{"id":"https://openalex.org/W7223679779","doi":"https://doi.org/10.18203/2319-2003.ijbcp20263782","title":"PCSK9 rs11591147 polymorphism and response to atorvastatin in patients with type 2 diabetes mellitus and/or hypertension","display_name":"PCSK9 rs11591147 polymorphism and response to atorvastatin in patients with type 2 diabetes mellitus and/or hypertension","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223679779","doi":"https://doi.org/10.18203/2319-2003.ijbcp20263782"},"language":"en","primary_location":{"id":"doi:10.18203/2319-2003.ijbcp20263782","doi":"https://doi.org/10.18203/2319-2003.ijbcp20263782","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2319-2003.ijbcp20263782","pdf_url":"https://www.ijbcp.com/index.php/ijbcp/article/download/6496/4151","source":{"id":"https://openalex.org/S2764844374","display_name":"International Journal of Basic & Clinical Pharmacology","issn_l":"2279-0780","issn":["2279-0780","2319-2003"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Basic &amp; Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ijbcp.com/index.php/ijbcp/article/download/6496/4151","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159643485","display_name":"Smita Tripathi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114546181","display_name":"Lady Hardinge Medical College","ror":"https://ror.org/03x8jdc94","country_code":"IN","type":"education","lineage":["https://openalex.org/I110166357","https://openalex.org/I114546181"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Smita Tripathi","raw_affiliation_strings":["Department of Biochemistry, Lady Hardinge Medical College, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Lady Hardinge Medical College, New Delhi, India","institution_ids":["https://openalex.org/I114546181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105933632","display_name":"Ghan Shyam Pangtey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114546181","display_name":"Lady Hardinge Medical College","ror":"https://ror.org/03x8jdc94","country_code":"IN","type":"education","lineage":["https://openalex.org/I110166357","https://openalex.org/I114546181"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ghan Shyam Pangtey","raw_affiliation_strings":["Department of Medicine, Lady Hardinge Medical College, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Lady Hardinge Medical College, New Delhi, India","institution_ids":["https://openalex.org/I114546181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159664876","display_name":"Animesh Ray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Animesh Ray","raw_affiliation_strings":["Department of Medicine, AIIMS, Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, AIIMS, Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159716715","display_name":"Subhradip Karmakar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subhradip Karmakar","raw_affiliation_strings":["Department of Biochemistry, AIIMS, Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, AIIMS, Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84183383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"6","first_page":"1297","last_page":"1301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pcsk9","display_name":"PCSK9","score":0.9810000061988831},{"id":"https://openalex.org/keywords/loss-of-function-variants","display_name":"loss-of-function mutations","score":0.9430000185966492},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.9490000009536743},{"id":"https://openalex.org/keywords/statin-response","display_name":"statin response","score":0.9779999852180481},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":1.0},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9049999713897705},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6930000185966492},{"id":"https://openalex.org/keywords/statin-naive-patients","display_name":"statin-naive patients","score":0.8130000233650208},{"id":"https://openalex.org/keywords/north-indian-population","display_name":"North Indian population","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.7260000109672546},{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.7217000126838684},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.6958000063896179},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6869999766349792},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6844000220298767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6500999927520752},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5422000288963318},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.5041000247001648},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43549999594688416},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.421099990606308},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.40619999170303345},{"id":"https://openalex.org/C175239580","wikidata":"https://www.wikidata.org/wiki/Q656595","display_name":"Genotype frequency","level":5,"score":0.3698999881744385},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36910000443458557},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3625999987125397},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3458000123500824},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.3328000009059906},{"id":"https://openalex.org/C2776104379","wikidata":"https://www.wikidata.org/wiki/Q21112670","display_name":"Lipoprotein(a)","level":4,"score":0.29750001430511475},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.27630001306533813},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.2720000147819519},{"id":"https://openalex.org/C76252995","wikidata":"https://www.wikidata.org/wiki/Q3395645","display_name":"Gene polymorphism","level":4,"score":0.27079999446868896},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.2612999975681305},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.25519999861717224}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18203/2319-2003.ijbcp20263782","doi":"https://doi.org/10.18203/2319-2003.ijbcp20263782","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2319-2003.ijbcp20263782","pdf_url":"https://www.ijbcp.com/index.php/ijbcp/article/download/6496/4151","source":{"id":"https://openalex.org/S2764844374","display_name":"International Journal of Basic & Clinical Pharmacology","issn_l":"2279-0780","issn":["2279-0780","2319-2003"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Basic &amp; Clinical Pharmacology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18203/2319-2003.ijbcp20263782","doi":"https://doi.org/10.18203/2319-2003.ijbcp20263782","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2319-2003.ijbcp20263782","pdf_url":"https://www.ijbcp.com/index.php/ijbcp/article/download/6496/4151","source":{"id":"https://openalex.org/S2764844374","display_name":"International Journal of Basic & Clinical Pharmacology","issn_l":"2279-0780","issn":["2279-0780","2319-2003"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Basic &amp; Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223679779.pdf","grobid_xml":"https://content.openalex.org/works/W7223679779.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2003217556","https://openalex.org/W2005335011","https://openalex.org/W2040612932","https://openalex.org/W2104549677","https://openalex.org/W2110124859","https://openalex.org/W2140380288","https://openalex.org/W2140822242","https://openalex.org/W2144861484","https://openalex.org/W2169881636","https://openalex.org/W2274766427","https://openalex.org/W2427995595","https://openalex.org/W2625591229","https://openalex.org/W3129818723","https://openalex.org/W3154607500"],"related_works":["https://openalex.org/W2064662882","https://openalex.org/W4408029580","https://openalex.org/W2274766427","https://openalex.org/W2165813375","https://openalex.org/W2411431695","https://openalex.org/W7131357299","https://openalex.org/W6941070553","https://openalex.org/W2027344602","https://openalex.org/W3024957253","https://openalex.org/W2953309479"],"abstract_inverted_index":{"Background:":[0],"The":[1,81,106],"loss-of-function":[2],"(LOF)":[3],"variant":[4,45],"rs11591147":[5,83],"of":[6,42,108,118],"PCSK9":[7,9,82],"reduces":[8],"activity":[10],"and":[11,20,35,50,93,102,123],"is":[12],"expected":[13],"to":[14,24,53,182,191],"lower":[15],"low-density":[16],"lipoprotein":[17],"cholesterol":[18],"(LDL-C)":[19],"improve":[21],"the":[22,40,43,51,94,109,142,168,180],"response":[23,52,181],"statins,":[25],"meaning":[26],"a":[27],"greater":[28],"LDL-C":[29,127,146,177],"reduction.":[30],"However,":[31],"studies":[32],"are":[33,189],"few":[34],"inconsistent.":[36],"This":[37],"study":[38],"explored":[39],"association":[41],"LOF":[44,110,169],"with":[46,61,115,175,179],"baseline":[47,176],"lipid":[48,95],"levels":[49],"atorvastatin":[54,77,148],"in":[55,73,130,145],"statin-na\u00efve":[56],"patients.":[57],"Methods:":[58],"Eligible":[59],"patients":[60],"type":[62],"2":[63],"diabetes":[64],"mellitus":[65],"and/or":[66],"hypertension":[67],"from":[68,158],"two":[69],"tertiary":[70],"care":[71],"hospitals":[72],"Delhi":[74],"(n=260)":[75],"received":[76],"for":[78],"10\u201312":[79],"weeks.":[80],"polymorphism":[84,91],"was":[85,99,113,128,141,172],"studied":[86],"by":[87],"PCR-restriction":[88],"fragment":[89],"length":[90],"(PCR-RFLP)":[92],"profile,":[96],"including":[97,186],"LDL-C,":[98],"measured":[100],"before":[101],"after":[103,147],"treatment.":[104],"Results:":[105],"frequency":[107],"T":[111,170],"allele":[112,171],"16.5%,":[114],"genotype":[116],"frequencies":[117],"GG":[119],"66.9%,":[120],"GT":[121,136,152],"33.1%":[122],"TT":[124,187],"0%.":[125],"Baseline":[126],"similar":[129],"both":[131],"groups":[132],"(GG":[133,149],"136.04\u00b143.89":[134],"vs.":[135,151],"134.79\u00b141.38":[137],"mg/dl;":[138],"p=0.813),":[139],"as":[140],"percentage":[143],"fall":[144],"28.7%":[150],"26.9%;":[153],"p=0.386).":[154],"Genotype":[155],"distribution":[156],"deviated":[157],"Hardy\u2013Weinberg":[159],"equilibrium":[160],"(p=0.001).":[161],"Conclusions:":[162],"In":[163],"this":[164],"North":[165],"Indian":[166],"cohort,":[167],"not":[173],"associated":[174],"or":[178],"atorvastatin.":[183],"Larger":[184],"studies,":[185],"homozygotes,":[188],"needed":[190],"confirm":[192],"these":[193],"findings.":[194]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-27T00:00:00"}
