{"id":"https://openalex.org/W7223680667","doi":"https://doi.org/10.1021/acs.bioconjchem.6c00447","title":"High-Throughput Polymer Design for the Biological Interface","display_name":"High-Throughput Polymer Design for the Biological Interface","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223680667","doi":"https://doi.org/10.1021/acs.bioconjchem.6c00447"},"language":"en","primary_location":{"id":"doi:10.1021/acs.bioconjchem.6c00447","doi":"https://doi.org/10.1021/acs.bioconjchem.6c00447","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.bioconjchem.6c00447","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010195063","display_name":"Supraja S. Chittari","orcid":"https://orcid.org/0000-0002-5010-5201","observed_orcids":["https://orcid.org/0000-0002-5010-5201"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Supraja S. Chittari","raw_affiliation_strings":["Rutgers, The State University of New Jersey , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers, The State University of New Jersey , , , ,","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078913363","display_name":"Adam J. Gormley","orcid":"https://orcid.org/0000-0002-2884-725X","observed_orcids":["https://orcid.org/0000-0002-2884-725X"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adam J. Gormley","raw_affiliation_strings":["Rutgers, The State University of New Jersey , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-2884-725X","affiliations":[{"raw_affiliation_string":"Rutgers, The State University of New Jersey , , , ,","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078913363"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65343291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10405","display_name":"Advanced Polymer Synthesis and Characterization","score":0.2078000009059906,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.033900000154972076,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-polymers","display_name":"synthetic polymers","score":0.8949999809265137},{"id":"https://openalex.org/keywords/polymer-libraries","display_name":"polymer libraries","score":0.6309999823570251},{"id":"https://openalex.org/keywords/flow-chemistry","display_name":"flow chemistry","score":0.8360000252723694},{"id":"https://openalex.org/keywords/polymer-screening","display_name":"polymer screening","score":0.7200000286102295},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.6209999918937683},{"id":"https://openalex.org/keywords/active-learning-machine-learning","display_name":"active learning (machine learning)","score":0.984000027179718},{"id":"https://openalex.org/keywords/self-driving-laboratories","display_name":"self-driving laboratories","score":0.9399999976158142},{"id":"https://openalex.org/keywords/agentic-ai","display_name":"agentic AI","score":0.9459999799728394},{"id":"https://openalex.org/keywords/inverse-design","display_name":"inverse design","score":0.9139999747276306},{"id":"https://openalex.org/keywords/polymer-therapeutics","display_name":"polymer therapeutics","score":0.9120000004768372},{"id":"https://openalex.org/keywords/biomaterials","display_name":"biomaterials","score":0.890999972820282},{"id":"https://openalex.org/keywords/biointerfaces","display_name":"biointerfaces","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.8241000175476074},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.6341000199317932},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6082000136375427},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.5486999750137329},{"id":"https://openalex.org/C99726746","wikidata":"https://www.wikidata.org/wiki/Q906396","display_name":"Chemical space","level":3,"score":0.5223000049591064},{"id":"https://openalex.org/C2992437751","wikidata":"https://www.wikidata.org/wiki/Q2105334","display_name":"Synthetic polymer","level":3,"score":0.4959999918937683},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4677000045776367},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.4523000121116638},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.4230000078678131},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39750000834465027},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.3458999991416931},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3312999904155731},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.2838999927043915},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.2720000147819519},{"id":"https://openalex.org/C139366241","wikidata":"https://www.wikidata.org/wiki/Q135707","display_name":"Interface design","level":2,"score":0.26249998807907104}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.bioconjchem.6c00447","doi":"https://doi.org/10.1021/acs.bioconjchem.6c00447","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.bioconjchem.6c00447","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":172,"referenced_works":["https://openalex.org/W1994072009","https://openalex.org/W2000106654","https://openalex.org/W2001186298","https://openalex.org/W2030751103","https://openalex.org/W2051663914","https://openalex.org/W2053545296","https://openalex.org/W2068145833","https://openalex.org/W2072623061","https://openalex.org/W2086842774","https://openalex.org/W2107660675","https://openalex.org/W2135001556","https://openalex.org/W2155534998","https://openalex.org/W2292454015","https://openalex.org/W2324024515","https://openalex.org/W2324492353","https://openalex.org/W2334332185","https://openalex.org/W2345159782","https://openalex.org/W2401559891","https://openalex.org/W2500581099","https://openalex.org/W2582007578","https://openalex.org/W2589743080","https://openalex.org/W2757831499","https://openalex.org/W2759655425","https://openalex.org/W2783030561","https://openalex.org/W2788471465","https://openalex.org/W2794774374","https://openalex.org/W2803069581","https://openalex.org/W2804012963","https://openalex.org/W2804806053","https://openalex.org/W2893976143","https://openalex.org/W2897269192","https://openalex.org/W2899261262","https://openalex.org/W2913300369","https://openalex.org/W2913828003","https://openalex.org/W2946620032","https://openalex.org/W2946684719","https://openalex.org/W2972712117","https://openalex.org/W2979555018","https://openalex.org/W2996239208","https://openalex.org/W2999449264","https://openalex.org/W2999882638","https://openalex.org/W3024101285","https://openalex.org/W3038606466","https://openalex.org/W3048377477","https://openalex.org/W3109043226","https://openalex.org/W3111451620","https://openalex.org/W3121210675","https://openalex.org/W3130634898","https://openalex.org/W3137583597","https://openalex.org/W3138661848","https://openalex.org/W3153313963","https://openalex.org/W3169838168","https://openalex.org/W3177708691","https://openalex.org/W3177828909","https://openalex.org/W3177829108","https://openalex.org/W3196846102","https://openalex.org/W3198463521","https://openalex.org/W3211080104","https://openalex.org/W4206305868","https://openalex.org/W4206504811","https://openalex.org/W4210352128","https://openalex.org/W4212772324","https://openalex.org/W4214653918","https://openalex.org/W4221101088","https://openalex.org/W4282913691","https://openalex.org/W4285077066","https://openalex.org/W4285171740","https://openalex.org/W4285245078","https://openalex.org/W4290642591","https://openalex.org/W4296126283","https://openalex.org/W4308326693","https://openalex.org/W4309438657","https://openalex.org/W4311576160","https://openalex.org/W4312839013","https://openalex.org/W4313281033","https://openalex.org/W4313450975","https://openalex.org/W4319079872","https://openalex.org/W4323543695","https://openalex.org/W4360949780","https://openalex.org/W4362458646","https://openalex.org/W4366424371","https://openalex.org/W4366609985","https://openalex.org/W4367357905","https://openalex.org/W4367609753","https://openalex.org/W4367609934","https://openalex.org/W4381510318","https://openalex.org/W4382502012","https://openalex.org/W4383483602","https://openalex.org/W4383982233","https://openalex.org/W4384835774","https://openalex.org/W4385459199","https://openalex.org/W4385520852","https://openalex.org/W4385568216","https://openalex.org/W4385693793","https://openalex.org/W4385740652","https://openalex.org/W4386169291","https://openalex.org/W4387732896","https://openalex.org/W4387935342","https://openalex.org/W4388566470","https://openalex.org/W4388578922","https://openalex.org/W4389132715","https://openalex.org/W4389386901","https://openalex.org/W4389941644","https://openalex.org/W4389961427","https://openalex.org/W4389987917","https://openalex.org/W4390331331","https://openalex.org/W4391853808","https://openalex.org/W4392862899","https://openalex.org/W4392963110","https://openalex.org/W4394835724","https://openalex.org/W4394907678","https://openalex.org/W4395005421","https://openalex.org/W4396541530","https://openalex.org/W4399309416","https://openalex.org/W4399523329","https://openalex.org/W4400274639","https://openalex.org/W4400280779","https://openalex.org/W4400359497","https://openalex.org/W4401535000","https://openalex.org/W4401636213","https://openalex.org/W4401694629","https://openalex.org/W4402295723","https://openalex.org/W4402412897","https://openalex.org/W4402570645","https://openalex.org/W4404596492","https://openalex.org/W4404751823","https://openalex.org/W4405811690","https://openalex.org/W4406151254","https://openalex.org/W4407348879","https://openalex.org/W4407349636","https://openalex.org/W4407597319","https://openalex.org/W4407661197","https://openalex.org/W4407953715","https://openalex.org/W4409256661","https://openalex.org/W4409424544","https://openalex.org/W4409788037","https://openalex.org/W4411606062","https://openalex.org/W4411882225","https://openalex.org/W4412474579","https://openalex.org/W4412487897","https://openalex.org/W4412664960","https://openalex.org/W4413286690","https://openalex.org/W4413391729","https://openalex.org/W4413682855","https://openalex.org/W4413956280","https://openalex.org/W4414934153","https://openalex.org/W4415644978","https://openalex.org/W4415681958","https://openalex.org/W4415707284","https://openalex.org/W7115733578","https://openalex.org/W7117163162","https://openalex.org/W7118011688","https://openalex.org/W7118080577","https://openalex.org/W7125813078","https://openalex.org/W7128297028","https://openalex.org/W7128777314","https://openalex.org/W7130656780","https://openalex.org/W7133326240","https://openalex.org/W7133345940","https://openalex.org/W7138939310","https://openalex.org/W7140095772","https://openalex.org/W7140272171","https://openalex.org/W7155941557","https://openalex.org/W7160532680","https://openalex.org/W7161995294","https://openalex.org/W7162391847","https://openalex.org/W7162670309","https://openalex.org/W7163426584","https://openalex.org/W7165956966","https://openalex.org/W7167839345","https://openalex.org/W7168051341","https://openalex.org/W7168260385"],"related_works":["https://openalex.org/W6977611836","https://openalex.org/W4389334473","https://openalex.org/W3110641297","https://openalex.org/W4318070558","https://openalex.org/W2034286210","https://openalex.org/W2141895247","https://openalex.org/W2505125307","https://openalex.org/W2943243030","https://openalex.org/W59276399","https://openalex.org/W2502906304"],"abstract_inverted_index":{"Abstract":[0],"High-throughput":[1],"experimentation":[2],"is":[3],"transforming":[4],"synthetic":[5,23,46,98],"polymer":[6,67,169],"design":[7,19,128],"for":[8,35,74,146],"biological":[9,41,85],"applications,":[10],"enabling":[11],"data-driven":[12],"approaches":[13],"that":[14,38,60],"map":[15],"the":[16,93,134,144,165],"vast":[17],"chemical":[18],"space":[20],"accessible":[21],"to":[22,65,101,125,163],"macromolecules.":[24],"In":[25],"this":[26],"Viewpoint,":[27],"we":[28,105],"survey":[29],"recent":[30],"advances":[31],"in":[32,82,140],"high-throughput":[33,123],"methodologies":[34],"discovering":[36],"polymers":[37,99],"interface":[39],"with":[40,122],"systems.":[42],"We":[43,69,87,132],"first":[44],"review":[45],"strategies,":[47],"such":[48],"as":[49],"well-plate":[50],"polymerizations,":[51],"immobilized":[52],"and":[53,56,79,84,114,129,143,155,171],"solid-phase":[54],"synthesis,":[55,153],"continuous":[57],"flow":[58],"chemistry,":[59],"enable":[61],"parallelized,":[62],"miniaturized":[63],"access":[64],"large":[66],"libraries.":[68],"then":[70],"discuss":[71],"screening":[72],"methods":[73],"structural":[75],"characterization,":[76,154],"target-binding":[77],"interactions,":[78],"functional":[80],"performance":[81],"cellular":[83],"contexts.":[86],"highlight":[88],"how":[89,107],"these":[90,152],"readouts":[91],"capture":[92],"disordered,":[94],"dynamic":[95],"nature":[96],"of":[97,136,167],"relative":[100],"structured":[102],"biomacromolecules.":[103],"Finally,":[104],"examine":[106],"machine":[108],"learning,":[109,111],"active":[110],"self-driving":[112],"laboratories,":[113],"emerging":[115],"agentic":[116],"AI":[117],"tools":[118],"are":[119],"being":[120],"integrated":[121],"workflows":[124],"accelerate":[126,164],"inverse":[127],"autonomous":[130],"experimentation.":[131],"underscore":[133],"potential":[135],"increasingly":[137],"automated":[138],"discovery":[139,166],"future":[141],"years":[142],"need":[145],"rigorous,":[147],"application-appropriate":[148],"workflow":[149],"design.":[150],"Together,":[151],"computational":[156],"strategies":[157],"form":[158],"a":[159],"synergistic":[160],"pipeline":[161],"poised":[162],"next-generation":[168],"therapeutics":[170],"biomaterials.":[172]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-27T00:00:00"}
