{"id":"https://openalex.org/W7223679554","doi":"https://doi.org/10.22146/jfps.28878","title":"The Effect of Total Flavonoid Content of Butterfly Pea Flower Kombucha on Reducing Serum Total Cholesterol Levels in vitro and in vivo in Rats","display_name":"The Effect of Total Flavonoid Content of Butterfly Pea Flower Kombucha on Reducing Serum Total Cholesterol Levels in vitro and in vivo in Rats","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223679554","doi":"https://doi.org/10.22146/jfps.28878"},"language":"en","primary_location":{"id":"doi:10.22146/jfps.28878","doi":"https://doi.org/10.22146/jfps.28878","is_oa":true,"landing_page_url":"https://doi.org/10.22146/jfps.28878","pdf_url":"https://jurnal.ugm.ac.id/v3/JFPS/article/download/28878/7668","source":{"id":"https://openalex.org/S2738601923","display_name":"Journal of Food and Pharmaceutical Sciences","issn_l":"2089-7200","issn":["2089-7200","2339-0948"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food and Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jurnal.ugm.ac.id/v3/JFPS/article/download/28878/7668","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103753158","display_name":"Agus Suprijono","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agus Suprijono","raw_affiliation_strings":["Semarang Pharmacy Foundation College of Pharmaceutical Science, Semarang, Central Java, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semarang Pharmacy Foundation College of Pharmaceutical Science, Semarang, Central Java, Indonesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092770731","display_name":"Aries Koes Sundoro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aries Koes Sundoro","raw_affiliation_strings":["Semarang Pharmacy Foundation College of Pharmaceutical Science, Semarang, Central Java, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semarang Pharmacy Foundation College of Pharmaceutical Science, Semarang, Central Java, Indonesia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159715338","display_name":"Ariani Hesti Wulan S","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ariani Hesti Wulan S","raw_affiliation_strings":["Semarang Pharmacy Foundation College of Pharmaceutical Science, Semarang, Central Java, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semarang Pharmacy Foundation College of Pharmaceutical Science, Semarang, Central Java, Indonesia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86467652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"579","last_page":"588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13479","display_name":"Food Science and Nutritional Studies","score":0.03480000048875809,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/total-flavonoid-content","display_name":"total flavonoid content","score":0.8460000157356262},{"id":"https://openalex.org/keywords/anthocyanins","display_name":"anthocyanins","score":0.9229999780654907},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cholesterol-lowering","display_name":"cholesterol lowering","score":0.6449999809265137},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8360000252723694},{"id":"https://openalex.org/keywords/functional-beverages","display_name":"functional beverages","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.7081000208854675},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.6593000292778015},{"id":"https://openalex.org/C2778605236","wikidata":"https://www.wikidata.org/wiki/Q1018085","display_name":"Butterfly","level":2,"score":0.6437000036239624},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.635200023651123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5040000081062317},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4235999882221222},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.4074999988079071},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.397599995136261},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.39739999175071716},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3522999882698059},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3447999954223633},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.29420000314712524},{"id":"https://openalex.org/C144027150","wikidata":"https://www.wikidata.org/wiki/Q48803","display_name":"Horticulture","level":1,"score":0.28859999775886536},{"id":"https://openalex.org/C57291850","wikidata":"https://www.wikidata.org/wiki/Q463451","display_name":"Flor","level":2,"score":0.28450000286102295},{"id":"https://openalex.org/C2778945092","wikidata":"https://www.wikidata.org/wiki/Q262547","display_name":"Anthocyanin","level":2,"score":0.2547999918460846}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22146/jfps.28878","doi":"https://doi.org/10.22146/jfps.28878","is_oa":true,"landing_page_url":"https://doi.org/10.22146/jfps.28878","pdf_url":"https://jurnal.ugm.ac.id/v3/JFPS/article/download/28878/7668","source":{"id":"https://openalex.org/S2738601923","display_name":"Journal of Food and Pharmaceutical Sciences","issn_l":"2089-7200","issn":["2089-7200","2339-0948"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food and Pharmaceutical Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22146/jfps.28878","doi":"https://doi.org/10.22146/jfps.28878","is_oa":true,"landing_page_url":"https://doi.org/10.22146/jfps.28878","pdf_url":"https://jurnal.ugm.ac.id/v3/JFPS/article/download/28878/7668","source":{"id":"https://openalex.org/S2738601923","display_name":"Journal of Food and Pharmaceutical Sciences","issn_l":"2089-7200","issn":["2089-7200","2339-0948"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food and Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6735000014305115}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320338223","display_name":"Direcci\u00f3 General de Recerca, Generalitat de Catalunya","ror":"https://ror.org/01gbnem66"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223679554.pdf","grobid_xml":"https://content.openalex.org/works/W7223679554.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415772255","https://openalex.org/W4400862542","https://openalex.org/W4393154129","https://openalex.org/W4313409259","https://openalex.org/W3206103404","https://openalex.org/W7202280137","https://openalex.org/W7120370532","https://openalex.org/W4408135662","https://openalex.org/W3187365018","https://openalex.org/W2108468234"],"abstract_inverted_index":{"High-cholesterol":[0],"foods":[1],"cause":[2],"metabolic":[3],"disorders":[4],"characterized":[5],"by":[6,20,98,162],"high":[7],"cholesterol":[8,161],"levels.":[9],"Butterfly":[10],"Pea":[11],"Flower":[12],"Kombucha,":[13],"which":[14,117,189],"contains":[15],"anthocyanins":[16],"(flavonoids),":[17],"was":[18],"obtained":[19],"fermenting":[21],"a":[22,30,76,87,139],"mixture":[23],"of":[24,34,45,60,89,104,133,143,165,184],"fresh":[25,70],"butterfly":[26,46,61,71,129,185,198],"pea":[27,47,62,72,130,186,199],"flowers":[28,73],"with":[29,57,75,86],"SCOBY":[31],"(Symbiotic":[32],"culture":[33],"bacteria":[35],"and":[36,68,111,136,150,157,175],"yeast).":[37],"This":[38,193],"study":[39,55,194],"aimed":[40],"to":[41,102],"determine":[42],"the":[43,58,182],"effect":[44,183],"flower":[48,63,131,187,200],"kombucha":[49,64,132,188,201],"in":[50,96],"reducing":[51],"total":[52,140],"cholesterol.":[53,192,204],"The":[54,125,155],"began":[56],"production":[59],"from":[65],"30%,":[66,134],"40%,":[67,135],"50%":[69,137],"fermented":[74,100],"SCOBY.":[77],"Total":[78],"flavonoid":[79,141],"levels":[80,93],"were":[81,94,119],"determined":[82,95],"using":[83],"visible":[84],"spectrophotometry":[85],"wavelength":[88],"439.00":[90],"nm.":[91],"Cholesterol":[92],"vivo":[97],"feeding":[99],"tea":[101],"groups":[103],"white":[105],"rats":[106],"(C-,":[107],"C+,":[108],"S1,":[109],"S2,":[110],"S3)":[112],"for":[113,122],"10":[114],"days,":[115],"after":[116],"they":[118],"fed":[120],"lard":[121],"14":[123],"days.":[124],"results":[126],"showed":[127,181],"that":[128,196],"had":[138],"content":[142],"55.75":[144],"+":[145,148,152,167,170,173,177],"0.656,":[146],"84.59":[147],"1.912,":[149],"154.38":[151],"0.476":[153],"mgQE/100mL.":[154],"sample":[156],"control":[158],"could":[159],"reduce":[160,203],"an":[163],"average":[164],"11.83":[166],"0.94%,":[168],"21.14":[169],"1.58%,":[171],"31.36":[172],"0.98%,":[174],"32.85":[176],"1.17%.":[178],"Statistical":[179],"tests":[180],"can":[190,202],"lower":[191],"shows":[195],"consuming":[197]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-27T00:00:00"}