{"id":"https://openalex.org/W7223678320","doi":"https://doi.org/10.1002/adma.75118","title":"Programmable Engineered Living Vehicles as Autonomous Biofactories for Synergistic Osteomyelitis Management and Bone Regeneration","display_name":"Programmable Engineered Living Vehicles as Autonomous Biofactories for Synergistic Osteomyelitis Management and Bone Regeneration","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223678320","doi":"https://doi.org/10.1002/adma.75118","pmid":"https://pubmed.ncbi.nlm.nih.gov/42929733"},"language":"en","primary_location":{"id":"doi:10.1002/adma.75118","doi":"https://doi.org/10.1002/adma.75118","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adma.75118","pdf_url":null,"source":{"id":"https://openalex.org/S99352657","display_name":"Advanced Materials","issn_l":"0935-9648","issn":["0935-9648","1521-4095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113481822","display_name":"Yang Lan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Lan","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100617835","display_name":"Xuemin Liu","orcid":"https://orcid.org/0000-0002-5853-8116","observed_orcids":["https://orcid.org/0000-0002-5853-8116"]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuemin Liu","raw_affiliation_strings":["Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-5853-8116","affiliations":[{"raw_affiliation_string":"Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai P. R. China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021951519","display_name":"Zhifeng SHI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhifeng Shi","raw_affiliation_strings":["Medical Devices Research & Testing Center South China University of Technology  Guangzhou P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Devices Research & Testing Center South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159662653","display_name":"Yuanlong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanlong Li","raw_affiliation_strings":["Orthopedics Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopedics Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou P. R. China","institution_ids":["https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083391614","display_name":"Ani Chi","orcid":"https://orcid.org/0009-0008-1035-9689","observed_orcids":["https://orcid.org/0009-0008-1035-9689"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ani Chi","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159719637","display_name":"Jiaqian Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaqian Zheng","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100932612","display_name":"Ye Tan","orcid":"https://orcid.org/0009-0000-4678-0813","observed_orcids":["https://orcid.org/0009-0000-4678-0813"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tan Ye","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China"],"raw_orcid":"https://orcid.org/0009-0000-4678-0813","affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159708059","display_name":"Chuang Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuang Xiao","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159619667","display_name":"Rui Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Zheng","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124932786","display_name":"Yifan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Yang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012733242","display_name":"Xuetao Shi","orcid":"https://orcid.org/0000-0003-3896-5097","observed_orcids":["https://orcid.org/0000-0003-3896-5097"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuetao Shi","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China"],"raw_orcid":"https://orcid.org/0000-0003-3896-5097","affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103115651","display_name":"Xufeng Zhu","orcid":"https://orcid.org/0009-0004-7931-6186","observed_orcids":["https://orcid.org/0009-0004-7931-6186"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xufeng Zhu","raw_affiliation_strings":["School of Ocean and Tropical Medicine The Marine Biomedical Research Institute Guangdong Medical University  Zhanjiang P. R. China"],"raw_orcid":"https://orcid.org/0009-0004-7931-6186","affiliations":[{"raw_affiliation_string":"School of Ocean and Tropical Medicine The Marine Biomedical Research Institute Guangdong Medical University  Zhanjiang P. R. China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024742812","display_name":"Muyuan Chai","orcid":"https://orcid.org/0000-0002-7955-2363","observed_orcids":["https://orcid.org/0000-0002-7955-2363"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Muyuan Chai","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-7955-2363","affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"National Engineering Research Centre For Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101464990","display_name":"Shengtao Yan","orcid":"https://orcid.org/0000-0003-3011-0051","observed_orcids":["https://orcid.org/0000-0003-3011-0051"]},"institutions":[{"id":"https://openalex.org/I2801051648","display_name":"China-Japan Friendship Hospital","ror":"https://ror.org/037cjxp13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801051648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengtao Yan","raw_affiliation_strings":["Department of Emergency China\u2010Japan Friendship Hospital  Beijing P. R. China"],"raw_orcid":"https://orcid.org/0000-0003-3011-0051","affiliations":[{"raw_affiliation_string":"Department of Emergency China\u2010Japan Friendship Hospital  Beijing P. R. China","institution_ids":["https://openalex.org/I2801051648"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":6070,"currency":"USD","value_usd":6070},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75775054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.7401999831199646,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.7401999831199646,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.07530000060796738,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteomyelitis","display_name":"osteomyelitis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.8289999961853027},{"id":"https://openalex.org/keywords/escherichia-coli-nissle-1917","display_name":"Escherichia coli Nissle 1917","score":0.9369999766349792},{"id":"https://openalex.org/keywords/biofilm-penetration","display_name":"biofilm penetration","score":0.6650000214576721},{"id":"https://openalex.org/keywords/lysostaphin","display_name":"lysostaphin","score":0.8610000014305115},{"id":"https://openalex.org/keywords/vasoactive-intestinal-peptide","display_name":"vasoactive intestinal peptide","score":0.9890000224113464},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9580000042915344},{"id":"https://openalex.org/keywords/drug-resistant-infections","display_name":"drug-resistant infections","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2775893736","wikidata":"https://www.wikidata.org/wiki/Q25324110","display_name":"Biomanufacturing","level":2,"score":0.6140999794006348},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.5867000222206116},{"id":"https://openalex.org/C512993513","wikidata":"https://www.wikidata.org/wiki/Q1068107","display_name":"Chassis","level":2,"score":0.5170000195503235},{"id":"https://openalex.org/C2780551157","wikidata":"https://www.wikidata.org/wiki/Q938983","display_name":"Osteomyelitis","level":2,"score":0.506600022315979},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.43529999256134033},{"id":"https://openalex.org/C2778673385","wikidata":"https://www.wikidata.org/wiki/Q5874320","display_name":"Lysostaphin","level":4,"score":0.42410001158714294},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4032000005245209},{"id":"https://openalex.org/C25516864","wikidata":"https://www.wikidata.org/wiki/Q1665949","display_name":"Interconnectivity","level":2,"score":0.36899998784065247},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.34119999408721924},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.32089999318122864},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.3208000063896179},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3077999949455261},{"id":"https://openalex.org/C9043230","wikidata":"https://www.wikidata.org/wiki/Q262657","display_name":"Microbial toxins","level":3,"score":0.3061000108718872},{"id":"https://openalex.org/C2776184637","wikidata":"https://www.wikidata.org/wiki/Q6506039","display_name":"Living systems","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2736999988555908},{"id":"https://openalex.org/C3020434087","wikidata":"https://www.wikidata.org/wiki/Q835718","display_name":"Opportunistic pathogen","level":4,"score":0.26759999990463257},{"id":"https://openalex.org/C134066672","wikidata":"https://www.wikidata.org/wiki/Q1424639","display_name":"Payload (computing)","level":3,"score":0.26579999923706055},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26420000195503235},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.25850000977516174},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.25270000100135803},{"id":"https://openalex.org/C2781336494","wikidata":"https://www.wikidata.org/wiki/Q5210237","display_name":"Dalbavancin","level":5,"score":0.25029999017715454}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/adma.75118","doi":"https://doi.org/10.1002/adma.75118","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adma.75118","pdf_url":null,"source":{"id":"https://openalex.org/S99352657","display_name":"Advanced Materials","issn_l":"0935-9648","issn":["0935-9648","1521-4095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Materials","raw_type":"journal-article"},{"id":"pmid:42929733","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42929733","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced materials (Deerfield Beach, Fla.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1595241211","https://openalex.org/W1833757183","https://openalex.org/W1966223820","https://openalex.org/W1972422447","https://openalex.org/W1991170357","https://openalex.org/W2000046950","https://openalex.org/W2043007466","https://openalex.org/W2062229108","https://openalex.org/W2083299002","https://openalex.org/W2148903697","https://openalex.org/W2156124327","https://openalex.org/W2171389339","https://openalex.org/W2545187638","https://openalex.org/W2550813149","https://openalex.org/W2604693432","https://openalex.org/W2762816177","https://openalex.org/W2803479625","https://openalex.org/W2950956759","https://openalex.org/W2951832587","https://openalex.org/W2967933500","https://openalex.org/W2981614789","https://openalex.org/W2982665975","https://openalex.org/W3166692572","https://openalex.org/W3174561819","https://openalex.org/W3178081083","https://openalex.org/W3183795942","https://openalex.org/W3217560133","https://openalex.org/W4206677002","https://openalex.org/W4211008331","https://openalex.org/W4212885218","https://openalex.org/W4214686079","https://openalex.org/W4220702606","https://openalex.org/W4221060164","https://openalex.org/W4298127946","https://openalex.org/W4306411918","https://openalex.org/W4366496923","https://openalex.org/W4385691296","https://openalex.org/W4387140966","https://openalex.org/W4387440676","https://openalex.org/W4387501961","https://openalex.org/W4387568373","https://openalex.org/W4388140917","https://openalex.org/W4388464492","https://openalex.org/W4396721167","https://openalex.org/W4396746532","https://openalex.org/W4399302728","https://openalex.org/W4399607722","https://openalex.org/W4400569889","https://openalex.org/W4403451246","https://openalex.org/W4404832114","https://openalex.org/W4408423674","https://openalex.org/W4408535956","https://openalex.org/W4409154663","https://openalex.org/W4411009957","https://openalex.org/W4411079441","https://openalex.org/W4412421026","https://openalex.org/W4412490658","https://openalex.org/W4412655048","https://openalex.org/W4414783674","https://openalex.org/W4415243878","https://openalex.org/W7117462270","https://openalex.org/W7124710003","https://openalex.org/W7133224430","https://openalex.org/W7135066093","https://openalex.org/W7150217324","https://openalex.org/W7161109333"],"related_works":["https://openalex.org/W4390977749","https://openalex.org/W4415054049","https://openalex.org/W7161109333","https://openalex.org/W7169855492","https://openalex.org/W7220733747","https://openalex.org/W4409485759","https://openalex.org/W4405983644","https://openalex.org/W7151637460","https://openalex.org/W4296037366","https://openalex.org/W4408988865"],"abstract_inverted_index":{"ABSTRACT":[0],"Conventional":[1],"static":[2],"biomaterials":[3],"and":[4,12,24,33,76,102,155],"synthetic":[5,185],"nanomedicines":[6],"struggle":[7],"to":[8,20,148,189],"penetrate":[9,153],"recalcitrant":[10],"biofilms":[11],"orchestrate":[13],"tissue":[14],"regeneration":[15],"in":[16,158],"deep\u2010seated":[17],"infections":[18],"due":[19],"limited":[21],"autonomous":[22,45],"navigation":[23,129],"a":[25,35,56,110,127,132,176],"lack":[26],"of":[27,51,98],"spatiotemporal":[28],"responsiveness.":[29],"Here,":[30],"we":[31,86],"conceptualize":[32],"develop":[34],"programmable":[36],"engineered":[37,87],"living":[38,68,182],"vehicle":[39],"(ELV)":[40],"that":[41,93],"functions":[42],"as":[43,126],"an":[44],"biofactory":[46],"for":[47,179],"the":[48,149,166],"synergistic":[49],"management":[50],"drug\u2010resistant":[52],"osteomyelitis.":[53],"Built":[54],"upon":[55],"self\u2010propelled":[57],"Escherichia":[58],"coli":[59],"Nissle":[60],"1917":[61],"chassis":[62],"with":[63,73,109,187],"innate":[64],"ecological":[65],"dominance,":[66],"these":[67],"biofactories":[69,145],"are":[70],"hierarchically":[71],"equipped":[72],"environmental":[74],"biosensors":[75],"logic\u2010gated":[77],"computing":[78],"modules.":[79],"Crucially,":[80],"leveraging":[81],"AlphaFold":[82],"3\u2010guided":[83],"molecular":[84],"docking,":[85],"multiscale":[88],"thermo\u2010responsive":[89],"genetic":[90],"logic":[91],"circuits":[92],"enable":[94],"precise,":[95],"temperature\u2010dependent":[96],"biomanufacturing":[97],"bacteriolytic":[99],"lysostaphin":[100],"(LYS)":[101],"vasoactive":[103],"intestinal":[104],"peptide":[105],"(VIP)":[106],"(\u226537\u00b0C),":[107],"coupled":[108],"fail\u2010safe":[111],"thermal":[112],"self\u2010destruct":[113],"mechanism":[114],"(\u226542\u00b0C).":[115],"Furthermore,":[116],"surface\u2010engineered":[117],"(DSS)":[118],"6":[119],"peptides":[120],"confer":[121],"robust":[122],"hydroxyapatite":[123],"affinity,":[124],"acting":[125],"bone\u2010homing":[128],"module.":[130],"In":[131],"rat":[133],"osteomyelitis":[134],"model":[135],"induced":[136],"by":[137],"methicillin\u2010resistant":[138],"Staphylococcus":[139],"aureus":[140],"(MRSA),":[141],"intravenously":[142],"deployed":[143],"ELV":[144],"autonomously":[146],"navigate":[147],"infected":[150],"niche,":[151],"actively":[152],"biofilms,":[154],"outperform":[156],"vancomycin":[157],"pathogen":[159],"clearance.":[160],"Concurrently,":[161],"localized":[162],"payload":[163],"secretion":[164],"reprograms":[165],"osteo\u2010immune":[167],"microenvironment,":[168],"significantly":[169],"accelerating":[170],"bone":[171],"repair.":[172],"This":[173],"work":[174],"establishes":[175],"versatile":[177],"paradigm":[178],"next\u2010generation":[180],"smart":[181],"therapeutics,":[183],"bridging":[184],"biology":[186],"micro\u2010engineering":[188],"address":[190],"complex":[191],"clinical":[192],"challenges.":[193]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-27T00:00:00"}