","display_name":"implantable cardioverter-defibrillator","score":0.8740000128746033},{"id":"https://openalex.org/keywords/vasopressor-support","display_name":"vasopressor therapy","score":0.7760000228881836},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/source-control","display_name":"source control","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8823000192642212},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7293999791145325},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.6784999966621399},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.6068999767303467},{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.5184000134468079},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.507099986076355},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.5033000111579895},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.45509999990463257},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.438400000333786},{"id":"https://openalex.org/C2779551797","wikidata":"https://www.wikidata.org/wiki/Q4652470","display_name":"AL amyloidosis","level":4,"score":0.42980000376701355},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.4097999930381775},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.33889999985694885},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3310000002384186},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.33009999990463257},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.3228999972343445},{"id":"https://openalex.org/C2777607188","wikidata":"https://www.wikidata.org/wiki/Q5038315","display_name":"Cardiac amyloidosis","level":3,"score":0.31929999589920044},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.3188000023365021},{"id":"https://openalex.org/C2909607560","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid disease","level":5,"score":0.3089999854564667},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3027999997138977},{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.29899999499320984},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C2779701055","wikidata":"https://www.wikidata.org/wiki/Q929833","display_name":"Rare disease","level":3,"score":0.2556000053882599},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2538999915122986}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/crcc/6794847","doi":"https://doi.org/10.1155/crcc/6794847","is_oa":true,"landing_page_url":"https://doi.org/10.1155/crcc/6794847","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/crcc/6794847","source":{"id":"https://openalex.org/S2764546890","display_name":"Case Reports in Critical Care","issn_l":"2090-6420","issn":["2090-6420","2090-6439"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Case Reports in Critical Care","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13700113","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13700113/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13700113/pdf/CRCC-2026-6794847.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Case Rep Crit Care","raw_type":"Text"},{"id":"pmid:42936115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42936115","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Case reports in critical care","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:81fb6ecb14094d62918264e89cad4bdf","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/81fb6ecb14094d62918264e89cad4bdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Case Reports in Critical Care, Vol 2026 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/crcc/6794847","doi":"https://doi.org/10.1155/crcc/6794847","is_oa":true,"landing_page_url":"https://doi.org/10.1155/crcc/6794847","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/crcc/6794847","source":{"id":"https://openalex.org/S2764546890","display_name":"Case Reports in Critical Care","issn_l":"2090-6420","issn":["2090-6420","2090-6439"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Case Reports in Critical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223684584.pdf","grobid_xml":"https://content.openalex.org/works/W7223684584.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1974873560","https://openalex.org/W2280404143","https://openalex.org/W2287751418","https://openalex.org/W2800126338","https://openalex.org/W3026743468","https://openalex.org/W3035308610","https://openalex.org/W3038459712","https://openalex.org/W3099862105","https://openalex.org/W3216141366","https://openalex.org/W4302276071","https://openalex.org/W4409696714"],"related_works":["https://openalex.org/W7223654573","https://openalex.org/W4304956782","https://openalex.org/W7149377085","https://openalex.org/W4409250466","https://openalex.org/W7161591917","https://openalex.org/W4413857285","https://openalex.org/W3195619411","https://openalex.org/W7213446692","https://openalex.org/W4414207188","https://openalex.org/W4403606384"],"abstract_inverted_index":{"Introduction":[0],"Systemic":[1],"light\u2010chain":[2],"(AL)":[3],"amyloidosis":[4,56,141],"is":[5],"a":[6,37,40],"complex":[7],"disorder":[8],"characterized":[9],"by":[10],"extracellular":[11],"fibril":[12],"deposition,":[13],"leading":[14],"to":[15,99,131,159],"severe":[16],"multisystem":[17],"dysfunction.":[18],"When":[19],"sepsis":[20,137],"superimposes":[21],"on":[22,58,138],"preexisting":[23,166],"organ":[24,168],"impairment,":[25],"early":[26,150],"clinical":[27,148],"recognition":[28],"becomes":[29],"particularly":[30],"challenging":[31],"yet":[32],"critical.":[33],"Methods":[34],"We":[35],"present":[36],"case":[38],"of":[39],"60\u2010year\u2010old":[41],"female":[42],"who":[43],"presented":[44],"with":[45,54,72,165],"generalized":[46],"edema,":[47],"dyspnea,":[48],"and":[49,64,74,87,111,119,129,145,153],"cardiac/renal":[50],"involvement,":[51],"subsequently":[52,88],"diagnosed":[53],"AL":[55],"based":[57],"laboratory,":[59],"imaging,":[60],"bone":[61],"marrow":[62],"biopsy,":[63],"Congo":[65],"red":[66],"staining":[67],"findings.":[68],"Results":[69],"Following":[70],"chemotherapy":[71],"bortezomib":[73],"cyclophosphamide,":[75],"the":[76,132],"patient":[77],"experienced":[78],"transient":[79],"cardiac":[80],"arrest,":[81],"received":[82],"an":[83],"implantable":[84],"cardioverter":[85],"defibrillator,":[86],"developed":[89],"massive":[90],"ascites.":[91],"Upon":[92],"developing":[93],"Pseudomonas":[94],"guariconensis":[95],"bacteremia,":[96],"she":[97],"progressed":[98],"septic":[100],"shock":[101],"requiring":[102],"intensive":[103],"care":[104,118],"unit":[105],"admission,":[106],"mechanical":[107],"ventilation,":[108],"vasopressor":[109],"support,":[110],"targeted":[112,155],"antimicrobial":[113],"therapy.":[114],"Through":[115],"aggressive":[116],"supportive":[117],"source":[120],"control,":[121],"hemodynamic":[122],"stabilization":[123],"was":[124],"achieved,":[125],"allowing":[126],"successful":[127],"extubation":[128],"transfer":[130],"general":[133],"ward.":[134],"Conclusions":[135],"Superimposed":[136],"severe,":[139],"multi\u2010organ":[140],"significantly":[142],"complicates":[143],"diagnosis":[144],"management.":[146],"High":[147],"vigilance,":[149],"infection":[151],"recognition,":[152],"prompt":[154],"therapy":[156],"are":[157],"essential":[158],"prevent":[160],"fatal":[161],"outcomes":[162],"in":[163],"patients":[164],"chronic":[167],"dysfunctions.":[169]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-27T00:00:00"}