{"id":"https://openalex.org/W7223681950","doi":"https://doi.org/10.1038/s41419-026-09237-4","title":"Calpain-5 mediates STIP1 degradation via triggering N-degron pathway to suppress epithelial ovarian cancer progression and CAPN5low-STIP1high status indicates Pimitespib susceptibility","display_name":"Calpain-5 mediates STIP1 degradation via triggering N-degron pathway to suppress epithelial ovarian cancer progression and CAPN5low-STIP1high status indicates Pimitespib susceptibility","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223681950","doi":"https://doi.org/10.1038/s41419-026-09237-4"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-026-09237-4","doi":"https://doi.org/10.1038/s41419-026-09237-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-026-09237-4","pdf_url":"https://www.nature.com/articles/s41419-026-09237-4_reference.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-026-09237-4_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5128830823","display_name":"Xiaolu Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolu Ma","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159689871","display_name":"Ling Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Hu","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101821100","display_name":"Lin Yang","orcid":"https://orcid.org/0000-0003-1547-8990","observed_orcids":["https://orcid.org/0000-0003-1547-8990"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Yang","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019546892","display_name":"Kai Zhou","orcid":"https://orcid.org/0000-0002-1231-1151","observed_orcids":["https://orcid.org/0000-0002-1231-1151"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaixia Zhou","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":"https://orcid.org/0000-0002-1231-1151","affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063663279","display_name":"Tianqing Yan","orcid":"https://orcid.org/0000-0003-3410-0395","observed_orcids":["https://orcid.org/0000-0003-3410-0395"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianqing Yan","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128877900","display_name":"Zhiyun Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyun Gong","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128900681","display_name":"Chen Shan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Shan","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159654591","display_name":"Ning Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Guo","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159711539","display_name":"Suhong Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suhong Xie","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159724995","display_name":"Hui Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Zheng","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086759438","display_name":"Ying Tong","orcid":"https://orcid.org/0000-0002-8460-0585","observed_orcids":["https://orcid.org/0000-0002-8460-0585"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Tong","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102011531","display_name":"Heng Zhang","orcid":"https://orcid.org/0000-0001-6426-3940","observed_orcids":["https://orcid.org/0000-0001-6426-3940"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Heng Zhang","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322813","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0002-8150-5486","observed_orcids":["https://orcid.org/0000-0002-8150-5486"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanchun Wang","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048417173","display_name":"Cuncun Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cuncun Chen","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077600873","display_name":"Lin Guo","orcid":"https://orcid.org/0000-0002-8419-3350","observed_orcids":["https://orcid.org/0000-0002-8419-3350"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Guo","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":"https://orcid.org/0000-0002-8419-3350","affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048843854","display_name":"Renquan Lu","orcid":"https://orcid.org/0000-0003-3291-5742","observed_orcids":["https://orcid.org/0000-0003-3291-5742","https://orcid.org/0000-0002-3199-2271","https://orcid.org/0000-0003-3564-5979"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Renquan Lu","raw_affiliation_strings":["Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China"],"raw_orcid":"https://orcid.org/0000-0003-3291-5742","affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical School, Fudan University, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of clinical laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048843854","https://openalex.org/A5077600873"],"corresponding_institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82118809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stip1","display_name":"STIP1","score":0.8809999823570251},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9120000004768372},{"id":"https://openalex.org/keywords/n-degron-pathway","display_name":"N-degron pathway","score":0.9800000190734863},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6079999804496765},{"id":"https://openalex.org/keywords/pimitespib","display_name":"pimitespib","score":0.7549999952316284},{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cisplatin-combination-therapy","display_name":"cisplatin combination therapy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7580000162124634},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7139999866485596},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6671000123023987},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6377999782562256},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5742999911308289},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5038999915122986},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4925999939441681},{"id":"https://openalex.org/C2992773878","wikidata":"https://www.wikidata.org/wiki/Q7645976","display_name":"Epithelial ovarian cancer","level":4,"score":0.43790000677108765},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4106999933719635},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.3732999861240387},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3619000017642975},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.36000001430511475},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3571999967098236},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3382999897003174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33809998631477356},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.33090001344680786},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33009999990463257},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3273000121116638},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2800000011920929},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.25440001487731934}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41419-026-09237-4","doi":"https://doi.org/10.1038/s41419-026-09237-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-026-09237-4","pdf_url":"https://www.nature.com/articles/s41419-026-09237-4_reference.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41419-026-09237-4","doi":"https://doi.org/10.1038/s41419-026-09237-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-026-09237-4","pdf_url":"https://www.nature.com/articles/s41419-026-09237-4_reference.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1429879718","display_name":null,"funder_award_id":"82373383","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1464145423","display_name":null,"funder_award_id":"81800190","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2262814874","display_name":null,"funder_award_id":"82372332","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2392796337","display_name":null,"funder_award_id":"81772774","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5801975114","display_name":null,"funder_award_id":"81772808","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7480806850","display_name":null,"funder_award_id":"19ZR1410300","funder_id":"https://openalex.org/F4320309612","funder_display_name":"Natural Science Foundation of Shanghai"},{"id":"https://openalex.org/G8379561274","display_name":null,"funder_award_id":"82072876","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320309612","display_name":"Natural Science Foundation of Shanghai","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223681950.pdf","grobid_xml":"https://content.openalex.org/works/W7223681950.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1660690186","https://openalex.org/W2619565683","https://openalex.org/W2323042018","https://openalex.org/W3022993181","https://openalex.org/W2754857535","https://openalex.org/W4390499342","https://openalex.org/W2600794193","https://openalex.org/W4289523710","https://openalex.org/W3106873655","https://openalex.org/W2162928279"],"abstract_inverted_index":{"Abstract":[0],"Rapid":[1],"progression":[2,163],"is":[3,174],"considered":[4],"the":[5,9,18,53,99,120,129,134,141,145,186],"major":[6],"contributor":[7],"to":[8,132,189,204],"poor":[10],"prognosis":[11],"of":[12,38,57,102,125,137],"epithelial":[13],"ovarian":[14],"cancer":[15],"(EOC),":[16],"while":[17,62],"underlying":[19],"mechanism":[20],"remains":[21],"elusive.":[22],"Herein,":[23],"we":[24],"identified":[25],"that":[26,93,111],"Calpain-5":[27],"(CAPN5),":[28],"a":[29,43,86,166,175,194],"well-known":[30],"protease,":[31],"was":[32],"significantly":[33],"downregulated":[34],"across":[35],"various":[36],"types":[37],"EOC,":[39,58,90],"and":[40,55,164,193],"acted":[41],"as":[42,182,201],"protective":[44],"indicator":[45,203],"for":[46,185],"prognosis.":[47],"Phenotypically,":[48],"CAPN5":[49,65,70,77,103,112,173,195],"overexpression":[50],"greatly":[51],"restrained":[52],"proliferation":[54],"invasion":[56],"but":[59],"induced":[60],"apoptosis,":[61],"knocking":[63],"down":[64],"exerted":[66,78],"opposite":[67],"effects.":[68],"Moreover,":[69],"markedly":[71],"inhibited":[72],"epithelial-to-mesenchymal":[73],"transition":[74],"(EMT).":[75],"Mechanistically,":[76],"its":[79],"inhibitory":[80],"effect":[81,168],"mainly":[82],"via":[83],"downregulating":[84],"STIP1,":[85,126],"well-recognized":[87],"oncoprotein":[88],"in":[89,178],"evidenced":[91],"by":[92,140,180],"silencing":[94],"STIP1":[95,114,138,147,191],"could":[96],"almost":[97],"abolish":[98],"promotional":[100],"effects":[101],"knockdown":[104],"on":[105],"EOC":[106,162,179],"progression.":[107],"Further":[108],"experiments":[109],"demonstrated":[110],"catalyzes":[113],"cleavage":[115],"at":[116],"R160":[117],"residue,":[118],"exposing":[119],"novel":[121,176],"Asn-initiated":[122],"N-terminal":[123],"fragment":[124,139,148],"which":[127],"triggered":[128],"Arg/N-degron":[130],"pathway":[131,188],"mediate":[133],"K169":[135],"ubiquitination":[136],"ATE1-UBR4":[142],"cascade.":[143],"Consequently,":[144],"ubiquitinated":[146],"underwent":[149],"proteasomal":[150],"degradation.":[151],"Notably,":[152],"applying":[153],"an":[154,183,202],"approved":[155],"HSP90i,":[156],"Pimitespib,":[157],"can":[158],"effectively":[159],"suppress":[160],"CAPN5-low/STIP1-high":[161],"exert":[165],"synergetic":[167],"with":[169],"Cisplatin.":[170],"In":[171],"summary,":[172],"suppressor":[177],"acting":[181],"initiator":[184],"N-degron":[187],"induce":[190],"degradation,":[192],"low":[196],"-STIP1":[197],"high":[198],"status":[199],"served":[200],"guide":[205],"Pimitespib":[206],"application.":[207]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-27T00:00:00"}
